KEGG   ENZYME: 5.5.1.24
Entry
EC 5.5.1.24                 Enzyme                                 
Name
tocopherol cyclase;
VTE1 (gene name);
SXD1 (gene name);
delta/gamma-tocopherol lyase (decyclizing)
Class
Isomerases;
Intramolecular lyases;
Intramolecular lyases (only sub-subclass identified to date)
Sysname
delta/gamma-tocopherol lyase (ring-opening)
Reaction(IUBMB)
(1) delta-tocopherol = 2-methyl-6-phytylbenzene-1,4-diol  [RN:R07503];
(2) gamma-tocopherol = 2,3-dimethyl-6-phytylbenzene-1,4-diol  [RN:R07502];
(3) delta-tocotrienol = 6-geranylgeranyl-2-methylbenzene-1,4-diol  [RN:R10623];
(4) gamma-tocotrienol = 6-geranylgeranyl-2,3-dimethylbenzene-1,4-diol [RN:R10624]
Reaction(KEGG)
Substrate
delta-tocopherol [CPD:C14151];
gamma-tocopherol [CPD:C02483];
delta-tocotrienol [CPD:C14156];
gamma-tocotrienol [CPD:C14155]
Product
2-methyl-6-phytylbenzene-1,4-diol [CPD:C15882];
2,3-dimethyl-6-phytylbenzene-1,4-diol [CPD:C15883];
6-geranylgeranyl-2-methylbenzene-1,4-diol [CPD:C20737];
6-geranylgeranyl-2,3-dimethylbenzene-1,4-diol [CPD:C20738]
Comment
The enzyme has been described from plants and cyanobacteria. It has similar activity with all four listed benzoquinol substrates. Involved in the biosynthesis of vitamin E (tocopherols and tocotrienols).
History
EC 5.5.1.24 created 2013
Pathway
ec00130  Ubiquinone and other terpenoid-quinone biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K09834  tocopherol cyclase
Genes
MMER123544384
ATHAT4G32770(VTE1)
ALY9305317
CRB17877607
CSAT104716894 104720514 104721549 104729992
EUSEUTSA_v10025006mg
BRP103862197
BNA106411207 106423312 106423394
BOE106301700
RSZ108851396
THJ104803808
CPAP110822117
CIT102615028
CICCICLE_v10008169mg
PVY116114612 116114613
MINC123194912 123194913
TCC18587955
GRA105762967 105769163
GHI107900519 107906956 107953842 121229241
GAB108459692 108472002
DZI111302940
EGR104437768
GMX100791679 100809310
GSJ114409109 114415137
PVUPHAVU_009G108200g
VRA106762339
VAR108318687
VUN114164033
CCAJ109801639
APRC113864761
MTR25490120
CAM101502250
ADU107470774
AIP107623139
AHF112716148 112784216
LANG109339295
FVE101304641
RCN112173193
PPER18791199
PMUM103320200
PAVI110761173
PDUL117616313
MDM103428784 103456033
PXB103937837 103957110 103957461
ZJU107407439 107407440
MNT21390651 21390653
CSV101206720
CMO103488188
BHJ120075560
MCHA111004926
CMAX111496186
CMOS111454510
CPEP111799319
RCU8271188
JCU105638244
HBR110669879
MESC110603804
POP18100669 18107478
PEU105127155
PALZ118032790 118051181 118053486
JRE109007374 109009500
QSU112016280
QLO115971144
TWL119997389
VVI100268095
VRI117912811
SLY101263925
SPEN107026784
SOT102577462(SXD1)
SSTN125842392
CANN107839135
NTA107798727 107806714(TC)
NSY104221249
NTO104098970
NAU109234037
INI109178717
ITR116005566
SIND105164753
OEU111385234
EGT105977167
SSPL121785062
HAN110873807
ECAD122578737
LSV111907085
DCR108225390
CSIN114295292
BVG104885180
SOE110775274
CQI110705597
NNU104595147
MING122076820
TSS122654166
PSOM113348252 113349107
NCOL116254650
OSA4329007
DOSAOs02t0276500-01(Os02g0276500)
OBR102712058
BDI100846924
ATS109734383
TDC119276114 119340110
TAES123052679 123128989 123181719
TUA125514085
SBI8060379
ZMA541877
SITA101764913
SVS117851187
PVIR120655379 120697746
PHAI112886331
PDA103702550
EGU105040851
MUS103995049
DCT110106522
PEQ110025563
AOF109821288
ATR18426679
SMOSELMODRAFT_143592 SELMODRAFT_172178
PPP112273462 112284896
CRECHLRE_01g013801v5
VCNVOLCADRAFT_42287
MNGMNEG_11580
CSLCOCSUDRAFT_12504
CVRCHLNCDRAFT_19624
APROF751_1103
OLUOSTLU_39591
OTAOT_ostta01g01855
BPGBathy01g01730
MISMICPUN_68115
MPPMICPUCDRAFT_33085
CMECYME_CML326C
PNOSNOG_07016
BORCOCMIDRAFT_92776
AALTCC77DRAFT_1019104
PCOPHACADRAFT_254191
PTIPHATRDRAFT_bd1025(VTE1)
FCYFRACYDRAFT_242143(VTE1)
TPSTHAPSDRAFT_263019
AAFAURANDRAFT_65060
EHXEMIHUDRAFT_237937 EMIHUDRAFT_54133 EMIHUDRAFT_98577
EHREHR_02320
ECASECBG_00190
EMUEMQU_0164
EGAAL523_09215
EIEENLAB_26220
CRNCAR_c02300
CAWQ783_00780
CARCNY10_1012
CVDLHA31_05915
JEPBW721_01460
JDABW727_101359
JEHEJN90_00875
JPOG7058_09500
CCBClocel_0502
CLBClo1100_2348
CARGRSJ17_06920
CGASJ1C67_16955
CMAHC1I91_09090
CRWCROST_043670
CFBCLFE_004350
CAUNCLAUR_031430
AMTAmet_3459
AOEClos_0174
CCECcel_1994
CCELCCDG5_0731
CFEMHCR03_10095
LASAL9O85_09640
BPBbpr_I1006
BHUbhn_I1975
CLEClole_2217
CEWEKH84_13735
CSHClosa_1049
ANRAna3638_07040
ACHTbsdcttw_10320
TEMJW646_11335
TGCL0P85_16420
DEDDHBDCA_p2010
DECDCF50_p2022
AWOAwo_c01810
AWICHL1_000153
ALKAJ0B03_11880
VPYHZI73_14995 HZI73_19765
ACAEHYG86_14240
ETMCE91St48_12760
TURAT726_05395
TSGHLK68_04145
TBBJ0J69_08315
ACLACL_1398
AOCAocu_02520
ABRABN85314670
MANRMPAN_016600
TBMBK010_09890
TBZBK011_09920
TBKHF295_07915
MMALCKJ54_17760
MULMUL_2705
MMIMMAR_3430
MMAEMMARE11_33380
MLIMULP_03697
MPSEMPSD_35110
MSHOMSHO_48460
MKNMKAN_03880
MPAGC0J29_08880
MBAIMB901379_03072
MSEOMSEO_20150
MOTLTS72_07270
MGIMflv_4428
MSPMspyr1_38280
CEFCE1100
CHNA605_05105
CHMB842_04640
CTEDCTEST_04575
RERRER_16120
REYO5Y_07695
REBXU06_07935
RHODAOT96_18540
DITC3V38_00415
DIZCT688_10440
DPCA6048_10625
DLUA6035_10140
MHOSCXR34_15730
MPRTET475_06200
AGYATC03_02330
ARLAFL94_11610
ARYATC04_06615
TFLRPIT_10805
TDFH9L22_03675
RAINRai3103_16110
PRVG7070_13760
BRTJ4N02_07000
FSLEJO69_11060
SYNslr1737
SYZMYO_112090
SYYSYNGTS_1199(slr1737)
SYTSYNGTI_1199(slr1737)
SYSSYNPCCN_1198(slr1737)
SYQSYNPCCP_1198(slr1737)
SYJD082_16890
SYOC7I86_06215
SYPSYNPCC7002_A0670
CYACYA_0654 CYA_0896
CYBCYB_0605
SYNESyn6312_3402
SYNPSyn7502_02454
SYVAWQ23_03505
SYLAWQ21_04120
DSLDacsa_1404
CMPCha6605_5219
AMRAM1_2430
WNAKA717_23275
LEPLepto7376_2265
LENLEP3755_10640
LETO77CONTIG1_04231
LBOLBWT_47570
KOVK9N68_14070
LSCKIK02_22075
LSKJ5X98_13100
HHGXM38_007350
PSEUPse7367_1064
THEUHPC62_20290
GLPGlo7428_3471
CHONNIES4102_16140
MARMAE_59750
MPKVL20_741
MIQB5D77_23570
MVZmyaer102_31940
HAOPCC7418_3554
ENNFRE64_00920
CYTcce_3689
CWACwatDRAFT_6621
CYPPCC8801_1078
CYHCyan8802_1107
CYCPCC7424_0003
CYJCyan7822_0003
CYNCyan7425_2596
TERTery_1802
ARPNIES39_E00630
PAGHNIES204_01690
PPSUNO713_04432(VTE1)
OXYHCG48_06465
LFSHFV01_20990
MICMic7113_1871
GEIGEI7407_2531
OACOscil6304_3929
ONIOsc7112_5394
MPROBJP34_30130
PHORJWS08_03365
PYHNEA10_08895
CEPCri9333_2174
GVIglr3089
GLJGKIL_0805
GMLISF26_14305
ANAall0245
NPUNpun_R0149
NOSNos7107_1763
NOPNos7524_3438
NONNOS3756_32540
NFLCOO91_05004
NOECLI64_21410
NSHGXM_05592
NEDHUN01_08115
AVAAva_2735
NAZAazo_3505
ANBANA_C10369
ACYAnacy_5164
AWAAA650_24360
ANNEH233_14325
CSGCylst_5807
RSINB6N60_00008
CALOCal7507_3269
CALTCal6303_4731
CALHIJ00_12110
CALNNIES2098_38250
RIVRiv7116_0097
FISFIS3754_00340
NSPBMF81_02295
NSPHBDGGKGIB_01888
DOUBMF77_01243
DFSHGD76_10995
DHTNG743_11410
CCURIAR63_12000
CRKL3I90_01335
AFLOHEQ12_13190
TOQHCG51_00045
NCNBZZ01_27980
CTHEChro_1644
PLPPle7327_0186
SCSSta7437_3667
STANSTA3757_38860
PBFCFX0092_A3137
PMETG4Y79_17120
SFCSpiaf_2472
SPEREW093_08460
SBUSpiBuddy_2579
SGPSpiGrapes_2372
SASSMUG09_13800
DRCG0Q07_01490
HHYHalhy_2751
TAFTHA_709
MPGTheba_2038
MINFMESINF_1223
ASACATHSA_1559
METBAW729_02110
MRUmru_0432
MMILsm9_0735
MEYETL18_03560
MOLYLM1_0103
MELMetbo_1072
MEMEHYG87_02110
MBAKMSBR3_0408
MMAMM_0519
MMAZMmTuc01_0540
MMJMSMAS_0787
MMACMSMAC_0766
MTHRMSTHT_0418
MTHEMSTHC_0303
MFZAOB57_000120
LOKILokiarch_32970
PSYTDSAG12_01668
 » show all
Reference
1  [PMID:12213958]
  Authors
Porfirova S, Bergmuller E, Tropf S, Lemke R, Dormann P.
  Title
Isolation of an Arabidopsis mutant lacking vitamin E and identification of a cyclase essential for all tocopherol biosynthesis.
  Journal
Proc Natl Acad Sci U S A 99:12495-500 (2002)
DOI:10.1073/pnas.182330899
  Sequence
[ath:AT4G32770]
Reference
2  [PMID:12913173]
  Authors
Sattler SE, Cahoon EB, Coughlan SJ, DellaPenna D
  Title
Characterization of tocopherol cyclases from higher plants and cyanobacteria. Evolutionary implications for tocopherol synthesis and function.
  Journal
Plant Physiol 132:2184-95 (2003)
DOI:10.1104/pp.103.024257
  Sequence
[ath:AT4G32770] [zma:541877] [syn:slr1737]
Other DBs
ExplorEnz - The Enzyme Database: 5.5.1.24
IUBMB Enzyme Nomenclature: 5.5.1.24
ExPASy - ENZYME nomenclature database: 5.5.1.24
BRENDA, the Enzyme Database: 5.5.1.24
LinkDB

DBGET integrated database retrieval system