KEGG   ENZYME: 5.4.1.3
Entry
EC 5.4.1.3                  Enzyme                                 
Name
2-methylfumaryl-CoA isomerase;
mesaconyl-CoA C1-C4 CoA transferase;
Mct
Class
Isomerases;
Intramolecular transferases;
Transferring acyl groups
Sysname
2-methylfumaryl-CoA 1,4-CoA-mutase
Reaction(IUBMB)
2-methylfumaryl-CoA = 3-methylfumaryl-CoA [RN:R09283]
Reaction(KEGG)
R09283
Substrate
2-methylfumaryl-CoA [CPD:C06028]
Product
3-methylfumaryl-CoA [CPD:C18323]
Comment
The enzyme, purified from the bacterium Chloroflexus aurantiacus, acts as an intramolecular CoA transferase and does not transfer CoA to free mesaconate. It is part of the 3-hydroxypropanoate cycle for carbon assimilation.
History
EC 5.4.1.3 created 2014
Pathway
ec00720  Carbon fixation pathways in prokaryotes
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K14470  2-methylfumaryl-CoA isomerase
Genes
PMUDNCTC8068_02062(frc_4)
PSETTHL1_4232
PIEHU724_013975
MARIACP86_19420
MANPEHN06_02530
ALKMNKI27_11380
ASEMNNL22_07735
STAWNCG89_13785
THIPN838_00830
GAIIMCC3135_16905(mct)
OMEOLMES_2172
CBWRR42_s1516
BUZAYM40_06765
TVLFAZ95_10115 FAZ95_35735
BPEBP0435
BPCBPTD_0450
BPERBN118_0286
BPETB1917_3384
BPEUQ425_33760
BPARBN117_0457
BPABPP0464
BBHBN112_2948
BBRBB0464
BBMBN115_0451
BBXBBS798_0461
ACHBDVB37_15020
PARKLSG25_05970
VAMC4F17_14125
ADNAlide_3213
ADKAlide2_1234
HYBQ5W_20080
HYNF9K07_11940
XYKGT347_20755
APPCAP2UW1_2507
MESWA9K65_031180
EMXFKV68_30910
RFVRFYW14_04034
VGOGJW-30_1_01671(fldA_2)
APOLK9D25_22035
MEEDA075_00045
ACUTMRB58_00800
PZUPHZ_c3026
PHBHYN04_06120
RLIRLO149_c031960
DSHDshi_2494
REDroselon_02264
SUALKDD17_12265
TOMBWR18_13435
RMMROSMUCSMR3_03781(mct)
ROKRAK1035_2623
RIDRIdsm_00212(bbsF_2)
ROHFIU89_16605(frc4)
SAGUCDO87_15525
THAACFI11_02315
ROTFIV09_02235(frc2)
MALUKU6B_14500(mct)
RMAIMACH21_17130(mct)
PMEHJWJ88_18480
PVERE3U25_12545
RBGBG454_05635
HBCAEM38_02600
NARSaro_1223
NPPPP1Y_AT31398 PP1Y_AT31978
NPNJI59_17595
NOTC7W88_08755
NORFA702_12990
NGFFRF71_05170
NOGGKE62_16825
SALSala_2895
SPHKSKP52_19820
SPHPLH20_06650
SMAGAN936_15830
SMAZLH19_02460
STERAOA14_14415
SGISGRAN_3008
SPHQBWQ93_19060
SPHOC3E99_10410
SPHXE5675_00370
SINAKNJ79_05725
SPHUSPPYR_3583
SPHDHY78_18265
SPKCKC8_19695
SPHAD3Y57_03960
SLANGV829_02835
SPAPH3Z74_06275
SRADLLW23_12465
SCHSphch_0992
SYBTZ53_19645
SPHBEP837_03072
SPHTK426_13800
SYAA6768_05915
SCLOSCLO_1006520
SUFLFIL70_08820 FIL70_14450
SBARH5V43_06490
CIJWG74_11810
BLASBSY18_3596
BMAAT8S45_12500
AEPAMC99_02359
ALHG6N82_07865
ARUEQQX03_00995
AMXAM2010_1644
PMASNCF86_09185
ADOA6F68_00320(fldA_1)
TFVIDJ81_09105
EFVCHH26_00235
QCINCF85_15360
QSPL1F33_02170
QSOIRL76_13690
QARK3148_06855
QGEK3136_06950
QPSK3166_11285
ELIELI_12030
ELQGa0102493_11760
ERKCD351_03090
ERRDVR09_01635
ERFFIU90_03320(fldA)
EMVHQR01_04835
PNSA9D12_05440
PORLBG023_11590
PHZCHX26_03250
POTE2E27_01885
NTDEGO55_04520
AFLVQQW98_03940
RAPRHOA_5785(mct)
SHUMSTHU_30030(mct)
SVCSTVA_20880(mct)
STELSTAQ_26630(mct)
ABSAZOBR_p410036
ABQABAZ39_30400
ABFAMK58_26100
ATIAL072_22110
AZTTSH58p_19335
AZMDM194_21385
AARED3093_29570
HADHFRZ61_46020
NACINUH88_21205
THART8K17_09585
ERZER308_08210
MPAMAP_2406c
MAOMAP4_1417
MAVIRC58_07025
MAVURE97_07025
MAVMAV_1574
MITOCO_16360
MIAOCU_16560
MIDMIP_02258
MYOOEM_14390
MCHIAN480_08065
MIROCQ_14040
MMALCKJ54_06925
MLPMLM_2882
MMANMMAN_25340
MSAMycsm_02339
MULMUL_3896
MMIMMAR_4031
MMAEMMARE11_38380
MLIMULP_04196
MPSEMPSD_39900
MSHOMSHO_00120 MSHO_61630
MMCMmcs_1977
MKMMkms_2023
MJLMjls_1957
MMMW7S_06865
MKNMKAN_06110
MYVG155_11820
MYEAB431_01015
MDXBTO20_23015
MSHGMSG_03617
MFJMFLOJ_50560
MSTOMSTO_54780
MSIMMSIM_40220
MSAKMSAS_19040
MKUI2456_19120
MLWMJO58_19890
MXEMYXE_16820
MNVMNVI_03100
MPAGC0J29_22200
MNMMNVM_20030
MGORH0P51_20175
MCOOMCOO_16820
MBAIMB901379_03512(frc_5)
MSEOMSEO_24150
MHEKJMUB5695_01748
MGAUMGALJ_06700
MLJMLAC_10180
MBRDMBRA_31450
MMAMK3U93_17265
MSPGF6B93_16130
MOTLTS72_05120
MPAAMKK62_07580
MKYIWGMT90018_42210
MADIA7U43_19910
MWUPT015_09470
MSMMSMEG_2468
MSGMSMEI_2407
MSBLJ00_12285
MSNLI99_12285
MSHLI98_12290
MVAMvan_2197
MGIMflv_4144
MSPMspyr1_34870
MCBMycch_1953
MNED174_11125
MYNMyAD_10910
MFTXA26_24360
MPHLMPHLCCUG_02140(fldA_3)
MVQMYVA_2097
MLLB1R94_00700
MRHMycrhN_5794
MTHN4412656_01628(frc_7)
MHASMHAS_01026(mct)
MDUMDUV_23040
MCHTMCHIJ_09340
MDRMDOR_13680
MAUUNCTC10437_02049(frc_6)
MMAGMMAD_21790
MMORMMOR_42620
MFXMFAL_26480
MAICMAIC_55280
MIJMINS_06440
MALVMALV_15080
MTYMTOK_12220
MPSCMPSYJ_44710
MARZMARA_18630
MGADMGAD_17330
MHEVMHEL_20730
MSARMSAR_17300
MANYMANY_37030
MAUBMAUB_54860
MPOFMPOR_25280
MPHUMPHO_14280
MMUCC1S78_011140
MMATMMAGJ_54560
MBOKMBOE_50690
MFGK6L26_20530
MSEIMSEDJ_34070
MFLVNCTC10271_03318(frc_12)
MCEEMCEL_15590
MMONEWR22_10040
MGOAFA91_27155
MHOLK3U96_16765
MSENK3U95_17970
MPAEK0O64_00650
MRFMJO55_09920
MDFK0O62_11125
MCROMI149_01185
MGROFZ046_16075
MKRMKOR_29920
MPAKMIU77_18320
MJDJDM601_4181
MTER4434518_04118(frc_11)
MMINMMIN_16210
MHIBMHIB_34980
MHERK3U94_22800
MVMMJO54_22865
NNONONO_c28540 NONO_c32800
RHARHA1_ro02874
RERRER_51910
REYO5Y_24555
REBXU06_24975
RQIC1M55_26175
ROPROP_26000
ROAPd630_LPD07035
RPYY013_15560
RBYCEJ39_02065
RAVAAT18_25020 AAT18_25220
RRZCS378_14600 CS378_14800
RHUA3Q40_03009(mct)
RHQIM25_05515
RHODAOT96_05985
RRT4535765_04732(frc_13)
RCRNCTC10994_02797(frc_2)
RTMG4H71_12190
RKOJWS14_15115
RGOKYT97_16010
ROZCBI38_28365
RPSKJWS13_29700
RGORNMQ04_20225
GBRGbro_4182
GPOGPOL_c45170
GORKTR9_4108
GOQACH46_19985
GTABCM27_21700
GOCCXX93_03660
GITC6V83_01010
GRUGCWB2_20770(fldA6)
GOMD7316_02274(mct)
GAVC5O27_07270
GODGKZ92_19970
GAMGII34_15840
GPDGII33_15275
GJIH1R19_20085
GOILK459_02760
GHNMVF96_20770
GAMIIHQ52_00540
GMGNWF22_16155
GSIP5P27_18550
SPINKV203_05340
TSDMTP03_07210 MTP03_14840(mct)
DIZCT688_10225
DPCA6048_10565
DLUA6035_10075
DKNNHB83_09955
SCINCP977_30950
SAKBK1J60_08820
YIALO772_33375 LO772_34925
MIOAOA12_04730
LARIKI794_06445
SUBALQ955_15165
BLYA2T55_01930
BLINBLSMQ_0281
BRIFDF13_04985
BSPOL1F31_01550
GYUFE374_03300
NOIFCL41_02445
AEFGEV26_00915
ASEZH9L21_11795
TCUTcur_4637
ACTWF7P10_36610
AMAZLUW76_41975
ACIROG979_04365
SPIQOHA34_37775
ACTQOG417_31730
NOWGBF35_13590
NCXNocox_12120(frc3)
TBITbis_2092
FREFranean1_6828
FRIFraEuI1c_2687
SACGFDZ84_27925
AMQAMETH_3799 AMETH_4503
AMYCCU254_18695
AACDLWP59_31300
ARHDVSH64_11445
PDXPsed_1949
PSEEFRP1_10200
PSEHXF36_06540
PSEQAD006_17750 AD006_31860
PECQAD017_25585 AD017_28385
PAUTPdca_37090
PBROHOP40_32820
PPELH6H00_19855
PMADBAY61_15145
SACEGIY23_17080
PSUUPsuf_001410(mct)
BSOLFSW04_02105
CWOCwoe_4298
SBAEDSM104329_02454(mct)
RRSRoseRS_4174
RCARcas_0911
CAUCaur_0175
CHLChy400_0188
CAGCagg_1329
GGRHKW67_06655
 » show all
Reference
1  [PMID:19955419]
  Authors
Zarzycki J, Brecht V, Muller M, Fuchs G
  Title
Identifying the missing steps of the autotrophic 3-hydroxypropionate CO2 fixation cycle in Chloroflexus aurantiacus.
  Journal
Proc Natl Acad Sci U S A 106:21317-22 (2009)
DOI:10.1073/pnas.0908356106
  Sequence
[cau:Caur_0175]
Other DBs
ExplorEnz - The Enzyme Database: 5.4.1.3
IUBMB Enzyme Nomenclature: 5.4.1.3
ExPASy - ENZYME nomenclature database: 5.4.1.3
BRENDA, the Enzyme Database: 5.4.1.3
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