Entry |
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Name |
N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol 4-epimerase;
GlcNAc-P-P-Und epimerase;
GlcNAc-P-P-Und 4-epimerase;
gne (gene name)
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Class |
Isomerases;
Racemases and epimerases;
Acting on carbohydrates and derivatives
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Sysname |
N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol 4-epimerase
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Reaction(IUBMB) |
N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol = N-acetyl-alpha-D-galactosaminyl-diphospho-ditrans,octacis-undecaprenol [RN: R10554]
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Reaction(KEGG) |
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Substrate |
N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [CPD: C01289]
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Product |
N-acetyl-alpha-D-galactosaminyl-diphospho-ditrans,octacis-undecaprenol [CPD: C20620]
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Comment |
The enzyme is involved in biosynthesis of the repeating tetrasaccharide unit of the O-antigen produced by some Gram-negative bacteria.
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History |
EC 5.1.3.26 created 2013
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Orthology |
K19997 | GlcNAc-P-P-Und epimerase |
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Genes |
SOF: | NCTC11214_03911(rmlB) |
PRG: | RB151_044070(galE_3) |
LRI: | NCTC12151_01024(galE_1) |
PCQ: | PcP3B5_48010(galE_1) |
LADL: | NCTC12735_01331(galE_3) |
MPAD: | KEF85_04055 KEF85_11835 |
COX: | E0W60_29830 E0W60_31350 |
MAUU: | NCTC10437_05040(galE_3) |
MFF: | MFFC18_01490(galE_1) |
BTHO: | Btheta7330_02119(rmd) |
BFS: | BF9343_1488 BF9343_2511 BF9343_3583 |
BHL: | Bache_1980 Bache_2164 Bache_2248 Bache_2957 |
BOA: | Bovatus_00886 Bovatus_01171(galE_1) Bovatus_04914(galE_2) |
BCEL: | BcellWH2_04981(rmd_3) |
BIS: | DXK01_010855 DXK01_020645 |
BDH: | GV66_15720 GV66_17420 |
SMIZ: | 4412673_02365(galE_2) |
SDJ: | NCTC13534_03419 NCTC13534_03420(galE_1) |
» show all
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Reference |
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Authors |
Rush JS, Alaimo C, Robbiani R, Wacker M, Waechter CJ |
Title |
A novel epimerase that converts GlcNAc-P-P-undecaprenol to GalNAc-P-P-undecaprenol in Escherichia coli O157. |
Journal |
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Sequence |
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Other DBs |
ExplorEnz - The Enzyme Database: | 5.1.3.26 |
ExPASy - ENZYME nomenclature database: | 5.1.3.26 |
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LinkDB |
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