KEGG   ENZYME: 4.2.3.35
Entry
EC 4.2.3.35                 Enzyme                                 
Name
syn-pimara-7,15-diene synthase;
9beta-pimara-7,15-diene synthase;
OsDTS2;
OsKS4
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
Sysname
9alpha-copalyl-diphosphate diphosphate-lyase (9beta-pimara-7,15-diene-forming)
Reaction(IUBMB)
9alpha-copalyl diphosphate = 9beta-pimara-7,15-diene + diphosphate [RN:R09117]
Reaction(KEGG)
R09117
Substrate
9alpha-copalyl diphosphate [CPD:C11902]
Product
9beta-pimara-7,15-diene [CPD:C18225];
diphosphate [CPD:C00013]
Comment
This enzyme is a class I terpene synthase [1]. 9beta-Pimara-7,15-diene is a precursor of momilactones A and B, rice diterpenoid phytoalexins that are produced in response to attack (by a pathogen, elicitor or UV irradiation) and are involved in the defense mechanism of the plant. Momilactone B can also act as an allochemical, being constitutively produced in the root of the plant and secreted to the rhizosphere where it suppresses the growth of neighbouring plants and soil microorganisms [1].
History
EC 4.2.3.35 created 2008
Pathway
ec00904  Diterpenoid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K14046  syn-pimara-7,15-diene synthase
Genes
OSA4335094
DOSAOs04t0179700-01(Os04g0179700)
TAES100873130 100873132 123040055 123040057 123048259 123055484 123184297 123184304
Reference
1  [PMID:15299118]
  Authors
Wilderman PR, Xu M, Jin Y, Coates RM, Peters RJ
  Title
Identification of syn-pimara-7,15-diene synthase reveals functional clustering of terpene synthases involved in rice phytoalexin/allelochemical biosynthesis.
  Journal
Plant Physiol 135:2098-105 (2004)
DOI:10.1104/pp.104.045971
  Sequence
Reference
2  [PMID:15388982]
  Authors
Otomo K, Kanno Y, Motegi A, Kenmoku H, Yamane H, Mitsuhashi W, Oikawa H, Toshima H, Itoh H, Matsuoka M, Sassa T, Toyomasu T
  Title
Diterpene cyclases responsible for the biosynthesis of phytoalexins, momilactones A, B, and oryzalexins A-F in rice.
  Journal
Biosci Biotechnol Biochem 68:2001-6 (2004)
DOI:10.1271/bbb.68.2001
  Sequence
[osa:4335094]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.35
IUBMB Enzyme Nomenclature: 4.2.3.35
ExPASy - ENZYME nomenclature database: 4.2.3.35
BRENDA, the Enzyme Database: 4.2.3.35
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