KEGG   ENZYME: 4.2.3.229
Entry
EC 4.2.3.229                Enzyme                                 
Name
ent-beyerene synthase;
ent-kaurene synthase like 2;
RcKSL4;
OsKSL2;
PpCPS/KS (ambiguous)
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
Sysname
ent-copalyl-diphosphate diphosphate-lyase (cyclizing, ent-beyerene-forming)
Reaction(IUBMB)
ent-copalyl diphosphate = ent-beyerene + diphosphate [RN:R13313]
Reaction(KEGG)
R13313
Substrate
ent-copalyl diphosphate [CPD:C06089]
Product
ent-beyerene [CPD:C22911];
diphosphate [CPD:C00013]
Comment
The enzyme has been shown to occur in castor bean (Ricinus communis) and rice (Oryza sativa). ent-Beyerene is also a product of EC 4.2.3.19 (ent-kaurene synthase) of the moss Physcomitrella patens.
History
EC 4.2.3.229 created 2024
Orthology
K27636  ent-copalyl diphosphate/ent-kaurene/ent-beyerene synthase
K27637  ent-beyerene synthase
Genes
MEAN: 126665073 126681140 126681417 130014690
OSA: 4336962(KSL2)
OBR: 102713627
OGL: 127771036
PPP: 112284636
Reference
1  [PMID:24810014]
  Authors
Jackson AJ, Hershey DM, Chesnut T, Xu M, Peters RJ.
  Title
Biochemical characterization of the castor bean ent-kaurene synthase(-like) family supports quantum chemical view of diterpene cyclization.
  Journal
Phytochemistry 103:13-21 (2014)
DOI:10.1016/j.phytochem.2014.04.005
Reference
2  [PMID:25824047]
  Authors
Tezuka D, Ito A, Mitsuhashi W, Toyomasu T, Imai R.
  Title
The rice ent-KAURENE SYNTHASE LIKE 2 encodes a functional ent-beyerene synthase.
  Journal
Biochem Biophys Res Commun 460:766-71 (2015)
DOI:10.1016/j.bbrc.2015.03.104
  Sequence
[osa:4336962]
Reference
3  [PMID:26248039]
  Authors
Zhan X, Bach SS, Hansen NL, Lunde C, Simonsen HT.
  Title
Additional diterpenes from Physcomitrella patens synthesized by copalyl diphosphate/kaurene synthase (PpCPS/KS).
  Journal
Plant Physiol Biochem 96:110-4 (2015)
DOI:10.1016/j.plaphy.2015.07.011
  Sequence
[ppp:112284636]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.229
IUBMB Enzyme Nomenclature: 4.2.3.229
ExPASy - ENZYME nomenclature database: 4.2.3.229
BRENDA, the Enzyme Database: 4.2.3.229
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