Entry
Name
Na+-exporting diphosphatase;
Na+-translocating membrane pyrophosphatase;
sodium-translocating pyrophosphatase
Class
Translocases;
Catalysing the translocation of inorganic cations
BRITE hierarchy
Sysname
diphosphate phosphohydrolase (Na+-transporting)
Reaction(IUBMB)
diphosphate + H2O + Na+[side 1] = 2 phosphate + Na+[side 2]
Substrate
Product
phosphate [CPD:
C00009 ];
Na+[side 2]
Comment
Requires Na+ and K+. This enzyme, found in some bacteria and archaea, couples the energy from diphosphate hydrolysis to active sodium translocation across the membrane. The enzyme is electrogenic, as the Na+ transport results in generation of a positive potential in the inner side of the membrane.
History
EC 7.2.3.1 created 2021 as EC 7.1.3.2, transferred 2022 to EC 7.2.3.1
Orthology
K15987 K(+)-stimulated pyrophosphate-energized sodium pump
Genes
AAF : AURANDRAFT_28746(VPP3)
XPH : XppCFBP6546_16995(XppCFBP6546P_16995)
XHD : LMG31886_09350(hppA)
LLZ : LYB30171_00556(hppA)
SALH : HMF8227_00254(hppA)
PMAW : MACH26_36810(hppA1)
METU : GNH96_09885 GNH96_12060
MMEO : OOT43_03725 OOT43_19060
MMOB : F6R98_02845 F6R98_12750
MOZ : MoryE10_07980(hppA1)
MISZ : MishRS11D_06980(hppA) MishRS11D_09080(hppA1)
MLAU : ACEPPP_06390 ACEPPP_19325
MEIY : MIN45_P0105 MIN45_P2225
MCAU : MIT9_P1783 MIT9_P1791
MMAF : GCM100_26790(hppA1)
NWR : E3U44_13600 E3U44_14005
TVI : Thivi_1825 Thivi_3567
MPUR : MARPU_03125 MARPU_15450
THIM : KFB96_12335 KFB96_14295
TBOG : LT988_08010 LT988_11380
TFRI : Thiofri_04440(hppA)
TNI : TVNIR_2003(hppA_[H])
THIC : TspCOW1_19320(hppA)
ATY : A9R16_000875 A9R16_007700
CBLY : IPM89_04085 IPM89_13330 IPM89_14435
LIM : L103DPR2_01551(hppA)
SMIO : CATMQ487_40010(hppA)
URU : DSM104443_03253(hppA)
UPL : DSM104440_02802(hppA)
APP : CAP2UW1_0384 CAP2UW1_3693
RBS : RHODOSMS8_01216(hppA)
SMEL : SM2011_c01780(hppA)
SFD : USDA257_c09420(hppA)
SAME : SAMCFNEI73_Ch1291(hppA)
AGR : AGROH133_05392(hppA)
AVV : RvVAT039_28290(hppA)
AVF : RvVAR031_15470(hppA)
REC : RHECIAT_CH0001598(rrpP)
REL : REMIM1_CH01544(hppA)
REP : IE4803_CH01528(hppA)
REI : IE4771_CH01579(hppA)
RGA : RGR602_CH01405(hppA)
RPHA : AMC79_CH01554(hppA)
NGL : RG1141_CH11060(pumP)
NEN : NCHU2750_11050(hppA)
BIO : BR141012304_11879(hppA)
BRC : BCCGELA001_21305(hppA)
VGO : GJW-30_1_03112(hppA)
MAQU : Maq22A_1p33305(ovp1)
MTUN : MTUNDRAET4_1367(hppA)
FIL : BN1229_v1_3293(hppA)
FIY : BN1229_v1_2628(hppA)
CAUB : AMEJIAPC_01828(hppA_1) AMEJIAPC_02959(hppA_4)
BVY : NCTC9239_01746(hppA)
BREN : KKHFBJBL_01296(hppA)
TSV : DSM104635_02133(hppA)
SBIN : SBA_ch1_04330(hppA)
SPAG : sphantq_02242(hppA)
SFLA : SPHFLASMR4Y_00036(hppA)
DEX : HWD60_14430 HWD60_17440
DVN : HQ394_00350 HQ394_03585
GBN : GEOBRER4_05720(hppA)
DVE : DESUT3_07040(hppA) DESUT3_29890(hppA1)
MSD : MYSTI_00676 MYSTI_02527
MFB : MFUL124B02_03850 MFUL124B02_13520
MLAN : JY572_13730 JY572_23180
AVM : JQX13_20415 JQX13_28920
PBRU : LZC95_24615 LZC95_29485
PRUE : LVJ94_23775 LVJ94_28760
PALJ : LZC94_01565 LZC94_16695
SCL : sce0934 sce2989(rrpP) sce5649(ppa)
SCU : SCE1572_06555 SCE1572_06975 SCE1572_18170
CCRO : CMC5_020090 CMC5_043250(hppA)
PAUU : E8A73_028590 E8A73_047930
MRM : A7982_03996 A7982_04771 A7982_06284
LLU : AKJ09_04906 AKJ09_06407 AKJ09_07660
WCH : wcw_0725 wcw_1262(rrpP)
OBG : Verru16b_00899(hppA1)
OBA : ASA1KI_01080 ASA1KI_05810
ABIW : Abiwalacus_02310(hppA)
LCRE : Pla8534_55910(hppA1)
SNEP : Enr13x_00880(hppA1)
AMUC : Pan181_38990(hppA1_1) Pan181_39020(hppA1_2)
AMOB : HG15A2_16250(hppA1)
BGOK : Pr1d_10490(hppA1_1) Pr1d_21450(hppA1_2)
PLH : VT85_23150(hppA_1) VT85_25215(hppA_2)
GAZ : Pan241w_42850(hppA1)
PLON : Pla110_31970(hppA1)
CCOP : Mal65_04760(hppA1_1) Mal65_44110(hppA1_2)
PBOR : BSF38_00662(hppA_1) BSF38_05683(hppA_2)
PBAP : Pla133_37660(hppA1)
MCAD : Pan265_01170(hppA1)
LBV : JYG24_06550 JYG24_07950
SFC : Spiaf_0076 Spiaf_1708
SLR : L21SP2_2114 L21SP2_2602
TPX : Turpa_1207 Turpa_1943
GGR : HKW67_08340 HKW67_18490
BTHO : Btheta7330_04888(hppA1)
BOA : Bovatus_03549(hppA1)
BCEL : BcellWH2_02408(hppA1)
COPR : Cop2CBH44_12510(hppA)
POC : NCTC13071_00471(hppA1)
ACOU : A5CBH24_20770(hppA)
ADA : A5CPEGH6_20630(hppA)
MBAS : ALGA_1345 ALGA_2940
FLP : LK994_09610 LK994_13170
CBAM : PIECOFPK_02038(hppA1)
SMIZ : 4412673_03074(hppA)
SDJ : NCTC13534_04353(hppA1)
MGOT : MgSA37_04187(hppA1)
RHOZ : GXP67_02485 GXP67_04240
PSEZ : HME7025_01499(hppA)
PHG : KCTC32516_01266(hppA1)
AALG : AREALGSMS7_00373(hppA1)
AANR : KCTC52924_00500(hppA1)
KOS : KORDIASMS9_01940(hppA1)
KAN : IMCC3317_37020(hppA)
SPON : HME9304_02236(hppA)
CGLE : NCTC11432_00386(hppA1)
CTAI : NCTC12078_00392(hppA1)
CTAK : 4412677_00156(hppA1)
CSAL : NBC122_02326(hppA1)
CJG : NCTC13459_00735(hppA1)
CANT : NCTC13489_00804(hppA1)
PTAN : CRYO30217_03322(hppA1)
CLZ : BIU88_05050 BIU88_05055
PROC : Ptc2401_00776(hppA1)
FML : FMIA91_04270 FMIA91_18500
CCB : Clocel_0614 Clocel_3368
CCOH : SAMEA4530647_0251(hppA)
CGEL : psyc5s11_54230(hppA2)
PFAA : MM59RIKEN_17170(hppA)
VCOP : MM50RIKEN_01610(hppA)
PETR : QKW49_00465 QKW49_08510 QKW49_10715 QKW49_14460 QKW49_20910
FWA : DCMF_15990 DCMF_16115
THEF : E1B22_02940 E1B22_06150
THEP : DYI95_002255 DYI95_011190
TCP : Q5761_02325 Q5761_11620
BPRO : PMF13cell1_04686(hppA1)
CSCI : HDCHBGLK_00205(hppA1)
CHYL : CE91St63_07620(hppA1)
ACHT : bsdcttw_28500(hppA)
CBOL : CGC65_12770 CGC65_18455
CASP : NQ535_16980 NQ535_21045
CBIL : EUBC25_17720(hppA1)
HHJ : NQ487_12345 NQ487_21340
CBAR : PATL70BA_1615(hppA)
AMIJ : EQM06_08285 EQM06_08460
ABUT : Ami103574_12040 Ami103574_12340
ETM : CE91St48_20740(hppA1)
AHAD : FRZ06_03255 FRZ06_20835
TPD : Teth39_1572 Teth39_1590
TBO : Thebr_1608 Thebr_1629
TPZ : Tph_c08020(hppA1) Tph_c26670(hppA2)
MTHO : MOTHE_c03540(hppA) MOTHE_c13350(hppA1)
MTHZ : MOTHA_c04430(hppA) MOTHA_c14210(hppA1)
PHAR : NCTC13077_00147(hppA1)
PIV : NCTC13079_00419(hppA1)
MANA : MAMMFC1_02457(hppA)
PFAC : PFJ30894_01992(hppA1)
FCZ : IMF26_05330 IMF26_09565
CDIA : CaldiYA01_17130(hppA2)
RTS : CE91St31_18630(hppA1) CE91St31_21420(hppA)
SAMB : SAM23877_4119(hppA)
SLE : sle_32640(sle_32640)
SGM : GCM10017557_45650(hppA)
STUI : GCM10017668_38650(hppA)
SXT : KPP03845_103572(hppA)
PSIC : J4E96_01290 J4E96_11225
PPHP : VTA80_07350 VTA80_15670
BFA : Bfae_22640 Bfae_25260
BGG : CFK41_03775 CFK41_05325
CGA : Celgi_2257 Celgi_2599
CELH : GXP71_03385 GXP71_12105
CPAL : F1D97_08880 F1D97_16945
CELC : K5O09_01615 K5O09_06060
CXIE : NP048_07520 NP048_13970
CELE : P9841_04300 P9841_09145
CELN : CELD12_24000(hppA) CELD12_28320(ppa_1)
PSEK : GCM125_07760(ppa_1)
GEZ : FE251_01035 FE251_14675
DEM : LGT36_005615 LGT36_009670
DSS : GCM25873_16910(hppA) GCM25873_18730(ppa_2)
DCP : RN607_01725 RN607_07700
PAK : HMPREF0675_4623(hppA)
PAV : TIA2EST22_07805(hppA)
PAX : TIA2EST36_07785(hppA)
PAZ : TIA2EST2_07715(hppA)
PCN : TIB1ST10_07990(hppA)
CGRN : 4412665_01068(hppA)
PPC : HMPREF9154_3118(hppA)
BRT : J4N02_05910 J4N02_05915
PSOI : PCC79_12015 PCC79_12020
AFUV : AADG42_04560 AADG42_10850
NAQU : ENKNEFLB_00423(hppA)
MGG : MPLG2_2041(hppA) MPLG2_3567(hppA)
AWS : ACN3XK_62450 ACN3XK_62455
MSAG : GCM10017556_30140(hppA)
VMA : VAB18032_06345(hppA)
ACTR : Asp14428_43120(hppA)
MCU : HMPREF0573_11845(hppA)
AHW : NCTC11636_02569(hppA)
BALA : DSM104299_03425(hppA)
SBAE : DSM104329_03820(hppA)
LEPV : J4558_11315 J4558_14795 J4558_27440
DEH : cbdbA738 cbdbA761(hppA)
DEB : DehaBAV1_0692 DehaBAV1_0710
DEV : DhcVS_672(vpp1) DhcVS_690(vpp2)
DEG : DehalGT_0653 DehalGT_0671
DMC : btf_688(hppA1) btf_707(hppA2)
DMD : dcmb_734(hppA1) dcmb_753(hppA2)
DMG : GY50_0650(hppA) GY50_0668(hppA)
DMX : X792_03555(hppA) X792_03645
DMY : X793_03305(hppA) X793_03395
DMZ : X794_03055(hppA) X794_03150
DUC : UCH007_06390(hppA) UCH007_06570(hppA)
KBS : EPA93_20825 EPA93_21905
KBB : ccbrp13_04360(hppA2)
CPOR : BED41_05840 BED41_10170
PPIO : CE91St28_05490(hppA)
TLE : Tlet_1318 Tlet_1947 Tlet_2017
PHY : AJ81_03275 AJ81_03605
THP : BG95_00740 BG95_01055
THER : Y592_00745 Y592_01060
TFE : JYK00_06730 JYK00_09605
FRR : IB67_00350 IB67_02885
MPZ : Marpi_0400 Marpi_1780
MARN : LN42_02335 LN42_09455
MAEO : JRV97_01655 JRV97_06845
DTN : DTL3_0529(hppA1) DTL3_1759(hppA3)
OCS : OF820_03980 OF820_05055
MPG : Theba_0766 Theba_1009
MINF : MESINF_0081(hppA) MESINF_0265(hppA)
FPOL : ERS445057_00092(hppA1)
DPB : BABL1_gene_415(hppA1)
BGW : VE98_C0001G0532(hppA)
BBGW : UT28_C0001G0355(hppA)
MBA : Mbar_A0186 Mbar_A0187
MBW : MSBRW_0809 MSBRW_0810
MAC : MA_3879(ppa) MA_3880(ppa)
MMJ : MSMAS_0612 MSMAS_0613
MMAC : MSMAC_0614 MSMAC_0615
METM : MSMTP_0668 MSMTP_0671
MEF : MSWH1_0779 MSWH1_0780
MEQ : MSWHS_0831 MSWHS_0832
MSJ : MSSAC_3615 MSSAC_3616
MSZ : MSSIH_3154 MSSIH_3155
MSW : MSSIT_3227 MSSIT_3228
MTHR : MSTHT_2323 MSTHT_2324
MTHE : MSTHC_0956 MSTHC_0957
MHOR : MSHOH_0719 MSHOH_0720
MHAB : RSJ42_12540 RSJ42_12545
METW : AAY43_05800 AAY43_05805
LOKI : Lokiarch_23730(hppA1)
LOB : NEF87_000743 NEF87_000747
AGW : QT03_C0001G0242(hppA)
ยป show all
Taxonomy
Reference
Authors
Belogurov GA, Malinen AM, Turkina MV, Jalonen U, Rytkonen K, Baykov AA, Lahti R.
Title
Membrane-bound pyrophosphatase of Thermotoga maritima requires sodium for activity.
Journal
Sequence
Reference
Authors
Malinen AM, Belogurov GA, Baykov AA, Lahti R
Title
Na+-pyrophosphatase: a novel primary sodium pump.
Journal
Sequence
Reference
Authors
Luoto HH, Belogurov GA, Baykov AA, Lahti R, Malinen AM.
Title
Na+-translocating membrane pyrophosphatases are widespread in the microbial world and evolutionarily precede H+-translocating pyrophosphatases.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 7.2.3.1
ExPASy - ENZYME nomenclature database: 7.2.3.1
BRENDA, the Enzyme Database: 7.2.3.1
LinkDB
All DBs