Entry
Name
precorrin-8X methylmutase;
precorrin isomerase;
hydrogenobyrinic acid-binding protein;
cobH (gene name)
Class
Isomerases;
Intramolecular transferases;
Transferring other groups
BRITE hierarchy
Sysname
precorrin-8X 11,12-methylmutase
Reaction(IUBMB)
precorrin-8X = hydrogenobyrinate [RN:
R05177 ]
Reaction(KEGG)
Substrate
Product
hydrogenobyrinate [CPD:
C06399 ]
Comment
The enzyme, which participates in the aerobic (late cobalt insertion) adenosylcobalamin biosynthesis pathway, catalyses the conversion of precorrin-8X to hydrogenobyrinate by methyl rearrangement. The equivalent enzyme in the anaerobic pathway is EC
5.4.99.60 , cobalt-precorrin-8 methylmutase.
History
EC 5.4.99.61 created 1999 as EC 5.4.1.2, transferred 2014 to EC 5.4.99.61
Pathway
Orthology
K06042 precorrin-8X/cobalt-precorrin-8 methylmutase
Genes
SEM : STMDT12_C20550(cbiC)
SETC : CFSAN001921_06620(cbiC)
SEEN : SE451236_16375(cbiC)
SENH : CFSAN002069_21655(cbiC)
SEEH : SEEH1578_19445(cbiC)
SENJ : CFSAN001992_01270(cbiC)
SEEC : CFSAN002050_17125(cbiC)
SEEB : SEEB0189_009300(cbiC)
SENC : SEET0819_17310(cbiC)
KIE : NCTC12125_04862(cbiC)
BUF : D8682_20835 D8682_24210
BAGE : BADSM9389_15290(cbiC)
BFT : MNO13_05055 MNO13_08190
BSEL : RHD99_04860 RHD99_08225
METY : MRY16398_18650(cbiC)
PPRC : PFLCHA0_c06650(cobH)
PMUD : NCTC8068_00607(cobH)
PFW : PF1751_v1c05670(cobH)
PFF : PFLUOLIPICF705345(cobH)
PPUU : PputUW4_00539(cobH)
PTW : TUM18999_08430(cobH)
PTAE : NCTC10697_03994(cobH)
PKK : QQ992_01935 QQ992_25105
ASEM : NNL22_18505 NNL22_18510
MDN : JT25_008970 JT25_023595
TFRI : Thiofri_03989(cobH)
GAI : IMCC3135_08935(cobH)
HAAH : HALA3H3_800139(cobH)
BMV : BMASAVP1_A1603(cobH)
BML : BMA10229_A0265(cobH)
BPM : BURPS1710b_2112(cobH)
BPL : BURPS1106A_1966(cobH)
PDIO : PDMSB3_1862.1(cobH)
PLG : NCTC10937_00831(cobH)
LMIR : NCTC12852_01758(cobH)
MPT : Mpe_B0440(cobH) Mpe_B0475(cobH)
AZA : AZKH_4157(cbiC_cobH)
THAG : CKCBHOJB_02806(cbiC)
SMEL : SM2011_c03192(cobH)
SFD : USDA257_c53960(cobH)
SAME : SAMCFNEI73_Ch3352(cobH)
AGR : AGROH133_09255(cobH)
REC : RHECIAT_PA0000377(cobH)
REL : REMIM1_PD00477(cobH)
REP : IE4803_PA00413(cobH)
REI : IE4771_PC00426(cobH)
RTR : RTCIAT899_PC06995(cobH)
RHL : LPU83_pLPU83d0186(cobH)
RGA : RGR602_PC01215(cobH)
RPHA : AMC79_PB00386(cobH)
NEN : NCHU2750_36460(cbiC)
BIO : BR141012304_11410(cobH)
BRC : BCCGELA001_14700(cobH)
MAQU : Maq22A_c09435(cobH)
MTUN : MTUNDRAET4_2075(cobH)
FIL : BN1229_v1_3174(cobH)
FIY : BN1229_v1_2748(cobH)
DEQ : XM25_19465 XM25_19540
YTI : FNA67_00775(cobH) FNA67_00850
JAV : OXU80_04940 OXU80_15685
RLI : RLO149_c006190(cobH)
PHP : PhaeoP97_00782(cobH)
PPIC : PhaeoP14_00737(cobH)
SINL : DSM14862_03171(cobH)
SPSE : SULPSESMR1_02790(cobH)
RMM : ROSMUCSMR3_03052(cobH)
AHT : ANTHELSMS3_02547(cobH)
LVS : LOKVESSMR4R_00334(cobH)
GEH : HYN69_05155 HYN69_19265 HYN69_20075
GBN : GEOBRER4_34650(cbiC)
PPOR : JCM14722_30990(cobH)
PARG : PspKH34_20150(cbiC)
LMOC : LMOSLCC5850_1183(cobH)
LMW : LMOSLCC2755_1186(cobH)
LMX : LMOSLCC2372_1190(cobH)
LMZ : LMOSLCC2482_1234(cobH)
LMON : LMOSLCC2376_1144(cobH)
LMOS : LMOSLCC7179_1161(cobH)
LMOO : LMOSLCC2378_1199(cobH)
LMOY : LMOSLCC2479_1191(cobH)
LMOT : LMOSLCC2540_1172(cobH)
LMOA : LMOATCC19117_1193(cobH)
BAYD : BSPP4475_15705(cobH)
PPQ : PPSQR21_047930(cobH)
SIP : N597_05050(cbiC) N597_05055(cbiC)
SMEN : SAMEA4412692_0354(cbiC_1) SAMEA4412692_0355(cbiC_2)
LRU : HMPREF0538_20907(cbiC)
AUR : HMPREF9243_1741(cobH)
CCOH : SAMEA4530647_0616(cbiC)
CGEL : psyc5s11_38590(cbiC)
AWO : Awo_c10410(cbiC1) Awo_c30500(cbiC2)
BPRO : PMF13cell1_04253(cbiC)
CSCI : HDCHBGLK_00109(cbiC)
CHYL : CE91St63_25630(cbiC)
ACEL : acsn021_39540(cbiC)
ACHT : bsdcttw_22280(cbiC)
CBAR : PATL70BA_0231(cbiC)
AMIC : Ami3637_15840(cbiC)
ETM : CE91St48_20970(cbiC)
PDF : CD630DERM_34300(cbiC)
PHX : KGNDJEFE_00480(cbiC)
EAC : EAL2_808p00990(cbiC)
PIV : NCTC13079_00687(cbiC)
VRM : 44547418_01209(cobH)
VDN : NCTC11831_00754(cobH)
DHO : Dia5BBH33_07670(cbiC)
MANA : MAMMFC1_00029(cobH_1) MAMMFC1_02507(cobH_2) MAMMFC1_02860(cobH_3) MAMMFC1_04000(cobH_4)
SOVA : SOV_16350(cobH_1) SOV_25670(cobH_2)
PFAC : PFJ30894_01748(cbiC)
MMAE : MMARE11_29680(cobH)
MBAI : MB901379_02824(cobH)
MHEK : JMUB5695_02276(cobH)
MKY : IWGMT90018_27310(cobH)
MPHL : MPHLCCUG_02698(cobH)
MTHN : 4412656_01958(cobH)
MAUU : NCTC10437_03305(cobH)
MFLV : NCTC10271_02123(cobH)
MGO : AFA91_20125(cobH) AFA91_20700
MSAL : DSM43276_01912(cobH)
MTER : 4434518_03149(cobH)
CDIP : ERS451417_01232(cobH)
CUN : Cul210932_1134(cobH)
CUQ : Cul210931_1086(cobH)
CUJ : CUL131002_1118(cobH)
NFR : ERS450000_00922(cobH)
NAD : NCTC11293_04431(cobH)
NWL : NWFMUON74_32390(cobH)
NSPU : IFM12276_23870(cobH)
RPY : Y013_10500(cobH) Y013_14620(cobH)
RCR : NCTC10994_03358(cobH)
TPUL : TPB0596_23910(cobH)
SAMB : SAM23877_1930(cobH)
STRF : ASR50_09015 ASR50_31640(cobH)
SLE : sle_07910(sle_07910)
SPAV : Spa2297_00585(cobH)
SGM : GCM10017557_05130(cobH)
STRO : STRMOE7_19270(cobH)
SGF : HEP81_05442 HEP81_05910
SXT : KPP03845_105798(cobH)
DCO : SAMEA4475696_1934(cobH)
PAK : HMPREF0675_3464(cobH)
PACN : TIA1EST1_02120(cobH)
CGRN : 4412665_00764(cobH)
PAUS : NCTC13651_00955(cobH)
PPC : HMPREF9154_0400(cobH_1) HMPREF9154_1241(cobH_2)
TEZ : BKM78_01680(cobH) BKM78_05725(cobH)
TLA : TLA_TLA_00342(cobH_1) TLA_TLA_01158(cobH_2)
RAIN : Rai3103_03675 Rai3103_07670
BROO : brsh051_09550 brsh051_09860
NAQU : ENKNEFLB_00280(cobH_1) ENKNEFLB_01627(cobH_2)
AEB : C6I20_00050 C6I20_00405
ACTW : F7P10_03350 F7P10_08665
AGRA : AGRA3207_000945 AGRA3207_001863
AMAZ : LUW76_07320 LUW76_13540
ACIR : OG979_28045 OG979_33705
SPIQ : OHA34_08325 OHA34_13530
FAL : FRAAL2332(cobH) FRAAL3733
KUT : JJ691_59040 JJ691_93710
MSAG : GCM10017556_51980(cobH)
ACTR : Asp14428_65780(cobH)
BALA : DSM104299_01727(cobH)
PARQ : DSM112329_00642(cobH)
SYN : sll0794(merR) sll0916(cbiC) slr1467
SYZ : MYO_116800 MYO_118410(cbiC) MYO_127660(merR)
SYY : SYNGTS_1664(slr1467) SYNGTS_1824(cbiC) SYNGTS_2740(corR)
SYT : SYNGTI_1664(slr1467) SYNGTI_1824(cbiC) SYNGTI_2739(corR)
SYS : SYNPCCN_1663(slr1467) SYNPCCN_1823(cbiC) SYNPCCN_2738(corR)
SYQ : SYNPCCP_1663(slr1467) SYNPCCP_1823(cbiC) SYNPCCP_2738(corR)
SYJ : D082_01040 D082_20500(cobH)
SYO : C7I86_08635 C7I86_09500 C7I86_14345
SYNH : HTZ78_03760 HTZ78_15660
SYNS : OLK001_00970(cbiC2) OLK001_04360
SYR : SynRCC307_0077(cobH)
SYX : SynWH7803_0083(cobH)
CYA : CYA_0461(cobH-1) CYA_1574(cobH-2)
CYB : CYB_0225(cobH-1) CYB_0379(cobH-2)
SYNE : Syn6312_2218 Syn6312_2231
SYNP : Syn7502_01376 Syn7502_02115
SYH : Syncc8109_0080(cobH)
DSL : Dacsa_0662 Dacsa_0848
WNA : KA717_06535 KA717_25400
CMP : Cha6605_0987 Cha6605_1889 Cha6605_5141
CYN : Cyan7425_1281 Cyan7425_1287
CEP : Cri9333_1753 Cri9333_2468
TVN : NIES2134_104550(cobH) NIES2134_106760
SLW : BRW62_03080 BRW62_12130
TEL : tll0173(cobH) tlr1064
THN : NK55_01170(cbiC1) NK55_01830(cbiC2)
THEC : FFX45_10535 FFX45_11595
THEY : JW907_01785 JW907_07365
TSQ : D3A95_00630 D3A95_01625
TSZ : OOK60_04995 OOK60_11980
LEN : LEP3755_49210 LEP3755_50930 LEP3755_63990
LET : O77CONTIG1_02838(cobH) O77CONTIG1_03230(cbiC)
LBO : LBWT_18190 LBWT_53940
LEPB : GFS31_09380 GFS31_40090
LSC : KIK02_14585 KIK02_24040
LSK : J5X98_25075 J5X98_25100
HHG : XM38_025030(cbiC_1) XM38_026830(cbiC_2)
PSEU : Pse7367_0299 Pse7367_2031
PSER : ABRG53_1413(cobH) ABRG53_2807(cobH) ABRG53_b020
PGX : OA858_03690 OA858_22060
THEU : HPC62_05290 HPC62_16980
TOG : HNI00_00110 HNI00_09505
TSIN : OXH18_08950 OXH18_13080
GLP : Glo7428_1869 Glo7428_4217
CHON : NIES4102_08650(cobH) NIES4102_26350(cbiC2) NIES4102_42590(corR)
GDU : P0S91_02675 P0S91_19280
GEN : GM3709_2236 GM3709_3414
GEE : GM3708_1113 GM3708_1350
CAN : Cyan10605_0906 Cyan10605_3167
SYP : SYNPCC7002_A0528(cobH)
SYNN : NIES970_10350(cobH)
MVZ : myaer102_37800(cobH)
HAO : PCC7418_0364 PCC7418_0818 PCC7418_1941
ENN : FRE64_03405 FRE64_04200
CYT : cce_1970(cbiC2) cce_3969(cbiC1)
CWA : CwatDRAFT_1001 CwatDRAFT_1728
CYP : PCC8801_1312 PCC8801_1477
CYH : Cyan8802_1340 Cyan8802_1504
CYC : PCC7424_4511 PCC7424_5060
CYJ : Cyan7822_2678 Cyan7822_3293
ARP : NIES39_E02190(cobH) NIES39_G00860(cobH)
PAGH : NIES204_03470(cobH_1) NIES204_04450(cobH_2)
PPSU : NO713_02515(cbiC) NO713_04080(cbiC)
PRUN : PCC7821_03840(cobH) PCC7821_03965(cbiC)
MVAG : D0A34_04190 D0A34_08265 D0A34_25620
LFS : HFV01_15575 HFV01_23785
LIX : H2674_03440 H2674_10835
OXY : HCG48_07645 HCG48_11460
OAC : Oscil6304_2048 Oscil6304_2326 Oscil6304_5872
ONI : Osc7112_1118 Osc7112_2345 Osc7112_5590
MPRO : BJP34_02980 BJP34_11145
PHOR : JWS08_06610 JWS08_18340
PYH : NEA10_00355 NEA10_05240
MIC : Mic7113_1386 Mic7113_1764 Mic7113_1914
GEI : GEI7407_1469 GEI7407_1558 GEI7407_2575
NPU : Npun_F4020 Npun_F6482 Npun_R4919
NOS : Nos7107_0372 Nos7107_0441 Nos7107_0489
NOP : Nos7524_1795 Nos7524_2281
NON : NOS3756_35290 NOS3756_49990
NFL : COO91_03588 COO91_04273
NOE : CLI64_08480 CLI64_17135
NSH : GXM_04234 GXM_05856 GXM_05955
NED : HUN01_08650 HUN01_28725 HUN01_34565
NPZ : ACX27_01925 ACX27_20395 ACX27_23040
NLK : NIES25_25380 NIES25_54140 NIES25_55640
NCW : NIES2107_19200 NIES2107_59110
NCF : ANSO36C_10560 ANSO36C_16330
ANB : ANA_C11102 ANA_C20544(cobH)
ACY : Anacy_0609 Anacy_5142 Anacy_5827
AWA : AA650_11955 AA650_22520
ANN : EH233_17500 EH233_22185
CSG : Cylst_2113 Cylst_3296 Cylst_4829
RSIN : B6N60_01031 B6N60_03064 B6N60_03126
HBQ : QI031_16525 QI031_22025 QI031_25170
CALO : Cal7507_0240 Cal7507_0649 Cal7507_2495
CALT : Cal6303_3429 Cal6303_5350
CALH : IJ00_17450 IJ00_25370 IJ00_25395
CALN : NIES2098_42900 NIES2098_52340
CALS : NIES3974_22070(cobH) NIES3974_34400
RIV : Riv7116_3406 Riv7116_3805 Riv7116_4739 Riv7116_6711
MDP : NIES3275_12840 NIES3275_42940
FIS : FIS3754_01060 FIS3754_04920 FIS3754_24810
NSPH : BDGGKGIB_00329(cbiC_1) BDGGKGIB_02940(cbiC_2)
DOU : BMF77_00725(cbiC) BMF77_04145(cobH)
DFS : HGD76_15010 HGD76_18775
DHT : NG743_02770 NG743_13340
DOT : EZY12_11855 EZY12_26925
AFLO : HEQ12_03080 HEQ12_14765
AEE : IM676_00405 IM676_13515
OCF : WJM97_02735 WJM97_04975
TOQ : HCG51_00955 HCG51_18205 HCG51_32310
TTQ : NIES37_36300 NIES37_53690
ALAX : NIES50_32860 NIES50_50290
SCYT : SAMD_61510 SAMD_73690
SCYS : NIES4073_24160 NIES4073_37300
BSEN : DP114_13745 DP114_21430
BOX : DP113_13685 DP113_21355
NCN : BZZ01_21235 BZZ01_28205 BZZ01_29860
CTHE : Chro_1234 Chro_4979 Chro_5334 Chro_5651
PLP : Ple7327_0785 Ple7327_1118
SCS : Sta7437_1247 Sta7437_1525
STAN : STA3757_06310(cobH) STA3757_36000(cbiC2)
PPIO : CE91St28_12030(cbiC)
FPOL : ERS445057_01258(cbiC)
MFEG : GCM10025860_16120(cbiC)
MEHF : MmiHf6_04720 MmiHf6_06020
MEES : MmiEs2_04010 MmiEs2_05300
MCJ : MCON_0651(cbiC) MCON_1680(cbiC)
TVO : TVG0974537(TVG0974537)
» show all
Taxonomy
Reference
Authors
Thibaut D, Couder M, Famechon A, Debussche L, Cameron B, Crouzet J, Blanche F.
Title
The final step in the biosynthesis of hydrogenobyrinic acid is catalyzed by the cobH gene product with precorrin-8x as the substrate.
Journal
Sequence
Reference
Authors
Crouzet J, Cameron B, Cauchois L, Rigault S, Rouyez MC, Blanche F, Thibaut D, Debussche L
Title
Genetic and sequence analysis of an 8.7-kilobase Pseudomonas denitrificans fragment carrying eight genes involved in transformation of precorrin-2 to cobyrinic acid.
Journal
Sequence
Reference
Authors
Shipman LW, Li D, Roessner CA, Scott AI, Sacchettini JC
Title
Crystal structure of precorrin-8x methyl mutase.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 5.4.99.61
LinkDB
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