KEGG   ENZYME: 5.1.1.24
Entry
EC 5.1.1.24                 Enzyme                                 
Name
histidine racemase;
cntK (gene name)
Class
Isomerases;
Racemases and epimerases;
Acting on amino acids and derivatives
Sysname
histidine racemase
Reaction(IUBMB)
L-histidine = D-histidine [RN:R12313]
Reaction(KEGG)
R12313
Substrate
L-histidine [CPD:C00135]
Product
D-histidine [CPD:C06419]
Comment
The enzyme, characterized from the bacterium Staphylococcus aureus, participates in the biosynthesis of the metallophore staphylopine, which is involved in the acquisition of nickel, copper, and cobalt.
History
EC 5.1.1.24 created 2019
Pathway
ec00470  D-Amino acid metabolism
ec01100  Metabolic pathways
Orthology
K01780  histidine racemase
Genes
CGEOCGEO_0432
CBLACBLAS_1471
CCORCCORG_1384
DVUDVU_2746
DVLDvul_0561
DVMDvMF_1168
DVGDeval_2536
DDSDdes_1977
DFIAXF13_11085
DPGDESPIGER_2298
DEFCNY67_02250
DFLDFE_2755
DBADbac_1615
DOAAXF15_03775
SDOSD1155_03785
BSONS101395_03013
BBADK7T73_01185
BHABH2071
ANDGRQ40_16010
LYBC3943_14835
LMACI6G82_11185
VNECFK40_16070
MEKUHUW50_21740
SAUSA2258
SAVSAV2470
SAWSAHV_2454
SAHSaurJH1_2546
SAJSaurJH9_2497
SAMMW2394
SASSAS2361
SARSAR2557
SACSACOL2479
SAXUSA300HOU_2461
SAASAUSA300_2414
SAOSAOUHSC_02770
SAENWMN_2367
SADSAAV_2536
SUUM013TW_2430(cntK)
SUVSAVC_11220
SUESAOV_2520c
SUJSAA6159_02367(dapF)
SUKSAA6008_02511(dapF)
SUCECTR2_2327
SUTSAT0131_02669
SUQHMPREF0772_10719
SUZMS7_2483
SUDST398NM01_2520
SUXSAEMRSA15_23680
SUWSATW20_25980
SUGSAPIG2520
SUFSARLGA251_22500
SAUASAAG_00296
SAUERSAU_002308
SAUNSAKOR_02454
SAUSSA40_2218
SAUUSA957_2302
SAUGSA268_2375
SAUZSAZ172_2573
SAUTSAI1T1_2018400
SAUJSAI2T2_1018410
SAUKSAI3T3_1018400
SAUQSAI4T8_1018410
SAUVSAI7S6_1018400
SAUWSAI5S5_1018340
SAUXSAI6T6_1018340
SAUYSAI8T7_1018380
SAUFX998_2454
SABSAB2353c
SUYSA2981_2407
SAUBC248_2520
SAUMBN843_25100
SAUCCA347_2549
SAURSABB_02982
SAUIAZ30_12970
SAUDCH52_06635
SAMSNI36_12280
SUHSAMSHR1132_22950
SERSERP2375
SEPSE_0201
SEPPSEB_00129
SEPSDP17_1263
SSDSPSINT_0076
SDTSPSE_2401
SDPNCTC12225_02596
SWAA284_00410
SPASSTP1_1306
SXYBE24_11765
SXLSXYLSMQ121_0067
SXOSXYL_00068
SHUSHYC_11655
SCAPAYP1020_1968
SSCHLH95_11160
SSCZRN70_11910
SAGQEP23_10510(cntK)
SLZB5P37_06425
SFQC7J90_03765
SCHRDWB92_11730(cntK)
SSHNCTC13712_02422
SLLOISP08_00440(cntK)
SFFFOB90_08230(cntK)
SSTESAMEA4384403_1088
BBEBBR47_28200
BFMBP422_09275
BAGRBA6348_01055
GYMGYMC10_2835
PMSKNP414_01893
PMQPM3016_2178
PMWB2K_11195
PAEAR70723_16820
PNPIJ22_24990
PVOPVOR_17339
PLWD5F53_15610
PCHIPC41400_19310
PBACHUB98_11430
PTRIKDC22_17085
PALOE6C60_2224
PANABBH88_13395
SURESporoP32a_07155
SPOSDV702_00150
LTIJW886_02775
CTCCTC_02312
CTETBN906_02523
CACECACET_c28190
CFMBJL90_00610 BJL90_20915
CCOHSAMEA4530647_1986
AMTAmet_2050
CRSFQB35_12585
OVAOBV_13890
VFAMM35RIKEN_15870
BYLA4V09_20630
BHANCGC63_14650
BLAUDQQ01_02000
BPROPMF13cell1_01326
CPROCPRO_28700(dapF_2)
TEBT8CH_1255
DMTDESME_14740
FWADCMF_00910 DCMF_25690
VPYHZI73_24760
AMICAmi3637_14300
ETMCE91St48_30360
TEPTepRe1_0771
TAETepiRe1_0835
KMEH0A61_01263
PEDING2D1G_0166
PHARNCTC13077_00489
MEDMELS_2057
MHWACT01_00490
MEGDKB62_02595
MMAXLCQ47_11300
SSGSelsp_0678
AFNAcfer_1540
AINAcin_0749
GPDGII33_20960
AAIAARI_10880
GARAOZ07_05765
GLUF0M17_05425
PAEYKUF55_05510
APRECNX65_19690
AMIAmir_3920
PLKCIK06_26255
TAZTREAZ_1278
TPITREPR_0956
FNUFN1732
FNCHMPREF0946_01324
FNTHMPREF0405_00071
FUSHMPREF0409_01840
FNEFSDG_02337
FHWRN87_01210
FPDCTM68_03690
FNFBSQ88_10095
FPEIC4N17_08665
FCII6I83_02190
 » show all
Reference
1  [PMID:27230378]
  Authors
Ghssein G, Brutesco C, Ouerdane L, Fojcik C, Izaute A, Wang S, Hajjar C, Lobinski R, Lemaire D, Richaud P, Voulhoux R, Espaillat A, Cava F, Pignol D, Borezee-Durant E, Arnoux P
  Title
Biosynthesis of a broad-spectrum nicotianamine-like metallophore in Staphylococcus aureus.
  Journal
Science 352:1105-9 (2016)
DOI:10.1126/science.aaf1018
  Sequence
[sav:SAV2470]
Other DBs
ExplorEnz - The Enzyme Database: 5.1.1.24
IUBMB Enzyme Nomenclature: 5.1.1.24
ExPASy - ENZYME nomenclature database: 5.1.1.24
BRENDA, the Enzyme Database: 5.1.1.24
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