KEGG   ENZYME: 6.2.1.40
Entry
EC 6.2.1.40                 Enzyme                                 
Name
4-hydroxybutyrate---CoA ligase (AMP-forming);
4-hydroxybutyrate-CoA synthetase (ambiguous);
4-hydroxybutyrate:CoA ligase (ambiguous);
hbs (gene name);
4-hydroxybutyrate---CoA ligase
Class
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
Sysname
4-hydroxybutanoate:CoA ligase (AMP-forming)
Reaction(IUBMB)
ATP + 4-hydroxybutanoate + CoA = AMP + diphosphate + 4-hydroxybutanoyl-CoA [RN:R09279]
Reaction(KEGG)
R09279
Substrate
ATP [CPD:C00002];
4-hydroxybutanoate [CPD:C00989];
CoA [CPD:C00010]
Product
AMP [CPD:C00020];
diphosphate [CPD:C00013];
4-hydroxybutanoyl-CoA [CPD:C11062]
Comment
Isolated from the archaeon Metallosphaera sedula. Involved in the 3-hydroxypropanoate/4-hydroxybutanoate cycle. cf. EC 6.2.1.56, 4-hydroxybutyrate---CoA ligase (ADP-forming).
History
EC 6.2.1.40 created 2014, modified 2019
Pathway
ec00720  Carbon fixation pathways in prokaryotes
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K14466  4-hydroxybutyrate---CoA ligase (AMP-forming)
K14467  4-hydroxybutyrate---CoA ligase (AMP-forming)
K18861  4-hydroxybutyrate---CoA ligase (AMP-forming)
K25774  4-hydroxybutyrate---CoA ligase (AMP-forming)
Genes
AFUAF_1287
AFGAFULGI_00013960
APOArcpr_1040
GACGACE_0172
IHOIgni_0475
IISEYM_04520
IPCIPA_02910
PFMPyrfu_1031
STOSTK_20950
SOHD1869_11480
SSOSSO1595(alkK-1)
SOLSsol_2425
SSOASULA_2450
SSOLSULB_2451
SSOFSULC_2448
SSHIJ5U23_01463
SCASSACC_13950 SACC_26260
SAISaci_2146
SACNSacN8_05595 SacN8_10445
SACRSacRon12I_05585 SacRon12I_10700
SACSSUSAZ_05485 SUSAZ_09795
SISLS215_1135
SIAM1425_0518
SIMM1627_0847
SIDM164_0543
SIYYG5714_0492
SIILD85_0554
SIHSiH_0833
SIRSiRe_0517
SICSiL_0542
SULABFU36_11215
SULEGFS03_05380
SULOGFS33_10670
SULLEWF20_12640
MSEMsed_0394 Msed_0406 Msed_1422
MEMJMJ1HA_0488 MJ1HA_0500 MJ1HA_1635
MCNMcup_0813 Mcup_1674 Mcup_1685
MHKDFR87_04145 DFR87_04415 DFR87_11765
MPRUDFR88_04555 DFR88_04635 DFR88_11205
MTENGWK48_03480 GWK48_07380 GWK48_07475
MJNMjAS7_1080 MjAS7_1095 MjAS7_2493
AHOAhos_0918 Ahos_2275
AMANB6F84_02735
ABRIDFR85_01145 DFR85_14760 DFR85_15495
ASULDFR86_02735
AAMBD1866_06370
ACIHHS5_10870 HS5_22950
SAZOD1868_09495
CSTYKN1_05110 KN1_25190 KN1_28400
STEPIC006_1474
PAIPAE2474
PISPisl_0250
PCLPcal_1386
PYRP186_0721 P186_1145
POGPogu_1296
TNETneu_0420
TTNTTX_1100(acsA)
TUZTUZN_0914
 » show all
Reference
1  [PMID:21169482]
  Authors
Ramos-Vera WH, Weiss M, Strittmatter E, Kockelkorn D, Fuchs G
  Title
Identification of missing genes and enzymes for autotrophic carbon fixation in crenarchaeota.
  Journal
J Bacteriol 193:1201-11 (2011)
DOI:10.1128/JB.01156-10
  Sequence
[tne:Tneu_0420]
Reference
2  [PMID:23258541]
  Authors
Hawkins AS, Han Y, Bennett RK, Adams MW, Kelly RM
  Title
Role of 4-hydroxybutyrate-CoA synthetase in the CO2 fixation cycle in thermoacidophilic archaea.
  Journal
J Biol Chem 288:4012-22 (2013)
DOI:10.1074/jbc.M112.413195
  Sequence
[mse:Msed_0406]
Other DBs
ExplorEnz - The Enzyme Database: 6.2.1.40
IUBMB Enzyme Nomenclature: 6.2.1.40
ExPASy - ENZYME nomenclature database: 6.2.1.40
BRENDA, the Enzyme Database: 6.2.1.40
LinkDB

DBGET integrated database retrieval system