KEGG ENZYME: 6.4.1.11

ENZYME: 6.4.1.11

Entry

EC 6.4.1.11                 Enzyme

Name

polyporic acid synthase;
polyporic acid synthetase;
corA (gene name);
hapA1 (gene name);
hapA2 (gene name)

Class

Ligases;
Forming carbon-carbon bonds;
Ligases that form carbon-carbon bonds (only sub-subclass identified to date)

Sysname

3-phenyl-2-oxopropanoate:3-phenyl-2-oxopropanoate ligase (polyporic acid-forming)

Reaction(IUBMB)

2 ATP + 2 3-phenyl-2-oxopropanoate = 2 AMP + 2 diphosphate + polyporic acid (overall reaction) [RN:R13509];
(1a) ATP + 3-phenyl-2-oxopropanoate + [polyporic acid synthase] = AMP + diphosphate + 3-pheny-2-oxopropanoyl-[polyporic acid synthase] [RN:R13510];
(1b) ATP + 3-phenyl-2-oxopropanoate + 3-pheny-2-oxopropanoyl-[polyporic acid synthase] = AMP + diphosphate + polyporic acid + [polyporic acid synthase] [RN:R13511]

Reaction(KEGG)

R13509 R13510 R13511

Substrate

ATP [CPD:C00002];
3-phenyl-2-oxopropanoate [CPD:C00166];
[polyporic acid synthase];
3-pheny-2-oxopropanoyl-[polyporic acid synthase]

Product

AMP [CPD:C00020];
diphosphate [CPD:C00013];
polyporic acid [CPD:C23049];
3-pheny-2-oxopropanoyl-[polyporic acid synthase];
[polyporic acid synthase]

Comment

Requires Mg2+. The enzyme, found in mushrooms of the Basidiomycota and Ascomycota phyla, is a non-ribosomal peptide synthase-like enzyme comprising three domains - an adelylation (A) domain, an ayl-carrier protein (ACP) domain, and a thioesterase (TE) domain. The enzyme activates 3-phenyl-2-oxopropanoate by adenylation and catalyses the dimerization/cyclization of two such molecules to form polyporic acid. Polyporic acid is a precursor for assorted metabolites produced by the fungi, such as the corticins.

History

EC 6.4.1.11 created 2025

Reference

1 [PMID:36094086]

Authors

Lawrinowitz S, Wurlitzer JM, Weiss D, Arndt HD, Kothe E, Gressler M, Hoffmeister D.

Title

Blue Light-Dependent Pre-mRNA Splicing Controls Pigment Biosynthesis in the Mushroom Terana caerulea.

Journal

Microbiol Spectr 10:e0106522 (2022)
DOI:10.1128/spectrum.01065-22

Sequence

[ag:UVV38562]