KEGG   ENZYME: 4.2.3.185
Entry
EC 4.2.3.185                Enzyme                                 
Name
ent-atiserene synthase;
IrKSL4;
AcKSL1;
ApKSL1;
AtKSL1;
AsKSL1
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
Sysname
ent-copalyl-diphosphate diphosphate-lyase (cyclizing, ent-atiserine-forming)
Reaction(IUBMB)
ent-copalyl diphosphate = ent-atiserene + diphosphate [RN:R11850]
Reaction(KEGG)
R11850
Substrate
ent-copalyl diphosphate [CPD:C06089]
Product
ent-atiserene [CPD:C21711];
diphosphate [CPD:C00013]
Comment
Isolated from the plant Isodon rubescens and several species of Aconitum as well as species of Streptomyces.
History
EC 4.2.3.185 created 2017
Reference
1  [PMID:21825154]
  Authors
Smanski MJ, Yu Z, Casper J, Lin S, Peterson RM, Chen Y, Wendt-Pienkowski E, Rajski SR, Shen B.
  Title
Dedicated ent-kaurene and ent-atiserene synthases for platensimycin and platencin biosynthesis.
  Journal
Proc Natl Acad Sci U S A 108:13498-503 (2011)
DOI:10.1073/pnas.1106919108
Reference
2  [PMID:28381502]
  Authors
Jin B, Cui G, Guo J, Tang J, Duan L, Lin H, Shen Y, Chen T, Zhang H, Huang L
  Title
Functional Diversification of Kaurene Synthase-Like Genes in Isodon rubescens.
  Journal
Plant Physiol 174:943-955 (2017)
DOI:10.1104/pp.17.00202
  Sequence
Reference
3  [PMID:37619270]
  Authors
Tian M, Jin B, Chen L, Ma R, Ma Q, Li X, Chen T, Guo J, Ge H, Zhao X, Lai C, Tang J, Cui G, Huang L.
  Title
Functional diversity of diterpene synthases in Aconitum plants.
  Journal
Plant Physiol Biochem 202:107968 (2023)
DOI:10.1016/j.plaphy.2023.107968
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.185
IUBMB Enzyme Nomenclature: 4.2.3.185
ExPASy - ENZYME nomenclature database: 4.2.3.185
BRENDA, the Enzyme Database: 4.2.3.185
LinkDB

DBGET integrated database retrieval system