KEGG   ENZYME: 4.4.1.38
Entry
EC 4.4.1.38                 Enzyme                                 
Name
isethionate sulfite-lyase;
islA (gene name)
Class
Lyases;
Carbon-sulfur lyases;
Carbon-sulfur lyases (only sub-subclass identified to date)
Sysname
isethionate sulfite-lyase
Reaction(IUBMB)
isethionate = acetaldehyde + sulfite [RN:R12763]
Reaction(KEGG)
R12763
Substrate
isethionate [CPD:C05123]
Product
acetaldehyde [CPD:C00084];
sulfite [CPD:C00094]
Comment
The enzyme, characterized from the human gut bacterium Bilophila wadsworthia, participates in a taurine degradation pathway that leads to sulfide production. The active form of the enzyme contains a glycyl radical that is generated by a dedicated activating enzyme via chemistry involving S-adenosyl-L-methionine (SAM) and a [4Fe-4S] cluster.
History
EC 4.4.1.38 created 2021
Pathway
ec00430  Taurine and hypotaurine metabolism
ec01100  Metabolic pathways
Orthology
K25261  isethionate sulfite-lyase
Genes
PWA: Pecwa_3461
PPAR: A8F97_01320
PEC: W5S_3597
PWS: A7983_13280
PCAC: OI450_00875
PARL: PEC302110_30690
BGJ: AWC36_05935
BNG: EH206_07475
BIZ: HC231_15860
SLIG: GTU79_10120
DDS: Ddes_1436
DFI: AXF13_05515
DPG: DESPIGER_1590
DEF: CNY67_06110
DDE: Dde_1273
DPI: BN4_11150
PPRF: DPRO_3546
PTHE: LF599_13280
PMEN: V8V93_03760
PBIZ: LWC08_09755
DVU: DVU_2824
DVL: Dvul_0491
DVG: Deval_2606
CLIH: KPS_000048
DBA: Dbac_1587
DESU: NLA06_05930
DPS: DP3027
DEO: CAY53_09700
LUB: TBR22_A12620
PBD: PBOR_26450
CPAS: Clopa_0943
DSY: DSY0416
DHD: Dhaf_0366
DDH: Desde_0364
DRM: Dred_2750
DRU: Desru_0475
DFG: B0537_01450
DKU: Desku_2520
ABUT: Ami103574_01305
MANA: MAMMFC1_01805(bssA_1) MAMMFC1_01806(bssA_2)
STED: SPTER_02740(cutC_1) SPTER_04740(cutC_2)
SSPH: SPSPH_029460(pflD_1) SPSPH_029620(cutC)
SSID: SPSIL_046360(pflD) SPSIL_046550(cutC_1)
 » show all
Reference
1  [PMID:30718429]
  Authors
Peck SC, Denger K, Burrichter A, Irwin SM, Balskus EP, Schleheck D.
  Title
A glycyl radical enzyme enables hydrogen sulfide production by the human intestinal bacterium Bilophila wadsworthia.
  Journal
Proc Natl Acad Sci U S A 116:3171-3176 (2019)
DOI:10.1073/pnas.1815661116
Reference
2  [PMID:30962433]
  Authors
Xing M, Wei Y, Zhou Y, Zhang J, Lin L, Hu Y, Hua G, N Nanjaraj Urs A, Liu D, Wang F, Guo C, Tong Y, Li M, Liu Y, Ang EL, Zhao H, Yuchi Z, Zhang Y.
  Title
Radical-mediated C-S bond cleavage in C2 sulfonate degradation by anaerobic bacteria.
  Journal
Nat Commun 10:1609 (2019)
DOI:10.1038/s41467-019-09618-8
  Sequence
[dvu:DVU_2824]
Other DBs
ExplorEnz - The Enzyme Database: 4.4.1.38
IUBMB Enzyme Nomenclature: 4.4.1.38
ExPASy - ENZYME nomenclature database: 4.4.1.38
BRENDA, the Enzyme Database: 4.4.1.38
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