KEGG ENZYME: 4.6.1.26

ENZYME: 4.6.1.26

Entry

EC 4.6.1.26                 Enzyme

Name

uridylate cyclase;
pycC (gene name) (ambiguous)

Class

Lyases;
Phosphorus-oxygen lyases;
Phosphorus-oxygen lyases (only sub-subclass identified to date)

Sysname

UTP diphosphate-lyase (cyclizing; 3',5'-cyclic-UMP-forming)

Reaction(IUBMB)

UTP = 3',5'-cyclic UMP + diphosphate [RN:R12998]

Reaction(KEGG)

R12998

Substrate

UTP [CPD:C00075]

Product

3',5'-cyclic UMP [CPD:C22509];
diphosphate [CPD:C00013]

Comment

The enzyme, found in bacteria and archaea, forms cUMP, which functions as a second messenger in bacterial immunity against viruses. The enzyme is synthesized following phage infection and activates immune effectors that execute an antiviral response.

History

EC 4.6.1.26 created 2022

Pathway

ec00240

Pyrimidine metabolism

Orthology

K27603

uridylate cyclase

Genes

XPE:	BJD13_11320

XAS:	HEP74_02063

XAI:	HEP75_02409

SACZ:

AOT14_04600

STEN:

CCR98_10730

SPAQ:

STNY_R21620

STEJ:

FQS62_011745

RHD:	R2APBS1_3636

DCS:	ISN74_09815

PALK:

PSAKL28_39520

PUM:	HGP31_19450

VOX:	LCH97_16365

CHIC:

N8I74_06595

CUPP:

CTP10_R69450

BUG:	BC1001_4678

HPSE:

HPF_13995

MIU:	ABE85_14580

MMS:

mma_1001

JAL:	BZG29_17010

HEW:	HBDW_23940

REP:	IE4803_PB00019

RHR:	CKA34_11345

OIN:	IAR37_11935

LNE:	FZC33_15915

DRI:	QOV41_03145

PSIN:

CAK95_11700

CCR:

CC_2703

CCS:	CCNA_02786

YPAC:

CEW88_04790

TOM:	BWR18_12670

PALS:

PAF20_04525

RHM:	B5V46_03430

PSEB:

EOK75_05250

POZ:	I0K15_19590

NPN:	JI59_05180

SBD:	ATN00_12490

SBAR:

H5V43_04145

CMAN:

A9D14_00770

RMUC:

FOB66_00725

GEB:

GM18_2895

DAT:	HRM2_19350(cyaA1)

MSD:	MYSTI_03259

ACA:	ACP_3208 ACP_3209

MSP:	Mspyr1_25370

MARZ:

MARA_02520

MFG:	K6L26_30760

ASD:	AS9A_P20103

CACC:

CACC_00460

CPSP:

L9H27_00185

RHOH:

CPI83_29160 CPI83_29165

SGRS:

V9K83_00025 V9K83_33055

SSPN:

LXH13_14945

PPHP:

VTA80_16675

MAUR:

BOH66_08560

PNV:	JMY29_20240 JMY29_20245

MICU:

SOY78_04445

KSE:	Ksed_05370

TED:	U5C87_07765

CCOT:

CCAX7_35420

» show all

Reference

1 [PMID:34644530]

Authors

Tal N, Morehouse BR, Millman A, Stokar-Avihail A, Avraham C, Fedorenko T, Yirmiya E, Herbst E, Brandis A, Mehlman T, Oppenheimer-Shaanan Y, Keszei AFA, Shao S, Amitai G, Kranzusch PJ, Sorek R.

Title

Cyclic CMP and cyclic UMP mediate bacterial immunity against phages.

Journal

Cell 184:5728-5739.e16 (2021)
DOI:10.1016/j.cell.2021.09.031

Sequence

[ag:WP_048245919]

Other DBs

ExplorEnz - The Enzyme Database:

4.6.1.26

IUBMB Enzyme Nomenclature:

4.6.1.26

ExPASy - ENZYME nomenclature database:

4.6.1.26

BRENDA, the Enzyme Database:

4.6.1.26

LinkDB

DBGET integrated database retrieval system