KEGG   ENZYME: 4.2.3.217
Entry
EC 4.2.3.217                Enzyme                                 
Name
somaliensene B synthase;
stsC (gene name)
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
Sysname
geranylfarnesyl-diphosphate diphosphate-lyase (cyclizing, (-)-somaliensene B-forming)
Reaction(IUBMB)
geranylfarnesyl diphosphate = (-)-somaliensene B + diphosphate [RN:R13232]
Reaction(KEGG)
R13232
Substrate
geranylfarnesyl diphosphate [CPD:C04217]
Product
(-)-somaliensene B [CPD:C22842];
diphosphate [CPD:C00013]
Comment
A sesterterpenoid synthase enzyme isolated from the bacterium Streptomyces somaliensis. The enzyme also produces somaliensene A (cf. EC 4.2.3.216, somaliensene A synthase).
History
EC 4.2.3.217 created 2023
Orthology
K27204  somaliensene A/B synthase
Reference
1  [PMID:29553734]
  Authors
Yang Y, Zhang Y, Zhang S, Chen Q, Ma K, Bao L, Tao Y, Yin W, Wang G, Liu H.
  Title
Identification and Characterization of a Membrane-Bound Sesterterpene Cyclase from Streptomyces somaliensis.
  Journal
J Nat Prod 81:1089-1092 (2018)
DOI:10.1021/acs.jnatprod.7b01033
  Sequence
[ag:WP_010468024]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.217
IUBMB Enzyme Nomenclature: 4.2.3.217
ExPASy - ENZYME nomenclature database: 4.2.3.217
BRENDA, the Enzyme Database: 4.2.3.217
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