KEGG   ENZYME: 6.3.4.8
Entry
EC 6.3.4.8                  Enzyme                                 
Name
imidazoleacetate---phosphoribosyldiphosphate ligase;
5-phosphoribosylimidazoleacetate synthetase
Class
Ligases;
Forming carbon-nitrogen bonds;
Other carbon-nitrogen ligases
Sysname
imidazoleacetate:5-phosphoribosyl-diphosphate ligase (ADP- and diphosphate-forming)
Reaction(IUBMB)
ATP + imidazole-4-acetate + 5-phosphoribosyl diphosphate + H2O = ADP + phosphate + 1-(5-phosphoribosyl)imidazole-4-acetate + diphosphate [RN:R04068]
Reaction(KEGG)
R04068
Substrate
ATP [CPD:C00002];
imidazole-4-acetate [CPD:C02835];
5-phosphoribosyl diphosphate [CPD:C00119];
H2O [CPD:C00001]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
1-(5-phosphoribosyl)imidazole-4-acetate [CPD:C04437];
diphosphate [CPD:C00013]
History
EC 6.3.4.8 created 1972
Pathway
ec00340  Histidine metabolism
Reference
1  [PMID:14235540]
  Authors
CROWLEY GM.
  Title
THE ENZYMATIC SYNTHESIS OF 5'-PHOSPHORIBOSYLIMIDAZOLEACETIC ACID.
  Journal
J Biol Chem 239:2593-601 (1964)
Other DBs
ExplorEnz - The Enzyme Database: 6.3.4.8
IUBMB Enzyme Nomenclature: 6.3.4.8
ExPASy - ENZYME nomenclature database: 6.3.4.8
BRENDA, the Enzyme Database: 6.3.4.8
CAS: 37318-65-3
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