KEGG ENZYME: 5.4.3.9

ENZYME: 5.4.3.9

Entry

EC 5.4.3.9                  Enzyme

Name

glutamate 2,3-aminomutase

Class

Isomerases;
Intramolecular transferases;
Transferring amino groups

Sysname

L-glutamate 2,3-aminomutase

Reaction(IUBMB)

L-glutamate = 3-aminopentanedioate [RN:R10153]

Reaction(KEGG)

R10153

Substrate

L-glutamate [CPD:C00025]

Product

3-aminopentanedioate [CPD:C05574]

Comment

This enzyme is a member of the 'AdoMet radical' (radical SAM) family. It contains pyridoxal phosphate and a [4Fe-4S] cluster, which is coordinated by 3 cysteines and binds an exchangeable S-adenosyl-L-methionine molecule. During the reaction cycle, the AdoMet forms a 5'-deoxyadenosyl radical, which is regenerated at the end of the reaction.

History

EC 5.4.3.9 created 2012

Orthology

K19814

glutamate 2,3-aminomutase

Genes

DFL:	DFE_1413(kamA)

PNW:

SYK_01640

DESU:

NLA06_00180

DLM:	DPPLL_04560

DAK:	DaAHT2_2229

DAL:

Dalk_3854

DOV:	DSCO28_56710

DVR:	Dvar_71380

DML:	Dmul_08000

DLI:

dnl_63690

DMM:	dnm_029430

SBU:	SpiBuddy_0173

SGP:	SpiGrapes_1752

SASS:

MUG09_00855

BTH:

BT_4474

BTHO:

Btheta7330_03611(eam)

BFR:

BF3578

BFS:	BF9343_3293

BFG:	BF638R_3409

BFB:	VU15_16030

BHL:	Bache_1580

BXY:

BXY_35830

BOA:	Bovatus_04693(eam)

BCEL:

BcellWH2_04542(eam)

BCAC:

CGC64_08570

BIS:	DXK01_011780

BUN:	Bun01g_19770

BSTE:

K6V31_06120

BFE:	K6V30_10810

BNO:	K8P02_02700

BHUM:

JXR92_009185

BFC:	BacF7301_12335

BSAL:

K6V25_10055

BFIN:

BFINE_27020

BACE:

H1A11_02735

BVU:

BVU_2729

BDO:	EL88_06930

BDH:	GV66_14865

PDI:

BDI_0607

PARC:

CI960_06970

PMER:

INE87_01150

PGOL:

K6V26_07110

PJO:	LK449_05530

PFAI:

NXY11_09545

TFO:

BFO_1787

CFAS:

Cfast33896_10380

BUY:	D8S85_01050

BVIR:

I6J59_14220

BFH:	F1611_08170

PHER:

prwr041_25780

PCLR:

PC1C4_12230

AFD:

Alfi_1114

ASH:

AL1_22930

AOK:	A3BBH6_17760

ASEN:

NQ519_08975

BLQ:	L21SP5_02659(kamA)

DORI:

FH5T_04755

DRC:	G0Q07_03915

MCOS:

GM418_09210

SHYR:

LA303_13405

PDU:	PDUR_16085

CCB:	Clocel_2678

CACE:

CACET_c07510(kamA1)

CFM:	BJL90_09905

CSEP:

CP523_02425(eam)

OCW:	OW730_21130(eam)

PROQ:

P6M73_07410

HSC:	HVS_09740(eam)

CSS:	Cst_c09560(kamA1)

CSD:

Clst_0916

SWO:

Swol_1121

SLP:

Slip_1437

SALQ:

SYNTR_0636

DSY:

DSY4027

DHD:

Dhaf_1337

DDH:	Desde_0983 Desde_1272

DDL:	Desdi_1057

DMT:	DESME_03065 DESME_04100

SGY:

Sgly_2707

DOR:	Desor_0517

DAI:	Desaci_0733

DMI:	Desmer_0614

DED:	DHBDCA_p1654

DEC:	DCF50_p1663

DRS:	DEHRE_12100

DCA:	Desca_1530

PTH:	PTH_0616(KamA)

DRM:

Dred_2148

DRU:	Desru_1637

DFG:	B0537_10675

DAE:	Dtox_0599 Dtox_2931

DKU:	Desku_1193

TJR:	TherJR_1812

DGI:	Desgi_3039

HCV:	FTV88_2322

ALKA:

J0B03_02685

ACAE:

HYG86_17310(eam)

CTHM:

CFE_1096 CFE_1097

CSH:	Closa_2267

AMT:

Amet_2738

PBIF:

KXZ80_10945(eam)

PSOR:

RSJ16_12680

CDF:	CD630_22520(kamA)

PDC:	CDIF630_02487(eam)

CDC:	CD196_2109(kamA)

CDL:	CDR20291_2152(kamA)

PDF:	CD630DERM_22520(kamA)

ROC:	HF520_03610(eam)

TEB:	T8CH_0897(eam)

THYR:

P4S50_12610(eam)

DAU:

Daud_1068

TTE:	TTE1204(KamA2)

CHY:

CHY_2479

ADG:

Adeg_1408

TPZ:	Tph_c22230(kamA)

GEK:	kuro4_08900 kuro4_08940

MTA:

Moth_0457

MTHO:

MOTHE_c03930(eam)

MTHZ:

MOTHA_c04820(eam)

MHUI:

MHLNE_04110(eam)

DBC:	MFMK1_002183(eam)

NTH:	Nther_1768

NCD:	ACONDI_00898(eam_2)

MHAP:

JFY71_03305

CAD:	Curi_c04320(kamA)

CAZO:

G3A45_02895(eam)

CALK:

HUE98_06730(eam)

CSC:

Csac_0232

ATE:

Athe_2274

COB:	COB47_2039

CHD:	Calhy_0483

COW:	Calow_1972

CKI:	Calkr_2290

CLC:	Calla_0160

CKN:	Calkro_0356

CCHA:

ELD05_01180(eam)

CDIA:

CaldiYA01_03110(eam)

CNAG:

OTJ99_002263(eam)

CMOR:

OTK00_000190(eam)

CDAN:

SOJ16_002405(eam)

XCL:	G4Z02_00090

MBJ:	KQ51_01031(eam)

IPO:	Ilyop_0443

MJA:

MJ_0634

MFE:	Mefer_0245

MVU:	Metvu_0851

MFS:	MFS40622_1045

MIF:	Metin_0158

MJH:	JH146_0854

MESG:

MLAUSG7_0743

MESA:

MLASG1_0098

MIG:	Metig_0413

MMQ:	MmarC5_0609 MmarC5_1350

MMZ:	MmarC7_1783

MMAK:

MMKA1_08470(kamA)

MVN:	Mevan_1195

MMIL:

sm9_1912

MEYE:

TL18_07795

GAC:

GACE_1289

TON:

TON_1269

TBA:	TERMP_00188

THS:

TES1_0278

TPIE:

A7C91_01935

TBS:	A3L01_02200

TTD:	A3L14_03645

MCJ:

MCON_3114

MHI:

Mhar_1745

MEZ:	Mtc_0931 Mtc_0932

RCI:

RRC148

IHO:

Igni_1382

IIS:

EYM_06940

IPC:

IPA_01815

PDL:	Pyrde_1540

PABI:

PABY_15340

PARE:

PYJP_16420

» show all

Reference

1 [PMID:17222594]

Authors

Ruzicka FJ, Frey PA

Title

Glutamate 2,3-aminomutase: a new member of the radical SAM superfamily of enzymes.

Journal

Biochim Biophys Acta 1774:286-96 (2007)
DOI:10.1016/j.bbapap.2006.11.008

Sequence

[cdf:CD630_22520]

Other DBs

ExplorEnz - The Enzyme Database:

5.4.3.9

IUBMB Enzyme Nomenclature:

5.4.3.9

ExPASy - ENZYME nomenclature database:

5.4.3.9

BRENDA, the Enzyme Database:

5.4.3.9

LinkDB

DBGET integrated database retrieval system