KEGG   ENZYME: 5.1.3.19
Entry
EC 5.1.3.19                 Enzyme                                 
Name
chondroitin-glucuronate 5-epimerase;
polyglucuronate 5-epimerase;
dermatan-sulfate 5-epimerase;
urunosyl C-5 epimerase;
chondroitin D-glucuronosyl 5-epimerase
Class
Isomerases;
Racemases and epimerases;
Acting on carbohydrates and derivatives
Sysname
chondroitin-D-glucuronate 5-epimerase
Reaction(IUBMB)
chondroitin D-glucuronate = dermatan L-iduronate [RN:R04104]
Reaction(KEGG)
R04104
Substrate
chondroitin D-glucuronate
Product
dermatan L-iduronate [CPD:C01490]
Comment
Not identical with EC 5.1.3.17 heparosan-N-sulfate-glucuronate 5-epimerase.
History
EC 5.1.3.19 created 1986
Pathway
ec00532  Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate
ec01100  Metabolic pathways
Orthology
K01794  chondroitin-glucuronate 5-epimerase
Genes
HSA29940(DSE)
PTR462957(DSE)
PPS100992267(DSE)
GGO101136014(DSE)
PON100449623(DSE)
NLE100594165(DSE)
MCC716054(DSE)
MCF102115486(DSE)
CSAB103240515(DSE)
CATY105581416(DSE)
PANU101017592(DSE)
TGE112623683(DSE)
RRO104670054(DSE)
RBB108517485(DSE)
TFN117096964(DSE)
PTEH111547301(DSE)
CJC100408506(DSE)
SBQ101034473(DSE)
CSYR103257575(DSE)
MMUR105864972(DSE)
LCAT123633193(DSE)
OGA100960199(DSE)
MMU212898(Dse)
MCAL110303344(Dse)
MPAH110326742(Dse)
RNO365583(Dse)
MCOC116074365(Dse)
MUN110557084(Dse)
CGE100775050(Dse)
MAUA101838489(Dse)
PLEU114696867(Dse)
MORG121450178(Dse)
MFOT126499005
AAMP119821560(Dse)
NGI103749321(Dse)
HGL101706845(Dse)
CPOC100712994(Dse)
CCAN109694217(Dse)
DORD105998178(Dse)
DSP122108046(Dse)
NCAR124989669
OCU100357395(DSE)
OPI101534936(DSE)
TUP102488933(DSE)
CFA476271(DSE)
CLUD112644449(DSE)
VVP112922775(DSE)
VLG121484384(DSE)
AML100477586(DSE)
UMR103663473(DSE)
UAH113247886 113247919
UAR123792979(DSE)
ELK111158324
LLV125102210
MPUF101683856(DSE)
ORO101362128(DSE)
EJU114219529(DSE)
ZCA113927004(DSE)
MLX118000588(DSE)
NSU110583106(DSE)
FCA101089441(DSE)
PYU121029938(DSE)
PBG122489898(DSE)
LRUF124528747
PTG102950359(DSE)
PPAD109260599(DSE)
AJU106984629(DSE)
HHV120224337(DSE)
BTA514028(DSE)
BOM102279883(DSE)
BIU109563797(DSE)
BBUB102391733(DSE)
CHX102174473(DSE)
OAS101105922(DSE)
ODA120862470(DSE)
CCAD122422600(DSE) 122438259
SSC100625171(DSE)
CFR102505940(DSE)
CBAI105077152(DSE)
CDK105088324(DSE)
VPC102541817(DSE)
BACU103018638(DSE)
LVE103086731(DSE)
OOR101275728(DSE)
DLE111164876(DSE)
PCAD102976317(DSE)
PSIU116763186(DSE)
ECB100072666(DSE)
EPZ103549678(DSE)
EAI106847032(DSE)
MYB102246837(DSE)
MYD102767369(DSE)
MMYO118659882(DSE)
MLF102441610(DSE)
MNA107526281(DSE)
PKL118705343(DSE)
HAI109396470(DSE)
DRO112297030(DSE)
SHON119000199(DSE)
AJM119058704(DSE)
PDIC114494200(DSE)
PHAS123822061(DSE)
MMF118621562(DSE)
RFQ117020351(DSE)
PALE102880482(DSE)
PGIG120608854(DSE)
PVP105295255(DSE)
RAY107520183(DSE)
MJV108392940(DSE)
TOD119252807 119252817
SARA101557670(DSE)
LAV100671521(DSE)
TMU101344455
DNM101436803(DSE)
MDO100022925(DSE)
GAS123247782(DSE)
SHR100928385(DSE)
PCW110197577(DSE)
OAA100093092(DSE)
GGA421745(DSE)
PCOC116240386(DSE)
MGP100539595(DSE)
CJO107311802(DSE)
NMEL110395471(DSE)
APLA101802820(DSE) 113839627
ACYG106032570(DSE)
AFUL116488280(DSE)
TGU100227259(DSE)
LSR110484657(DSE)
SCAN103818466(DSE)
PMOA120512836(DSE)
OTC121346290(DSE)
PRUF121359301(DSE)
GFR102039170(DSE)
FAB101810285(DSE)
PHI102105603(DSE)
PMAJ107201763(DSE)
CCAE111927170(DSE)
CCW104691209(DSE)
CBRC103619276(DSE)
ETL114065057(DSE)
ZAB102074486(DSE)
ACHL103797975(DSE)
FPG101919108(DSE)
FCH102056688(DSE)
CLV102091033(DSE)
EGZ104131988(DSE)
NNI104008625(DSE)
PLET104620008(DSE)
PCRI104031795(DSE)
ACUN113478391(DSE)
TALA104364275(DSE)
PADL103918364(DSE)
AFOR103907045(DSE)
ACHC115336283(DSE)
HALD104314382(DSE)
CCRI104166914(DSE)
CSTI104554153(DSE)
EHS104506860(DSE)
CMAC104472953(DSE)
MUI104548934(DSE)
FGA104076589(DSE)
GSTE104250780(DSE)
LDI104343656(DSE)
MNB103779045(DSE)
OHA104338788(DSE)
NNT104408872(DSE)
DPUB104297457(DSE)
PGUU104465128(DSE)
ACAR104527826(DSE)
AVIT104280711(DSE)
AAM106498030(DSE)
AROW112966157(DSE)
NPD112952761(DSE)
TGT104574997(DSE)
DNE112997473(DSE)
SCAM104148489(DSE)
ASN102376702
AMJ102565708(DSE)
CPOO109312144
GGN109299575
PSS102445811
CMY102946993(NT5DC1) 122461319(DSE)
CPIC101939866
TST117875010(NT5DC1)
CABI116823986(DSE)
MRV120400755
ACS100565745(dse)
PVT110088507(DSE)
SUND121919092(DSE)
PBI103064691(DSE)
PMUR107292481(DSE)
CTIG120313526(DSE)
TSR106546186
PGUT117660881(DSE)
VKO123021381(DSE)
PMUA114594067(DSE)
ZVI118082141(DSE)
GJA107108606(DSE)
STOW125430469(DSE)
XLA108716814(dse.L) 108717926(dse.S)
XTR100145321(dse)
NPR108792973(DSE)
RTEM120937230(DSE)
BBUF121000010(DSE)
BGAR122935686(DSE)
DRE568713(dse)
SRX107750401(dse) 107754999
SANH107670255(dse) 107704356
SGH107548286 107565442
CCAR109073756 109073796
CAUA113063509 113121284(dse)
PPRM120477153(dse)
MAMB125277714(dse)
IPU108255449(dse)
PHYP113525226(dse)
SMEO124401588(dse)
TFD113647323(dse)
AMEX103027569(dse)
EEE113590559(dse)
TRU101074978(dse)
TNGGSTEN00009139G001
LCO104932428(dse)
NCC104949999(dse)
CGOB115004057(dse)
ELY117271087(dse)
EFO125897634(dse)
PLEP121955185(dse)
SLUC116040352(dse)
ECRA117961931(dse)
ESP116683474
PFLV114573201(dse)
GAT120808034(dse)
PPUG119195156(dse)
MSAM119908594(dse)
CUD121521269(dse)
ALAT119012045(dse)
MZE101475897(dse)
ONL100712134(dse)
OAU116328420(dse)
OLA101165527(dse)
OML112158421(dse)
XMA102232258(dse)
XCO114158504(dse)
XHE116734107(dse)
PRET103458044(dse)
PFOR103131136 103131137
PLAI106943265(dse)
PMEI106912222(dse)
GAF122825466(dse)
CVG107100262(dse)
CTUL119774309(dse)
GMU124881992(dse)
NFU107396459(dse)
KMR108245670(dse)
ALIM106531122(dse)
NWH119418423(dse)
AOCE111587140(dse)
MCEP124999315(dse)
CSEM103380626(dse)
POV109632280(dse)
SSEN122762152 122784250
HHIP117758084(dse)
HSP118099343(dse)
LCF108899289
SDU111240358(dse)
SLAL111672919(dse)
XGL120788902(dse)
HCQ109509248(dse)
BPEC110166647(dse)
MALB109967396(dse)
BSPL114849682(dse)
SASA106571323 106607725
STRU115174906 115194213
OTW112217517(dse) 112250052
OMY110522129(dse) 110529514
OGO123990667 123995000
ONE115107665 115139515
SALP111954022 111972814
SNH120019662 120023871
CCLU121549016 121552471
ELS105017879(dse)
SFM108929390(dse)
PKI111843001(dse)
AANG118230512(dse)
LOC102695375(dse)
PSPA121315463 121317582
ARUT117403302 117410583
LCM102365874(DSE)
CMK103182570(dse)
RTP109920175(dse)
 » show all
Reference
1  [PMID:7092807]
  Authors
Malmstrom A, Aberg L.
  Title
Biosynthesis of dermatan sulphate. Assay and properties of the uronosyl C-5 epimerase.
  Journal
Biochem J 201:489-93 (1982)
DOI:10.1042/bj2010489
Other DBs
ExplorEnz - The Enzyme Database: 5.1.3.19
IUBMB Enzyme Nomenclature: 5.1.3.19
ExPASy - ENZYME nomenclature database: 5.1.3.19
BRENDA, the Enzyme Database: 5.1.3.19
CAS: 70766-66-4
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