Entry
Name
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate---2,6-diaminopimelate ligase;
MurE synthetase [ambiguous];
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:meso-2,6-diamino-heptanedioate ligase (ADP-forming);
UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelate synthetase;
UDP-N-acetylmuramoylalanyl-D-glutamate---2,6-diaminopimelate ligase;
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:meso-2,6-diaminoheptanedioate gamma-ligase (ADP-forming)
Class
Ligases;
Forming carbon-nitrogen bonds;
Acid-D-amino-acid ligases (peptide synthases)
BRITE hierarchy
Sysname
UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate:meso-2,6-diaminoheptanedioate gamma-ligase (ADP-forming)
Reaction(IUBMB)
ATP + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate + meso-2,6-diaminoheptanedioate = ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate [RN:
R02788 ]
Reaction(KEGG)
Substrate
ATP [CPD:
C00002 ];
UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate [CPD:
C00692 ];
meso-2,6-diaminoheptanedioate [CPD:
C00680 ]
Product
ADP [CPD:
C00008 ];
phosphate [CPD:
C00009 ];
UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate [CPD:
C04877 ]
Comment
Involved in the synthesis of a cell-wall peptide in bacteria. This enzyme adds diaminopimelate in Gram-negative organisms and in some Gram-positive organisms; in others EC
6.3.2.7 (UDP-N-acetylmuramoyl-L-alanyl-D-glutamate---L-lysine ligase) adds lysine instead. It is the amino group of the L-centre of the diaminopimelate that is acylated.
History
EC 6.3.2.13 created 1972, modified 2002, modified 2010
Pathway
Orthology
K01928 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase
K15792 MurE/MurF fusion protein
Genes
ECOH : ECRM13516_0092(murE)
ELR : ECO55CA74_00420(murE)
ECW : EcE24377A_0087(murE)
ECOA : APECO78_03875(murE)
EDJ : ECDH1ME8569_0082(murE)
ECOI : ECOPMV1_00088(murE)
SEM : STMDT12_C01230(murE)
SETC : CFSAN001921_16805(murE)
SEEN : SE451236_06630(murE)
SENH : CFSAN002069_08610(murE)
SEEH : SEEH1578_09645(murE)
SENJ : CFSAN001992_10390(murE)
SEEC : CFSAN002050_07060(murE)
SEEB : SEEB0189_018770(murE)
SENC : SEET0819_07495(murE)
RTG : NCTC13098_06210(murE)
REE : electrica_04248(murE)
CLAP : NCTC11466_03838(murE)
KIE : NCTC12125_02951(murE)
METY : MRY16398_47330(murE)
AHN : NCTC12129_04171(murE)
PTF : PROFFT_A_01700(murE)
PSHI : SAMEA2665130_0383(murE)
YPG : YpAngola_A2923(murE)
YPI : YpsIP31758_3392(murE)
SMW : SMWW4_v1c07420(murE)
SERS : SERRSCBI_03410(murE)
SFJ : SAMEA4384070_0780(murE)
SOF : NCTC11214_00770(murE)
PAQU : DMB82_0017190(murE)
DIC : Dpoa569_000599(murE)
EHD : ERCIPSTX3056_380(murE)
BAPF : BUMPF009_CDS00373(mure)
BAPG : BUMPG002_CDS00374(mure)
BAPU : BUMPUSDA_CDS00373(mure)
BAPW : BUMPW106_CDS00373(mure)
TPTY : NCTC11468_03100(murE)
PHEI : NCTC12003_01241(murE)
PRJ : NCTC6933_02768(murE)
LRI : NCTC12151_02617(murE)
HIC : NTHIC486_01609(murE)
HPIT : NCTC13334_01194(murE)
HHZ : NCTC10839_01086(murE)
HAEG : NCTC8502_01257(murE)
PDAG : 4362423_00237(murE)
ADP : NCTC12871_01083(murE)
ALIG : NCTC10568_00015(murE)
ASEG : NCTC10977_00972(murE)
AVT : NCTC3438_00975(murE)
RPNE : NCTC8284_03154(murE_3)
PAET : NCTC13378_01319(murE)
XFU : XFF4834R_chr07790(murE)
XPH : XppCFBP6546_07560(XppCFBP6546P_07560)
XHD : LMG31886_35570(murE)
LLZ : LYB30171_02237(murE)
VNI : VIBNI_A0224(murE) VIBNI_B0312
VAU : VANGNB10_cI2174c(murE)
VCY : IX92_12325(murE) IX92_23310
VCT : JV59_02030(murE) JV59_16240
VGI : MID13_02310(murE) MID13_22365
VPL : SA104470976_00420(murE)
PGB : H744_1c0649 H744_2c0698
PGH : FH974_01825(murE) FH974_21255
PAEB : NCGM1900_2247(murE)
PAEU : BN889_04911(murE_1)
PVD : CFBP1590__1168(murE)
PPRC : PFLCHA0_c50410(murE)
PFW : PF1751_v1c09020(murE)
PPUU : PputUW4_04508(murE)
PTW : TUM18999_13360(murE)
PTAE : NCTC10697_00856(murE)
PSYC : DABAL43B_2679(murE)
MCAT : MC25239_01689(murE)
MCUN : NCTC10297_00637(murE)
SCAA : TUM17387_03590(murE)
SALH : HMF8227_02475(murE)
CBS : COXBURSA331_A0213(murE)
LLG : 44548918_00814(murE)
LJR : NCTC11533_00944(murE)
LCJ : NCTC11976_01653(murE)
LWA : SAMEA4504053_1249(murE)
LSS : NCTC12082_00965(murE)
LADL : NCTC12735_01465(murE)
LANT : TUM19329_22880(murE)
MISZ : MishRS11D_06410(murE)
TSE : THMIRHAS_19300(murE)
TZO : THMIRHAT_06520(murE)
THIM : KFB96_07490 KFB96_13725(murE)
TBOG : LT988_03215 LT988_09270(murE)
TNI : TVNIR_2609(murE_[H])
GAI : IMCC3135_29205(murE)
THIC : TspCOW1_31430(murE)
AEL : NCTC12917_03787(murE)
CHJ : NCTC10426_02284(murE)
CDIZ : CEDIAZO_03164(murE)
NMQ : NMBM04240196_0422(murE)
NMZ : NMBNZ0533_1835(murE)
NMX : NMA510612_2338(murE)
NWE : SAMEA3174300_1595(murE)
NZO : SAMEA4504057_0369(murE)
NCI : NCTC10296_00551(murE)
NCZ : NCTC10294_01274(murE)
NANI : NCTC12227_02072(murE)
ECOR : SAMEA4412678_0485(murE)
BMV : BMASAVP1_A0477(murE)
BPM : BURPS1710b_3550(murE)
BPL : BURPS1106A_3555(murE)
BUE : BRPE67_ACDS23700(murE)
PLG : NCTC10937_01072(murE)
LMIR : NCTC12852_00827(murE)
BUO : BRPE64_ACDS24220(murE)
VTR : MYVALT_F_00030(murE)
BTRM : SAMEA390648700553(murE)
AXX : ERS451415_00801(murE)
LIM : L103DPR2_02757(murE)
LIH : L63ED372_02323(murE)
CFU : CFU_3307(murE) CFU_3947(murE2)
URU : DSM104443_00673(murE)
UPL : DSM104440_00638(murE)
FPHO : SHINM1_017290(murE)
HPO : HMPREF4655_20092(murE)
HPX : HMPREF0462_1477(murE)
HPYA : HPAKL117_07180(murE)
HPYK : HPAKL86_00465(murE)
HTY : BN2458_PEG1001 BN2458_PEG1009 BN2458_PEG1017
HCL : NCTC13205_01255(murE)
HSH : NHP194022_11240(murE)
HPUL : NCTC13154_00319(murE)
CJV : MTVDSCj20_1602(murE)
CFV : CFVI03293_0063(murE)
CAMP : CFT03427_0064(murE)
CCOC : CCON33237_1720(murE)
CLR : UPTC16701_0119(murE)
CLM : UPTC16712_0120(murE)
CAMR : CAQ16704_0112(murE)
CHV : CHELV3228_0282(murE)
CPIN : CPIN18020_0951(murE)
CAMZ : CVIC12175_0079(murE)
GBN : GEOBRER4_04840(murE)
PPOR : JCM14722_12380(murE)
PAUU : E8A73_002645(murE) E8A73_005885
MRM : A7982_00371 A7982_03229 A7982_04801
RTT : RTTH1527_02820(murE)
RTB : RTB9991CWPP_02820(murE)
PACA : ID47_03365 ID47_07605
RBS : RHODOSMS8_01901(murE)
SMEL : SM2011_c01861(murE)
SFD : USDA257_c45050(murE)
SAME : SAMCFNEI73_Ch2467(murE)
AGR : AGROH133_07455(murE)
REC : RHECIAT_CH0003003(murE)
REL : REMIM1_CH02900(murE)
REP : IE4803_CH03077(murE)
REI : IE4771_CH03115(murE)
RGA : RGR602_CH02501(murE)
RPHA : AMC79_CH03015(murE)
NEN : NCHU2750_14790(murE)
LAS : CLIBASIA_05020(murE)
VGO : GJW-30_1_01839(murE)
BHS : BM1374165_01169(murE)
BBK : BARBAKC583_0952(murE)
BTX : BM1374166_01523(murE)
BEZ : NCTC12898_01035(murE)
MAQU : Maq22A_c02210(murE)
MTUN : MTUNDRAET4_1818(murE)
FIL : BN1229_v1_3981(murE)
FIY : BN1229_v1_3968(murE)
BVY : NCTC9239_00710(murE)
TSV : DSM104635_02832(murE)
RLI : RLO149_c025770(murE)
PHP : PhaeoP97_00919(murE)
PPIC : PhaeoP14_00872(murE)
SINL : DSM14862_01092(murE)
SPSE : SULPSESMR1_01949(murE)
RMM : ROSMUCSMR3_03658(murE)
LVS : LOKVESSMR4R_00995(murE)
SBIN : SBA_ch1_35060(murE)
SFLA : SPHFLASMR4Y_00084(murC)
BAZ : BAMTA208_09560(murE)
BAE : BATR1942_05380(murE)
BSON : S101395_03218(murE)
BAH : BAMEG_0574(murE) BAMEG_2006
BAX : H9401_2467 H9401_3864
BANT : A16_26250 A16_40590
BANR : A16R_26580 A16R_41120
BANS : BAPAT_2487 BAPAT_3888
BANH : HYU01_12855 HYU01_19820
BANV : DJ46_1372(murE) DJ46_2753(murE)
BCA : BCE_2609(murE) BCE_3960(murE)
BCZ : BCE33L2337(murE) BCE33L3673(murE)
BCR : BCAH187_A2646 BCAH187_A2647 BCAH187_A3967(murE)
BCU : BCAH820_2609 BCAH820_3929(murE)
BAL : BACI_c25660(murE1) BACI_c38700(murE2)
BNC : BCN_2461 BCN_2462 BCN_3746
BCER : BCK_15660(murE) BCK_21885
BTK : BT9727_2371(murE) BT9727_3656(murE)
BTHR : YBT1520_20795(murE)
BTHU : YBT1518_21450(murE)
BWD : CT694_13645 CT694_21050
BTRO : FJR70_06300 FJR70_12980(murE)
BMOB : MLA2C4_13775 MLA2C4_20455
BIF : N288_09175 N288_24335
BFD : NCTC4823_02575(murE)
BDA : FSZ17_02610 FSZ17_09365
BACI : B1NLA3E_06085(murE)
BHK : B4U37_07870 B4U37_09470
BCOH : BC6307_09205 BC6307_13065 BC6307_22580
BMQ : BMQ_2153(murE) BMQ_4279(murE)
BMD : BMD_2109 BMD_4267(murE)
BMH : BMWSH_0947 BMWSH_3094(murE)
BMEG : BG04_1198(murE) BG04_4462(murE)
BFX : BC359_06335 BC359_08935
PKS : IE339_08180 IE339_13330 IE339_17670
BCL : ABC2360(murE) ABC3462
BLE : BleG1_0164 BleG1_0519 BleG1_2344
BKW : BkAM31D_13975(murE_1) BkAM31D_15275(murE_2)
BON : A361_08110 A361_09180 A361_28040
BKO : CKF48_01090 CKF48_01825
CSUA : IM538_10355 IM538_12290 IM538_13865
CFIR : NAF01_07575 NAF01_08685
CSOA : LIS82_02410(murE) LIS82_10760
OCN : CUC15_08715 CUC15_12665
PARG : PspKH34_27040(murE)
HHD : HBHAL_1204 HBHAL_2872(murE) HBHAL_2992 HBHAL_4976
HMN : HM131_02525 HM131_12285 HM131_18120 HM131_20340
HLI : HLI_02210 HLI_10375 HLI_20905
TAP : GZ22_03000 GZ22_06375
TAID : KS242_03920 KS242_07495
VIR : X953_03330 X953_12390
VHL : BME96_02565 BME96_11215
VIL : CFK37_03485 CFK37_04465 CFK37_07120 CFK37_07125 CFK37_16180
VNE : CFK40_02500 CFK40_02505 CFK40_12945 CFK40_20650
VNT : OLD84_08565 OLD84_13010
FPN : ABE65_008150 ABE65_009330
FAR : ABE41_009215 ABE41_010615
SJE : AAV35_000990 AAV35_007480
PASA : BAOM_1561(murE) BAOM_3394(murE)
PPSR : I6J18_00920 I6J18_07145
PFRI : L8956_07930 L8956_12765
PSYH : D0S48_03085 D0S48_06120 D0S48_12855(murE)
PSYO : PB01_05680 PB01_20135(murE)
PRD : F7984_06350 F7984_07640
POF : GS400_08685 GS400_09950
MDG : K8L98_02575 K8L98_10465 K8L98_22120
BLEN : NCTC4824_02073(murE_1) NCTC4824_02756(murE_2)
SEDD : ERJ70_08445 ERJ70_09830
MCUI : G8O30_04415 G8O30_14700
PSUA : FLK61_24325 FLK61_33080
SXY : BE24_13495 BE24_13935
LMOC : LMOSLCC5850_2100(murE)
LMW : LMOSLCC2755_2100(murE)
LMX : LMOSLCC2372_2105(murE)
LMZ : LMOSLCC2482_2096(murE)
LMON : LMOSLCC2376_1991(murE)
LMOS : LMOSLCC7179_2010(murE)
LMOO : LMOSLCC2378_2062(murE)
LMOY : LMOSLCC2479_2102(murE)
LMOT : LMOSLCC2540_2131(murE)
LMOA : LMOATCC19117_2058(murE)
LGZ : NCTC10812_00807(murE)
EAT : EAT1b_1488 EAT1b_2963
EAN : Eab7_1681(murE) Eab7_2023(murE)
EXM : U719_10380 U719_12100
EXU : ESP131_12480 ESP131_14205
EAP : KB235_03115 KB235_04265 KB235_10610
EACE : KKI46_10310 KKI46_12045
EAUR : NMQ00_01510 NMQ00_09255
GYM : GYMC10_1812 GYMC10_3943
PPQ : PPSQR21_033550(murE)
PLV : ERIC2_c17530(murE1) ERIC2_c24700(murE2)
POW : IJ21_19480 IJ21_29700
PIB : BBD41_01250 BBD41_05840 BBD41_25850
PCX : LPB68_01670 LPB68_05240
PVO : PVOR_11304 PVOR_21194
PLW : D5F53_10590 D5F53_20585 D5F53_32975
PALB : EJC50_04215(murE) EJC50_13285
PBK : Back11_25710(murE_1) Back11_62080(murE_2)
PRZ : GZH47_05670 GZH47_15650
PLYC : GXP70_01305 GXP70_10590
PALO : E6C60_1159 E6C60_1519 E6C60_2305
COH : EAV92_03960 EAV92_21210(murE)
COHN : KCTCHS21_34610(murE_1) KCTCHS21_40770(murE_2)
AAD : TC41_0400(murE) TC41_1197(murE)
AFX : JZ786_11510 JZ786_22810
ACUR : JZ785_08795 JZ785_21950
PMAR : B0X71_02080 B0X71_03675 B0X71_19160 B0X71_20040 B0X71_20315
PPLA : BBI15_10680 BBI15_13860
PLX : CW734_03210 CW734_16175
PAEK : D3873_02895 D3873_04295
PANC : E2636_10640 E2636_11790
PLAY : DNR44_001365 DNR44_001685 DNR44_010890
VIJ : JNUCC6_01155 JNUCC6_19365
LHO : LOOC260_122610(murE)
CRN : CAR_c01470(murE1) CAR_c07990(murE2) CAR_c16000(murE3)
CAW : Q783_03585 Q783_05495
CVD : LHA31_02975 LHA31_07425 LHA31_11225
MARR : BKP56_00180 BKP56_01470 BKP56_02295 BKP56_10930
CAC : CA_C2129(murE) CA_C2819(murE)
CAE : SMB_G2162(murE) SMB_G2855(murE2)
CAY : CEA_G2143 CEA_G2827(murE)
CBZ : Cbs_1308(murE1) Cbs_1580(murE2)
CBEI : LF65_01441 LF65_01796
CSR : Cspa_c15230(murE2) Cspa_c26260(murE3)
CSB : CLSA_c27320(murE2) CLSA_c31470(murE3)
CACE : CACET_c08000(murE1) CACET_c21840(murE2)
CFM : BJL90_10140 BJL90_17190
CARG : RSJ17_04700 RSJ17_12580 RSJ17_21490
CDY : F3K33_06985 F3K33_08195
CCOH : SAMEA4530647_1402(murE)
CMAH : C1I91_10390 C1I91_16695
CRW : CROST_021160(murE_1) CROST_036690(murE_2)
CFB : CLFE_011140(murE_1) CLFE_021070(murE_2)
CAUN : CLAUR_008780(murE_1) CLAUR_039060(murE_2)
CGEL : psyc5s11_30870(murE) psyc5s11_37260(murE2)
CTAG : LL095_02400 LL095_14915
AOE : Clos_0298 Clos_1374 Clos_2017
GFE : Gferi_01975 Gferi_04280
CRS : FQB35_05950 FQB35_09495
CPRF : K7H06_04495 K7H06_09815
CLO : HMPREF0868_0484(murE)
SMAN : C12CBH8_15410(murE1) C12CBH8_21080(murE2)
PFAA : MM59RIKEN_04140(murE)
VFA : MM35RIKEN_01010(murE) MM35RIKEN_21040(murE2)
VCOP : MM50RIKEN_05030(murE) MM50RIKEN_09850(murE1)
RHO : RHOM_10030 RHOM_11100
BPRO : PMF13cell1_04943(murE)
CSCI : HDCHBGLK_01839(murE_1)
ACEL : acsn021_28590(murE1)
ACHT : bsdcttw_32490(murE1)
SINT : K5I26_07870 K5I26_07880
WCP : H9Q76_08825 H9Q76_13395
WHJ : H9Q79_09650 H9Q79_10815
CLE : Clole_1573 Clole_2334
CEW : EKH84_10405 EKH84_14350
PDF : CD630DERM_26640(murE)
FAA : HMPREF0389_00596(murE)
ROC : HF520_04580 HF520_10150
PHX : KGNDJEFE_00799(murE)
TEM : JW646_02170 JW646_03500
TGC : L0P85_04800 L0P85_06000
IBR : NQ514_09455 NQ514_10875
CALK : HUE98_00415 HUE98_04325 HUE98_12690
CBAR : PATL70BA_0488(murE)
VPY : HZI73_13290 HZI73_18615
ACAE : HYG86_10190(murE) HYG86_16625 HYG86_16745
SAY : TPY_0160(murE) TPY_0575 TPY_3479(murE)
SAP : Sulac_1436 Sulac_2804 Sulac_3062
STHR : BXT84_02080 BXT84_10910
ETM : CE91St48_27230(murE) CE91St48_29890
GEK : kuro4_14580(murE_1) kuro4_22120(murE_2)
CDIA : CaldiYA01_16980(murE)
NTH : Nther_0040 Nther_1299 Nther_1603
NCD : ACONDI_00806(murE_1) ACONDI_02863(murE_2)
HOR : Hore_00700 Hore_09040
HALS : D7D81_00045(murE) D7D81_11100
IFN : GM661_08645 GM661_16020(murE)
AAR : Acear_0741 Acear_1073
HHL : Halha_0405 Halha_1773
AFT : BBF96_06295 BBF96_15605
PHAR : NCTC13077_00733(murE)
PIV : NCTC13079_00847(murE)
CAD : Curi_c08350(murE1) Curi_c12970(murE2)
VRM : 44547418_01186(murE)
VDN : NCTC11831_00776(murE)
DHO : Dia5BBH33_09830(murE)
MANA : MAMMFC1_01876(murE_1) MAMMFC1_03978(murE_2)
PFAC : PFJ30894_02059(murE)
AARG : Aargi30884_01110(murE_1) Aargi30884_04620(murE_2)
ABSI : A9CBEGH2_02690(murE_1) A9CBEGH2_06000(murE_2)
FIT : Fi14EGH31_18060(murE1) Fi14EGH31_23950(murE)
BULL : JOS54_02070 JOS54_04230
EBM : SG0102_19100(murE) SG0102_27020(murE1)
LCG : L3BBH23_15050(murE_1) L3BBH23_20260(murE_2)
ERB : A4V01_13970 A4V01_16075
TUR : AT726_00455 AT726_00645
TSG : HLK68_13295 HLK68_13500
TBB : J0J69_02985 J0J69_03175
CIU : G4D55_11125 G4D55_13220
ERM : EYR00_03970 EYR00_09675
MBO : BQ2027_MB2182C(murE)
MMAE : MMARE11_30980(murE)
MBAI : MB901379_02912(murE)
MHEK : JMUB5695_02200(murE)
MPHL : MPHLCCUG_03296(murE_2)
MTHN : 4412656_01879(murE)