KEGG   ENZYME: 5.1.3.11
Entry
EC 5.1.3.11                 Enzyme                                 
Name
cellobiose epimerase
Class
Isomerases;
Racemases and epimerases;
Acting on carbohydrates and derivatives
Sysname
cellobiose 2-epimerase
Reaction(IUBMB)
cellobiose = 4-O-beta-D-glucopyranosyl-D-mannose [RN:R01445 R06245]
Reaction(KEGG)
R01445 R06245(G);
(other) R10810
Substrate
cellobiose [CPD:C00185]
Product
4-O-beta-D-glucopyranosyl-D-mannose [CPD:C02964]
Comment
The enzyme catalyses the interconversion between D-glucose and D-mannose residues at the reducing end of beta-1,4-linked disaccharides by epimerizing the hydroxyl group at the C-2 position of the glucose moiety.
History
EC 5.1.3.11 created 1972
Orthology
K16213  cellobiose epimerase
Genes
VFU: vfu_B00537
VFL: AL536_06135
THAT: H3N35_22860
TACT: SG35_023915
ALE: AV939_12180
ALZ: AV940_11945
APEL: CA267_016830
GAG: Glaag_3289
PMES: FX988_01605
CATE: C2869_05850
AGQ: LQZ07_22450
CATT: OLW01_01895
CJA: CJA_0243(unk2)
CEB: B0D95_16675
CELL: CBR65_15155
CEK: D0B88_02295
CEG: D0C16_07760 D0C16_14115 D0C16_18795
SDE: Sde_0508
TTU: TERTU_4095
SAGA: M5M_16785
MARQ: MARGE09_P2967
GIL: NHM04_09040
MICC: AUP74_03277(ce_1)
HALC: EY643_17615 EY643_17675
ETB: N7L95_27555
STEL: STAQ_17780
BCO: Bcell_0277
AXL: AXY_22460
PRD: F7984_12605
GRC: GI584_07530
GCS: MUN88_20890
GSM: MUN87_20710
MEKU: HUW50_05295
MLIT: KDJ21_026460
SLMS: MM221_05570
ECTO: MUG87_17705
ALKL: MM271_17905
PJD: Pjdr2_2154
GYM: GYMC10_3611
PPY: PPE_04652
PPM: PPSC2_24205(rnbP)
PPO: PPM_4806(rnbP)
PPOL: X809_40740
PPQ: PPSQR21_049040
PPOY: RE92_13070
PMS: KNP414_02124
PMQ: PM3016_2411
PMW: B2K_12220
PTA: HPL003_05775
PBD: PBOR_10045
PGM: PGRAT_09435
POD: PODO_08035
PAEN: P40081_09765
PAEF: R50345_08085
PAEQ: R50912_09090
PSTE: PSTEL_08715
PAEA: R70723_09065
PAEE: R70331_08915
PAEH: H70357_09440
PAEJ: H70737_07850
PRI: PRIO_2006(bfce)
PSON: JI735_18250
PPEO: ABE82_24405
PBV: AR543_12195
PXL: BS614_01570
PDH: B9T62_03530
PIB: BBD41_27505
PCX: LPB68_13480
PKB: B4V02_01070
PAIH: ASL14_13515
PLW: D5F53_12180
PLEN: EIM92_12120
PPSC: EHS13_07920
PLUT: EI981_08160
PRZ: GZH47_00825
PLYC: GXP70_16220
PTRI: KDC22_17225
PALO: E6C60_0805
PCEL: HUB94_13190 HUB94_22925
PTJ: JRJ22_07460
PALR: HGI30_21530
PUI: PUW25_05110
PMAH: PTQ21_03760
PAMY: P9222_06835
PMAE: LMZ02_26760
PWN: QNH46_16595
PPOG: QPK24_13715
PHK: SK066_13500
PPAB: KET34_32775
PHEX: L0M14_24405
PLZH: C0638_09075
TCO: Theco_0999
COH: EAV92_11235
CCHL: FPL14_24305
CHEB: HH215_01835
SACA: FFV09_14425
CAW: Q783_10200
CCB: Clocel_3198
CLB: Clo1100_3758
CEU: A7L45_06540
CTHD: CDO33_11735
FSA: C5Q98_00290
CCE: Ccel_3002
CSS: Cst_c14700
CSD: Clst_1418
ESR: ES1_19350
ESU: EUS_11950
EHA: Ethha_0905
RAL: Rumal_0019
RCH: RUM_08680
RUS: RBI_II00318(ce)
FPA: FPR_17230
CAML: H6X83_11005
ALAC: JYE50_09195
AHC: JYE49_09055
CBAF: JS518_00260
RHO: RHOM_11450
RIX: RO1_18080
RIM: ROI_36330
RRK: H8S51_013945
COO: CCU_23010
CEV: LK421_05075
BYL: A4V09_07555
BLUI: Blut17040_02240
BCOC: BLCOC_19790(ce-ne1)
CPY: Cphy_2262
ANR: Ana3638_04600
ACEL: acsn021_43450
ACHT: bsdcttw_02300
SSUN: H9Q77_01910
MFOR: NQ534_10880
AHB: bsdtb5_34040
LBX: lbkm_1541
CLE: Clole_3362
CEW: EKH84_20040
CBAR: PATL70BA_2548
VPY: HZI73_19025
TTM: Tthe_1937
TTO: Thethe_01945
TSH: Tsac_2329
MAS: Mahau_2100
HALS: D7D81_09485
CSC: Csac_0294
ATE: Athe_2557
COB: COB47_2182
CHD: Calhy_0278
CKI: Calkr_2194
CLC: Calla_0266
CKN: Calkro_0294
CCHA: ELD05_01485
CDIA: CaldiYA01_02560
CMOR: OTK00_002193
CDAN: SOJ16_002545
AHK: NCTC10172_01381
DSS: GCM25873_03200
TLS: QH948_13375
HAU: Haur_0887
ATM: ANT_18730
OTE: Oter_2309 Oter_2742
OBG: Verru16b_01806(ce_1) Verru16b_02092(ce_2)
SLOM: PXH66_14330
AAQW: K1X11_021515
MFF: MFFC18_14270(ce)
AHEL: Q31a_20900(ce_1)
ALUS: STSP2_01937(ce)
TBE: Trebr_1916
STA: STHERM_c00950
STQ: Spith_0082
SLR: L21SP2_2183
SASS: MUG09_02555
PFER: IRI77_28255
BFR: BF0849
BFS: BF9343_0739
BFG: BF638R_0832(age)
BFB: VU15_03585
BHL: Bache_0225
BOA: Bovatus_02923(bfce)
BCEL: BcellWH2_02021(bfce)
BZG: C4H11_10955
BHF: C3V43_14595
BIS: DXK01_001885
BUN: Bun01g_02460 Bun01g_06710 Bun01g_06780
BNO: K8P02_00735
BHUM: JXR92_001575 JXR92_003660 JXR92_003700
BSAL: K6V25_08065
BSA: Bacsa_1717
BDO: EL88_18345
PBT: ING2E5B_0328 ING2E5B_2178(bfce)
PSAC: PSM36_3109
DYS: G7050_02455
DYH: G7051_02860
PPN: Palpr_1812
PDI: BDI_0057
PARC: CI960_03395
DUN: FDZ78_08870
DUQ: E7745_05165
COPR: Cop2CBH44_28010
PDN: HMPREF9137_1953
PMUF: J4864_09095
PHIS: J5A62_10990
PHER: prwr041_21370
PVF: J5A55_08625
PRU: PRU_1723
POC: NCTC13071_01500
PBY: L6471_05570
SHOI: KUA50_002325
SBAO: L6469_10305
AOK: A3BBH6_12800
ACOU: A5CBH24_10330
ADA: A5CPEGH6_09170
ASEN: NQ519_08090
DORI: FH5T_02000 FH5T_03390
MCOS: GM418_03030 GM418_17185
ANF: AQPE_0804
ASX: CDL62_07300
ALKQ: M9189_11265
MBAS: ALGA_0932
CPI: Cpin_5399
CBAE: COR50_11650
COY: HF329_18125
CHOR: MKQ68_20055
CSAC: SIO70_26730
CPOL: WJU16_03755
NKO: Niako_4392
ARK: D6B99_05370
AGI: FSB73_16955
ARAC: E0W69_014610
FLN: FLA_5531
PSEG: D3H65_07900
PGIN: FRZ67_03315
PGO: FSB84_12440
FLS: GLV81_05220
FLV: KJS94_00070
THEO: IMW88_00280
HHY: Halhy_0144 Halhy_5540
PHE: Phep_3983
PSN: Pedsa_2972
SHG: Sph21_0932
STHA: NCTC11429_04418
SMUI: I6J00_10090
SFAE: MUK51_12150
SCN: Solca_2509
MUC: MuYL_1513
MGOT: MgSA37_00580(ce_1) MgSA37_03676(bfce)
MUH: HYN43_001765 HYN43_016240
MGIN: FRZ54_11630
MGK: FSB76_21755
MRUB: DEO27_016585 DEO27_016850
MGOS: DIU38_000930 DIU38_017135
MMAB: HQ865_05355
MROB: HH214_11655
MJJ: PQO05_07310
CMR: Cycma_4636
CAMU: CA2015_4446
SLI: Slin_0271
SRD: SD10_06950
SMON: AWR27_14145
SPIR: CWM47_13160
SPIK: EXU85_28295
SPIB: G8759_13670
STAE: HNV11_05175
SOQ: LQ777_24190
SENF: GJR95_35455
RHOZ: GXP67_16780
LBY: Lbys_3430
ALS: DJ013_19300
MAQA: LAG90_09345
DFE: Dfer_1975
DSN: HWI92_08395
DYC: NFI80_09215
DFQ: NFI81_02555
DCN: MUK70_03215
DPF: ON006_14095
RSI: Runsl_3647 Runsl_4586
RUN: DR864_03550 DR864_07595
RUP: DTQ70_09315
FAE: FAES_1969
FIB: A6C57_20430
HYP: A0257_01745
HYZ: AXW84_13475
HNV: DDQ68_01360
HTB: MTX78_01845
PKO: PKOR_09255
PONT: C1N53_07090
RUF: TH63_14905
RTI: DC20_05260 DC20_06375
ADD: HUW48_19165
ASWU: HUW51_11915
FPF: DCC35_09340
FLM: MY04_5415
FLL: EI427_17605
FYA: KMW28_21530
FKA: KM029_25000
FBT: D770_13195 D770_23740
CHK: D4L85_32470
FMM: LVD15_18680
FUA: LVD17_00405
FLW: LVD16_15565
PRHO: PZB74_21040
GRS: C7S20_04555 C7S20_04610
FPSZ: AMR72_02965
FJO: Fjoh_4956
FJG: BB050_02608(bfce)
FAT: DVK85_01175
FKI: FK004_17240
FALB: HYN59_00885
FCR: HYN56_24400
FSE: DI487_13645
FNK: E1750_12030 E1750_16665
FAK: FUA48_00770
FFL: HYN86_20445
FEN: J0383_16470
FPB: NLJ00_24425
FBI: L0669_23065
FHU: M0M44_23235
FPEC: Q1W71_10875
ZPR: ZPR_0358 ZPR_3474
FBC: FB2170_14788
MARB: CJ263_08600
POB: LPB03_05820 LPB03_10220
TJE: TJEJU_2836
LUL: LPB138_13105
SALT: AO058_04390
FAY: Q4Q34_15300
MARF: CJ739_714
AQD: D1816_19015
EMAR: D1013_00700
SINH: LS482_08400 LS482_09970
FLG: LV716_01420
FLB: LV704_02325
SABU: MBM09_07310 MBM09_07805
FBE: FF125_04080
FBM: MQE35_05840
LUY: QZH61_02140
MANG: RBH95_15820
CHRZ: CO230_01230
CGAM: PFY09_04930
KAQ: L0B70_12215
RMR: Rmar_2439
RMG: Rhom172_2440
RLO: GQ464_000395
RBAR: AWN76_012255
MRO: MROS_0506 MROS_2629
DTH: DICTH_0488
DTU: Dtur_0652
SALI: L593_06560
HRR: HZS55_21510
HPEL: HZS54_24970
HLT: I7X12_15110
HTU: Htur_4659
HSAL: JMJ58_21300
HALY: HYG82_04125
HLR: HALLA_01820
 » show all
Reference
1  [PMID:6069974]
  Authors
Tyler TR, Leatherwood JM.
  Title
Epimerization of disaccharides by enzyme preparations from Ruminococcus albus.
  Journal
Arch Biochem Biophys 119:363-7 (1967)
DOI:10.1016/0003-9861(67)90466-3
Reference
2  [PMID:18392616]
  Authors
Ito S, Taguchi H, Hamada S, Kawauchi S, Ito H, Senoura T, Watanabe J, Nishimukai M, Ito S, Matsui H
  Title
Enzymatic properties of cellobiose 2-epimerase from Ruminococcus albus and the synthesis of rare oligosaccharides by the enzyme.
  Journal
Appl Microbiol Biotechnol 79:433-41 (2008)
DOI:10.1007/s00253-008-1449-7
  Sequence
[ag:BAF81108]
Reference
3  [PMID:23462136]
  Authors
Fujiwara T, Saburi W, Inoue S, Mori H, Matsui H, Tanaka I, Yao M
  Title
Crystal structure of Ruminococcus albus cellobiose 2-epimerase: structural insights into epimerization of unmodified sugar.
  Journal
FEBS Lett 587:840-6 (2013)
DOI:10.1016/j.febslet.2013.02.007
Other DBs
ExplorEnz - The Enzyme Database: 5.1.3.11
IUBMB Enzyme Nomenclature: 5.1.3.11
ExPASy - ENZYME nomenclature database: 5.1.3.11
BRENDA, the Enzyme Database: 5.1.3.11
CAS: 37318-37-9
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