KEGG ENZYME: 4.2.3.37

ENZYME: 4.2.3.37

Entry

EC 4.2.3.37                 Enzyme

Name

epi-isozizaene synthase;
SCO5222 protein

Class

Lyases;
Carbon-oxygen lyases;
Acting on phosphates

Sysname

(2E,6E)-farnesyl-diphosphate diphosphate-lyase [(+)-epi-isozizaene-forming]

Reaction(IUBMB)

(2E,6E)-farnesyl diphosphate = (+)-epi-isozizaene + diphosphate [RN:R07830]

Reaction(KEGG)

R07830

Substrate

(2E,6E)-farnesyl diphosphate [CPD:C00448]

Product

(+)-epi-isozizaene [CPD:C16269];
diphosphate [CPD:C00013]

Comment

Requires Mg2+ for activity. The displacement of the diphosphate group of farnesyl diphosphate occurs with retention of configuration [1]. In the soil-dwelling bacterium Streptomyces coelicolor A3(2), the product of this reaction is used by EC 1.14.15.39, epi-isozizaene 5-monooxygenase, to produce the sesquiterpene antibiotic albaflavenone [2].

History

EC 4.2.3.37 created 2008

Pathway

ec00909

Sesquiterpenoid and triterpenoid biosynthesis

ec01110

Biosynthesis of secondary metabolites

Orthology

K10156

epi-isozizaene synthase

Genes

NYA:	LTV02_37160

SCO:	SCO5222(SC7E4.19)

SALB:

XNR_1580

SMA:	SAVERM_3032(ezs)

SHY:

SHJG_6335

SHO:	SHJGH_6096

SDV:	BN159_3155(cyc1)

SALS:

SLNWT_2072

SCI:	B446_24610

SLV:	SLIV_12255(cyc1)

SGU:	SGLAU_22460

SCW:	TU94_21765

SAMB:

SAM23877_5010(cyc)

SCX:	AS200_17635

SRW:	TUE45_05742(cyc1)

STRF:

ASR50_23820

SLE:	sle_25180(sle_25180)

SPAV:

Spa2297_22085

STRT:

A8713_21090

SGS:	AVL59_06865

STSI:

A4E84_26810

SKY:	D0C37_09635

SALW:

CP975_23790

SGM:	GCM10017557_26720(cyc1)

SCAD:

DN051_14275

SPHW:

NFX46_06115

SGRS:

V9K83_10655(cyc1)

SLS:	SLINC_5614

SPLU:

LK06_022335

STRD:

NI25_13055

SSIA:

A7J05_12565

SPUN:

BFF78_14835

SALF:

SMD44_05799(eizS)

SFK:

KY5_5348

SNZ:	DC008_23210

SGE:	DWG14_02917(cyc1)

SRJ:

SRO_2586

SDX:	C4B68_13430

SGD:	ELQ87_13275

SCYA:

EJ357_30815

SAST:

CD934_10770

SNQ:	CP978_22465

SKA:	CP970_14420

SGZ:	C0216_13205

SVN:	CP980_02640

SHAW:

CEB94_27435

SGAL:

CP966_24280

SFY:	GFH48_14925

SAQU:

EJC51_32135

SGF:	HEP81_02794

SSEO:

D0Z67_19535

SSUB:

CP968_00775

SFUG:

CNQ36_23695

SPAC:

B1H29_12440

SCHA:

CP983_14570

SCOE:

CP976_28735

SSPB:

CP982_27720

SBRO:

GQF42_28695

STUI:

GCM10017668_47520(cyc1)

SCHF:

IPT68_24085

SCYG:

S1361_25895(cyc1)

SFEU:

IM697_37490

SVD:	CP969_25540

SFB:	CP974_28095

SPRA:

CP972_23860

SROI:

IAG44_13195

SXN:	IAG42_11640

SHK:	J2N69_24775

SDD:	D9753_11945

SACT:

DMT42_26020

SLF:	JEQ17_16415

SAOV:

G3H79_11735

SDUR:

M4V62_15480

SRUG:

F0345_20195

SVIO:

HWN34_08580

SCIR:

STRCI_005416

SLON:

LGI35_28875

STEE:

F3L20_05645

SGK:	PET44_30025

SARG:

HKX69_11540

SJN:	RI060_13605

SCYN:

N8I84_26385

SKG:	KJK29_11465

SCOA:

QU709_13410

SFP:	QUY26_12500

SCHG:

NRO40_27595

SINN:

ABB07_12995

SCAY:

PYS65_11955

KBU:	Q4V64_34945

STPB:

QR97_14165

SMIB:

SMIR_11630

SCAJ:

O1G22_14490

STRW:

QHG49_12470

STRL:

HEP84_33525(cyc1)

STSD:

HEP87_34665(cyc1)

SRPZ:

HEP85_26620(cyc1)

SABD:

N8I86_25190

STRV:

EZV63_24285

SMOD:

POD33_19440 POD33_27395

ARHD:

VSH64_33000

AMYD:

K1T34_47955

» show all

Reference

1 [PMID:16669656]

Authors

Lin X, Hopson R, Cane DE

Title

Genome mining in Streptomyces coelicolor: molecular cloning and characterization of a new sesquiterpene synthase.

Journal

J Am Chem Soc 128:6022-3 (2006)
DOI:10.1021/ja061292s

Sequence

[sco:SCO5222]

Reference

2 [PMID:18234666]

Authors

Zhao B, Lin X, Lei L, Lamb DC, Kelly SL, Waterman MR, Cane DE

Title

Biosynthesis of the sesquiterpene antibiotic albaflavenone in Streptomyces coelicolor A3(2).

Journal

J Biol Chem 283:8183-9 (2008)
DOI:10.1074/jbc.M710421200

Sequence

[sco:SCO5222]

Other DBs

ExplorEnz - The Enzyme Database:

4.2.3.37

IUBMB Enzyme Nomenclature:

4.2.3.37

ExPASy - ENZYME nomenclature database:

4.2.3.37

BRENDA, the Enzyme Database:

4.2.3.37

LinkDB

DBGET integrated database retrieval system