KEGG ENZYME: 4.4.1.9

ENZYME: 4.4.1.9

Entry

EC 4.4.1.9                  Enzyme

Name

L-3-cyanoalanine synthase;
beta-cyanoalanine synthase;
beta-cyanoalanine synthetase;
beta-cyano-L-alanine synthase;
L-cysteine hydrogen-sulfide-lyase (adding HCN)

Class

Lyases;
Carbon-sulfur lyases;
Carbon-sulfur lyases (only sub-subclass identified to date)

Sysname

L-cysteine hydrogen-sulfide-lyase (adding hydrogen cyanide; L-3-cyanoalanine-forming)

Reaction(IUBMB)

L-cysteine + hydrogen cyanide = L-3-cyanoalanine + hydrogen sulfide [RN:R03524]

Reaction(KEGG)

R03524;
(other) R02846

Substrate

L-cysteine [CPD:C00097];
hydrogen cyanide [CPD:C01326]

Product

L-3-cyanoalanine [CPD:C02512];
hydrogen sulfide [CPD:C00283]

Comment

Contains pyridoxal phospate.

History

EC 4.4.1.9 created 1972, deleted 1976, reinstated 1978

Pathway

ec00460

Cyanoamino acid metabolism

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K13034

L-3-cyanoalanine synthase/ cysteine synthase

Genes

ATH:	AT3G61440(CYSC1)

ALY:	9312681 9319720

CRB:

17886219

CSAT:

104699755 104747140 104749184 104788433

EUS:	EUTSA_v10006044mg

BRP:	103841966 103862824

BNA:	106396803 106415606 106415710 106444997

BOE:	106311835 106336914 106338498

RSZ:	108855811 108863440

THJ:	104802038 104817302

CPAP:

110820910

CIT:	102609716 127901209

CIC:	CICLE_v10020662mg

PVY:

116134250

MINC:

123217493

TCC:

18614120

GRA:	105802709 105802711

GHI:	107911578 107911579 107924412

GAB:	108473707 108473708

HSYR:

120181544

DZI:

111304748

EGR:

104443429

GMX:	100101899(OAS-TL3) 100806420

GSJ:	114397550 114425218

PVU:	PHAVU_008G061100g

VRA:

106759445

VAR:

108329722

VUN:

114186237

VUM:

124827367

CCAJ:

109802499

APRC:

113860583

MTR:

11436945

TPRA:

123888212 123923198

CAM:

101512608

PSAT:

127127069

VVO:

131627843

LJA:

130728272

ADU:	107472470 107485772

AIP:	107621508 107635094

AHF:	112726280 112730543 112744150 112797478

LANG:

109338383 109339915

PCIN:

129291428

QSA:	O6P43_017640 O6P43_027246

FVE:

101292050

RCN:	112172959 112181707

PPER:

18786519

PMUM:

103342779

PAVI:

110751794

PDUL:

117619863

MDM:	103401891 103405317

MSYL:

126629085 126632106

PXB:	103940809 103957376

ZJU:

107404050

MNT:

21395612

CSAV:

115707895

CSV:

101220896

CMO:

103497706

BHJ:

120068144

MCHA:

111024353

CMAX:

111499275

CMOS:

111460401

CPEP:

111807524

RCU:	8261899 8278514

MEAN:

126686745

JCU:

105642966

HBR:	110649537 110660627

MESC:

110615325 110615780

POP:	7457347 7494093

PEU:	105124856 105132437 105134042

PALZ:

118041630 118057778

PNZ:	133681958 133692396

JRE:

109021531

CILL:

122310197

CAVE:

132186540

QSU:	111999906 112022627

QLO:	115986890 115994564

TWL:

120003285

VVI:

100255091

VRI:	117912144 117931555

SLY:	101253940 101255033

SPEN:

107008051 107032363

SOT:	102601315(PCAS-2) 102604154(PCAS-1)

SSTN:

125841735 125864458

SDUL:

129877225 129886555

CANN:

107839203

LBB:	132632838 132645564

NTA:	107787097 107788814 107793495 107795843

NSY:	104231967 104243686

NTO:	104117492 104118550

NAU:	109231094 109243119

INI:	109171635 109184868

ITR:	116016603 116030521

SIND:

105172766

OEU:

111390009

EGT:

105963830

SSPL:

121795227 121798141

SMIL:

130999095

SHIS:

125204161

APAN:

127262616

HAN:	110864795 110937631

ECAD:

122591207

LSV:

111902665

CCAV:

112526366

DCR:

108210215

CSIN:

114281509

RVL:

131333122

AEW:

130753532

BVG:

104887240

SOE:

110789773

CQI:	110714064 110731553

ATRI:

130811333

MOF:

131166866

NNU:

104610634

MING:

122066723 122075314 122075315

TSS:	122662430 122662748

PSOM:

113274742

OSA:

4335048

OBR:

102715851

OGL:

127770310

BDI:

100835065

ATS:

109731680

TDC:	119302459 119311137

TAES:

100682425 123104403 123122184

TUA:

125510052

LPER:

127297363 127300391

LRD:	124654280 124658355 124682296

SBI:

8066013

ZMA:

100216722

MFLO:

136494393

SITA:

101779131

SVS:

117863762

PVIR:

120639762 120682197

PHAI:

112899701

PDA:

103715474

EGU:

105043037

MUS:

103985756

ZOF:	122041004 122045512

DCT:

110097663

PEQ:

110025102

AOF:

109837549

MSIN:

131231099

NCOL:

116265690

ATR:

18422839

» show all

Reference

1 [PMID:1055433]

Authors

Akopyan TN, Braunstein AE, Goryachenkova EV.

Title

Beta-cyanoalanine synthase: purification and characterization.

Journal

Proc Natl Acad Sci U S A 72:1617-21 (1975)
DOI:10.1073/pnas.72.4.1617

Reference

2 [PMID:5001194]

Authors

Castric PA, Conn EE.

Title

Formation of -cyanoalanine by O-acetylserine sulfhydrylase.

Journal

J Bacteriol 108:132-6 (1971)
DOI:10.1128/JB.108.1.132-136.1971

Reference

Authors

Hendrickson HR.

Title

The beta-cyanoalanine synthase of blue lupine.

Journal

Fed Proc 27:593 (1968)

Reference

4 [PMID:5769995]

Authors

Hendrickson HR, Conn EE.

Title

Cyanide metabolism in higher plants. IV. Purification and properties of the beta-cyanolanine synthase of blue lupine.

Journal

J Biol Chem 244:2632-40 (1969)

Other DBs

ExplorEnz - The Enzyme Database:

4.4.1.9

IUBMB Enzyme Nomenclature:

4.4.1.9

ExPASy - ENZYME nomenclature database:

4.4.1.9

BRENDA, the Enzyme Database:

4.4.1.9

CAS:

9059-53-4

LinkDB

DBGET integrated database retrieval system