| Entry |
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| Name |
corticosteroid side-chain-isomerase
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| Class |
Isomerases;
Intramolecular oxidoreductases;
Interconverting aldoses and ketoses, and related compounds
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| Sysname |
11-deoxycorticosterone aldose-ketose-isomerase
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| Reaction(IUBMB) |
11-deoxycorticosterone = 20-hydroxy-3-oxopregn-4-en-21-al [RN: R04165]
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| Reaction(KEGG) |
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| Substrate |
11-deoxycorticosterone [CPD: C03205]
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| Product |
20-hydroxy-3-oxopregn-4-en-21-al [CPD: C04108]
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| Comment |
An epimerization at C-20 and C-21 is probably catalysed by the same enzyme.
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| History |
EC 5.3.1.21 created 1983
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| Reference |
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| Authors |
Martin KO, Oh SW, Lee HJ, Monder C. |
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| Title |
Studies on 21-3H-labeled corticosteroids: evidence for isomerization of the ketol side chain of 11-deoxycorticosterone by a hamster liver enzyme. |
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| Journal |
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| Reference |
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| Authors |
Monder C, Martin KO, Bogumil J. |
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| Title |
Presence of epimerase activity in hamster liver corticosteroid side chain isomerase. |
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| Journal |
J Biol Chem 255:7192-8 (1980) |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 5.3.1.21 |
| ExPASy - ENZYME nomenclature database: | 5.3.1.21 |
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| LinkDB |
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