KEGG   ENZYME: 5.5.1.24
Entry
EC 5.5.1.24                 Enzyme                                 
Name
tocopherol cyclase;
VTE1 (gene name);
SXD1 (gene name);
delta/gamma-tocopherol lyase (decyclizing)
Class
Isomerases;
Intramolecular lyases;
Intramolecular lyases (only sub-subclass identified to date)
Sysname
delta/gamma-tocopherol lyase (ring-opening)
Reaction(IUBMB)
(1) delta-tocopherol = 2-methyl-6-phytylbenzene-1,4-diol  [RN:R07503];
(2) gamma-tocopherol = 2,3-dimethyl-6-phytylbenzene-1,4-diol  [RN:R07502];
(3) delta-tocotrienol = 6-geranylgeranyl-2-methylbenzene-1,4-diol  [RN:R10623];
(4) gamma-tocotrienol = 6-geranylgeranyl-2,3-dimethylbenzene-1,4-diol [RN:R10624]
Reaction(KEGG)
R07502 R07503 R10623 R10624
Substrate
delta-tocopherol [CPD:C14151];
gamma-tocopherol [CPD:C02483];
delta-tocotrienol [CPD:C14156];
gamma-tocotrienol [CPD:C14155]
Product
2-methyl-6-phytylbenzene-1,4-diol [CPD:C15882];
2,3-dimethyl-6-phytylbenzene-1,4-diol [CPD:C15883];
6-geranylgeranyl-2-methylbenzene-1,4-diol [CPD:C20737];
6-geranylgeranyl-2,3-dimethylbenzene-1,4-diol [CPD:C20738]
Comment
The enzyme has been described from plants and cyanobacteria. It has similar activity with all four listed benzoquinol substrates. Involved in the biosynthesis of vitamin E (tocopherols and tocotrienols).
History
EC 5.5.1.24 created 2013
Pathway
ec00130  Ubiquinone and other terpenoid-quinone biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K09834  tocopherol cyclase
Genes
ATH: AT4G32770(VTE1)
ALY: 9305317
CRB: 17877607
CSAT: 104716894 104720514 104721549 104729992
EUS: EUTSA_v10025006mg
BRP: 103862197
BNA: 106411207 106423394
BOE: 106301700
RSZ: 108851396 130511472
THJ: 104803808
CPAP: 110822117
CIT: 102615028
CIC: CICLE_v10008169mg
PVY: 116114612 116114613
MINC: 123194912 123194913
TCC: 18587955
GRA: 105762967 105769163
GHI: 107900519 107906956 107953842 121229241
GAB: 108459692 108472002
HSYR: 120114804 120136179 120166651
DZI: 111302940
EGR: 104437768
GMX: 100791679 100809310
GSJ: 114409109 114415137
PVU: PHAVU_009G108200g
VRA: 106762339
VAR: 108318687
VUN: 114164033
VUM: 124822643
CCAJ: 109801639
APRC: 113864761
MTR: 25490120
TPRA: 123893713
CAM: 101502250
PSAT: 127084642
VVO: 131660061 131660075
LJA: 130727554 130727567 130727573 130727575
ADU: 107470774
AIP: 107623139
AHF: 112716148 112784216
LANG: 109339295
PCIN: 129302420 129302421
QSA: O6P43_019281
FVE: 101304641
RCN: 112173193
PPER: 18791199
PMUM: 103320200
PAVI: 110761173
PDUL: 117616313
MDM: 103428784 103456033
MSYL: 126604527 126633257
PXB: 103937837 103957110 103957461
MNT: 21390651 21390653
CSAV: 115699277
CSV: 101206720
CMO: 103488188
BHJ: 120075560
MCHA: 111004926
CMAX: 111496186
CMOS: 111454510
CPEP: 111799319
RCU: 8271188
MEAN: 126664264
JCU: 105638244
HBR: 110669879
MESC: 110603804
POP: 18100669 18107478
PEU: 105127155
PALZ: 118032790 118051181 118053486
JRE: 109007374 109009500
CILL: 122317563 122318800
CAVE: 132189356 132190937
QSU: 112016280 136061426
QLO: 115971144
TWL: 119997389
VVI: 100268095
VRI: 117912811
SLY: 101263925
SPEN: 107026784
SOT: 102577462(SXD1)
SSTN: 125842392
SDUL: 129889444
CANN: 107839135
LBB: 132635633
NTA: 107798727 107806714(TC)
NSY: 104221249
NTO: 104098970
NAU: 109234037
INI: 109178717
ITR: 116005566
SIND: 105164753
OEU: 111385234
EGT: 105977167
SSPL: 121785062
SMIL: 131015255
SHIS: 125217021
APAN: 127265681
HAN: 110873807
ECAD: 122578737
LSV: 111907085
DCR: 108225390
CSIN: 114295292
RVL: 131316944
AEW: 130757223
BVG: 104885180
SOE: 110775274
CQI: 110705597
ATRI: 130802855 130802856
MOF: 131151929
NNU: 104595147
MING: 122076820
TSS: 122654166
PSOM: 113348252 113349107
OSA: 4329007(OsJ_06237)
OBR: 102712058
OGL: 127761124
BDI: 100846924
ATS: 109734383
TDC: 119276114 119340110
TAES: 123052679 123128989 123181719
TUA: 125514085
LPER: 127320950
LRD: 124692135 124692146
SBI: 8060379
ZMA: 541877
MFLO: 136466981 136476216
SITA: 101764913
SVS: 117851187
PVIR: 120655379 120697746
PHAI: 112886331
PDA: 103702550
EGU: 105040851
MUS: 103995049
ZOF: 122052195 122052197 122056681 122056683
DCT: 110106522
PEQ: 110025563
AOF: 109821288
MSIN: 131223037
NCOL: 116254650
ATR: 18426679
SMO: SELMODRAFT_143592 SELMODRAFT_172178
PPP: 112273462 112284896
CRE: CHLRE_01g013801v5
VCN: VOLCADRAFT_42287
MNG: MNEG_11580
CSL: COCSUDRAFT_12504
CVR: CHLNCDRAFT_19624
APRO: F751_1103
OLU: OSTLU_39591
OTA: OT_ostta01g01855
BPG: Bathy01g01730
MIS: MICPUN_68115
MPP: MICPUCDRAFT_33085
CME: CYME_CML326C
PNO: SNOG_07016
BOR: COCMIDRAFT_92776
AALT: CC77DRAFT_1019104
PCO: PHACADRAFT_254191
PTI: PHATRDRAFT_bd1025(VTE1)
FCY: FRACYDRAFT_242143(VTE1)
TPS: THAPSDRAFT_263019
AAF: AURANDRAFT_65060
EHX: EMIHUDRAFT_237937 EMIHUDRAFT_54133 EMIHUDRAFT_98577
EHR: EHR_02320
ECAS: ECBG_00190
EMU: EMQU_0164
EGA: AL523_09215
EIE: ENLAB_26220
CRN: CAR_c02300
CAW: Q783_00780
CARC: NY10_1012
CVD: LHA31_05915
JEP: BW721_01460
JDA: BW727_101359
JEH: EJN90_00875
JPO: G7058_09500
DINC: QNK01_00235
CCB: Clocel_0502
CLB: Clo1100_2348
CARG: RSJ17_06920
CGAS: J1C67_16955
CMAH: C1I91_09090
CRW: CROST_043670
CFB: CLFE_004350
CAUN: CLAUR_031430
CINT: HZF06_08550
CCE: Ccel_1994
RPAY: P0092_13525
CCEL: CCDG5_0731
LASA: L9O85_09640
CFEM: HCR03_10095
DED: DHBDCA_p2010
DEC: DCF50_p2022
AWO: Awo_c01810
AWI: CHL1_000153
ALKA: J0B03_11880
ACAE: HYG86_14240
BPB: bpr_I1006
BHU: bhn_I1975
CSH: Closa_1049
ANR: Ana3638_07040
ACHT: bsdcttw_10320
CLE: Clole_2217
CEW: EKH84_13735
VPY: HZI73_14995 HZI73_19765
AMT: Amet_3459
AOE: Clos_0174
TEM: JW646_11335
TGC: L0P85_16420
TMY: TEMA_25130
TPET: TPHSE_36230
TUR: AT726_05395
TSG: HLK68_04145
TBB: J0J69_08315
ACL: ACL_1398
AOC: Aocu_02520
ABRA: BN85314670
MANR: MPAN_016600
TBK: HF295_07915
TBM: BK010_09890
TBZ: BK011_09920
MMAL: CKJ54_17760
MUL: MUL_2705
MMI: MMAR_3430
MMAE: MMARE11_33380
MLI: MULP_03697
MPSE: MPSD_35110
MSHO: MSHO_48460
MKN: MKAN_03880
MPAG: C0J29_08880
MBAI: MB901379_03072
MSEO: MSEO_20150
MOT: LTS72_07270
MGI: Mflv_4428
MSP: Mspyr1_38280
CEF: CE1100
CHN: A605_05105
CHM: B842_04640
CTED: CTEST_04575
RER: RER_16120
REY: O5Y_07695
REB: XU06_07935
RHOD: AOT96_18540
DIT: C3V38_00415
DIZ: CT688_10440
DPC: A6048_10625
DLU: A6035_10140
MHOS: CXR34_15730
MPRT: ET475_06200
RHOK: RKAS3_01790
AGY: ATC03_02330
AMAV: GCM10025877_03940
ARL: AFL94_11610
ARY: ATC04_06615
DCP: RN607_01900
TFL: RPIT_10805
TDF: H9L22_03675
RAIN: Rai3103_16110
PRV: G7070_13760
BRT: J4N02_07000
FSL: EJO69_11060
SYN: slr1737
SYZ: MYO_112090
SYY: SYNGTS_1199(slr1737)
SYT: SYNGTI_1199(slr1737)
SYS: SYNPCCN_1198(slr1737)
SYQ: SYNPCCP_1198(slr1737)
SYJ: D082_16890
SYO: C7I86_06215
SYNH: HTZ78_09660
CYA: CYA_0654 CYA_0896
CYB: CYB_0605
SYNE: Syn6312_3402
SYNP: Syn7502_02454
DSL: Dacsa_1404
WNA: KA717_23275
CMP: Cha6605_5219
CYN: Cyan7425_2596
CEP: Cri9333_2174
AMR: AM1_2430
LEN: LEP3755_10640
LET: O77CONTIG1_04231
LBO: LBWT_47570
KOV: K9N68_14070
LSC: KIK02_22075
LSK: J5X98_13100
HHG: XM38_007350
PSEU: Pse7367_1064
THEU: HPC62_20290
TOG: HNI00_12125
TSIN: OXH18_20070
GLP: Glo7428_3471
CHON: NIES4102_16140
GDU: P0S91_01190
SYP: SYNPCC7002_A0670
SYV: AWQ23_03505
SYL: AWQ21_04120
LEP: Lepto7376_2265
SYNN: NIES970_00320
PIP: FEK30_07460
MAR: MAE_59750
MPK: VL20_741
MIQ: B5D77_23570
MVZ: myaer102_31940
HAO: PCC7418_3554
ENN: FRE64_00920
CYT: cce_3689
CWA: CwatDRAFT_6621
CYP: PCC8801_1078
CYH: Cyan8802_1107
CYC: PCC7424_0003
CYJ: Cyan7822_0003
TER: Tery_1802
ARP: NIES39_E00630
PAGH: NIES204_01690
PPSU: NO713_04432(VTE1)
PRUN: PCC7821_04230(VTE1)
OXY: HCG48_06465
LFS: HFV01_20990
LIX: H2674_05960
OAC: Oscil6304_3929
ONI: Osc7112_5394
MPRO: BJP34_30130
PHOR: JWS08_03365
PYH: NEA10_08895
MIC: Mic7113_1871
GEI: GEI7407_2531
GVI: glr3089
GLJ: GKIL_0805
GML: ISF26_14305
ANA: all0245
NPU: Npun_R0149
NOS: Nos7107_1763
NOP: Nos7524_3438
NON: NOS3756_32540
NFL: COO91_05004
NOE: CLI64_21410
NSH: GXM_05592
NED: HUN01_08115
NPZ: ACX27_26200
NLK: NIES25_15040
AVA: Ava_2735
NAZ: Aazo_3505
ANB: ANA_C10369
ACY: Anacy_5164
AWA: AA650_24360
ANN: EH233_14325
CSG: Cylst_5807
RSIN: B6N60_00008
HBQ: QI031_25465
CALO: Cal7507_3269
CALT: Cal6303_4731
CALH: IJ00_12110
CALN: NIES2098_38250
CALS: NIES3974_24340
RIV: Riv7116_0097
MDP: NIES3275_56340
FIS: FIS3754_00340
NSP: BMF81_02295
NSPH: BDGGKGIB_01888
DOU: BMF77_01243
DFS: HGD76_10995
DHT: NG743_11410
DCM: NIES806_09880
DOT: EZY12_08965
DOZ: HEP80_14690
CCUR: IAR63_12000
CRK: L3I90_01335
AFLO: HEQ12_13190
STOQ: K2F26_04000
SKV: NIES73_43970
AEE: IM676_11690
RCS: NIES932_02990
TOQ: HCG51_00045
ALAX: NIES50_17630
SCYT: SAMD_15250
SCYS: NIES4073_04180
BSEN: DP114_28330
BOX: DP113_28240
NCN: BZZ01_27980
CTHE: Chro_1644
PLP: Ple7327_0186
SCS: Sta7437_3667
STAN: STA3757_38860
PBF: CFX0092_A3137
PMET: G4Y79_17120
SFC: Spiaf_2472
SPER: EW093_08460
SBU: SpiBuddy_2579
SGP: SpiGrapes_2372
SASS: MUG09_13800
MICA: P0L94_17070
DRC: G0Q07_01490
ANF: AQPE_1782
HHY: Halhy_2751
TAF: THA_709
MAEO: JRV97_10160
MPG: Theba_2038
MINF: MESINF_1223
ASAC: ATHSA_1559
METB: AW729_02110
MRU: mru_0432
MMIL: sm9_0735
MEYE: TL18_03560
MOL: YLM1_0103
MEL: Metbo_1072
MEME: HYG87_02110
MBAK: MSBR3_0408
MMA: MM_0519
MMAZ: MmTuc01_0540
MMJ: MSMAS_0787
MMAC: MSMAC_0766
MTHR: MSTHT_0418
MTHE: MSTHC_0303
MFZ: AOB57_000120
LOKI: Lokiarch_32970
LOB: NEF87_000526
PSYT: DSAG12_01668
 » show all
Reference
1  [PMID:12213958]
  Authors
Porfirova S, Bergmuller E, Tropf S, Lemke R, Dormann P.
  Title
Isolation of an Arabidopsis mutant lacking vitamin E and identification of a cyclase essential for all tocopherol biosynthesis.
  Journal
Proc Natl Acad Sci U S A 99:12495-500 (2002)
DOI:10.1073/pnas.182330899
  Sequence
[ath:AT4G32770]
Reference
2  [PMID:12913173]
  Authors
Sattler SE, Cahoon EB, Coughlan SJ, DellaPenna D
  Title
Characterization of tocopherol cyclases from higher plants and cyanobacteria. Evolutionary implications for tocopherol synthesis and function.
  Journal
Plant Physiol 132:2184-95 (2003)
DOI:10.1104/pp.103.024257
  Sequence
[ath:AT4G32770] [zma:541877] [syn:slr1737]
Other DBs
ExplorEnz - The Enzyme Database: 5.5.1.24
IUBMB Enzyme Nomenclature: 5.5.1.24
ExPASy - ENZYME nomenclature database: 5.5.1.24
BRENDA, the Enzyme Database: 5.5.1.24
LinkDB

DBGET integrated database retrieval system