Entry
Name
trans-2-decenoyl-[acyl-carrier protein] isomerase;
beta-hydroxydecanoyl thioester dehydrase;
trans-2-cis-3-decenoyl-ACP isomerase;
trans-2,cis-3-decenoyl-ACP isomerase;
trans-2-decenoyl-ACP isomerase;
FabM;
decenoyl-[acyl-carrier-protein] Delta2-trans-Delta3-cis-isomerase
Class
Isomerases;
Intramolecular oxidoreductases;
Transposing C=C bonds
BRITE hierarchy
Sysname
decenoyl-[acyl-carrier protein] Delta2-trans-Delta3-cis-isomerase
Reaction(IUBMB)
a trans-dec-2-enoyl-[acyl-carrier protein] = a cis-dec-3-enoyl-[acyl-carrier protein] [RN:
R07639 ]
Reaction(KEGG)
Substrate
trans-dec-2-enoyl-[acyl-carrier protein] [CPD:
C05754 ]
Product
cis-dec-3-enoyl-[acyl-carrier protein] [CPD:
C04180 ]
Comment
While the enzyme from Escherichia coli is highly specific for the 10-carbon enoyl-ACP, the enzyme from Streptococcus pneumoniae can also use the 12-carbon enoyl-ACP as substrate in vitro but not 14- or 16-carbon enoyl-ACPs [3]. ACP can be replaced by either CoA or N-acetylcysteamine thioesters. The cis-3-enoyl product is required to form unsaturated fatty acids, such as palmitoleic acid and cis-vaccenic acid, in dissociated (or type II) fatty-acid biosynthesis.
History
EC 5.3.3.14 created 2006
Pathway
Orthology
K01716 3-hydroxyacyl-[acyl-carrier protein] dehydratase / trans-2-decenoyl-[acyl-carrier protein] isomerase
K18474 trans-2-decenoyl-[acyl-carrier protein] isomerase
Genes
ECOO : ECRM13514_1060(fabA)
ECOH : ECRM13516_0995(fabA)
ECW : EcE24377A_1068(fabA)
EDJ : ECDH1ME8569_0905(fabA)
ECOI : ECOPMV1_00984(fabA)
SEM : STMDT12_C10890(fabA)
REE : electrica_03338(fabA)
RTG : NCTC13098_04994(fabA)
CLAP : NCTC11466_02988(fabA)
KIE : NCTC12125_02011(fabA)
AHN : NCTC12129_01881(fabA)
METY : MRY16398_37330(fabA)
PTF : PROFFT_A_02390(fabA)
PSHI : SAMEA2665130_1935(fabA)
MPHG : MPHASIOC01_000625(fabA)
YPG : YpAngola_A1942(fabA)
YPI : YpsIP31758_2546(fabA)
SMW : SMWW4_v1c17330(fabA)
SFJ : SAMEA4384070_1789(fabA)
SOF : NCTC11214_05072(fabA)
SSAR : SSARUM_001703(fabA)
PAQU : DMB82_0008285(fabA)
PARL : PEC302110_14760(fabA)
DIC : Dpoa569_001470(fabA)
EHD : ERCIPSTX3056_357(fabA)
PALH : B1H58_00015 B1H58_20275
TPTY : NCTC11468_01389(fabA)
PHEI : NCTC12003_02722(fabA)
PRJ : NCTC6933_01358(fabA)
LRI : NCTC12151_01484(fabA)
HIC : NTHIC486_01237(fabA)
HPIT : NCTC13334_01664(fabA)
HHZ : NCTC10839_01367(fabA)
HAEG : NCTC8502_01684(fabA)
PDAG : 4362423_00869(fabA)
ALIG : NCTC10568_02292(fabA)
ASEG : NCTC10977_01500(fabA)
AVT : NCTC3438_01421(fabA)
RPNE : NCTC8284_02282(fabA_1)
PAET : NCTC13378_00708(fabA)
XFU : XFF4834R_chr35200(fabA)
XPH : XppCFBP6546_16220(fabA)
XHD : LMG31886_37120(fabA)
LLZ : LYB30171_00472(fabA)
DJI : CH75_00665 CH75_23745
VAU : VANGNB10_cI1267c(fabA)
VPL : SA104470976_01219(fabA)
VIB : VspSTUT11_15900(fabA)
VIS : VspSTUT16_16230(fabA)
PAEB : NCGM1900_4964(fabA)
PVD : CFBP1590__2068(fabA)
PPRC : PFLCHA0_c17750(fabA)
PMUD : NCTC8068_03702(fabA)
PFW : PF1751_v1c17830(fabA)
PPUU : PputUW4_04099(fabA2)
PTRT : HU722_0010035(fabA)
PTW : TUM18999_22810(fabA)
PTAE : NCTC10697_03076(fabA)
MSHE : MAALD49_31990(fabA)
SCAA : TUM17387_21800(fabA)
CATE : C2869_06345 C2869_14785
SALH : HMF8227_01430(fabA)
MISZ : MishRS11D_03920(fabA)
THIO : AYJ59_02445 AYJ59_03415
TIB : THMIRHAM_20080(fabA)
TSE : THMIRHAS_23220(fabA)
TZO : THMIRHAT_02520(fabA)
TFRI : Thiofri_04451(fabA)
TNI : TVNIR_2372(fabA_[H])
APRS : BI364_02200 BI364_02715
GAI : IMCC3135_06550(fabA)
THIC : TspCOW1_30240(fabA)
HAAH : HALA3H3_340097(fabA)
HAXH : J4377_00700(fabA) J4377_00840(fabA)
HAXI : HAALTHF_06700n(fabA)
ALCA : ASALC70_03847(fabA)
MME : Marme_0286 Marme_3568
BMAR : HF888_04110(fabA) HF888_09700(fabA)
OME : OLMES_2594(fabA2) OLMES_3772(fabA1)
AEL : NCTC12917_02137(fabA)
CHJ : NCTC10426_01482(fabA)
CDIZ : CEDIAZO_02045(fabA)
NCI : NCTC10296_02373(fabA)
ECOR : SAMEA4412678_0960(fabA)
PLG : NCTC10937_03277(fabA)
LMIR : NCTC12852_01029(fabA)
MESU : LHFGNBLO_000282(fabA)
RBS : RHODOSMS8_03223(fabA)
SMEL : SM2011_c00328(fabA)
SFD : USDA257_c60890(fabA)
SAME : SAMCFNEI73_Ch0269(fabA)
AGR : AGROH133_03089(fabA)
ALF : CFBP5473_00100(fabA)
AVV : RvVAT039_18090(fabA)
AVF : RvVAR031_05250(fabA)
ASAL : CFBP5507_13685(fabA)
RPUS : CFBP5875_13330(fabA)
ALEG : CFBP4996_13705(fabA)
REC : RHECIAT_CH0000143(fabA)
REL : REMIM1_CH00111(fabA)
REP : IE4803_CH00122(fabA)
REI : IE4771_CH00122(fabA)
RTR : RTCIAT899_CH00530(fabA)
RGA : RGR602_CH00151(fabA)
RPHA : AMC79_CH00146(fabA)
RLW : RlegWSM1455_22225(fabA)
RBW : RLCC275e_22500(fabA)
NEN : NCHU2750_38360(fabA)
LAS : CLIBASIA_01725(fabA)
BIO : BR141012304_10572(fabA)
BJA : bll4346(fabA) blr0769(fabA)
BJU : BJ6T_07730 BJ6T_54720
BJP : RN69_03800 RN69_26525
BRA : BRADO0063(fabA) BRADO2366(fabA)
BBT : BBta_0069(fabA) BBta_2720(fabA)
BRS : S23_00600(fabA) S23_39410(fabA)
BRAD : BF49_0066 BF49_0713
BIC : LMTR13_00725 LMTR13_01165
BRO : BRAD285_4975(fabA) BRAD285_7607
BRK : CWS35_05455 CWS35_29865
BOT : CIT37_10400(fabA) CIT37_32455(fabA)
BRQ : CIT40_14260(fabA) CIT40_31555(fabA)
BGQ : X265_00290 X265_18225
BSYM : CIT39_13435(fabA) CIT39_30615(fabA)
BBET : F8237_00085(fabA) F8237_14730(fabA) F8237_34330(fabA)
BARH : WN72_00310 WN72_23850
BVZ : BRAD3257_0059(fabA) BRAD3257_4700(fabA)
BEL : BE61_09370(fabA) BE61_44610(fabA)
BSEP : HAP48_0016220(fabA) HAP48_0045420(fabA)
BQB : J4P68_0004535(fabA) J4P68_0020070(fabA)
BSEI : KMZ68_00265(fabA) KMZ68_11640(fabA)
BBAN : J4G43_000345(fabA) J4G43_024940(fabA)
BCAN : BcanWSM471_00505(fabA) BcanWSM471_19015(fabA)
BAUT : QA635_00300(fabA) QA635_17580(fabA)
BBRA : QA636_00275(fabA) QA636_18190(fabA)
BGK : IC762_00260(fabA) IC762_22890(fabA)
BCOU : IC761_00300(fabA) IC761_19610(fabA)
BPAH : QA639_00290(fabA) QA639_27135(fabA)
BXN : I3J27_00285(fabA) I3J27_17865(fabA)
BROS : QUH67_00305(fabA) QUH67_14440(fabA)
BRAZ : LRP30_19100(fabA) LRP30_44185(fabA)
BOY : LQG66_12500(fabA) LQG66_23370(fabA)
VGO : GJW-30_1_02395(fabA)
TALZ : RPMA_00295(fabA) RPMA_15915(fabA)
BHS : BM1374165_00133(fabA)
BBK : BARBAKC583_1268(fabA)
BTX : BM1374166_00124(fabA)
BEZ : NCTC12898_00013(fabA)
MAQU : Maq22A_c08695(fabA)
MMES : MMSR116_06755(fabA)
MTUN : MTUNDRAET4_3871(fabA)
FIL : BN1229_v1_2245(fabA)
FIY : BN1229_v1_2244(fabA)
PEM : OF122_07180(fabA) OF122_19600(fabA)
DEQ : XM25_13490 XM25_18310
DNP : N8A98_08510(fabA) N8A98_09110(fabA)
YTI : FNA67_17230(fabA) FNA67_21720(fabA)
BVY : NCTC9239_03428(fabA)
TSV : DSM104635_03975(fabA)
RLI : RLO149_c005090(fabA)
PHP : PhaeoP97_02889(fabA)
PPIC : PhaeoP14_00384(fabA)
SINL : DSM14862_02341(fabA)
SPSE : SULPSESMR1_02306(fabA)
RMM : ROSMUCSMR3_01100(fabA)
AHT : ANTHELSMS3_01868(fabA)
LALG : LentiSH36_00737(fabA)
LVS : LOKVESSMR4R_02230(fabA)
AALK : LGT41_0006565(fabA)
SPYM : M1GAS476_1575(phaB)
SPH : MGAS10270_Spy1564(phaB)
SPI : MGAS10750_Spy1556(phaB)
SPJ : MGAS2096_Spy1524(phaB)
SPK : MGAS9429_Spy1498(phaB)
STG : MGAS15252_1342(phaB)
SPNG : HMPREF1038_00458(phaB)
SGG : SGGBAA2069_c03210(phaB)
SVB : NCTC12167_00416(paaG)
SMEN : SAMEA4412692_1681(phaB)
SFER : NCTC12278_01548(echA8)
SCAI : NCTC12191_01012(phaB)
SPSU : NCTC13786_01537(paaG)
SPOC : NCTC10925_01618(paaG)
SAUP : NCTC3168_00331(phaB)
SURN : NCTC13766_01738(phaB)
SVF : NCTC3166_00442(phaB)
SMIE : NCTC11169_00262(phaB)
VRM : 44547418_01525(echA8)
VDN : NCTC11831_01555(echA8)
» show all
Taxonomy
Reference
Authors
Brock DJ, Kass LR, Bloch K.
Title
Beta-hydroxydecanoyl thioester dehydrase. II. Mode of action.
Journal
J Biol Chem 242:4432-40 (1967)
Reference
2
Authors
Bloch K.
Title
Enzymatic synthesis of monounsaturated fatty acids.
Journal
Acc Chem Res 2:193-202 (1969)
Reference
Authors
Marrakchi H, Choi KH, Rock CO
Title
A new mechanism for anaerobic unsaturated fatty acid formation in Streptococcus pneumoniae.
Journal
Sequence
Reference
4
Authors
Cronan JE Jr, Rock CO.
Title
Biosynthesis of membrane lipids.
Journal
In: Neidhardt FC (ed). Escherichia coli and Salmonella: Cellular and Molecular Biology. 2nd ed. Vol. 1. Washington, DC: ASM Press; 1996. p. 612-636.
Other DBs
ExplorEnz - The Enzyme Database: 5.3.3.14
ExPASy - ENZYME nomenclature database: 5.3.3.14
LinkDB
All DBs