KEGG   ENZYME: 6.3.2.16
Entry
EC 6.3.2.16                 Enzyme                                 
Name
D-alanine---alanyl-poly(glycerolphosphate) ligase;
D-alanyl-alanyl-poly(glycerolphosphate) synthetase;
D-alanine:membrane-acceptor ligase;
D-alanylalanylpoly(phosphoglycerol) synthetase;
D-alanyl-poly(phosphoglycerol) synthetase;
D-alanine-membrane acceptor-ligase
Class
Ligases;
Forming carbon-nitrogen bonds;
Acid-D-amino-acid ligases (peptide synthases)
Sysname
D-alanine:alanyl-poly(glycerolphosphate) ligase (ADP-forming)
Reaction(IUBMB)
ATP + D-alanine + alanyl-poly(glycerolphosphate) = ADP + phosphate + D-alanyl-alanyl-poly(glycerolphosphate) [RN:R04369]
Reaction(KEGG)
R04369
Substrate
ATP [CPD:C00002];
D-alanine [CPD:C00133];
alanyl-poly(glycerolphosphate) [CPD:C03999]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
D-alanyl-alanyl-poly(glycerolphosphate) [CPD:C04457]
Comment
Involved in the synthesis of teichoic acids.
History
EC 6.3.2.16 created 1976
Pathway
ec00470  D-Amino acid metabolism
Reference
1  [PMID:4399593]
  Authors
Reusch VM Jr, Neuhaus FC.
  Title
D-Alanine: membrane acceptor ligase from Lactobacillus casei.
  Journal
J Biol Chem 246:6136-43 (1971)
Other DBs
ExplorEnz - The Enzyme Database: 6.3.2.16
IUBMB Enzyme Nomenclature: 6.3.2.16
ExPASy - ENZYME nomenclature database: 6.3.2.16
BRENDA, the Enzyme Database: 6.3.2.16
CAS: 9046-58-6
LinkDB

KEGG   REACTION: R04369
Entry
R04369                      Reaction                               
Name
D-alanine:alanyl-poly(glycerolphosphate) ligase (ADP-forming)
Definition
ATP + D-Alanine + Alanyl-poly(glycerolphosphate) <=> ADP + Orthophosphate + D-Alanyl-alanyl-poly(glycerolphosphate)
Equation
Reaction class
RC00002  C00002_C00008
RC00064  C03999_C04457
RC00141  C00133_C04457
Enzyme
Pathway
rn00470  D-Amino acid metabolism
Brite
Enzymatic reactions [BR:br08201]
 6. Ligase reactions
  6.3  Forming carbon-nitrogen bonds
   6.3.2  Acid-D-amino-acid ligases (peptide synthases)
    6.3.2.16
     R04369  ATP + D-Alanine + Alanyl-poly(glycerolphosphate) <=> ADP + Orthophosphate + D-Alanyl-alanyl-poly(glycerolphosphate)
LinkDB

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