KEGG   ENZYME: 4.2.3.134
Entry
EC 4.2.3.134                Enzyme                                 
Name
5-phosphooxy-L-lysine phospho-lyase;
5-phosphohydroxy-L-lysine ammoniophospholyase;
AGXT2L2 (gene name);
(5R)-5-phosphonooxy-L-lysine phosphate-lyase (deaminating;
(S)-2-amino-6-oxohexanoate-forming);
5-phosphonooxy-L-lysine phospho-lyase
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
Sysname
(5R)-5-phosphooxy-L-lysine phosphate-lyase (deaminating; (S)-2-amino-6-oxohexanoate-forming)
Reaction(IUBMB)
(5R)-5-phosphooxy-L-lysine + H2O = (S)-2-amino-6-oxohexanoate + NH3 + phosphate [RN:R10270]
Reaction(KEGG)
R10270
Substrate
(5R)-5-phosphooxy-L-lysine [CPD:C03366];
H2O [CPD:C00001]
Product
(S)-2-amino-6-oxohexanoate [CPD:C04076];
NH3 [CPD:C00014];
phosphate [CPD:C00009]
Comment
A pyridoxal-phosphate protein. Has no activity with phosphoethanolamine (cf. EC 4.2.3.2, ethanolamine-phosphate phospho-lyase).
History
EC 4.2.3.134 created 2012
Pathway
ec00310  Lysine degradation
ec01100  Metabolic pathways
Orthology
K18202  5-phosphonooxy-L-lysine phospho-lyase
Genes
HSA85007(PHYKPL)
PTR462320(PHYKPL)
PPS100991193(PHYKPL)
GGO101136630(PHYKPL)
PON100442768(PHYKPL)
NLE100580387(PHYKPL)
MCC702302(PHYKPL)
MCF102115019(PHYKPL)
MTHB126956912
CSAB103245075(PHYKPL)
CATY105590382(PHYKPL)
PANU101007803(PHYKPL)
TGE112625788(PHYKPL)
RRO104661301(PHYKPL)
RBB108544791(PHYKPL)
TFN117065405(PHYKPL)
PTEH111527442(PHYKPL)
CJC100391170(PHYKPL)
SBQ101029497(PHYKPL)
CSYR103255435(PHYKPL)
MMUR105883868(PHYKPL)
LCAT123623435(PHYKPL)
OGA100962753(PHYKPL)
MMU72947(Phykpl)
MCAL110305400(Phykpl)
MPAH110331232(Phykpl)
RNO100169747(Phykpl)
MCOC116077091(Phykpl)
MUN110549636(Phykpl)
CGE100767825(Phykpl)
MAUA106020746(Phykpl)
PLEU114683057(Phykpl)
MORG121456299(Phykpl)
MFOT126510892
AAMP119811257(Phykpl)
NGI103734701(Phykpl)
HGL101713270(Phykpl)
CPOC100724331(Phykpl)
CCAN109690864(Phykpl)
DORD105996766(Phykpl)
DSP122115417(Phykpl)
NCAR124986816
OCU100338220(PHYKPL)
OPI101522878(PHYKPL)
TUP102467962(PHYKPL)
CFA481448(PHYKPL)
CLUD112659609(PHYKPL)
VVP112932462(PHYKPL)
VLG121494744(PHYKPL)
AML100466352(PHYKPL)
UMR103679971(PHYKPL)
UAH113261578(PHYKPL)
UAR123790469(PHYKPL)
ELK111158929
LLV125099939
MPUF101687819(PHYKPL)
ORO101377479(PHYKPL)
EJU114200462(PHYKPL)
ZCA113928645(PHYKPL)
MLX118016518(PHYKPL)
NSU110591164(PHYKPL)
FCA101098679(PHYKPL)
PYU121010539(PHYKPL)
PBG122486224(PHYKPL)
LRUF124514876
PTG102972570(PHYKPL)
PPAD109278946(PHYKPL)
AJU106969712(PHYKPL)
HHV120246965(PHYKPL)
BTA537241(PHYKPL)
BOM102276016(PHYKPL)
BIU109561922(PHYKPL)
BBUB102394904(PHYKPL)
CHX102191693(PHYKPL)
OAS101108046(PHYKPL)
ODA120863834(PHYKPL)
CCAD122440015(PHYKPL)
SSC100521952(PHYKPL)
CFR102522088(PHYKPL)
CBAI105062024(PHYKPL)
CDK105099607(PHYKPL)
VPC102525733(PHYKPL)
BACU103000047(PHYKPL)
LVE103086842(PHYKPL)
OOR101272238(PHYKPL)
DLE111169819(PHYKPL)
PCAD102981791(PHYKPL)
PSIU116751190(PHYKPL)
ECB100068397(PHYKPL)
EPZ103563672(PHYKPL)
EAI106827133(PHYKPL)
MYB102249621(PHYKPL)
MYD102752367(PHYKPL)
MMYO118659355(PHYKPL)
MLF102428523(PHYKPL)
MNA107529786(PHYKPL)
PKL118711425(PHYKPL)
HAI109389777(PHYKPL)
DRO112320332(PHYKPL)
SHON118997275(PHYKPL)
AJM119062952(PHYKPL)
PDIC114510362(PHYKPL)
PHAS123807878(PHYKPL)
MMF118616149(PHYKPL)
RFQ117016554(PHYKPL)
PALE102886040(PHYKPL)
PGIG120616581(PHYKPL)
PVP105293628(PHYKPL)
RAY107517543(PHYKPL)
MJV108396242(PHYKPL)
TOD119237169(PHYKPL)
SARA101544365(PHYKPL)
LAV100665373(PHYKPL)
TMU101355834
DNM101440157(PHYKPL)
MDO100032008(PHYKPL)
GAS123237466(PHYKPL)
SHR100916686(PHYKPL)
PCW110216664(PHYKPL)
OAA100088790(PHYKPL)
GGA416374(PHYKPL)
PCOC116232188
MGP100538852
CJO107320110(PHYKPL)
NMEL110405158(PHYKPL)
APLA101797808
ACYG106032801(PHYKPL)
AFUL116495029(PHYKPL)
TGU100223371(PHYKPL)
LSR110482692(PHYKPL)
SCAN103817279(PHYKPL)
PMOA120498471(PHYKPL)
OTC121332213(PHYKPL)
PRUF121361453
GFR102042452(PHYKPL)
FAB101818003(PHYKPL)
PHI102111638(PHYKPL)
PMAJ107210644(PHYKPL)
CCAE111935568(PHYKPL)
CCW104689598
CBRC103614661(PHYKPL)
ETL114065203(PHYKPL)
ZAB102067419
ACHL103802152(PHYKPL)
FPG101922212(PHYKPL)
FCH102056780
CLV102087033(PHYKPL)
EGZ104128431(PHYKPL)
NNI104018449(PHYKPL)
PLET104614931(PHYKPL)
PCRI104025017(PHYKPL)
ACUN113485134
TALA104357872
PADL103915762(PHYKPL)
AFOR103904410(PHYKPL)
ACHC115334075(PHYKPL)
HALD104314609(PHYKPL)
CCRI104163575(PHYKPL)
CSTI104561399(PHYKPL)
EHS104504286(PHYKPL)
CMAC104474550(PHYKPL)
MUI104534647(PHYKPL)
FGA104072741(PHYKPL)
GSTE104251509(PHYKPL)
LDI104343926(PHYKPL)
MNB103768648(PHYKPL)
OHA104326880(PHYKPL)
NNT104413329(PHYKPL)
DPUB104309790(PHYKPL)
PGUU104459444(PHYKPL)
ACAR104525322(PHYKPL)
AVIT104268604(PHYKPL)
CVF104291870(PHYKPL)
AAM106487205(PHYKPL)
AROW112964748(PHYKPL)
NPD112954521(PHYKPL)
TGT104568682(PHYKPL)
DNE112984230(PHYKPL)
SCAM104153605(PHYKPL)
ASN102378538
AMJ102560645(PHYKPL)
CPOO109310123(PHYKPL)
GGN109289920(PHYKPL)
PSS102450136(PHYKPL)
CMY102946291(PHYKPL)
CPIC101930924(PHYKPL)
TST117881616(PHYKPL)
CABI116823418(PHYKPL)
MRV120370971(PHYKPL)
ACS100558326(phykpl)
PVT110073466(PHYKPL)
SUND121924290
PBI103068075
PMUR107289007
CTIG120310625
TSR106544342(PHYKPL)
PGUT117655608
VKO123035975(PHYKPL)
PMUA114591310(PHYKPL)
ZVI118080388
GJA107112613(PHYKPL)
STOW125429769(PHYKPL)
DRE557205(phykpl)
SRX107718273 107743705
SANH107683819 107690454
SGH107585546 107601730
CCAR109103449
CAUA113115075
PPRM120478579(phykpl)
MAMB125249736(phykpl)
IPU108277665(phykpl)
PHYP113533010
SMEO124394453(phykpl)
TFD113660506(phykpl)
AMEX103047782
EEE113579438
TRU101079232
TNGGSTEN00019899G001
LCO104922708(phykpl)
NCC104954680(phykpl)
CGOB115014502
ELY117261023(phykpl)
EFO125894158(phykpl)
PLEP121947847(phykpl)
SLUC116064325(phykpl)
ECRA117951631(phykpl)
ESP116697430
PFLV114563060
GAT120816883(phykpl)
PPUG119210534(phykpl)
MSAM119888567(phykpl)
CUD121516221(phykpl)
ALAT119007431(phykpl)
MZE101479762
ONL100691570
OAU116329121(phykpl)
OLA101162691(phykpl)
OML112153032(phykpl)
XMA102216628(phykpl)
XCO114138652
XHE116714905
PRET103471244(phykpl)
PFOR103135549(phykpl)
PLAI106962571(phykpl)
PMEI106934000(phykpl)
GAF122837406(phykpl)
CVG107101873
CTUL119792440(phykpl)
GMU124860771(phykpl)
NFU107375348(phykpl)
KMR108240593(phykpl)
ALIM106535159(phykpl)
NWH119408495(phykpl)
AOCE111573434(phykpl)
MCEP125008600(phykpl)
CSEM103391016(phykpl)
POV109641283(phykpl)
SSEN122778333(phykpl)
HHIP117769202(phykpl)
HSP118112487(phykpl)
LCF108899216
SDU111226427(phykpl)
SLAL111646524
XGL120785034(phykpl)
HCQ109518729
BPEC110157619(phykpl)
MALB109973167(phykpl)
BSPL114864017(phykpl)
SASA100286425(at2l1)
STRU115174637
OTW112220744(phykpl)
OMY110488596(phykpl)
OGO123993237(phykpl)
ONE115130512(phykpl)
SALP111965379(phykpl)
SNH120048206(phykpl)
CCLU121544721(phykpl)
ELS105030326
SFM108936849(phykpl)
PKI111855170(phykpl)
AANG118222844(phykpl)
LOC102687348
PSPA121296915(phykpl)
ARUT117413269 117431776 117973737
LCM102347768(PHYKPL)
CMK103183728(phykpl)
RTP109925830(phykpl)
PCLA123746371
PTRU123510224
LSM121130434
 » show all
Reference
1  [PMID:4412716]
  Authors
Tsai CH, Henderson LM
  Title
Degradation of O-phosphohydroxylysine by rat liver. Purification of the phospho-lyase.
  Journal
J Biol Chem 249:5784-9 (1974)
Reference
2  [PMID:22241472]
  Authors
Veiga-da-Cunha M, Hadi F, Balligand T, Stroobant V, Van Schaftingen E
  Title
Molecular identification of hydroxylysine kinase and of ammoniophospholyases acting on 5-phosphohydroxy-L-lysine and phosphoethanolamine.
  Journal
J Biol Chem 287:7246-55 (2012)
DOI:10.1074/jbc.M111.323485
  Sequence
[hsa:85007]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.134
IUBMB Enzyme Nomenclature: 4.2.3.134
ExPASy - ENZYME nomenclature database: 4.2.3.134
BRENDA, the Enzyme Database: 4.2.3.134
LinkDB

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