KEGG   ENZYME: 5.4.2.4
Entry
EC 5.4.2.4                  Enzyme                                 
Name
bisphosphoglycerate mutase;
diphosphoglycerate mutase;
glycerate phosphomutase;
bisphosphoglycerate synthase;
bisphosphoglyceromutase;
biphosphoglycerate synthase;
diphosphoglyceric mutase;
2,3-diphosphoglycerate mutase;
phosphoglyceromutase;
2,3-diphosphoglycerate synthase;
DPGM;
2,3-bisphosphoglycerate mutase;
BPGM;
diphosphoglyceromutase;
2,3-diphosphoglyceromutase
Class
Isomerases;
Intramolecular transferases;
Phosphotransferases (phosphomutases)
Sysname
3-phospho-D-glycerate 1,2-phosphomutase
Reaction(IUBMB)
3-phospho-D-glyceroyl phosphate = 2,3-bisphospho-D-glycerate [RN:R01662]
Reaction(KEGG)
R01662
Substrate
3-phospho-D-glyceroyl phosphate [CPD:C00236]
Product
2,3-bisphospho-D-glycerate [CPD:C01159]
Comment
In the direction shown, this enzyme is phosphorylated by 3-phosphoglyceroyl phosphate, to give phosphoenzyme and 3-phosphoglycerate. The latter is rephosphorylated by the enzyme to yield 2,3-bisphosphoglycerate, but this reaction is slowed by dissociation of 3-phosphoglycerate from the enzyme, which is therefore more active in the presence of added 3-phosphoglycerate. This enzyme also catalyses, slowly, the reaction of EC 5.4.2.11 [phosphoglycerate mutase (2,3-diphosphoglycerate-dependent)] and EC 5.4.2.12 [phosphoglycerate mutase (2,3-diphosphoglycerate-independent)].
History
EC 5.4.2.4 created 1961 as EC 2.7.5.4, transferred 1984 to EC 5.4.2.4
Pathway
ec00010  Glycolysis / Gluconeogenesis
ec01100  Metabolic pathways
Orthology
K01837  bisphosphoglycerate/phosphoglycerate mutase
Genes
HSA669(BPGM)
PTR463746(BPGM)
PPS100967755(BPGM)
GGO101148078(BPGM)
PON100445966(BPGM)
PPYG129040285(BPGM)
NLE100586238(BPGM)
HMH116814381(BPGM)
SSYN129485029(BPGM)
MCC706741(BPGM)
MCF101925598(BPGM)
MTHB126949690
MNI105471341(BPGM)
CSAB103226934(BPGM)
CATY105589610(BPGM)
PANU101022185(BPGM)
TGE112620672(BPGM)
MLEU105533670(BPGM)
RRO104655279(BPGM) 104657786
RBB108522539(BPGM)
TFN117073599(BPGM)
PTEH111524783(BPGM)
CANG105511140(BPGM)
CJC100386672(BPGM) 128928554
SBQ101031409(BPGM)
CIMI108307282(BPGM)
ANAN105726335(BPGM)
CSYR103275724(BPGM)
MMUR105860194(BPGM)
LCAT123647165(BPGM)
PCOQ105815458(BPGM)
OGA100956918(BPGM)
MMU12183(Bpgm)
MCAL110296243(Bpgm)
MPAH110316482(Bpgm)
RNO296973(Bpgm)
MCOC116098708(Bpgm)
ANU117720855(Bpgm)
MUN110561663(Bpgm)
CGE100757548(Bpgm)
MAUA101840847(Bpgm)
PROB127215423(Bpgm)
PLEU114691032(Bpgm)
MORG121463368(Bpgm)
MFOT126505296
AAMP119807579(Bpgm)
NGI103726061(Bpgm)
HGL101706859(Bpgm)
CPOC100722842(Bpgm)
CCAN109688796
DORD105989600(Bpgm)
DSP122099556(Bpgm) 122125320
PLOP125347168(Bpgm)
NCAR124986309 124990814
MMMA107149035(Bpgm)
OCU100009096(BPGM)
OPI101521357(BPGM)
TUP102496494(BPGM)
GVR103601037 103604804
CFA482704(BPGM)
CLUD112670467(BPGM)
VVP112908884(BPGM)
VLG121489532(BPGM)
NPO129516217(BPGM)
AML100479620(BPGM)
UMR103678255(BPGM)
UAH113264369(BPGM)
UAR123788931(BPGM)
ELK111151975
LLV125081060
MPUF101674272(BPGM)
MNP132015686(BPGM)
MLK131829792(BPGM)
NVS122905090(BPGM)
ORO101365932(BPGM)
EJU114211742(BPGM)
ZCA113911925(BPGM)
MLX118021113(BPGM)
NSU110582871(BPGM)
LWW102729597(BPGM)
FCA101095644(BPGM)
PYU121028302(BPGM) 121031877
PCOO112866662(BPGM)
PBG122488305(BPGM)
PVIV125160935(BPGM)
LRUF124524429
PTG102952979(BPGM)
PPAD109269034(BPGM)
PUC125930157
AJU106975708
HHV120238873(BPGM)
BTA112447087 533785(BPGM)
BOM102270409 102275256 102275503 102285424
BIU109557654(BPGM)
BBUB102402470(BPGM)
BBIS104982297(BPGM)
CHX102187916(BPGM)
OAS101121089(BPGM)
BTAX128046411(BPGM)
ODA120878223(BPGM)
CCAD122438665(BPGM)
MBEZ129552666(BPGM)
SSC106506774(BPGM)
CFR102514048(BPGM)
CBAI105063063(BPGM)
CDK105085404(BPGM)
VPC102540862(BPGM)
BACU103009787(BPGM) 103015640
BMUS118891256 118901329(BPGM)
LVE103089210(BPGM)
OOR101286738 101287641(BPGM)
DLE111178164(BPGM) 111178314
PCAD102985972(BPGM)
PSIU116759523(BPGM) 116764955
NASI112392791 112394975(BPGM)
ECB100065115(BPGM)
EPZ103551316(BPGM)
EAI106830008(BPGM)
MYB102254057(BPGM)
MYD102772643(BPGM)
MMYO118666381(BPGM) 118676662
MLF102437274(BPGM)
PKL118713079(BPGM)
EFUS103294121(BPGM)
MNA107544342(BPGM)
DRO112299894(BPGM)
SHON118989129(BPGM)
AJM119064246(BPGM)
PDIC114507744(BPGM)
PHAS123829765(BPGM)
MMF118619861(BPGM)
PPAM129062906(BPGM)
HAI109389371(BPGM)
RFQ117018353(BPGM)
PALE102886645(BPGM)
PGIG120600999(BPGM)
PVP105291639(BPGM)
RAY107510540(BPGM)
MJV108396501(BPGM)
TOD119247218(BPGM)
SARA101557521(BPGM)
SETR126011675(BPGM)
LAV100673907(BPGM)
TMU101360256
ETF101648579(BPGM)
DNM101418854(BPGM)
MDO100021814(BPGM)
GAS123249258(BPGM)
SHR100920227(BPGM)
AFZ127539411
PCW110219158(BPGM)
TVP118851759(BPGM)
OAA100075920(BPGM)
GGA418172(BPGM)
PCOC116226884(BPGM)
MGP100546129(BPGM)
CJO107314945(BPGM)
TPAI128073371(BPGM)
LMUT125703131(BPGM)
NMEL110395716(BPGM)
APLA101803151(BPGM)
ACYG106030917(BPGM)
CATA118250121(BPGM)
AFUL116501828(BPGM)
TGU100221163(BPGM)
LSR110482586(BPGM)
SCAN103820477(BPGM)
PMOA120501586(BPGM)
OTC121332759(BPGM)
PRUF121362704(BPGM)
GFR102033451(BPGM)
FAB101817641(BPGM)
OMA130263199(BPGM)
PHI102108959(BPGM)
PMAJ107204390(BPGM)
CCAE111928156(BPGM)
CCW104692259(BPGM)
CBRC103624705(BPGM)
ETL114066474(BPGM)
ZAB102069397(BPGM)
ZLE135459378(BPGM)
ACHL103809151(BPGM)
SVG106849441(BPGM)
MMEA130588970(BPGM)
HRT120751396(BPGM)
FPG101915204(BPGM)
FCH102046661(BPGM)
CLV102089457(BPGM)
EGZ104134376(BPGM)
NNI104017943(BPGM)
PCRI104026196(BPGM)
PLET104624741(BPGM)
EHS104516903(BPGM)
PCAO104045004(BPGM)
ACUN113491488(BPGM)
TALA104361469(BPGM)
PADL103924352(BPGM)
AFOR103898662(BPGM)
ACHC115352328(BPGM)
HALD104314996(BPGM)
HLE104830915(BPGM)
AGEN126048074
GCL127029695
CCRI104162724(BPGM)
CSTI104551983(BPGM)
CMAC104480596(BPGM)
MUI104535330(BPGM)
BREG104639226(BPGM)
FGA104072180(BPGM)
GSTE104252617(BPGM)
LDI104341706(BPGM)
MNB103768831(BPGM)
OHA104337122(BPGM)
NNT104404033(BPGM)
SHAB115605757(BPGM)
DPUB104304682(BPGM)
PGUU104469551(BPGM)
ACAR104529043(BPGM)
CPEA104384749 104393436(BPGM)
AVIT104272414(BPGM)
CVF104281617(BPGM)
RTD128904048(BPGM)
CUCA104064597(BPGM)
TEO104371170(BPGM)
BRHI104489910(BPGM)
AAM106488955(BPGM)
AROW112968285(BPGM)
NPD112945515(BPGM)
TGT104573508(BPGM)
DNE112993366(BPGM)
SCAM104147258(BPGM)
ASN102373803(BPGM)
AMJ102568684(BPGM)
CPOO109316438(BPGM)
GGN109296253(BPGM)
PSS102447629(BPGM)
CMY102946921(BPGM)
CCAY125625700(BPGM)
DCC119863402(BPGM)
CPIC101941911(BPGM)
TST117882902(BPGM)
CABI116835612(BPGM)
MRV120380589(BPGM)
ACS100564984(bpgm)
ASAO132775754(BPGM)
PVT110088825(BPGM)
SUND121930490(BPGM)
PBI103062795(BPGM)
PMUR107294354(BPGM)
CTIG120319426(BPGM)
TSR106545025(BPGM)
PGUT117655757(BPGM)
APRI131202358(BPGM)
PTEX113445814(BPGM)
NSS113419342(BPGM)
VKO123036382(BPGM)
PMUA114605263(BPGM)
PRAF128422059(BPGM)
ZVI118091307(BPGM)
HCG128327076(BPGM)
GJA107125358(BPGM)
STOW125435616(BPGM)
EMC129335707(BPGM)
XLA444102(bpgm.L) 444279(bpgm.S)
XTR549353(bpgm)
NPR108792024(BPGM)
RTEM120932636(BPGM)
BBUF121007153(BPGM)
BGAR122928322(BPGM)
MUO115477952(BPGM)
GSH117364109(BPGM)
DRE436903(bpgm)
SRX107716700 107753699
SANH107661509
SGH107576414 107590805
CAUA113043324 113066900
CGIB127946682 128014707
PTET122331198(bpgm)
LROH127156434(bpgm)
OMC131534269(bpgm)
PPRM120469137(bpgm)
RKG130104475(bpgm)
MAMB125247216(bpgm)
CIDE127507562
MASI127436034 127437701
TROS130551704(bpgm)
TDW130414431(bpgm)
MANU129433957(bpgm)
IPU108269072
IFU128611580(bpgm)
PHYP113529410(bpgm)
SMEO124386517(bpgm)
TFD113635654(bpgm)
TVC132856232(bpgm)
TRN134319054(bpgm)
AMEX103029505(bpgm)
CMAO118806774(bpgm)
EEE113579716(bpgm)
CHAR105888494(bpgm)
TRU101074347(bpgm)
TFS130535769(bpgm)
TNGGSTEN00029715G001
LCO104940663(bpgm)
NCC104946798(bpgm)
TBEN117495010(bpgm)
CGOB115010217(bpgm)
PGEO117448569(bpgm)
GACU117547903(bpgm)
EMAC134859598(bpgm)
ELY117261671(bpgm)
EFO125887994(bpgm)
PLEP121950612(bpgm)
SLUC116038699(bpgm)
ECRA117949451(bpgm)
ESP116693930(bpgm)
PFLV114560377(bpgm)
GAT120809117(bpgm)
PPUG119196237(bpgm)
AFB129108357(bpgm)
CLUM117732233(bpgm)
PSWI130194852(bpgm)
MSAM119893483(bpgm)
SCHU122874868(bpgm)
CUD121515662(bpgm)
ALAT119023925(bpgm)
MZE101473870(bpgm)
ONL100708072(bpgm)
OAU116332722(bpgm)
OLA101172407(bpgm)
OML112152318(bpgm)
CSAI133443797(bpgm)
XMA102233730(bpgm)
XCO114133815(bpgm)
XHE116708874(bpgm)
PRET103465823(bpgm)
PFOR103134420(bpgm)
PLAI106945301(bpgm)
PMEI106929157(bpgm)
GAF122835778(bpgm)
PPRL129360473(bpgm)
CVG107095033(bpgm)
CTUL119799137(bpgm)
GMU124879263(bpgm)
NFU107388481(bpgm)
KMR108229885(bpgm)
ALIM106525486(bpgm)
NWH119416394(bpgm)
AOCE111567052(bpgm)
MCEP125015235(bpgM)
CSEM103380563(bpgm)
POV109623942(bpgm)
SSEN122775377(bpgm)
HHIP117763052(bpgm)
HSP118110035(bpgm)
PPLT128444923(bpgm)
SMAU118315021(bpgm)
LCF108888560
SDU111229658(bpgm)
SLAL111651502(bpgm)
XGL120793177(bpgm)
HCQ109530859(bpgm)
SSCV125970865
SBIA133501972 133502515(bpgm)
PEE133402671(bpgm)
PTAO133477980 133478226(bpgm)
BPEC110169450(bpgm)
MALB109951197(bpgm)
BSPL114857824(bpgm)
SJO128358446(bpgm)
SASA100196266(pmge) 106561646
STRU115152372 115197620
OTW112218898 112252694
OMY110500043 110524766
OGO124004499 124032856(bpgm)
ONE115109699(bpgm) 115115104
OKI109867194 109889656
OKE118371666 118400884
SALP111952995 111962766
SNH120053540 120066779
CCLU121531280 121577059
ELS105021856(bpgm)
SFM108920769 108931367
PKI111843107 111854613
AANG118219313 118232037(bpgm)
LOC102690514(bpgm)
PSPA121318552 121319494
ARUT117415332 117419669
PSEX120539400(bpgm)
LCM102350982(BPGM)
CMK103185559(bpgm)
RTP109927982
CPLA122561630(bpgm)
HOC132826914(bpgm)
LERI129707707(bpgm)
PMRN116944455
LRJ133343690(BPGM)
 » show all
Reference
1
  Authors
Ray, W.J., Jr. and Peck, E.J., Jr.
  Title
Phosphomutases.
  Journal
In: Boyer, P.D. (Ed.), The Enzymes, 3rd ed., vol. 6, 1972, p. 407-477.
Reference
2  [PMID:5687724]
  Authors
Rose ZB.
  Title
The purification and properties of diphosphoglycerate mutase from human erythrocytes.
  Journal
J Biol Chem 243:4810-20 (1968)
Reference
3  [PMID:6255773]
  Authors
Rose ZB.
  Title
The enzymology of 2,3-bisphosphoglycerate.
  Journal
Adv Enzymol Relat Areas Mol Biol 51:211-53 (1980)
DOI:10.1002/9780470122969.ch5
Other DBs
ExplorEnz - The Enzyme Database: 5.4.2.4
IUBMB Enzyme Nomenclature: 5.4.2.4
ExPASy - ENZYME nomenclature database: 5.4.2.4
BRENDA, the Enzyme Database: 5.4.2.4
CAS: 37211-69-1
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