KEGG   ENZYME: 4.3.1.12
Entry
EC 4.3.1.12                 Enzyme                                 
Name
ornithine cyclodeaminase;
ornithine cyclase;
ornithine cyclase (deaminating);
L-ornithine ammonia-lyase (cyclizing)
Class
Lyases;
Carbon-nitrogen lyases;
Ammonia-lyases
Sysname
L-ornithine ammonia-lyase (cyclizing; L-proline-forming)
Reaction(IUBMB)
L-ornithine = L-proline + NH3 [RN:R00671]
Reaction(KEGG)
R00671
Substrate
L-ornithine [CPD:C00077]
Product
L-proline [CPD:C00148];
NH3 [CPD:C00014]
Comment
Requires NAD+. The enzyme is a member of the mu-crystallin protein family [4]. The reaction is stimulated by the presence of ADP or ATP and is inhibited by O2 [2].
History
EC 4.3.1.12 created 1976
Pathway
ec00330  Arginine and proline metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K01750  ornithine cyclodeaminase
Genes
RSAN119404038
SFJSAMEA4384070_0399
EBIEbC_pEb10200380
RPNENCTC8284_02732
RHAEIHV77_05160
RGLCS053_10430
XBAC7S18_00305
VNAPN96_18395
VEJVEJY3_17956
PCQPcP3B5_20880(rapL_2)
PMUIG4G71_13415
PPUPP_3533
PPFPput_2240
PPGPputGB1_1891 PputGB1_2392
PPWPputW619_1731
PPTPPS_2421
PPBPPUBIRD1_2260
PPIYSA_00067
PPXT1E_0019(arcB)
PPUHB479_09255
PPUTL483_18510
PPUNPP4_23000
PPUDDW66_2681
PMONX969_07215
PMOTX970_07190
PMOSO165_013995
PPJRK21_03164
PMOLCLJ08_22330
PFLPFL_3641(arcB)
PPRCPFLCHA0_c36820(arcB1)
PPROPPC_3781
PFNHZ99_06350
PFSPFLU_3970
PFCPflA506_3344(arcB)
PFBVO64_1052
PTVAA957_04000
PVRPverR02_20305
PAZOAYR47_17555
POIBOP93_08860
PFWPF1751_v1c34300(arcB)
PFFPFLUOLIPICF718770
PFXA7318_16940
PENPSEEN1859(arcB)
PBAPSEBR_a2902
PSVPVLB_08190
PSKU771_21045
PALKPSAKL28_35790
PSECCCOS191_1758(arcB2)
PSOSPOS17_3783
PANRA7J50_3626
PSILPMA3_14245
PYMAK972_1815
PPSHG5J76_16275
PVKEPZ47_14800
PDWBV82_1074
PZEHU754_020320
PVWHU752_015660
PTRTHU722_0011025
PXAKSS93_12240
PSAMHU731_005150
PTZHU718_020500
PQIKH389_18225
PSHHHU773_017095
PXNHU772_008750
PASGKSS96_18625
PFAKKSS94_09120
PMUYKSS95_18470
PMAMKSS90_09155
PORYEJA05_09920
PTKEXN22_10180
PZAHU749_015780
PWYHU734_017165
PGFJ0G10_20320
PCRPcryo_1795
PSOPSYCG_09555
PALIA3K91_2015
PSPGAK823_10580
PSYGAK825_10835
PSYPE5677_03335
SINVK8B83_11655
PHAPSHAb0543
PTNPTRA_b0777(ocd)
PPHEPP2015_2157
PBWD172_020060
PEAPESP_b0847(ocd)
PNGPNIG_b0727(ocd)
PAGAPAGA_b0945(ocd)
PCARPC2016_3194
PDVFFU37_17275
GAGGlaag_2847
PMESFX988_01147
PSYPCNPT3_02815
MVSMVIS_1158(arcB)
MYAMORIYA_4287(ocd)
MMAAFR932_11860
KIMG3T16_01960
CBUCBU_1727(arcB)
CBSCOXBURSA331_A1919(arcB)
CBDCBUD_0275(arcB)
CBGCbuG_0108(arcB)
CBCCbuK_0280(arcB)
CEYCleRT_01960(arcB)
MAHMEALZ_0771(arcB)
FTWFTW_0394
FTLFTL_0578
FTAFTA_0612
FTSF92_03155
FTCDA46_105
FTVCH67_891
FTZCH68_625
FTNFTN_1444
FTXAW25_557
FTDAS84_1058
FTYCH70_486
FCFFNFX1_1481
FCNFN3523_1510
FHIFSC454_07450
FPHFphi_1230
FPTBZ13_774
FPIBF30_1477
FPMLA56_960
FPXKU46_82
FPZLA55_1680
FPJLA02_848
FRTF7308_0826
FNAOOM_0787
FNLM973_08425
FRFLO80_08420
FHACDV26_09240
FRXF7310_02730
FRMBBG19_0336
FRCKX01_1779
FADCDH04_07565
FMIF0R74_06155
FOOCGC45_01670
FNNFSC774_03675
FSRKQR59_07540
FGUSD28_05725
AFRIE3E15_03025
AIIE4K63_03275
RHHE0Z06_02870
GAIIMCC3135_33495(rapL)
ADIB5T_03949(arcB)
AXEP40_19150
ZDFAN401_05650
SDFACG33_06465
NBACUN60_08955
RSORSp0483
RSLRPSI07_mp0417(arcB)
RSNRSPO_m00318(arcB)
RSMCMR15_mp10460(arcB)
RSEF504_3884
RSYRSUY_37340(rapL_3)
RPJN234_03465
RPUCDC45_20035
RSGJK151_13975
REHH16_A0689(h16_A0689)
CNCCNE_1c06810(arcB1)
CUHBJN34_03865
REUReut_A2671
RMERmet_0586(arcB)
CTIRALTA_A0646
CBWRR42_m0815 RR42_s1855
CGDCR3_2039
CPAUEHF44_02455 EHF44_14210
COXE0W60_13930
BOKDM82_5356
BOCBG90_5252
BSAVWS86_29670
BURBcep18194_B2542 Bcep18194_B2946
BCHBcen2424_3577
BCMBcenmc03_3943
BCJBCAM0604
BCENDM39_4558
BCEOI35_4500
BAMBamb_5311
BACBamMC406_3492
BCTGEM_5158
BCEDDM42_4486
BCEPAPZ15_21430
BPYRABD05_18790
BCONNL30_22780
BUBBW23_4328
BDFWI26_16910
BTEIWS51_01570
BSEMWJ12_23010
BPSLWS57_10850
BMECWJ16_22040
BSTGWT74_21255 WT74_22065
BSTLBBJ41_30645
BANNJFN94_20560
BGDbgla_2g28110
BGOBM43_2894 BM43_4121 BM43_6554
BGPBGL_1c14730(arcB)
BPLAbpln_1g14430
BURKDM992_28605
BPXBUPH_04873
BUZAYM40_15810
PHSC2L64_35540
PTERC2L65_31300
PCAFDSC91_000487 DSC91_007361
PMEGFNZ07_03115 FNZ07_12515
PTXABW99_12315
PNRAT302_25935
PLGNCTC10937_03502
HYFDTO96_101630
LMIRNCTC12852_01501
CABASBC2_69380(ocd_2)
LIMNHKT17_02235
BPTBpet0748
BAVBAV0458(arcB)
BHZACR54_00645(rapL_1)
BTRMSAMEA390648701743(arcB)
BBROBAU06_08925
BPDZBBN53_18480
BOHAKI39_08735
BOJCBF45_07835
AXYAXYL_00273(arcB)
AXONH44784_019261
AXNAX27061_0270
AXXERS451415_00270
ADTAPT56_01560
AISBUW96_27095
ASWCVS48_04540
ACHRC2U31_27590
ACHBDVB37_01295
ADYHLG70_20380
TEQTEQUI_1395
TEAKUI_0789(arcB)
TEGKUK_0627(arcB)
TASTASI_0895
TATKUM_0109(arcB)
AKATKWG_25100
AMIMMIM_c40550(arcB)
CDNBN940_08081
BPSIIX83_00315
PIGEGT29_14180
PACRFXN63_07375
KGYEHF36_08020
PARKLSG25_08505
RFRRfer_3883
RSBRS694_18800
RACRA876_17415
RHYRD110_02890
RHGEXZ61_03520
POLBpro_4602
PNAPnap_3771
POSDT070_08180
POOF7R28_01240
PVACHC248_00245(ocd_1)
AAVAave_0121
AJSAjs_0613
AAAAcav_0154
ACKC380_02505
ACRABSY15_1884
ACIDCBP33_11605 CBP33_16305
ACIPCBP36_16755
ACINCBP34_17095
ACISCBP35_02165
ACIOEAG14_03255
AMONH9L24_17580
AANTHUK68_20870
ARADKI609_02530
DACDaci_0682
DELDelCs14_5849
DTSBI380_21320
DHKBO996_03475
DLAI6G47_21255
VAPVapar_4693
VPEVarpa_5329
VPDVAPA_1c48470(arcB)
VBOCKY39_29200
VAMC4F17_22595
CTTCtCNB1_4177
CTESO987_24910
CSERCCO03_01685
CAQTKAQ61_08015
CODOLAD35_09240
ADNAlide_0698
ADKAlide2_0653
OTDJ1M35_08330
LIML103DPR2_01265(rapL)
LIHL63ED372_00198(rapL)
HYRBSY239_28
HYLLPB072_04060
HYCE5678_11090
HPSEHPF_05975(rapL)
HYNF9K07_23435
HTNKI616_20770
DPYBA022_11910
DIHG7047_12575
DAERH9K75_21635
DRGH9K76_12660
DIADtpsy_0592
SIMPC6571_10535
KIAG8A07_22070
HSEHsero_0061
HSZACP92_00300
HHTF506_14345
HEEhmeg3_14350
HHFE2K99_00310
UPVEJN92_13860
UPIEJG51_016300
NOKFAY22_04195
LCHLcho_0279
RDPRD2015_3905
PKTAT984_02610
RGUA4W93_05310
AONDEH84_05115
SNNEWH46_17780
TTWLCC91_00400
IDCLRM40_16240
NCOAAW31_16860
ARESIWH25_08610
APETToN1_36090
AZAAZKH_3290(ocd-2)
AZIAzCIB_3179
AZDCDA09_05625
TMZTmz1t_0586
AZQG3580_03085
ALKALEK_1697(arcB)
ALPLPB137_02235
MLOmll6776
MLNA9174_13975
MCIMesci_2494 Mesci_5621
MOPMesop_3028 Mesop_6204
MAMMesau_02624 Mesau_02786 Mesau_05673
MAMOA6B35_16735
MESWA9K65_013045 A9K65_030505
MESMEJ066_20340
MESPC1M53_04775 C1M53_19735
MHUAMCHK_0400
MJREB229_14090
MERDEB233_27110
MESRFGU64_20125
MESOBSQ44_22085
MESMeso_3962
HOEIMCC20628_03341
AAKAA2016_0895
PHTBLM14_26880 BLM14_28535
NIYFQ775_13315
NKIKW403_04495
ORMHTY61_11105
KMNHW532_09415
SMESM_b21494(ocd)
SMKSinme_4410
SMQSinmeB_4904
SMXSM11_pD0294(ocd)
SMIBN406_05372(arcB)
SMEGC770_GR4pD0291
SMELSM2011_b21494(ocd)
SMERDU99_26935
RHINGR_b18880(ocd1)
SFHSFHH103_05325(ocd1)
SFDUSDA257_c14360(arcB1)
SIXBSY16_5739
SAMESAMCFNEI73_pC1311(arcB)
SINOSS05631_b54920
EADOV14_a0459(ocd1)
EAHFA04_22405 FA04_28080
ESJSJ05684_b45390
EAKEKH55_5492
ATUAtu6016(ocd)
ARAArad_10025(ocdch2) Arad_14151
ATAAWN88_05785
AGRAGROH133_12682
ATFAch5_37900(ocd) Ach5_51550
AVIAvi_5979(ocd)
AGCBSY240_2216
AROB0909_17715 B0909_19190
AGTEYD00_19340
ALFCFBP5473_20470 CFBP5473_23915
ARUIG6M88_16135
AVQHRR99_18325
RLERL3095(arcB1)
RTRRTCIAT899_PC06950
RIRBN877_II1136(arcB)
RPUSCFBP5875_19550
RHLLPU83_pLPU83c0744(arcB)
RGARGR602_PB00420
RHRCKA34_23565
RGRFZ934_23230
ROYG3A56_21215 G3A56_22235
RRGJ3P73_15845
RLSHB780_11865
NGLRG1141_PA09880
NGGRG540_PA08710
NEOCYG48_17590
NENNCHU2750_47100(ocd) NCHU2750_55520(ocd)
RHTNT26_3751(arcB)
RFVRFYW14_03635
SHZshn_29375
SZOK8M09_20750(ocd)
SOJK6301_17230
ABAWD5400_18020
PDESFE840_018490
KAIK32_10430
BMEBMEII0397
BMELDK63_2841
BMIBMEA_B0880
BMZBM28_B0863
BMGBM590_B0862
BMWBMNI_II0836
BMEEDK62_2556
BMFBAB2_0338
BMBBruAb2_0334(arcB)
BMCBAbS19_II03200
BAABAA13334_II00772
BABODK55_2329
BABRDO74_2749
BABTDK49_2903
BABBDK48_2362
BABUDK53_2339
BABSDK51_2918
BABCDO78_2721
BMSBRA0899(arcB)
BSIBS1330_II0891(arcB)
BSFBSS2_II0851(arcB)
BSUIBSSP1_II0844
BSUPBSPT1_II0841
BSUVBSPT2_II0842
BSUCBSSP2_II0853
BMTBSUIS_B0892
BSZDK67_2852
BSVBSVBI22_B0890(arcB)
BSWIY71_15480
BSGIY72_15430
BOVBOV_A0842(arcB)
BCSBCAN_B0918(arcB)
BSKBCA52141_II1767
BOLBCOUA_II0899(arcB)
BCARDK60_2589
BCASDA85_14770
BMRBMI_II893(arcB)
BPPBPI_II955(arcB)
BPVDK65_2752
BCETV910_200393(arcB)
BCEEV568_200442(arcB)
BVLBF3285c2_0422(arcB)
BRUBFS01_12015
BRJBKD03_02080
OINIAR37_12075
BIOBR141012304_20120(arcB)
OANOant_1471
OAHDR92_1038
OPSA8A54_07600 A8A54_10655
OCHCES85_1840 CES85_5141
OCRHGK82_08680
OCLGTN27_08990
PSCQKHQ08_08135
BOPAXW83_18090
BOSBSY19_2010
BOFFQV39_15965
STARG3545_23110
LNEFZC33_09155
APRAG3A50_10955
MEAMex_1p3003(arcB)
MDIMETDI3569(arcB)
MEXMext_2802
MCHMchl_3030
MPOMpop_2926
MZAB2G69_21565
METM446_1826
MNOMnod_1216
METAY590_13520
MAQUMaq22A_c19655
MEEDA075_05460
METDC0214_15670
MTEADK419_24160
MINDmvi_29560
MIVC4E04_14940
MICOGDR74_05805
BBARRHAL1_02560(ocd)
DEAFPZ08_06065
DSALK1X15_06555
MMYRMXMO3_03094
MSCBN69_2878
MROSEHO51_02220
MHEYH2LOC_008905
MPARF7D14_04555
PLEOOHA_1_00570(rapL)
MEYTM49_09640
MLUTJET14_20795
THDBHV28_07820(arcb3)
NOHG5V57_20355
PSFPSE_0777(arcB) PSE_2943(arcB)
PPHRAPZ00_22330
LAPACP90_00665
LABRCHH27_19720
LABPFJ695_03920
LABTFIU93_05740(rapL2)
LAGGB0E33_12165
PSTGE8M01_24025
SILSPO2121(arcB)
SITTM1040_1163
RUAD1823_07010
RUTFIU92_06215(rapL1)
RDERD1_1415(arcB)
RLIRLO149_c033720(arcB)
RPONG3256_09570
DSHDshi_2310
PGAPGA1_c16390(arcB)
PGLPGA2_c16220(arcB)
PGDGal_01704
PHPPhaeoP97_01647(arcB)
PPICPhaeoP14_01541(arcB)
PHQD1820_04170
OATOAN307_c23960(arcB2)
OAROA238_c21340(arcB)
OTMOSB_15220(rapL_3)
OCTFTO60_07375
LMDMETH_08475
LEJETW24_09785
LAQUR2C4_08710
CIDP73_4323
CMARIMCC12053_1020
CEHCEW89_03540
MALGMALG_01627
YPACCEW88_14105
YANAYJ57_16315
SUAMBOO69_09400
SULZC1J03_13170
SULIC1J05_09240
SULDB5M07_10495
SPOTG6548_09160 G6548_16485
SMEDJNX03_03620
SINLDSM14862_01269(ocd)
SPSESULPSESMR1_01739(arcB)
TOMBWR18_05970
RMMROSMUCSMR3_04003
ROKRAK1035_2839
RIDRIdsm_02486
ROMEI983_07450 EI983_15425
ROHFIU89_08840(rapL3)
AHTANTHELSMS3_04135
THAACFI11_10535
MARUFIU81_06900(rapL2)
ROTFIV09_11025(rapL2)
TGLHFZ77_13085
HATRC74_17170
RCPRCAP_rcc02113(arcB1)
RBLB6K69_11065
PDEPden_4637
PAMIJCM7686_pAMI5p044
PYEA6J80_16535
PZHCX676_03500
PAROCUV01_00650
PARUCYR75_05535 CYR75_15485
PAMNpAMV3p0337(arcB)
PARREOJ32_15535
PMAUCP157_00500(ocd)
PTPRCA23_c24410(arcB)
RMBK529_007560
DONBSK21_06280
THWBMG03_14400
TECAKL02_013750
LVSLOKVESSMR4R_01472(arcB)
RBGBG454_17045
GFUKM031_16125
TAWEI545_01100
SEDIEBB79_12005
HMLHmaOT1_18180
BOOE2K80_03460
PSEBEOK75_13900
LITFPZ52_18485
PAEDG5B38_01525
PAMOBAR1_08715
PSHQF3W81_11135
PPAFI8N54_12890
CACTHZ995_15425
RBZB9057_07230
THASC6Y53_00125
HDHG5B40_17820
CMAGCBW24_15765
GCEKYE46_16460
NSMJO391_06445
NOVTQ38_023115
NDRHT578_10860
SMAGAN936_15455
SMAZLH19_02825
SWISwit_1052
SPHDHY78_21245
SPHITS85_10390
SPANAWL63_10540
SPHCCVN68_20360
SSUAFPZ54_09335
SPYGYGS_C2P1357
GOYGLS_c16230(arcB)
GALA0U94_03395 A0U94_12435
GSPIGS75_08750
AMVACMV_19460(arcB)
RGIRGI145_18290
ROSCTJ15_18365
RMUCFOB66_20160
AZLAZL_b04900(ocd)
ALIAZOLI_p20520(ocd)
ATIAL072_26780
AZMDM194_19800
AZZDEW08_26475
TMOTMO_a0011
HJOAY555_11280
ECOGFIV45_03025 FIV45_07905
SNEANBZ79_02770
PARHI5S86_09520
CBLCLK_0333
CLDCLSPO_c08830(arcB1)
CCAAKQH81_04965
PBIFKXZ80_08170
CARcauri_1343(arcB)
CRDCRES_0238(arcB)
CCJUL81_05640(arcB)
CGVCGLAU_07290(rapL)
CKFI6I12_07130
CPRPI6I69_10625
CLIZG7Y31_05460
CTUBI6I74_10695
CLUJIAU68_06775
CCYCSCMU_08240
CORYFQV43_03385
CMFGWO64_006590
CUWLH390_10545
MIXAB663_000786
MIHBJP65_11420
MCHNHCR76_17195
MRNK8F61_08910
AMAUDSM26151_19720(ocd)
SALAESZ53_13470
PLAPEAO79_04080
GLNF1C58_09475
ARHAHiyo8_39970
ARZAUT26_02050
ARXARZXY2_3448(ocd)
PSEYGU243_18780
KPLKPaMU14_01900
RMURMDY18_00780
RDNHMPREF0733_10802
RAJRA11412_0629
RTERIDM49_09350
RAMAIDM48_00425
BFABfae_06630
BRXBH708_17200
BRVCFK39_11375 CFK39_11395
BGGCFK41_13565
BRZCFK38_16100 CFK38_16135
BSAUDWV08_00690
BRRC1N80_00060
XCEXcel_3303
XYLET495_12580
XYAET471_04835
IVAIsova_2937
IDOI598_2651(rapL_2)
DEMLGT36_008940
NAROCFH99_12085
AEBC6I20_14005
MUZH4N58_03095
BSDBLASA_2548(arcB)
ARDAXF14_08480
AHWNCTC11636_00832
FSLEJO69_00320
FLHEJ997_01405
AYMYM304_01710(ocd)
SOAG3M56_005800
TDETDE_2754(arcB)
TPKJO40_05945
HMTMTP16_10255
 » show all
Reference
1  [PMID:4399881]
  Authors
Costilow RN, Laycock L.
  Title
Ornithine cyclase (deaminating). Purification of a protein that converts ornithine to proline and definition of the optimal assay conditions.
  Journal
J Biol Chem 246:6655-60 (1971)
Reference
2  [PMID:4373469]
  Authors
Muth WL, Costilow RN.
  Title
Ornithine cyclase (deaminating). II. Properties of the homogeneous enzyme.
  Journal
J Biol Chem 249:7457-62 (1974)
Reference
3  [PMID:10468639]
  Authors
Espineda CE, Linford AS, Devine D, Brusslan JA.
  Title
The AtCAO gene, encoding chlorophyll a oxygenase, is required for chlorophyll b synthesis in Arabidopsis thaliana.
  Journal
Proc Natl Acad Sci U S A 96:10507-11 (1999)
DOI:10.1073/pnas.96.18.10507
Reference
4  [PMID:15518536]
  Authors
Goodman JL, Wang S, Alam S, Ruzicka FJ, Frey PA, Wedekind JE
  Title
Ornithine cyclodeaminase: structure, mechanism of action, and implications for the mu-crystallin family.
  Journal
Biochemistry 43:13883-91 (2004)
DOI:10.1021/bi048207i
  Sequence
[ppu:PP_3533]
Reference
5  [PMID:15103146]
  Authors
Alam S, Wang SC, Ruzicka FJ, Frey PA, Wedekind JE.
  Title
Crystallization and X-ray diffraction analysis of ornithine cyclodeaminase from Pseudomonas putida.
  Journal
Acta Crystallogr D Biol Crystallogr 60:941-4 (2004)
DOI:10.1107/S0907444904005256
  Sequence
[ppu:PP_3533]
Other DBs
ExplorEnz - The Enzyme Database: 4.3.1.12
IUBMB Enzyme Nomenclature: 4.3.1.12
ExPASy - ENZYME nomenclature database: 4.3.1.12
BRENDA, the Enzyme Database: 4.3.1.12
CAS: 9054-76-6
LinkDB

DBGET integrated database retrieval system