Entry
Name
tRNA pseudouridine38/39 synthase;
Deg1;
Pus3p;
pseudouridine synthase 3
Class
Isomerases;
Intramolecular transferases;
Transferring other groups
BRITE hierarchy
Sysname
tRNA-uridine38/39 uracil mutase
Reaction(IUBMB)
tRNA uridine38/39 = tRNA pseudouridine38/39
Substrate
tRNA uridine38/39
Product
Comment
The enzyme from Saccharomyces cerevisiae is active only towards uridine38 and uridine39, and shows no activity with uridine40 (cf. EC
5.4.99.12 , tRNA pseudouridine38-40 synthase) [1]. In vitro the enzyme from mouse is active on uridine39 and very slightly on uridine38 (human tRNALeu) [2].
History
EC 5.4.99.45 created 2011
Orthology
K01855 tRNA pseudouridine38/39 synthase
Genes
PYU : 121029914 121035604(PUS3)
CCAD : 122430556 122430557(PUS3)
MREE : 136169542 136169543
PMUR : 107291135 107300457
SANH : 107667175 107677177
CCAR : 109049464 109075414(pus3)
CAUA : 113042592 113084860
MASI : 127431568 127434437
TNG : GSTEN00008649G001 GSTEN00019536G001
XMA : 102237414 111609847 111609913 111609914 111609915 111609916
XCO : 114152129 114152130 114152397
SCLV : 120330842 120330850 120341174
PFLL : 139126873 139137311
DSI : Dsimw501_GD15210(Dsim_GD15210)
AALB : 109401663 109420372 115257469 115257598
CPII : 120414223 120424753
CFEL : 113377274 113378607
PCHN : 125039467 125039492
PMOO : 119586149 119586486
HAME : 121875327 121879962
PCLA : 123757259 123757301 138364245
PORN : 139749529 139749588
PPOI : 119111180 119111182
CEL : CELE_E02H1.3(tag-124)
CBR : CBG_00960(Cbr-tag-124)
MAEA : 128203093 128246025 128246611 128246657
CSAT : 104741987 104757759 104777405
HSYR : 120155797 120218517
LANG : 109335812 109353518
PCIN : 129295571 129298274
CSIN : 114261806 114300948
PSOM : 113347442 113357248
TAES : 123060259 123068763 123077271
MFLO : 136497735 136498221 136529723 136530727
SMO : SELMODRAFT_105100 SELMODRAFT_181988
VCN : VOLCADRAFT_121625(pus4)
CGR : 2891098(GVI51_L08965)
NCS : NCAS_0B04790(NCAS0B04790)
NDI : NDAI_0B02200(NDAI0B02200)
TPF : TPHA_0D00760(TPHA0D00760) TPHA_0P00530(TPHA0P00530)
TBL : TBLA_0C00580(TBLA0C00580)
TDL : TDEL_0C01170(TDEL0C01170)
KAF : KAFR_0B01890(KAFR0B01890)
KNG : KNAG_0D02400(KNAG0D02400)
LBG : 92210819(LODBEIA_P56230)
CAL : CAALFM_C501610WA(CaO19.6297)
CAUR : CJI96_0004840 CJI96_0004900
ASAU : 88173761(PUMCH_002697)
YLI : 2908670(YALI2_F00611g)
NTE : NEUTE1DRAFT83903(NEUTE1DRAFT_83903)
SMP : 10808353(SMAC4_02466)
RTHE : 98127933(VTJ83DRAFT_6564)
TATV : 25779647(TrAtP1_003705)
TASP : 36609474(TrAFT101_007332)
PLJ : 28888879(PLICBS_009300)
CDET : 87943250(CDEST_06747)
BFU : BCIN_05g05620(Bcdeg1)
CPW : 9694197(D8B26_003041)
PTRR : 6340735(PtrM4_060620)
ADAC : 96089714(ACET3X_009392)
CDEP : 91087143(L203_102932)
KMG : 30163844(I203_103875)
KNE : 92179220(IAR55_001961)
CCAC : CcaHIS019_0701280(DEG1)
ABP : AGABI1DRAFT108952(AGABI1DRAFT_108952)
ABV : AGABI2DRAFT188010(AGABI2DRAFT_188010)
SCM : SCHCO_01133390(SCHCODRAFT_01133390) SCHCO_02638611(SCHCODRAFT_02638611)
EHI : EHI_151650(2.t00106)
PLAG : 39741609(PADL01_0907900)
PBRS : 92369966(MKS88_001878)
SPAR : SPRG_05529 SPRG_15172
TCR : 507023.30 511751.180
LMAT : 92513818(LSCM1_03773)
LOI : 92358046(LSCM4_02076)
LEIS : 94178217(GH5_02713)
LENR : 94170308(CUR178_03060)
LEIN : 94187120(JIQ42_03441)
PHET : 94289043(JKF63_02942)
SSAO : 94294044(SS50377_20021) 94294053(SS50377_20030) 94301646(SS50377_27623)
» show all
Taxonomy
Reference
Authors
Lecointe F, Simos G, Sauer A, Hurt EC, Motorin Y, Grosjean H
Title
Characterization of yeast protein Deg1 as pseudouridine synthase (Pus3) catalyzing the formation of psi 38 and psi 39 in tRNA anticodon loop.
Journal
Sequence
Reference
Authors
Chen J, Patton JR
Title
Pseudouridine synthase 3 from mouse modifies the anticodon loop of tRNA.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 5.4.99.45
LinkDB
All DBs