Entry
Name
7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase;
FO synthase;
fbiC (gene name) (ambiguous);
cofG (gene name)
Class
Lyases;
Carbon-nitrogen lyases;
Ammonia-lyases
BRITE hierarchy
Sysname
5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil ammonia-lyase (7,8-didemethyl-8-hydroxy-5-deazariboflavin-forming)
Reaction(IUBMB)
5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + S-adenosyl-L-methionine = 7,8-didemethyl-8-hydroxy-5-deazariboflavin + NH3 + L-methionine + 5'-deoxyadenosine [RN:
R12162 ]
Reaction(KEGG)
Substrate
5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil [CPD:
C21971 ];
S-adenosyl-L-methionine [CPD:
C00019 ]
Product
7,8-didemethyl-8-hydroxy-5-deazariboflavin [CPD:
C19154 ];
NH3 [CPD:
C00014 ];
L-methionine [CPD:
C00073 ];
5'-deoxyadenosine [CPD:
C05198 ]
Comment
The enzyme produces the 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) precursor of factor 420 (coenzyme F420), a metabolite found in methanogens and in various actinobacteria. FO is also produced by some cyanobacteria and eukaryotes. The enzyme, which forms a complex with EC
2.5.1.147 , 5-amino-6-(D-ribitylamino)uracil---L-tyrosine 4-hydroxyphenyl transferase, is a radical SAM enzyme that uses the 5'-deoxyadenosyl radical to catalyse the condensation reaction.
History
EC 4.3.1.32 created 2010 as EC 2.5.1.77, part transferred 2018 to EC 4.3.1.32
Pathway
ec01120 Microbial metabolism in diverse environments
Orthology
K11780 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase
Genes
VAQ : FIV01_04135(bioB1) FIV01_04140(mqnE)
ALT : ambt_18390(cofG) ambt_18395
AAL : EP13_00575 EP13_00580
ASP : AOR13_3368 AOR13_3369
ASQ : AVL57_01940 AVL57_01945
AAW : AVL56_00750 AVL56_00755
ALE : AV939_00755 AV939_00760
ALZ : AV940_00755 AV940_00760
ALTE : ALT761_00154 ALT761_00155
MPC : Mar181_0278 Mar181_0279
MPRI : MP3633_0352(cofG) MP3633_0353(cofH)
MFOI : JSY38_07525(cofH) JSY38_07530(cofG)
MRHI : KDW99_18330(cofH) KDW99_18335(cofG)
MPON : MACH16_28810 MACH16_28820
MARS : A8C75_03565 A8C75_03570
MRZ : KDW95_12775(cofH) KDW95_12780(cofG)
BPY : Bphyt_4251 Bphyt_4252
DOE : DENOEST_1265(fbiC) DENOEST_3709(fbiC)
DENI : B9N43_02535(fbiC) B9N43_10395(fbiC) B9N43_13410(fbiC)
THAG : CKCBHOJB_02347(fbiC_1) CKCBHOJB_02385(fbiC_2)
MESP : C1M53_21080(cofH) C1M53_21085(cofG)
METG : HT051_05445(cofH) HT051_12625(cofH)
PSF : PSE_2792(fbiC) PSE_2793(fbiC)
LMD : METH_04450 METH_04455
LAQU : R2C4_00575(cofH) R2C4_00580(cofG)
LCAE : K3721_20520(cofH) K3721_20525(cofG)
PALP : JHW40_21090(cofH) JHW40_21095(cofG)
RMB : K529_001420 K529_001425
THAS : C6Y53_09640(cofH) C6Y53_09645(cofG)
LVR : T8T21_15005(cofH) T8T21_15010(cofG)
NRE : BES08_02715(fbiC) BES08_26705(fbiC)
SPHD : HY78_17635(fbiC) HY78_23110(fbiC)
SPKC : KC8_02690 KC8_06240
SCH : Sphch_0610 Sphch_2129
SYB : TZ53_17125(fbiC) TZ53_18465(fbiC)
SPHT : K426_12255(fbiC) K426_23844(fbiC)
SBAR : H5V43_00775(cofH) H5V43_05145(cofH)
SPAG : sphantq_03828(fbiC)
SPRS : EGM87_04120(cofH) EGM87_05495(cofH)
SPJS : NUH86_09700(cofH) NUH86_20265(cofH)
SPHJ : BSL82_04895(fbiC) BSL82_08920(fbiC)
TRO : trd_A0899(cofH) trd_A0900(cofG)
BBEV : BBEV_1716(cofG) BBEV_1717(fbiC)
NCD : ACONDI_01246(fbiC_2)
MMAE : MMARE11_40940(fbiC)
MHEK : JMUB5695_01421(fbiC)
MKY : IWGMT90018_48980(fbiC)
MYJ : BCA37_19790(fbiC) BCA37_24185(fbiC)
MPHL : MPHLCCUG_04074(mqnE)
MTY : MTOK_03550 MTOK_55600(fbiC)
MSAL : DSM43276_01185(mqnE)
MTER : 4434518_01112(fbiC)
RHA : RHA1_ro05944 RHA1_ro11041
RKO : JWS14_25800 JWS14_32470
RPSK : JWS13_11460 JWS13_28415(cofH)
RHOJ : JVH1_02570(cofH) JVH1_06610
RHJS : OYT95_06920 OYT95_22355 OYT95_40130(cofH)
GPO : GPOL_c31220(fbiC1) GPOL_c31240(fbiC2)
GTA : BCM27_17075 BCM27_17085
GRU : GCWB2_17295 GCWB2_17305(mqnE)
GOM : D7316_05361(fbiC_1) D7316_05363(fbiC_2)
GAV : C5O27_10895 C5O27_10905(cofG)
GOD : GKZ92_16225(cofG) GKZ92_16235
GOJ : GR168_16030(cofG) GR168_16040
GAM : GII34_16115(cofG) GII34_16125
GPD : GII33_15575(cofG) GII33_15585
GJI : H1R19_16160(cofG) H1R19_16170
GHN : MVF96_16540(cofG) MVF96_16550
GAMI : IHQ52_20080(cofG) IHQ52_20090
SRC : M271_20760(fbiC) M271_38995(fbiC)
SMAL : SMALA_4583 SMALA_6223
SSOI : I1A49_26975 I1A49_34955
SAMB : SAM23877_3304(fbiC)
SLE : sle_40200(sle_40200)
SPAV : Spa2297_14305(fbiC)
SGM : GCM10017557_35530(fbiC)
SAUO : BV401_26765(fbiC) BV401_35045(fbiC)
STRO : STRMOE7_16995(fbiC)
SFY : GFH48_04685 GFH48_23250
STUI : GCM10017668_29810(fbiC)
SXT : KPP03845_103369(fbiC)
SANT : QR300_18265 QR300_34400
SLUO : PS467_08745 PS467_24705
STSD : HEP87_24420 HEP87_55090 HEP87_55410
STRI : C7M71_018075 C7M71_029935
FSB : GCM10025867_09910(fbiC)
AMAU : DSM26151_01330(fbiC)
NCA : Noca_0814 Noca_0863 Noca_3619
NARO : CFH99_19185(fbiC) CFH99_24610(fbiC)
NAQU : ENKNEFLB_01161(fbiC)
NOCD : QJ852_01775 QJ852_20590
BLAP : MVA48_07520 MVA48_08880
MSAG : GCM10017556_35230(fbiC)
VMA : VAB18032_09475(fbiC)
AMS : AMIS_34700 AMIS_8560
ACTR : Asp14428_35930(fbiC)
PFLA : Pflav_062050 Pflav_062060
PSUU : Psuf_023990 Psuf_024000
BALA : DSM104299_01943(fbiC)
CWO : Cwoe_4090 Cwoe_4147 Cwoe_4165
PARQ : DSM112329_01794(fbiC)
SBAE : DSM104329_01345(fbiC_1) DSM104329_02932(fbiC_2)
PAGH : NIES204_39250(cofG)
PRUN : PCC7821_04671(cofG)
NCW : NIES2107_66830(cofG)
RSIN : B6N60_02160 B6N60_02715
NSPH : BDGGKGIB_02391(fbiC_2)
CALN : NIES2098_66750(cofG)
CALS : NIES3974_20250(cofG)
MEHF : MmiHf6_01030(fbiC_1)
MEES : MmiEs2_08840(fbiC_2)
MJK : N2V74_01230(cofG) N2V74_04630(cofG)
HALA : Hrd1104_08990(cofG)
HALQ : Hrr1229_010315(cofG)
HACB : Hbl1158_13140(cofG)
HAKZ : J0X25_10530(cofG) J0X25_19505(cofG)
» show all
Taxonomy
Reference
Authors
Decamps L, Philmus B, Benjdia A, White R, Begley TP, Berteau O
Title
Biosynthesis of F0, precursor of the F420 cofactor, requires a unique two radical-SAM domain enzyme and tyrosine as substrate.
Journal
Reference
Authors
Philmus B, Decamps L, Berteau O, Begley TP
Title
Biosynthetic versatility and coordinated action of 5'-deoxyadenosyl radicals in deazaflavin biosynthesis.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 4.3.1.32
ExPASy - ENZYME nomenclature database: 4.3.1.32
LinkDB
All DBs