Entry
Name
adenosylcobyric acid synthase (glutamine-hydrolysing);
CobQ;
cobyric acid synthase;
5'-deoxy-5'-adenosylcobyrinic-acid-a,c-diamide:L-glutamine amido-ligase;
Ado-cobyric acid synthase [glutamine hydrolyzing]
Class
Ligases;
Forming carbon-nitrogen bonds;
Carbon-nitrogen ligases with glutamine as amido-N-donor
BRITE hierarchy
Sysname
adenosylcobyrinic-acid-a,c-diamide:L-glutamine amido-ligase (ADP-forming)
Reaction(IUBMB)
4 ATP + adenosylcobyrinic acid a,c-diamide + 4 L-glutamine + 4 H2O = 4 ADP + 4 phosphate + adenosylcobyric acid + 4 L-glutamate [RN:
R05225 ]
Reaction(KEGG)
Substrate
Product
Comment
Requires Mg2+. NH3 can act instead of glutamine. This enzyme catalyses the four-step amidation sequence from cobyrinic acid a,c-diamide to cobyric acid via the formation of cobyrinic acid triamide, tetraamide and pentaamide intermediates.
History
EC 6.3.5.10 created 2004
Pathway
Orthology
K02232 adenosylcobyric acid synthase
Genes
REE : electrica_00893(cobQ)
RTG : NCTC13098_01305(cobQ)
KIE : NCTC12125_04878(cobQ_1) NCTC12125_04879(cobQ_2)
BUF : D8682_20895 D8682_24280
BFT : MNO13_05115 MNO13_08260
BSEL : RHD99_04925 RHD99_08295
AHN : NCTC12129_00860(cbiP)
METY : MRY16398_18790(cobQ)
PSHI : SAMEA2665130_0605(cobQ)
EIC : NT01EI_1850 NT01EI_2180
ETD : ETAF_1667 ETAF_1798(cbiO)
ETE : ETEE_3895(cobQ) ETEE_4047(cobQ)
ETR : ETAE_1848(cbiP1) ETAE_1989(cbiP2)
ETC : ETAC_08470 ETAC_09090
EDW : QY76_10315 QY76_11035
HAV : AT03_05715 AT03_08680
OPO : DSM2777_13935 DSM2777_20745
LRI : NCTC12151_01593(cobQ)
XFU : XFF4834R_chr14420(cobQ)
XPH : XppCFBP6546_18105(XppCFBP6546P_18105)
VCE : Vch1786_II0412(cobQ)
VAU : VANGNB10_cII0675c(cobQ)
VZI : G5S32_07565 G5S32_19650
VPL : SA104470976_03475(cobQ)
VIB : VspSTUT11_42590(cobQ)
VIS : VspSTUT16_31450(cobQ)
PAEB : NCGM1900_5297(cobQ)
PPUD : DW66_1250 DW66_1612
PVD : CFBP1590__1588(cobQ)
PPRC : PFLCHA0_c44990(cobQ)
PMUD : NCTC8068_03844(cobQ)
PFW : PF1751_v1c39800(cobQ)
PPUU : PputUW4_03770(cobQ)
PTW : TUM18999_41210(cobQ)
PTAE : NCTC10697_01156(cobQ)
MSHE : MAALD49_02370(cobQ)
SLJ : EGC82_06050 EGC82_11300
SCAA : TUM17387_32350(cobQ)
SYOU : RGE70_03180 RGE70_08440
MESL : KKZ03_12295 KKZ03_16880
TMB : Thimo_0473 Thimo_0484 Thimo_3406
TFRI : Thiofri_00360(cobQ)
HHK : HH1059_08900(cobQ_1) HH1059_08960 HH1059_09380(cobQ_2)
HHC : M911_01040 M911_01045 M911_11120
EBS : ECTOBSL9_0035 ECTOBSL9_0896 ECTOBSL9_0897
TNI : TVNIR_3489(cobQ_[H])
GAI : IMCC3135_06025(cobQ)
HAAH : HALA3H3_820016(cobQ)
ALCA : ASALC70_01948(cobQ)
PAGI : ABHF91_07895 ABHF91_08265
BMV : BMASAVP1_A2316(cobQ)
BML : BMA10229_A2971(cobQ)
BPM : BURPS1710b_1200(cobQ)
BPL : BURPS1106A_1045(cobQ)
PLG : NCTC10937_04023(cobQ)
LMIR : NCTC12852_02417(cobQ)
BUE : BRPE67_ACDS06000(cobQ)
RAC : RA876_06645 RA876_06650
RHF : EUB48_03055 EUB48_08765
LIM : L103DPR2_02086(cobQ)
MPT : Mpe_A2304(copQ) Mpe_B0518(cobQ)
RGE : RGE_15080(cobQ) RGE_44400(cobQ) RGE_44410(cobQ)
RBN : RBXJA2T_12432 RBXJA2T_16392 RBXJA2T_16397
SMIO : CATMQ487_18790(cobQ)
ACTB : RHM62_08885 RHM62_11495
DOE : DENOEST_1202(cobQ) DENOEST_3183(cobQ)
DENI : B9N43_10030 B9N43_10480
AZA : AZKH_4148(cbiP_cobQ)
THAG : CKCBHOJB_00470(cobQ)
RBS : RHODOSMS8_03449(cobQ)
SMEL : SM2011_c04309(cobQ)
SFD : USDA257_c42370(cobQ)
SAME : SAMCFNEI73_Ch2200(cobQ)
AGR : AGROH133_09261(cbiP)
AVV : RvVAT039_00670(cobQ)
AVF : RvVAR031_21890(cobQ)
REC : RHECIAT_CH0002598(cobQ)
REL : REMIM1_CH02518(cobQ)
REP : IE4803_CH02545(cobQ)
REI : IE4771_CH02632(cobQ)
RTR : RTCIAT899_CH10635(cobQ)
RGA : RGR602_CH02281(cobQ)
RPHA : AMC79_CH02625(cobQ)
NEN : NCHU2750_36400(cobQ)
BIO : BR141012304_11386(cobQ)
RPA : TX73_003715 TX73_010800
RPX : Rpdx1_0770 Rpdx1_3418
MAQU : Maq22A_1p37770(cobQ)
MTUN : MTUNDRAET4_2068(cobQ)
HMC : HYPMC_0683(cobQ) HYPMC_2290(cobQ)
RLAC : QMO75_12200 QMO75_16435
FIL : BN1229_v1_3180(cobQ)
FIY : BN1229_v1_2742(cobQ)
BLAG : BLTE_12850(cobQ_1) BLTE_24580(cobQ_2)
CCS : CCNA_01827(cobQ) CCNA_02776
BVY : NCTC9239_00637(cobQ)
RLI : RLO149_c013140(cobQ)
PHP : PhaeoP97_02272(cobQ)
PPIC : PhaeoP14_02188(cobQ)
SINL : DSM14862_02236(cobQ)
SPSE : SULPSESMR1_02111(cobQ)
RMM : ROSMUCSMR3_03954(cobQ)
AHT : ANTHELSMS3_02538(cobQ)
LALG : LentiSH36_02164(cobQ)
RED : roselon_02145 roselon_02146 roselon_02152
RSH : Rsph17029_2453 Rsph17029_3563 Rsph17029_3564
RSK : RSKD131_2158 RSKD131_4281 RSKD131_4282
CAZT : LV780_01710 LV780_20980 LV780_20985
RBL : B6K69_04460 B6K69_12305 B6K69_12310
RSU : NHU_00529(cobQ) NHU_02596(cobQ3) NHU_02597(cobQ2)
RHM : B5V46_10830 B5V46_10835 B5V46_15290
RHC : RGUI_0575 RGUI_1459 RGUI_1460
LVS : LOKVESSMR4R_02651(cobQ)
GEH : HYN69_05120 HYN69_19295
RCP : RCAP_rcc02051(cobQ1) RCAP_rcc03354(cobQ2) RCAP_rcc03355(cobQ3)
NOR : FA702_01495 FA702_20570
NOVO : IM701_04420 IM701_21405
SBIN : SBA_ch1_25410(cobQ)
SHAN : PPZ50_01250 PPZ50_08560
SBD : ATN00_04760 ATN00_12855
SPHT : K426_11000 K426_13535
SPPH : KFK14_02845 KFK14_09785
SPAG : sphantq_00120(cobQ)
NTD : EGO55_10940 EGO55_18890
GXY : GLX_11350 GLX_12120 GLX_29590
KSC : CD178_01760(cobQ) CD178_03193(cobQ)
ATO : CIW82_17640 CIW82_18605
RAP : RHOA_2163(cobQ) RHOA_5251(cobQ)
RRU : Rru_A3381 Rru_A3549 Rru_A3550
RRF : F11_17330 F11_18170 F11_18175
RPM : RSPPHO_00442 RSPPHO_00630(cobQ) RSPPHO_01816
GSK : KN400_2935(cbiH_cbiP)
GME : Gmet_0485(cbiH_cbiP)
GEO : Geob_0038(cbiH_cbiP)
GBM : Gbem_3539(cbiH_cbiP)
GBN : GEOBRER4_34590(cbiH)
DES : DSOUD_0630(cbiH_cbiP)
PSEF : PSDVSF_28760(cobDQ)
PPOR : JCM14722_13240(cobDQ)
DBK : DGMP_15220 DGMP_15230
ABIW : Abiwalacus_00590(cobDQ)
TPI : TREPR_0529(cobQ_2) TREPR_0534(cobQ_1)
BCEL : BcellWH2_00334(cobQ)
PCRE : NCTC12858_00654(cobQ)
PCAG : NCTC12856_00653(cobQ)
HNV : DDQ68_01225 DDQ68_09710
PROC : Ptc2401_01262(cobQ)
GTL : EP073_08550 EP073_11200
NMV : NITMOv2_1611(cobQ) NITMOv2_1842(cobQ)
ACOP : RI196_06650 RI196_07745
LMOC : LMOSLCC5850_1197(cobQ)
LMW : LMOSLCC2755_1200(cobQ)
LMX : LMOSLCC2372_1204(cobQ)
LMZ : LMOSLCC2482_1248(cobQ)
LMON : LMOSLCC2376_1159(cobQ)
LMOS : LMOSLCC7179_1175(cobQ)
LMOO : LMOSLCC2378_1213(cobQ)
LMOY : LMOSLCC2479_1205(cobQ)
LMOT : LMOSLCC2540_1187(cobQ)
LMOA : LMOATCC19117_1207(cobQ)
PPQ : PPSQR21_013620(cobQ)
AFX : JZ786_07565 JZ786_18885 JZ786_24460
ACUR : JZ785_03245 JZ785_03440
SPOR : SporoP33_07670 SporoP33_11300
SPOP : SporoP37_08105 SporoP37_11715
SMEN : SAMEA4412692_0370(cobQ_1)
LRU : HMPREF0538_20892(cobQ)
AUR : HMPREF9243_1729(cobQ)
CBV : U729_238(cobQ) U729_2762(cobQ)
CBUT : ATN24_00835 ATN24_14215
CCOH : SAMEA4530647_0604(cbiP)
CGEL : psyc5s11_37580(cobQ)
HHW : NCTC503_00906(cobQ_1)
RHER : EHE19_000545 EHE19_016035
BPRO : PMF13cell1_04254(cobQ_2)
CSCI : HDCHBGLK_00110(cobQ_1)
CHYL : CE91St63_25710(cobQ)
ACEL : acsn021_39560(cobQ)
ACHT : bsdcttw_22200(cobQ)
CBAR : PATL70BA_0701(cobQ)
ETM : CE91St48_20990(cobQ)
PDF : CD630DERM_34350(cobQ)
PHX : KGNDJEFE_00475(cobQ)
EAC : EAL2_808p00840(cobQ)
MTHO : MOTHE_c10580(cobQ2)
MTHZ : MOTHA_c11470(cobQ2)
HAS : Halsa_2205 Halsa_2206
HPK : Hprae_1536 Hprae_1537
HALS : D7D81_15705 D7D81_15710
IFN : GM661_12840 GM661_12845
AAR : Acear_0840 Acear_0841
HHL : Halha_1705 Halha_1706
PIV : NCTC13079_00949(cobQ)
VRM : 44547418_00923(cobQ)
VDN : NCTC11831_01040(cobQ)
DHO : Dia5BBH33_09520(cobQ)
MANA : MAMMFC1_03997(cobQ)
PFAC : PFJ30894_01750(cobQ)
CALK : HUE98_10570 HUE98_10575
MBO : BQ2027_MB0261C(cobQ1)
MAVM : MAA44156_02037(cobQ)
MMAE : MMARE11_37230(cobQ1)
MBAI : MB901379_01663(cobQ)
MHEK : JMUB5695_03250(cobQ)
MKY : IWGMT90018_49580(cobQ)
MPHL : MPHLCCUG_02214(cobQ_2)
MTHN : 4412656_01674(cobQ)
MAUU : NCTC10437_00332(cobQ)
MFLV : NCTC10271_03240(cobQ)
MGO : AFA91_20075 AFA91_26725
MSAL : DSM43276_02955(cobQ)
MTER : 4434518_03163(cobQ)
CDIP : ERS451417_01520(cobQ_2)
CUN : Cul210932_1477(cobQ2)
CUQ : Cul210931_1364(cobQ2)
CUZ : Cul05146_1444(cobQ2)
CUJ : CUL131002_1398c(cobQ2)
CUS : CulFRC11_1381(cobQ2)
NFR : ERS450000_05825(cobQ)
NAD : NCTC11293_05287(cobQ)
NWL : NWFMUON74_22280(cobQ)
NSPU : IFM12276_15930(cobQ)
RPY : Y013_10560 Y013_14680
RCR : NCTC10994_03348(cobQ)
TPUL : TPB0596_29040(cobQ)
SAMB : SAM23877_1920(cobQ)
SLE : sle_52850(sle_52850)
SGM : GCM10017557_64100(cobQ)
SALF : SMD44_01995 SMD44_01996
STUI : GCM10017668_14450(cobQ)
SXT : KPP03845_102097(cobQ_2)
SABD : N8I86_10315 N8I86_36610
DCO : SAMEA4475696_1826(cobQ)
PAK : HMPREF0675_3452(cobQ)
CGRN : 4412665_00753(cobQ_1)
PFR : PFREUD_12200(cbiP_cobQ)
PAUS : NCTC13651_01043(cobQ_2)
PPC : HMPREF9154_1122(cobQ)
ACIJ : JS278_02452(cobQ_2)
TEZ : BKM78_01600 BKM78_05785
TLA : TLA_TLA_00324(cobQ_1) TLA_TLA_01170(cobQ_2)
NSN : EXE58_09905 EXE58_16790
NPI : G7071_10150 G7071_14495
NAQU : ENKNEFLB_00263(cobQ_1) ENKNEFLB_01614(cobQ_2)
AMYZ : HUW46_01734(cobQ_1)
MSAG : GCM10017556_12560(cobQ)
ACTR : Asp14428_31600(cobQ)
BALA : DSM104299_01709(cobQ)
PARQ : DSM112329_00624(cobQ)
SYR : SynRCC307_1699(cobQ)
SYX : SynWH7803_1658(cobQ)
SYH : Syncc8109_1940(cobB)
SYNW : SynWH8103_01955(cobQ)
TVN : NIES2134_116340(cobQ)
LET : O77CONTIG1_01655(cobQ)
SYP : SYNPCC7002_A1650(cobQ)
SYNN : NIES970_15580(cobQ)
MVZ : myaer102_29350(cobQ)
PAGH : NIES204_27240(cobQ)
PRUN : PCC7821_01039(cobQ)
PHOR : JWS08_10860 JWS08_16040(cobQ)
PYH : NEA10_00160(cobQ) NEA10_01600
NSPH : BDGGKGIB_04410(cobQ)
DFO : Dform_01017(cobQ|cbiP)
PPIO : CE91St28_00620(cobQ)
FNC : HMPREF0946_00444 HMPREF0946_01923
FNT : HMPREF0405_00791 HMPREF0405_01663
FUS : HMPREF0409_00700 HMPREF0409_01981
FNE : FSDG_00487 FSDG_02196
FHW : RN87_01775 RN87_06830
FPD : CTM68_08050 CTM68_10365
FVA : FV113G1_14450(cobQ) FV113G1_23980
FUL : C4N20_00515 C4N20_15100
FMO : C4N19_05525 C4N19_10230
FGO : C4N16_00360 C4N16_05045
FNF : BSQ88_01110 BSQ88_03675
FPEI : C4N17_01030 C4N17_03540
FCI : I6I83_00740 I6I83_06765
FHO : H9Q81_01745 H9Q81_03375
FPOL : ERS445057_00055(cobQ_1) ERS445057_01252(cobQ_2)
IPO : Ilyop_1222 Ilyop_2373
TVO : TVG0030868(TVG0030868)
TAR : TALC_01048 TALC_01049
MAX : MMALV_09820 MMALV_09830
MER : MMINT_08250 MMINT_08260
MEAR : Mpt1_c06670(cobQ1) Mpt1_c06680(cobQ2)
MEUZ : KRP56_03470 KRP56_03475
MARC : AR505_1136 AR505_1137
» show all
Taxonomy
Reference
Authors
Blanche F, Couder M, Debussche L, Thibaut D, Cameron B, Crouzet J
Title
Biosynthesis of vitamin B12: stepwise amidation of carboxyl groups b, d, e, and g of cobyrinic acid a,c-diamide is catalyzed by one enzyme in Pseudomonas denitrificans.
Journal
Sequence
Reference
Authors
Warren MJ, Raux E, Schubert HL, Escalante-Semerena JC.
Title
The biosynthesis of adenosylcobalamin (vitamin B12).
Journal
Other DBs
ExplorEnz - The Enzyme Database: 6.3.5.10
ExPASy - ENZYME nomenclature database: 6.3.5.10
LinkDB
All DBs