Entry
Name
7-carboxy-7-deazaguanine synthase;
7-carboxy-7-carbaguanine synthase;
queE (gene name)
Class
Lyases;
Carbon-nitrogen lyases;
Other carbon-nitrogen lyases
BRITE hierarchy
Sysname
6-carboxy-5,6,7,8-tetrahydropterin ammonia-lyase
Reaction(IUBMB)
6-carboxy-5,6,7,8-tetrahydropterin = 7-carboxy-7-carbaguanine + NH3 [RN:
R10002 ]
Reaction(KEGG)
Substrate
6-carboxy-5,6,7,8-tetrahydropterin [CPD:
C20239 ]
Product
Comment
Requires Mg2+. The enzyme is a member of the superfamily of S-adenosyl-L-methionine-dependent radical (radical AdoMet) enzymes. Binds a [4Fe-4S] cluster that is coordinated by 3 cysteines and an exchangeable S-adenosyl-L-methionine molecule. The S-adenosyl-L-methionine is catalytic as it is regenerated at the end of the reaction. The reaction is part of the biosynthesis pathway of queuosine.
History
EC 4.3.99.3 created 2012
Pathway
Orthology
K10026 7-carboxy-7-deazaguanine synthase
Genes
GSL : Gasu_00310 Gasu_64340
ECOO : ECRM13514_3633(ygcF)
ECOH : ECRM13516_3498(ygcF)
EDJ : ECDH1ME8569_2686(ygcF)
ECOI : ECOPMV1_03030(queE)
SDZ : Asd1617_03996 Asd1617_03997
REE : electrica_00938(queE)
RTG : NCTC13098_01397(queE_1) NCTC13098_01398(queE_2)
CLAP : NCTC11466_00727(queE)
KIE : NCTC12125_04926(queE)
AHN : NCTC12129_03961(queE)
METY : MRY16398_10320(queE)
PTF : PROFFT_A_00750(queE)
PSHI : SAMEA2665130_1261(queE)
MPHG : MPHASIOC01_003193(queE)
SMW : SMWW4_v1c07900(queE)
SFJ : SAMEA4384070_0839(queE)
SOF : NCTC11214_00695(queE)
SSAR : SSARUM_000733(queE)
PAQU : DMB82_0004545(queE)
PARL : PEC302110_31350(queE)
DIC : Dpoa569_0000812(queE)
EHD : ERCIPSTX3056_600(queE)
BAPF : BUMPF009_CDS00183(ygcf)
BAPG : BUMPG002_CDS00183(ygcf)
BAPU : BUMPUSDA_CDS00183(ygcf)
BAPW : BUMPW106_CDS00183(ygcf)
TPTY : NCTC11468_00906(queE)
PHEI : NCTC12003_00940(queE)
PRJ : NCTC6933_03113(queE_2)
HIC : NTHIC486_01556(queE)
HPIT : NCTC13334_01341(queE)
HAEG : NCTC8502_01315(queE)
PDAG : 4362423_01166(queE)
ADP : NCTC12871_00352(queE)
ALIG : NCTC10568_01372(queE)
AVT : NCTC3438_01933(queE)
PAET : NCTC13378_01692(queE)
XPH : XppCFBP6546_03305(queE)
XHD : LMG31886_12090(queE)
SLM : BIZ42_05210 BIZ42_17175
LLZ : LYB30171_02181(queE)
VSI : MTO69_07205(queE) MTO69_08440(queE)
VPL : SA104470976_01112(queE)
VIB : VspSTUT11_16280(queE)
VIS : VspSTUT16_16700(queE)
PVD : CFBP1590__2942 CFBP1590__3969(queE)
PMUD : NCTC8068_04076(queE)
PTRT : HU722_0023400(queE)
PTW : TUM18999_45090(queE)
PTAE : NCTC10697_03199(queE)
PGF : J0G10_17155(queE) J0G10_24230(queE)
PNB : NK667_02275(queE) NK667_16265(queE)
PKJ : Q1W70_00190(queE) Q1W70_16545(queE)
PSJY : AA098_03730 AA098_20990
PBAM : NUH87_10255(queE) NUH87_28325(queE)
MSHE : MAALD49_01120(queE)
MCAT : MC25239_00378(queE)
MCUN : NCTC10297_00069(queE)
SCAA : TUM17387_18570(queE)
COM : CMT41_07455 CMT41_07885
COZ : A3Q34_04850 A3Q34_19345
SALH : HMF8227_00950(queE)
AGAR : OAG1_07010(ygcF) OAG1_16400(queE)
LLG : 44548918_02242(nrdG)
LJR : NCTC11533_02324(nrdG)
LCJ : NCTC11976_01506(nrdG)
LWA : SAMEA4504053_2295(nrdG)
LSS : NCTC12082_01457(nrdG)
LADL : NCTC12735_01493(nrdG)
LANT : TUM19329_27190(queE)
METL : U737_15210(queE) U737_19645(queE)
MISZ : MishRS11D_08970(queE)
TIB : THMIRHAM_15250(queE)
TSE : THMIRHAS_17620(queE)
TZO : THMIRHAT_17110(queE)
TFRI : Thiofri_01075(queE)
TNI : TVNIR_3366(queE_[H])
THIC : TspCOW1_15610(queE)
HAAH : HALA3H3_830156(queE)
HAAZ : HaloA020_27630(queE)
ALCA : ASALC70_00851(queE_1)
GSN : YC6258_01025 YC6258_04144
AHY : AHML_05770 AHML_09985
AHR : V428_05975 V428_10245
AHP : V429_05975 V429_10250
AHJ : V469_13250 V469_17370
AEL : NCTC12917_02342(queE)
CDIZ : CEDIAZO_02318(queE)
NWE : SAMEA3174300_1289(queE)
NZO : SAMEA4504057_0888(queE)
NCI : NCTC10296_02344(queE)
NCZ : NCTC10294_00178(queE)
NANI : NCTC12227_01578(queE)
REH : H16_A1925(h16_A1925)
BDF : WI26_15105 WI26_17165
BPX : BUPH_03965 BUPH_08415
PSAA : QEN71_00205(queE) QEN71_41915(queE)
POLT : TUM22923_10890(queE)
PLG : NCTC10937_01544(queE_1) NCTC10937_02639(queE_2)
LMIR : NCTC12852_00339(queE)
BUE : BRPE67_ACDS00350(queE)
BTRM : SAMEA390648703555(queE)
AXX : ERS451415_03135(queE)
OUE : I6G29_01285 I6G29_01655
ASAH : AVXHC19_38960(queE)
KIA : G8A07_00060(queE) G8A07_00420(queE)
JLV : G3257_09365(queE) G3257_16810(queE)
URU : DSM104443_00489(queE)
THAG : CKCBHOJB_03162(queE)
FPHO : SHINM1_000180(queE)
FMY : HO273_02210(queE) HO273_07135(queE)
MLN : A9174_32270 A9174_33000
MJR : EB229_32990(queE) EB229_33760(queE)
MERD : EB233_30625(queE) EB233_31420(queE)
MESU : LHFGNBLO_006122(queE)
AMIS : Amn_09980 Amn_11280 Amn_pc00550
RBS : RHODOSMS8_00915(queE)
SMEL : SM2011_b20938(exsD)
SFD : USDA257_c04440 USDA257_c13690(queE)
SAME : SAMCFNEI73_pC1242(queE)
EAW : ACEP9W_18975(queE) ACEP9W_30345 ACEP9W_30675(queE)
ALF : CFBP5473_17405(queE)
AVV : RvVAT039_10250(exsD)
AVF : RvVAR031_30170(exsD)
ASAL : CFBP5507_22300(queE)
RPUS : CFBP5875_21285(queE)
ALEG : CFBP4996_16190(queE)
REC : RHECIAT_CH0003986(exsD)
REL : REMIM1_CH03791(queE)
REP : IE4803_CH04099(queE)
REI : IE4771_CH04040(queE)
RTR : RTCIAT899_PC05455(queE)
RGA : RGR602_PC02216(queE)
RPHA : AMC79_CH03916(queE)
RJG : CCGE525_32600(queE) CCGE525_34810(queE)
RLW : RlegWSM1455_19120(queE)
RBW : RLCC275e_19425(queE)
NEN : NCHU2750_27580(queE)
BIO : BR141012304_10743(queE)
BSEP : HAP48_0006825(queE) HAP48_0035050(queE)
BCAN : BcanWSM471_11500(queE)
BXN : I3J27_08620(queE) I3J27_33045(queE) I3J27_33945(queE)
VGO : GJW-30_1_02583(queE)
MAQU : Maq22A_c27695(nrdG)
METX : A3862_18870 A3862_29720
MMES : MMSR116_21525(queE)
MLD : U0023_25640(queE) U0023_27790(queE) U0023_29100
MTUN : MTUNDRAET4_2150(queE)
FIL : BN1229_v1_2818(queE)
FIY : BN1229_v1_3095(queE)
CAUB : AMEJIAPC_03225(queE)
CAUL : KCG34_18935(queE) KCG34_25430(queE)
BDM : EQG53_01320(queE) EQG53_11195(queE)
BVY : NCTC9239_01716(queE)
BND : KWG56_05900(queE) KWG56_08980(queE)
ASTM : MMA231_02191(queE_2)
TSV : DSM104635_00685(queE)
PHP : PhaeoP97_02793(queE)
SINL : DSM14862_02083(queE)
RMM : ROSMUCSMR3_03729(queE)
LVS : LOKVESSMR4R_00077(queE)
SKR : BRX40_06545 BRX40_20435
SBIN : SBA_ch1_12420(queE)
SQO : NMP03_00160(queE) NMP03_15450(queE)
SPAG : sphantq_02572(queE)
SFLA : SPHFLASMR4Y_00735(queE)
BOMB : GT348_07590(queE) GT348_07610
SROE : JL101_014905(queE) JL101_029365(queE)
CJV : MTVDSCj20_0159(queE)
CFV : CFVI03293_0222(queE)
CAMP : CFT03427_0229(queE)
CCOC : CCON33237_0249(queE)
CLR : UPTC16701_1396(queE)
CLM : UPTC16712_1416(queE)
CAMR : CAQ16704_1433(queE)
CHV : CHELV3228_1503(queE)
CPIN : CPIN18020_1095(queE)
CAMZ : CVIC12175_1386(queE)
SMAB : LN246_01295 LN246_13835
GBN : GEOBRER4_28090(queE)
DALK : DSCA_07360(queE) DSCA_19980
MBD : MEBOL_002465 MEBOL_003977
OBG : Verru16b_01064(queE_1) Verru16b_03198(queE_2)
LCRE : Pla8534_59030(queE)
TPLA : ElP_53610(queE_1) ElP_59900(queE_2)
VBL : L21SP4_01105(queE_1)
PSPC : Strain318_002439(queE)
BTHO : Btheta7330_03632(queE)
BCEL : BcellWH2_04538(queE)
PCOP : I6J50_00745 I6J50_01525
PCRE : NCTC12858_00325(queE)
PSOE : CE91St14_04610(queE)
COPR : Cop2CBH44_06360(queE)
PHER : prwr041_03910(queE)
POC : NCTC13071_02719(queE)
ACOU : A5CBH24_02290(queE)
ADA : A5CPEGH6_05390(queE)
CBAM : PIECOFPK_00168(queE)
SMIZ : 4412673_01020(queE)
SDJ : NCTC13534_03736(queE)
STHA : NCTC11429_05012(queE)
PSEZ : HME7025_01118(queE)
FOK : KK2020170_10920(queE)
PHG : KCTC32516_01713(queE_1)
POLQ : JOP69_14715 JOP69_17085
LUT : Lupro_02030 Lupro_04180
AALG : AREALGSMS7_00228(queE)
AANR : KCTC52924_02142(queE)
KOS : KORDIASMS9_02116(queE)
KAN : IMCC3317_38790(queE)
SPON : HME9304_00746(queE)
CGLE : NCTC11432_03068(queE)
CTAI : NCTC12078_02577(queE)
CTAK : 4412677_01437(queE)
CHRJ : CHRYMOREF3P_2655(queE)
CJG : NCTC13459_02288(queE)
CANT : NCTC13489_02346(queE)
PTAN : CRYO30217_00729(queE)
PROC : Ptc2401_01841(queE)
BAZ : BAMTA208_10265(queE)
BSON : S101395_02377(queE) S101395_03384
BMYC : DJ92_3984(queE) DJ92_771(queE)
BWD : CT694_07205(queE) CT694_32695(queE)
BGY : BGLY_1467(queE) BGLY_2475
BFD : NCTC4823_01602(queE)
BACW : QR42_02360 QR42_06490
BKW : BkAM31D_13685(queE_2)
BLEN : NCTC4824_01076(queE)
PARG : PspKH34_28210(queE)
PCAL : BV455_00871(queE_1)
SAX : USA300HOU_0733(exsD)
SUQ : HMPREF0772_12477(queE)
SEPS : DP17_1342 DP17_1783(queE)
SDP : NCTC12225_02256(queE)
SPIC : SAMEA4384060_2160(queE)
SSH : NCTC13712_00675(queE)
SSIM : SAMEA4384339_0655(queE)
SSTE : SAMEA4384403_2106(queE)
BAYD : BSPP4475_04105(queE)
PPM : PPSC2_01035(queE1) PPSC2_05565(queE3)
PPO : PPM_0186(queE1) PPM_1044(queE3)
PPQ : PPSQR21_011210(nrdG)
PVO : PVOR_07300 PVOR_09215
PCHI : PC41400_05705(queE)
PNK : AASFL403_13925(queE)
PGLU : A3958_14090 A3958_15670
ANX : ACH33_11320 ACH33_14230
ATHE : K3F53_04680 K3F53_07685
SGG : SGGBAA2069_c12870(QueE)
SVB : NCTC12167_00835(queE)
CGEL : psyc5s11_26530(queE)
VRM : 44547418_01274(queE)
VDN : NCTC11831_00684(queE)
DHO : Dia5BBH33_15740(queE)
MANA : MAMMFC1_03772(queE)
CDIA : CaldiYA01_22070(queE)
CNAG : OTJ99_000155(queE) OTJ99_000206(queE)
SGS : AVL59_29110 AVL59_32215 AVL59_32405
SALF : SMD44_08781 SMD44_p10117
SRIM : CP984_09135 CP984_39305
NCG : KGD84_07515 KGD84_18865
NOW : GBF35_15795 GBF35_30365(queE)
FRA : Francci3_1753 Francci3_3380
AROO : NQK81_22225 NQK81_27515
PSDS : K1T35_11375(queE) K1T35_11570
UME : RM788_06850 RM788_18780
MSAG : GCM10017556_22820(queE)
ACTR : Asp14428_74550(queE)
ASIC : Q0Z83_089960(queE) Q0Z83_111530
DVC : Dvina_01690(queE) Dvina_05490(queE)
SYY : SYNGTS_1136(sll2011)
SYT : SYNGTI_1136(sll2011)
SYS : SYNPCCN_1135(sll2011)
SYQ : SYNPCCP_1135(sll2011)
LEPT : JVX88_07515 JVX88_23830
PRUN : PCC7821_01189(queE)
NSPH : BDGGKGIB_02673(queE)
MCHK : MchiMG62_25260(queE)
MJK : N2V74_01370 N2V74_04495
HSIN : KDQ40_00095 KDQ40_22900
HSN : DV733_01190 DV733_08695
HALY : HYG82_00610 HYG82_18340
NBG : DV706_00875 DV706_16395
TVO : TVG0308581(TVG0308581)
» show all
Taxonomy
Reference
Authors
McCarty RM, Somogyi A, Lin G, Jacobsen NE, Bandarian V
Title
The deazapurine biosynthetic pathway revealed: in vitro enzymatic synthesis of PreQ(0) from guanosine 5'-triphosphate in four steps.
Journal
Sequence
Reference
Authors
McCarty RM, Krebs C, Bandarian V
Title
Spectroscopic, steady-state kinetic, and mechanistic characterization of the radical SAM enzyme QueE, which catalyzes a complex cyclization reaction in the biosynthesis of 7-deazapurines.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 4.3.99.3
ExPASy - ENZYME nomenclature database: 4.3.99.3
LinkDB
All DBs