KEGG ENZYME: 4.2.3.11

ENZYME: 4.2.3.11

Entry

EC 4.2.3.11                 Enzyme

Name

sabinene-hydrate synthase;
sabinene hydrate cyclase

Class

Lyases;
Carbon-oxygen lyases;
Acting on phosphates

Sysname

geranyl-diphosphate diphosphate-lyase (cyclizing, sabinene-hydrate-forming)

Reaction(IUBMB)

geranyl diphosphate + H2O = sabinene hydrate + diphosphate [RN:R02006]

Reaction(KEGG)

R02006

Substrate

geranyl diphosphate [CPD:C00341];
H2O [CPD:C00001]

Product

sabinene hydrate [CPD:C02462];
diphosphate [CPD:C00013]

Comment

Both cis- and trans- isomers of sabinene hydrate are formed. (3R)-Linalyl diphosphate is an intermediate in the reaction

History

EC 4.2.3.11 created 1992 as EC 4.6.1.9, transferred 2000 to EC 4.2.3.11

Pathway

ec00902

Monoterpenoid biosynthesis

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Reference

1 [PMID:3401015]

Authors

Hallahan TW, Croteau R.

Title

Monoterpene biosynthesis: demonstration of a geranyl pyrophosphate:sabinene hydrate cyclase in soluble enzyme preparations from sweet marjoram (Majorana hortensis).

Journal

Arch Biochem Biophys 264:618-31 (1988)
DOI:10.1016/0003-9861(88)90328-1

Reference

2 [PMID:2916845]

Authors

Hallahan TW, Croteau R.

Title

Monoterpene biosynthesis: mechanism and stereochemistry of the enzymatic cyclization of geranyl pyrophosphate to (+)-cis- and (+)-trans-sabinene hydrate.

Journal

Arch Biochem Biophys 269:313-26 (1989)
DOI:10.1016/0003-9861(89)90113-6

Other DBs

ExplorEnz - The Enzyme Database:

4.2.3.11

IUBMB Enzyme Nomenclature:

4.2.3.11

ExPASy - ENZYME nomenclature database:

4.2.3.11

BRENDA, the Enzyme Database:

4.2.3.11

CAS:	117164-95-1

LinkDB

DBGET integrated database retrieval system