KEGG   ENZYME: 4.2.3.214
Entry
EC 4.2.3.214                Enzyme                                 
Name
dolasta-1(15),8-diene synthase;
Cg113742 (gene name);
CgDS
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
Sysname
geranylgeranyl-diphosphate diphosphate-lyase [cyclizing, dolasta-1(15),8-diene-forming]
Reaction(IUBMB)
geranylgeranyl diphosphate = (5R,12R,14S)-dolasta-1(15),8-diene + diphosphate [RN:R13229]
Reaction(KEGG)
R13229
Substrate
geranylgeranyl diphosphate [CPD:C00353]
Product
(5R,12R,14S)-dolasta-1(15),8-diene [CPD:C22840];
diphosphate [CPD:C00013]
Comment
Isolated from Colletotrichum gloeosporioides, a pathogenic fungus that causes bitter rot in variety of crops.
History
EC 4.2.3.214 created 2023
Orthology
K27203  dolasta-1(15),8-diene / delta-araneosene synthase
Genes
MGRMGG_07506
PGRIPgNI_04844
CHIGCH63R_06464
Reference
1  [PMID:30277637]
  Authors
Bian G, Rinkel J, Wang Z, Lauterbach L, Hou A, Yuan Y, Deng Z, Liu T, Dickschat JS.
  Title
A Clade II-D Fungal Chimeric Diterpene Synthase from Colletotrichum gloeosporioides Produces Dolasta-1(15),8-diene.
  Journal
Angew Chem Int Ed Engl 57:15887-15890 (2018)
DOI:10.1002/anie.201809954
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.214
IUBMB Enzyme Nomenclature: 4.2.3.214
ExPASy - ENZYME nomenclature database: 4.2.3.214
BRENDA, the Enzyme Database: 4.2.3.214
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