KEGG ENZYME: 4.6.1.22

ENZYME: 4.6.1.22

Entry

EC 4.6.1.22                 Enzyme

Name

Bacillus subtilis ribonuclease;
Proteus mirabilis RNase;
ribonucleate nucleotido-2'-transferase (cyclizing);
bacterial RNA lyase;
Bacillus subtilis intracellular ribonuclease

Class

Lyases;
Phosphorus-oxygen lyases;
Phosphorus-oxygen lyases (only sub-subclass identified to date)

Sysname

[RNA] 5'-hydroxy-ribonucleotide-3'-[RNA fragment]-lyase (cyclicizing; [RNA fragment]-3'- nucleoside -2',3'-cyclophosphate-forming)

Reaction(IUBMB)

RNA = a 5'-hydroxy-ribonucleotide + n nucleoside-2',3'-cyclophosphates

Substrate

RNA [CPD:C00046]

Product

5'-hydroxy-ribonucleotide;
nucleoside-2',3'-cyclophosphates

Comment

This enzyme catalyses endonucleolytic cleavage to 2',3'-cyclic nucleotides. The cyclic products may be hydrolysed to the corresponding 3'-phosphates by 2',3'-cyclic-nucleotide 2'-phosphodiesterase (EC 3.1.4.16). The enzyme from B. subtilis is inhibited by ATP.

History

EC 4.6.1.22 created 1978 as EC 3.1.27.2, transferred 2018 to EC 4.6.1.22

Reference

1 [PMID:13854124]

Authors

NISHIMURA S, MARUO B.

Title

Intracellular ribonuclease from Bacillus subtilis.

Journal

Biochim Biophys Acta 40:355-7 (1960)
DOI:10.1016/0006-3002(60)91364-0

Reference

2 [PMID:4962137]

Authors

Yamasaki M, Arima K.

Title

Regulation of intracellular ribonuclease of Bacillus subtilis by ATP and ADP.

Journal

Biochim Biophys Acta 139:202-4 (1967)
DOI:10.1016/0005-2744(67)90135-0

Reference

3 [PMID:4981632]

Authors

Yamasaki M, Arima K.

Title

Intracellular ribonuclease of Bacillus subtilis; specific inhibition by ATP and dATP.

Journal

Biochem Biophys Res Commun 37:430-6 (1969)
DOI:10.1016/0006-291X(69)90933-4

Reference

4 [PMID:4296400]

Authors

Center MS, Behal FJ

Title

Studies on the ribonuclease activity of Proteus mirabilis.

Journal

Biochim Biophys Acta 151:698-9 (1968)
DOI:10.1016/0005-2744(68)90022-3

Other DBs

ExplorEnz - The Enzyme Database:

4.6.1.22

IUBMB Enzyme Nomenclature:

4.6.1.22

ExPASy - ENZYME nomenclature database:

4.6.1.22

BRENDA, the Enzyme Database:

4.6.1.22

LinkDB

DBGET integrated database retrieval system