KEGG   ENZYME: 4.2.3.134
Entry
EC 4.2.3.134                Enzyme                                 
Name
5-phosphooxy-L-lysine phospho-lyase;
5-phosphohydroxy-L-lysine ammoniophospholyase;
AGXT2L2 (gene name);
(5R)-5-phosphonooxy-L-lysine phosphate-lyase (deaminating;
(S)-2-amino-6-oxohexanoate-forming);
5-phosphonooxy-L-lysine phospho-lyase
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
Sysname
(5R)-5-phosphooxy-L-lysine phosphate-lyase (deaminating; (S)-2-amino-6-oxohexanoate-forming)
Reaction(IUBMB)
(5R)-5-phosphooxy-L-lysine + H2O = (S)-2-amino-6-oxohexanoate + NH3 + phosphate [RN:R10270]
Reaction(KEGG)
R10270
Substrate
(5R)-5-phosphooxy-L-lysine [CPD:C03366];
H2O [CPD:C00001]
Product
(S)-2-amino-6-oxohexanoate [CPD:C04076];
NH3 [CPD:C00014];
phosphate [CPD:C00009]
Comment
A pyridoxal-phosphate protein. Has no activity with phosphoethanolamine (cf. EC 4.2.3.2, ethanolamine-phosphate phospho-lyase).
History
EC 4.2.3.134 created 2012
Pathway
ec00310  Lysine degradation
ec01100  Metabolic pathways
Orthology
K18202  5-phosphonooxy-L-lysine phospho-lyase
Genes
HSA85007(PHYKPL)
PTR462320(PHYKPL)
PPS100991193(PHYKPL)
GGO101136630(PHYKPL)
PON100442768(PHYKPL)
NLE100580387(PHYKPL)
HMH116471924(PHYKPL)
MCC702302(PHYKPL)
MCF102115019(PHYKPL)
MTHB126956912
MNI105484094(PHYKPL)
CSAB103245075(PHYKPL)
CATY105590382(PHYKPL)
PANU101007803(PHYKPL)
TGE112625788(PHYKPL)
MLEU105529816(PHYKPL)
RRO104661301(PHYKPL)
RBB108544791(PHYKPL)
TFN117065405(PHYKPL)
PTEH111527442(PHYKPL)
CANG105519537(PHYKPL)
CJC100391170(PHYKPL)
SBQ101029497(PHYKPL)
CIMI108295924(PHYKPL)
CSYR103255435(PHYKPL)
MMUR105883868(PHYKPL)
LCAT123623435(PHYKPL)
PCOQ105818603(PHYKPL)
OGA100962753(PHYKPL)
MMU72947(Phykpl)
MCAL110305400(Phykpl)
MPAH110331232(Phykpl)
RNO100169747(Phykpl)
MCOC116077091(Phykpl)
ANU117710440(Phykpl)
MUN110549636(Phykpl)
CGE100767825(Phykpl)
MAUA106020746(Phykpl)
PROB127219326(Phykpl)
PLEU114683057(Phykpl)
MORG121456299(Phykpl)
MFOT126510892
AAMP119811257(Phykpl)
NGI103734701(Phykpl)
HGL101713270(Phykpl)
CPOC100724331(Phykpl)
CCAN109690864(Phykpl)
DORD105996766(Phykpl)
DSP122115417(Phykpl)
PLOP125342199(Phykpl)
NCAR124986816
MMMA107148143(Phykpl)
OCU100338220
OPI101522878(PHYKPL)
TUP102467962(PHYKPL)
GVR103589038(PHYKPL)
CFA481448(PHYKPL)
CLUD112659609(PHYKPL)
VVP112932462(PHYKPL)
VLG121494744(PHYKPL)
NPO129494724(PHYKPL)
AML100466352(PHYKPL)
UMR103679971(PHYKPL)
UAH113261578(PHYKPL)
UAR123790469(PHYKPL)
ELK111158929
LLV125099939
MPUF101687819(PHYKPL)
MNP132027404(PHYKPL)
MLK131832626(PHYKPL)
NVS122915973(PHYKPL)
ORO101377479(PHYKPL)
EJU114200462(PHYKPL)
ZCA113928645(PHYKPL)
MLX118016518(PHYKPL)
NSU110591164(PHYKPL)
LWW102732075(PHYKPL)
FCA101098679(PHYKPL)
PYU121010539(PHYKPL)
PCOO112861189(PHYKPL)
PBG122486224(PHYKPL)
LRUF124514876
PTG102972570(PHYKPL)
PPAD109278946(PHYKPL)
PUC125935382
AJU106969712
HHV120246965(PHYKPL)
BTA537241(PHYKPL)
BOM102276016(PHYKPL)
BIU109561922(PHYKPL)
BBUB102394904(PHYKPL)
BBIS104993314(PHYKPL)
CHX102191693(PHYKPL)
OAS101108046(PHYKPL)
BTAX128050266(PHYKPL)
ODA120863834(PHYKPL)
CCAD122440015(PHYKPL)
MBEZ129558196(PHYKPL)
SSC100521952(PHYKPL)
CFR102522088(PHYKPL)
CBAI105062024(PHYKPL)
CDK105099607(PHYKPL)
VPC102525733(PHYKPL)
BACU103000047(PHYKPL)
LVE103086842(PHYKPL)
OOR101272238(PHYKPL)
DLE111169819(PHYKPL)
PCAD102981791(PHYKPL)
PSIU116751190(PHYKPL)
NASI112400067(PHYKPL)
ECB100068397(PHYKPL)
EPZ103563672(PHYKPL)
EAI106827133(PHYKPL)
MYB102249621(PHYKPL)
MYD102752367(PHYKPL)
MMYO118659355(PHYKPL)
MLF102428523(PHYKPL)
MNA107529786(PHYKPL)
PKL118711425(PHYKPL)
EFUS103287515(PHYKPL)
HAI109389777(PHYKPL)
DRO112320332(PHYKPL)
SHON118997275(PHYKPL)
AJM119062952(PHYKPL)
PDIC114510362(PHYKPL)
PHAS123807878(PHYKPL)
MMF118616149(PHYKPL)
RFQ117016554(PHYKPL)
PPAM129066728(PHYKPL)
PALE102886040(PHYKPL)
PGIG120616581(PHYKPL)
PVP105293628(PHYKPL)
RAY107517543(PHYKPL)
MJV108396242(PHYKPL)
TOD119237169(PHYKPL)
SARA101544365(PHYKPL)
LAV100665373(PHYKPL)
TMU101355834
ETF101664381(PHYKPL)
DNM101440157(PHYKPL)
MDO100032008(PHYKPL)
GAS123237466(PHYKPL)
SHR100916686(PHYKPL)
AFZ127550300
PCW110216664(PHYKPL)
OAA100088790(PHYKPL)
GGA416374(PHYKPL)
PCOC116232188
MGP100538852
CJO107320110(PHYKPL)
TPAI128084123(PHYKPL)
LMUT125700039(PHYKPL)
NMEL110405158(PHYKPL)
APLA101797808
ACYG106032801(PHYKPL)
CATA118254893(PHYKPL)
AFUL116495029(PHYKPL)
TGU100223371(PHYKPL)
LSR110482692(PHYKPL)
SCAN103817279(PHYKPL)
PMOA120498471(PHYKPL)
OTC121332213(PHYKPL)
PRUF121361453
GFR102042452(PHYKPL)
FAB101818003(PHYKPL)
OMA130258745(PHYKPL)
PHI102111638(PHYKPL)
PMAJ107210644(PHYKPL)
CCAE111935568(PHYKPL)
CCW104689598
CBRC103614661(PHYKPL)
ETL114065203(PHYKPL)
ZAB102067419
ACHL103802152(PHYKPL)
SVG106857369(PHYKPL)
MMEA130577956(PHYKPL)
HRT120759045(PHYKPL)
FPG101922212(PHYKPL)
FCH102056780
CLV102087033(PHYKPL)
EGZ104128431(PHYKPL)
NNI104018449(PHYKPL)
PCRI104025017(PHYKPL)
PLET104614931(PHYKPL)
EHS104504286(PHYKPL)
PCAO104040021(PHYKPL)
ACUN113485134
TALA104357872
PADL103915762(PHYKPL)
AFOR103904410(PHYKPL)
ACHC115334075(PHYKPL)
HALD104314609(PHYKPL)
HLE104838878(PHYKPL)
AGEN126051153
GCL127021929
CCRI104163575(PHYKPL)
CSTI104561399(PHYKPL)
CMAC104474550(PHYKPL)
MUI104534647(PHYKPL)
BREG104630615(PHYKPL)
FGA104072741(PHYKPL)
GSTE104251509(PHYKPL)
LDI104343926(PHYKPL)
MNB103768648(PHYKPL)
OHA104326880(PHYKPL)
NNT104413329(PHYKPL)
SHAB115615876(PHYKPL)
DPUB104309790(PHYKPL)
PGUU104459444(PHYKPL)
ACAR104525322(PHYKPL)
CPEA104386616(PHYKPL)
AVIT104268604(PHYKPL)
CVF104291870(PHYKPL)
RTD128916295(PHYKPL)
CUCA104059243(PHYKPL)
TEO104370487(PHYKPL)
BRHI104496337(PHYKPL)
AAM106487205(PHYKPL)
AROW112964748(PHYKPL)
NPD112954521(PHYKPL)
TGT104568682(PHYKPL)
DNE112984230(PHYKPL)
SCAM104153605(PHYKPL)
ASN102378538
AMJ102560645(PHYKPL)
CPOO109310123(PHYKPL)
GGN109289920(PHYKPL)
PSS102450136(PHYKPL)
CMY102946291(PHYKPL)
CCAY125640785(PHYKPL)
DCC119859757(PHYKPL)
CPIC101930924(PHYKPL)
TST117881616(PHYKPL)
CABI116823418(PHYKPL)
MRV120370971(PHYKPL)
ACS100558326(phykpl)
ASAO132768916(PHYKPL)
PVT110073466(PHYKPL)
SUND121924290
PBI103068075
PMUR107289007
CTIG120310625
TSR106544342(PHYKPL)
PGUT117655608
APRI131191794
PTEX113433779
NSS113424829
VKO123035975(PHYKPL)
PMUA114591310(PHYKPL)
PRAF128407914
ZVI118080388
HCG128344395(PHYKPL)
GJA107112613(PHYKPL)
STOW125429769(PHYKPL)
EMC129327366(PHYKPL)
MUO115476954
GSH117351492(PHYKPL)
DRE557205(phykpl)
SRX107718273 107743705
SANH107683819 107690454
SGH107585546 107601730
CCAR109103449
CAUA113115075
CGIB127972685
PTET122359304(phykpl)
LROH127177152(phykpl)
OMC131520462(phykpl)
PPRM120478579(phykpl)
RKG130096742(phykpl)
MAMB125249736(phykpl)
CIDE127496122
MASI127430088
TROS130564374(phykpl)
TDW130428978(phykpl)
MANU129438003(phykpl)
IPU108277665(phykpl)
IFU128621822(phykpl)
PHYP113533010
SMEO124394453(phykpl)
TFD113660506(phykpl)
TVC132857641(phykpl)
AMEX103047782
CMAO118800825(phykpl)
EEE113579438
CHAR105906708(phykpl)
TRU101079232
TFS130531377(phykpl)
TNGGSTEN00019899G001
LCO104922708(phykpl)
NCC104954680(phykpl)
TBEN117475744(phykpl)
CGOB115014502
PGEO117453362(phykpl)
GACU117555998(phykpl)
ELY117261023(phykpl)
EFO125894158(phykpl)
PLEP121947847(phykpl)
SLUC116064325(phykpl)
ECRA117951631(phykpl)
ESP116697430
PFLV114563060
GAT120816883(phykpl)
PPUG119210534(phykpl)
AFB129089677(phykpl)
CLUM117737274(phykpl)
MSAM119888567(phykpl)
SCHU122880401(phykpl)
CUD121516221(phykpl)
ALAT119007431(phykpl)
MZE101479762
ONL100691570
OAU116329121(phykpl)
OLA101162691(phykpl)
OML112153032(phykpl)
XMA102216628(phykpl)
XCO114138652
XHE116714905
PRET103471244(phykpl)
PFOR103135549(phykpl)
PLAI106962571(phykpl)
PMEI106934000(phykpl)
GAF122837406(phykpl)
PPRL129362479(phykpl)
CVG107101873
CTUL119792440(phykpl)
GMU124860771(phykpl)
NFU107375348(phykpl)
KMR108240593(phykpl)
ALIM106535159(phykpl)
NWH119408495(phykpl)
AOCE111573434(phykpl)
MCEP125008600(phykpl)
CSEM103391016(phykpl)
POV109641283(phykpl)
SSEN122778333(phykpl)
HHIP117769202(phykpl)
HSP118112487(phykpl)
LCF108899216
SDU111226427(phykpl)
SLAL111646524
XGL120785034(phykpl)
HCQ109518729
SSCV125983246
SBIA133508339(phykpl)
PEE133407550(phykpl)
PTAO133484449(phykpl)
BPEC110157619(phykpl)
MALB109973167(phykpl)
BSPL114864017(phykpl)
SJO128362930(phykpl)
SASA100286425(at2l1)
STRU115174637
OTW112220744(phykpl)
OMY110488596(phykpl)
OGO123993237(phykpl)
ONE115130512(phykpl)
OKI109864600(phykpl)
OKE118375781(phykpl)
SALP111965379(phykpl)
SNH120048206(phykpl)
CCLU121544721(phykpl)
ELS105030326
SFM108936849(phykpl)
PKI111855170(phykpl)
AANG118222844(phykpl)
LOC102687348
PSPA121296915(phykpl)
ARUT117413269 117431776 117973737
PSEX120541926(phykpl)
LCM102347768(PHYKPL)
CMK103183728(phykpl)
RTP109925830(phykpl)
CPLA122556636(phykpl)
HOC132823405(phykpl)
LERI129701744(phykpl)
HVI124362607
SGRE126268217
PCLA123746371
CQD128702637
PTRU123510224
ESN126996234
LSM121130434
HSY130628909
 » show all
Reference
1  [PMID:4412716]
  Authors
Tsai CH, Henderson LM
  Title
Degradation of O-phosphohydroxylysine by rat liver. Purification of the phospho-lyase.
  Journal
J Biol Chem 249:5784-9 (1974)
Reference
2  [PMID:22241472]
  Authors
Veiga-da-Cunha M, Hadi F, Balligand T, Stroobant V, Van Schaftingen E
  Title
Molecular identification of hydroxylysine kinase and of ammoniophospholyases acting on 5-phosphohydroxy-L-lysine and phosphoethanolamine.
  Journal
J Biol Chem 287:7246-55 (2012)
DOI:10.1074/jbc.M111.323485
  Sequence
[hsa:85007]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.134
IUBMB Enzyme Nomenclature: 4.2.3.134
ExPASy - ENZYME nomenclature database: 4.2.3.134
BRENDA, the Enzyme Database: 4.2.3.134
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