Entry
Name
tubulin---tyrosine ligase
Class
Ligases;
Forming carbon-nitrogen bonds;
Acid-D-amino-acid ligases (peptide synthases)
BRITE hierarchy
Sysname
alpha-tubulin:L-tyrosine ligase (ADP-forming)
Reaction(IUBMB)
ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate [RN:
R04730 ]
Reaction(KEGG)
Substrate
Product
Comment
L-Tyrosine is linked via a peptide bond to the C-terminus of de-tyrosinated alpha-tubulin (des-Tyromega-alpha-tubulin). The enzyme is highly specific for alpha-tubulin and moderately specific for ATP and L-tyrosine. L-Phenylalanine and 3,4-dihydroxy-L-phenylalanine are transferred but with higher Km values.
History
EC 6.3.2.25 created 1999
Orthology
K06047 tubulin---tyrosine ligase
Genes
SBQ : 101050847(TTL) 104652891
MCAL : 110285528(Ttl) 110295428
CCAN : 109692039 109692049
MYUM : 139020104 139020120(TTL)
TOD : 119258618(TTL) 119259193
APLA : 101798438 119716451 119716471
SANH : 107678537 107698152
SGH : 107577318 107582496(ttl)
CCAR : 109068870 109094090(ttl)
CAUA : 113057189 113112963
CGIB : 127970537 128026427
MASI : 127412101 127413848
AOCE : 111573098 129350815(ttl)
SASA : 106576805 106604770
STRU : 115153031 115193982
OTW : 112252826 112252858(ttl)
OMY : 110502294(ttl) 110526580
OCLA : 139381851 139410003
SALP : 111951844 111977769
CCLU : 121553177 121569066(ttl)
PSPA : 121315654 121316727
ARUT : 117402225 117410344
VCN : VOLCADRAFT_105441(ttlD)
CGR : 2888797(GVI51_H08393)
NCS : NCAS_0I01240(NCAS0I01240)
NDI : NDAI_0A07760(NDAI0A07760)
TPF : TPHA_0A03720(TPHA0A03720)
TBL : TBLA_0B02540(TBLA0B02540)
TDL : TDEL_0C04770(TDEL0C04770)
KAF : KAFR_0G01640(KAFR0G01640)
KNG : KNAG_0J02490(KNAG0J02490)
LBG : 92210194(LODBEIA_P49980)
CAL : CAALFM_C401730CA(CaO19.4621)
ASAU : 88172597(PUMCH_001532)
BNN : FOA43_003579 FOA43_003580
YLI : 2909428(YALI2_B00096g)
SLB : AWJ20_3514(PBY1) AWJ20_3515(PBY1)
NTE : NEUTE1DRAFT87071(NEUTE1DRAFT_87071)
SMP : 10810714(SMAC4_03377)
PAN : PODANSg174 PODANSg3000
PBEL : QC761_001170 QC761_0067370
PPSD : QC762_001170 QC762_408550
PPSP : QC763_001170 QC763_0067330
PPSA : QC764_001170 QC764_0066920
MTM : MYCTH_2306820 MYCTH_74402
CTHR : CTHT_0042910 CTHT_0049290
RTHE : 98125629(VTJ83DRAFT_4490) 98126691(VTJ83DRAFT_5446)
FGR : FGSG_03182 FGSG_09516
FPU : FPSE_01062 FPSE_05997
FPOA : FPOAC1_005533 FPOAC1_012145
FVN : FVRRES_06106 FVRRES_13220
FVR : FVEG_08450 FVEG_15395
FOX : FOXG_06212 FOXG_10053 FOXG_12440 FOXG_14097
NHE : NECHADRAFT_102179 NECHADRAFT_58510
FFC : NCS54_00296400 NCS54_01454100
FKR : NCS57_00291600 NCS57_01436900
FMU : J7337_004071 J7337_012890
TATV : 25778335(TrAtP1_007667)
TASP : 36616760(TrAFT101_007766)
MAW : 19247023(J3458_000479)
MBRN : 26239664(G6M90_00g037400)
PLJ : 28886134(PLICBS_007628)
VAL : VDBG_08145 VDBG_08146 VDBG_09123
VDA : VDAG_07271 VDAG_10040
CFJ : CFIO01_03847 CFIO01_05151
CHIG : CH63R_13490 CH63R_14087
CDET : 87947068(CDEST_10568) 87947658(CDEST_11158)
ELA : UCREL1_1880 UCREL1_2419 UCREL1_4197
CPW : 9694144(D8B26_003100)
PNO : SNOG_07971 SNOG_10458
PTRR : 6346896(PtrM4_146100) 6348361(PtrM4_083220)
BZE : COCCADRAFT_1329 COCCADRAFT_27323
BOR : COCMIDRAFT_2314 COCMIDRAFT_24749
AALT : CC77DRAFT_242281 CC77DRAFT_403761
ADAC : 96080512(ACET3X_000190) 96082758(ACET3X_002436)
ARAB : EKO05_0004986 EKO05_0007913
ZTR : MYCGRDRAFT_103350 MYCGRDRAFT_37793
PFJ : MYCFIDRAFT_201668 MYCFIDRAFT_202394
BCOM : BAUCODRAFT_273847 BAUCODRAFT_32516
NPA : UCRNP2_5182 UCRNP2_5216
CNE : CNA01340 CNL06170 CNL06540
CNG : CNAG_00146 CNAG_04997
CGI : CGB_B1570C CGB_D0270W CGB_D0570C
CDEU : CNBG_0412 CNBG_4683
CDEP : 91086877(L203_102666) 91087610(L203_103399)
KMG : 30160558(I203_104308) 30163389(I203_102592)
KNE : 92178783(IAR55_001524) 92182390(IAR55_005132)
TMS : TREMEDRAFT_42822 TREMEDRAFT_68211
TASA : A1Q1_07249 A1Q1_07338
CCAC : CcaHIS019_0108720(PBY1) CcaHIS019_0204020(CcaverHIS019_0204020) CcaHIS019_0601760(PBY1)
DSQ : DICSQDRAFT_123228 DICSQDRAFT_45990
SHS : STEHIDRAFT_129909 STEHIDRAFT_151781 STEHIDRAFT_90330
HIR : HETIRDRAFT_307270 HETIRDRAFT_431094
FME : FOMMEDRAFT_167210 FOMMEDRAFT_82892
GTR : GLOTRDRAFT_113331 GLOTRDRAFT_118917
RSX : RhiXN_00515 RhiXN_00800
LBC : LACBIDRAFT_242904 LACBIDRAFT_243814
CCI : CC1G_03660 CC1G_06724
ABP : AGABI1DRAFT110465(AGABI1DRAFT_110465) AGABI1DRAFT66676(AGABI1DRAFT_66676)
ABV : AGABI2DRAFT189636(AGABI2DRAFT_189636) AGABI2DRAFT197617(AGABI2DRAFT_197617)
MRR : Moror_104 Moror_13257
SCM : SCHCO_02490054(SCHCODRAFT_02490054) SCHCO_02528156(SCHCODRAFT_02528156)
CPUT : CONPUDRAFT_115032 CONPUDRAFT_78963
UMA : UMAG_03366 UMAG_05266
PFP : PFL1_05398 PFL1_06524
SGRA : EX895_003022 EX895_005489
PGR : PGTG_18918 PGTG_21394
PTRC : PtA15_3A99 PtA15_5A514
PSTR : Pst134EA_006827 Pst134EA_032001
NGD : NGA_2076410 NGA_2076420
SPAR : SPRG_02342 SPRG_07498
LMAT : 92513653(LSCM1_03606)
LOI : 92360252(LSCM4_04332)
LEIS : 94180159(GH5_04737)
LENR : 94170973(CUR178_03734)
LEIN : 94187884(JIQ42_04221)
PHET : 94291015(JKF63_04967)
SSAO : 94299058(SS50377_25035)
» show all
Taxonomy
Reference
Authors
Wehland J, Schroder HC, Weber K.
Title
Isolation and purification of tubulin tyrosine ligase.
Journal
Reference
Authors
Rudiger M, Wehland J, Weber K.
Title
The carboxy-terminal peptide of detyrosinated alpha tubulin provides a minimal system to study the substrate specificity of tubulin-tyrosine ligase.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 6.3.2.25
ExPASy - ENZYME nomenclature database: 6.3.2.25
LinkDB
All DBs