KEGG ENZYME: 4.2.3.118

ENZYME: 4.2.3.118

Entry

EC 4.2.3.118                Enzyme

Name

2-methylisoborneol synthase;
sco7700;
2-MIB cyclase;
MIB synthase;
MIBS

Class

Lyases;
Carbon-oxygen lyases;
Acting on phosphates

Sysname

(E)-2-methylgeranyl-diphosphate diphosphate-lyase (cyclizing, 2-methylisoborneol-forming)

Reaction(IUBMB)

(E)-2-methylgeranyl diphosphate + H2O = 2-methylisoborneol + diphosphate [RN:R09973]

Reaction(KEGG)

R09973

Substrate

(E)-2-methylgeranyl diphosphate [CPD:C20235];
H2O [CPD:C00001]

Product

2-methylisoborneol [CPD:C20243];
diphosphate [CPD:C00013]

Comment

The product, 2-methylisoborneol, is a characteristc odiferous compound with a musty smell produced by soil microorganisms.

History

EC 4.2.3.118 created 2012

Orthology

K16218

2-methylisoborneol synthase

Genes

PFUV:

NLK61_22620

PFO:	Pfl01_1841

PGY:	AWU82_02175

PATA:

JWU58_18120

PZE:	HU754_010805

PSAM:

HU731_003800

PASG:

KSS96_10535

PIE:	HU724_009960

PFIT:

KJY40_10575

PQE:	OSC50_14730

NANN:

O0S08_17685

NBR:	O3I_014430

NNO:	NONO_c25610

NTP:	CRH09_13810

NOZ:	DMB37_04600

NOD:	FOH10_10105

NAH:	F5544_16850

NAD:	NCTC11293_03086

NWL:	NWFMUON74_46170

NIE:	KV110_12995

NHU:	H0264_35815

NYA:	LTV02_08300

NGP:	LTT66_01310

NSPU:

IFM12276_42340

NYU:	D7D52_22670

NVU:	V7968_22160

SCO:	SCO7700(SCBAC12C8.01)

SGR:

SGR_1269

SANL:

KZO11_31020

SGRF:

SGFS_015730

SCB:	SCAB_5041 SCAB_82161

SVL:	Strvi_5648

SRC:	M271_41390

SMAL:

SMALA_1169

SSOI:

I1A49_09325

SFA:

Sfla_5667

SBH:

SBI_08957

SVE:

SVEN_7111

SDV:	BN159_8264

STRP:

F750_0931

SCI:	B446_04425

SLV:	SLIV_00800

SVT:	SVTN_32730

STRE:

GZL_00392 GZL_09219

SLD:	T261_0348 T261_0999

SLC:	SL103_24335

STRM:

M444_04660

STRC:

AA958_14455

SAMB:

SAM23877_0409

SPAV:

Spa2297_00460

STRT:

A8713_31595

SCLF:

BB341_02180

SGS:	AVL59_27410 AVL59_29235 AVL59_39200

STSI:

A4E84_39415

SALW:

CP975_03255

SGM:	GCM10017557_74180

SCAD:

DN051_34585

SLS:	SLINC_0498

SNR:	SNOUR_01185 SNOUR_41450

SALU:

DC74_7952

SALL:

SAZ_41055

SNW:	BBN63_07290

SAUO:

BV401_09615

SPUN:

BFF78_28970 BFF78_39085

SGV:	B1H19_05230 B1H19_35415

SLAU:

SLA_6491

SALJ:

SMD11_0058(mibs) SMD11_0841(mibs)

SLX:	SLAV_04745

STRO:

STRMOE7_31125

SFK:

KY5_0684

SGE:	DWG14_07887

SRJ:

SRO_0472

SCYA:

EJ357_44455

SKA:	CP970_39580

SGZ:	C0216_28055

SVN:	CP980_02680

SHAW:

CEB94_39485

SRK:	FGW37_01930 FGW37_32355

SFIC:

EIZ62_30005

SPAD:

DVK44_33305

SAQU:

EJC51_43075

SGF:	HEP81_00455

SRIM:

CP984_02515

SSUB:

CP968_00375

SPHV:

F9278_00485 F9278_03905

SCIN:

CP977_29565

SCHA:

CP983_40850

SGX:	H4W23_02775

SBAT:

G4Z16_17840

SNF:	JYK04_07625

SPLA:

CP981_14275

SBRO:

GQF42_05890

STUI:

GCM10017668_01900

SHUN:

DWB77_01162

SFEU:

IM697_25785

SMOB:

J7W19_26425

SROI:

IAG44_02635

SXN:	IAG42_34310

SANU:

K7396_32465

SLF:	JEQ17_04895

SDEC:

L3078_05395 L3078_40635(tcp)

SAOV:

G3H79_01805 G3H79_34955 G3H79_38800

SDUR:

M4V62_02700

SYAN:

NRK68_31495

SAKB:

K1J60_03050(tcp) K1J60_40655

STAA:

LDH80_06875

SNIG:

HEK616_77090

SCAE:

IHE65_04050 IHE65_40850

STUB:

MMF93_30825

SSPN:

LXH13_02485

SCIR:

STRCI_000420

SXT:	KPP03845_100514

SLON:

LGI35_41050

STUD:

STRTU_004586

SGK:	PET44_03230

SANT:

QR300_37550

SYUN:

MOV08_01420 MOV08_42815

SOV:	QZH56_01770

SKG:	KJK29_37670

SCOA:

QU709_43165

SLAI:

P8A22_06355

SFP:	QUY26_00845

STTN:

BSL84_31405

SINN:

ABB07_34905

SLUO:

PS467_03685

SRPA:

HEP86_15335

SCAJ:

O1G22_28890 O1G22_37855

STRW:

QHG49_32920

STRL:

HEP84_02280

SRPZ:

HEP85_02540

SGLY:

P8A20_32910

STII:

DRB96_31980

STIC:

DRB89_31385

SABD:

N8I86_04490

STRV:

EZV63_00780

SPAZ:

ABXI76_05695

SPIH:

ABXR15_02990

SMOD:

POD33_32245

KSK:

KSE_70210

KIT:	CFP65_5033 CFP65_6965

KIS:	HUT16_33510

KCH:	O1G21_03200

YIA:	LO772_33755

AGLA:

OIE69_40505

AREV:

RVR_1458

NDA:

Ndas_2620

NAL:

B005_4057

NEX:	NE857_13500

NEC:	KGD82_17075

NAKE:

KGD83_12565

NCG:	KGD84_21200

SNAH:

OUQ99_11115

ACTW:

F7P10_26540

AGRA:

AGRA3207_007829

AMAZ:

LUW76_36550

ACIR:

OG979_09485

ACTQ:

OG417_08210

NOA:	BKM31_10725

NOW:	GBF35_07420

NGN:	LCN96_30650

NFS:	OIE67_17575

SEN:

SACE_3722

SACG:

FDZ84_36940

AMD:

AMED_3240

AMN:

RAM_16480

AMM:

AMES_3205

AMZ:

B737_3205

AOI:

AORI_4062

AJA:	AJAP_18590

AMYC:

CU254_16060

AMYB:

BKN51_13190

AAB:	A4R43_03950

AMYY:

YIM_16995

AORI:

SD37_20725

APRT:

MUY14_19220

AROO:

NQK81_00545

ACOR:

LCL61_24255

AMYZ:

HUW46_02312(tpc)

ANW:	QP939_44945

AMYE:

MJQ72_07835

AMYS:

CVV72_07845

PSDS:

K1T35_39390

SESP:

BN6_59350

SSYI:

EKG83_30420

KAL:

KALB_4605

KUT:	JJ691_11940

KBR:	Q4V65_45065

KPHY:

AOZ06_24430

LED:	BBK82_32020

ALO:

CRK56091

CROS:

N8J89_36205

UME:	RM788_47965

ASE:

ACPL_2023

ACTS:

ACWT_1901

AIH:	Aiant_63900

ACTL:

L3i22_020270

ASIC:

Q0Z83_001890

AOU:	ACTOB_001988

ATL:	Athai_37800

CAI:	Caci_4612 Caci_4614

SNA:

Snas_1991

» show all

Reference

1 [PMID:18563898]

Authors

Wang CM, Cane DE

Title

Biochemistry and molecular genetics of the biosynthesis of the earthy odorant methylisoborneol in Streptomyces coelicolor.

Journal

J Am Chem Soc 130:8908-9 (2008)
DOI:10.1021/ja803639g

Sequence

[sco:SCO7700]

Reference

2 [PMID:18492804]

Authors

Komatsu M, Tsuda M, Omura S, Oikawa H, Ikeda H

Title

Identification and functional analysis of genes controlling biosynthesis of 2-methylisoborneol.

Journal

Proc Natl Acad Sci U S A 105:7422-7 (2008)
DOI:10.1073/pnas.0802312105

Sequence

[sen:SACE_3722] [ag:CAJ89344 BAI77523]

Reference

3 [PMID:21174459]

Authors

Giglio S, Chou WK, Ikeda H, Cane DE, Monis PT

Title

Biosynthesis of 2-methylisoborneol in cyanobacteria.

Journal

Environ Sci Technol 45:992-8 (2011)
DOI:10.1021/es102992p

Other DBs

ExplorEnz - The Enzyme Database:

4.2.3.118

IUBMB Enzyme Nomenclature:

4.2.3.118

ExPASy - ENZYME nomenclature database:

4.2.3.118

BRENDA, the Enzyme Database:

4.2.3.118

LinkDB

DBGET integrated database retrieval system