Entry
Name
ABC-type vitamin B12 transporter;
BtuCDF;
vitamin B12 ABC transporter;
vitamin B12-transporting ATPase
Class
Translocases;
Catalysing the translocation of other compounds;
Linked to the hydrolysis of a nucleoside triphosphate
BRITE hierarchy
Sysname
ATP phosphohydrolase (ABC-type, vitamin B12-importing)
Reaction(IUBMB)
ATP + H2O + vitamin B12-[cobalamin-binding protein][side 1] = ADP + phosphate + vitamin B12[side 2] + [cobalamin-binding protein][side 1]
Substrate
ATP [CPD:
C00002 ];
H2O [CPD:
C00001 ];
vitamin B12-[cobalamin-binding protein][side 1]
Product
ADP [CPD:
C00008 ];
phosphate [CPD:
C00009 ];
vitamin B12[side 2];
[cobalamin-binding protein][side 1]
Comment
An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. Does not undergo phosphorylation during the transport process. A bacterial enzyme that interacts with an extracytoplasmic substrate binding protein and mediates the high affinity uptake of cobalamin derivatives.
History
EC 7.6.2.8 created 2000 as EC 3.6.3.33, transferred 2018 to EC 7.6.2.8
Orthology
K05678 ATP-binding cassette, subfamily D (ALD), member 4
K06074 vitamin B12 transport system ATP-binding protein
K25028 cobalamin transport system ATP-binding protein
Genes
PANU : 101011797 116275703
ANAN : 105707165(ABCD4) 105729313
NCAR : 124977786 124994117
SRX : 107717496(abcd4) 107732056
SANH : 107667197 107677172
CCAR : 109049108 109083591(abcd4)
PTET : 122328648 122329769(abcd4)
PPRM : 120488047 120488405
MASI : 127432101 127434428
TBEN : 117492633(abcd4) 117499344
SSEN : 122761555 122784501
OCLA : 139396596 139396825
PSPA : 121324986 121330297
ARUT : 117418797 117422714
LERI : 129700007 129700009
LPIC : 129262951 129262976
AFIL : 140143746 140153105
LSM : 121116060 121121338 121129625
PPOI : 119093500 119093503 119093504
RSAN : 119371855 119386860
DPTE : 113791265 113795802
CEL : CELE_C54G10.3(pmp-3) CELE_T10H9.5(pmp-5)
CBR : CBG_04568(Cbr-pmp-3) CBG_18988(Cbr-pmp-5)
CRQ : GCK72_017466 GCK72_017970
NAI : NECAME_09308 NECAME_09801
BMY : BM_BM2945(Bma-pmp-3)
HASI : 137294589 137294590
HCRA : 139442898 139443904
ATEN : 116292305 116293342
DPP : DICPUDRAFT_160365(ABCD1) DICPUDRAFT_48982(ABCD3)
DFA : DFA_07783(abcD3) DFA_07799
TVA : TVAG_2v0004950 TVAG_2v0707210
GTT : GUITHDRAFT_106292 GUITHDRAFT_110537
ECOO : ECRM13514_2206(btuD)
ECOH : ECRM13516_2111(btuD)
ECW : EcE24377A_1928(btuD)
EDJ : ECDH1ME8569_1653(btuD)
ECOI : ECOPMV1_01808(btuD)
REE : electrica_02101(btuD)
RTG : NCTC13098_03070(btuD)
CLAP : NCTC11466_02639(btuD)
KIE : NCTC12125_01139(btuD)
AHN : NCTC12129_02302(btuD)
YRE : HEC60_06920(btuD) HEC60_20865(btuD)
METY : MRY16398_23120(btuD)
PSHI : SAMEA2665130_1515(btuD)
PSGC : G163CM_09720(btuD_2)
MPHG : MPHASIOC01_001054(btuD)
YPI : YpsIP31758_1722(btuD)
SMW : SMWW4_v1c21820(btuD)
SFJ : SAMEA4384070_2211(btuD)
SOF : NCTC11214_04682(btuD)
SSAR : SSARUM_002076(btuD)
PAQU : DMB82_0011950(btuD)
PARL : PEC302110_23730(btuD)
DIC : Dpoa569_0001552(btuD)
PHEI : NCTC12003_02335(btuD)
PRJ : NCTC6933_01640(btuD)
PFQ : QQ39_08335 QQ39_14890
LRI : NCTC12151_01698(btuD)
VAU : VANGNB10_cI1522c(btuD)
VPL : SA104470976_00991(btuD)
VIB : VspSTUT11_13970(btuD)
VIS : VspSTUT16_18390(btuD)
PMUD : NCTC8068_01032(yusV)
MOQ : HWV03_05905 HWV03_06755
AEL : NCTC12917_02565(btuD)
CDIZ : CEDIAZO_01654(btuD_6)
RHF : EUB48_03080 EUB48_08725
DEL : DelCs14_0851 DelCs14_3963
DTS : BI380_09715 BI380_26305
DHK : BO996_12895 BO996_26905
DLA : I6G47_10255 I6G47_26860
CSER : CCO03_13205 CCO03_19285
AANT : HUK68_12070 HUK68_12190
LIM : L103DPR2_02087(yusV)
LIH : L63ED372_01586(yusV)
HTN : KI616_11645 KI616_14455
HYDA : ABSY19_05335 ABSY19_25520
RBN : RBXJA2T_02567 RBXJA2T_12427
BVY : NCTC9239_02678(yusV)
CJV : MTVDSCj20_1573(chuC)
CFV : CFVI03293_1818(chuC)
CAMP : CFT03427_1705(chuC)
CCOO : ATE51_00314(fhuC_1)
CPIN : CPIN18020_0550(chuC)
PEF : A7E78_06240 A7E78_11470
DAK : DaAHT2_1560 DaAHT2_1579
DPR : Despr_3027 Despr_3112
DAL : Dalk_0442 Dalk_0760 Dalk_4058
DAT : HRM2_02330 HRM2_41760
DTO : TOL2_C34230 TOL2_C41990 TOL2_C43360
DOV : DSCO28_12140 DSCO28_30700 DSCO28_31570
DWD : DSCW_15780 DSCW_33940
DALK : DSCA_15350 DSCA_61550
DML : Dmul_03930(hmuV2) Dmul_19550
DEK : DSLASN_01940 DSLASN_33950
DAX : FDQ92_03435 FDQ92_05485
SAMY : DB32_001471 DB32_002971
OBG : Verru16b_00888(fhuC_2)
PBU : L21SP3_01699(yusV_1) L21SP3_01808(yusV_2)
TPI : TREPR_0533 TREPR_0540
SSM : Spirs_1019 Spirs_1130
SLR : L21SP2_0607 L21SP2_2856
BTHO : Btheta7330_00944(yusV_1) Btheta7330_04066(yusV_2) Btheta7330_04237(yusV_3)
BFG : BF638R_1796 BF638R_2306
BOA : Bovatus_02155(yusV_1) Bovatus_04184(yusV_2)
BCEL : BcellWH2_00367(yusV) BcellWH2_01515(fhuC)
BCAE : A4V03_08025 A4V03_13715
BIS : DXK01_017350 DXK01_022035
BUN : Bun01g_23130 Bun01g_25440
BEG : INE88_00400 INE88_02489(fpuD) INE88_03892
BSTE : K6V31_04255 K6V31_06695 K6V31_13130
BFE : K6V30_13250 K6V30_24915
BHUM : JXR92_005695 JXR92_012145
BFIN : BFINE_10170 BFINE_57520
BACE : H1A11_05915 H1A11_09710
BDO : EL88_03255 EL88_08835
BDH : GV66_10580 GV66_16850
PCOP : I6J50_11860 I6J50_16160
PGT : PGTDC60_1774 PGTDC60_1797
PAH : Poras_0020 Poras_0318
PCAG : NCTC12856_00129(yusV)
PSOE : CE91St14_05150 CE91St14_12140
PSAC : PSM36_1128 PSM36_1716
DYS : G7050_11340 G7050_17020
DYH : G7051_11640 G7051_17710
PARC : CI960_01530 CI960_08800
PMER : INE87_00959 INE87_02041
PGOL : K6V26_07025 K6V26_17935
PJO : LK449_00315 LK449_06805
PARY : A4V02_03695 A4V02_08680
OSP : Odosp_2046 Odosp_2415 Odosp_2783 Odosp_3625 Odosp_3630
BUY : D8S85_10915 D8S85_11255 D8S85_16235
BVIR : I6J59_04580 I6J59_04895
BFH : F1611_18370 F1611_18735
POC : NCTC13071_00485(fhuC)
AOK : A3BBH6_17720 A3BBH6_25380
ADA : A5CPEGH6_01460 A5CPEGH6_08830
RBC : BN938_2404 BN938_3057
DORI : FH5T_00485 FH5T_13730
HLAM : K4L44_07905 K4L44_12540
HXY : K5X82_03390 K5X82_13970
FPF : DCC35_03960 DCC35_03965
CLIT : OQ292_28830 OQ292_37915
FUA : LVD17_05160 LVD17_09240
PHG : KCTC32516_02238(fecE)
AALG : AREALGSMS7_04744(fecE)
AANR : KCTC52924_00068(fpuD)
KOS : KORDIASMS9_04012(yusV)
KAN : IMCC3317_11520(yusV)
CGLE : NCTC11432_00430(yusV)
CTAI : NCTC12078_00521(yusV)
CTAK : 4412677_00321(yusV)
CJG : NCTC13459_00359(yusV)
CANT : NCTC13489_00538(yusV_1)
CLZ : BIU88_04970 BIU88_09420
PROC : Ptc2401_01258(yusV)
PROS : CHL67_04940 CHL67_05150
PROI : OO005_06600 OO005_06770
DDF : DEFDS_0536 DEFDS_2058
CNI : Calni_1882 Calni_2113
BAZ : BAMTA208_16785(yvrA)
BFD : NCTC4823_00411(hmuV)
CSPG : LS684_01380 LS684_23180
LYP : MTP04_05480 MTP04_07100(yvrA)
PRD : F7984_08055 F7984_15615
NMK : CHR53_02845 CHR53_11210
BLEN : NCTC4824_03909(fhuC_2)
PARG : PspKH34_12420(yvrA)
PPQ : PPSQR21_013580(fepC)
POW : IJ21_11690 IJ21_22730
PLEN : EIM92_18290 EIM92_20600
AFX : JZ786_00035 JZ786_07530
SPOO : J3U78_18495 J3U78_19510
ABAE : CL176_02985 CL176_09040
CTC : CTC_00783(fepC) CTC_01370(fepC)
CTET : BN906_00823(fepC_1) BN906_01477(fepC_3)
CCOH : SAMEA4530647_0643(fepC)
CCAA : KQH81_00745 KQH81_16635
CRW : CROST_030860(btuD_5)
CAUN : CLAUR_000050(btuD_1)
CRS : FQB35_11065 FQB35_14315
PROQ : P6M73_08320 P6M73_15955
DRS : DEHRE_01440 DEHRE_12850
DGI : Desgi_0690 Desgi_2382
ELIM : B2M23_09715 B2M23_11470
AWO : Awo_c10290(fepC) Awo_c30530
ACAE : HYG86_01555 HYG86_03310
AHC : JYE49_01010 JYE49_14665
CBAF : JS518_08635 JS518_10110
WHJ : H9Q79_05710 H9Q79_10280 H9Q79_13335
TEM : JW646_11930 JW646_11945
TGC : L0P85_15765 L0P85_15780
TMY : TEMA_23840(yclP_1) TEMA_23880(yclP_2)
TPET : TPHSE_35010(fepC_2) TPHSE_35040(yclP_2)
TEX : Teth514_0298 Teth514_1932
TPZ : Tph_c03430 Tph_c15800(hmuV)
CAZO : G3A45_03470 G3A45_05495
SEDZ : JYG23_00880 JYG23_11775
SEDM : RBQ61_05295 RBQ61_14685
VRM : 44547418_00070(fhuC_1)
MANA : MAMMFC1_01675(fhuC) MAMMFC1_02578(yusV_2) MAMMFC1_02845(hmuV_3)
STED : SPTER_03480(btuD_1) SPTER_42940(fecE_3)
SSPH : SPSPH_007120(btuD_1)
SSID : SPSIL_008290(btuD_2)
SACV : SPACI_010380(btuD_3)
PFAC : PFJ30894_01772(yusV_2)
CALK : HUE98_10580 HUE98_13775
MHEK : JMUB5695_03666(btuD_2)
MTHN : 4412656_00540(yusV_1)
MTER : 4434518_03169(yusV)
CGL : Cgl0675(Cgl0675) Cgl2112(Cgl2112)
CGS : C624_04195 C624_10215
CGG : C629_04195 C629_10225
CGQ : CGLAR1_03825 CGLAR1_09880
CGX : SB89_03570 SB89_09665
CUN : Cul210932_2181(potA)
CUQ : Cul210931_2134(potA)
CUJ : CUL131002_2090c(potA)
CCJZ : ccrud_03355 ccrud_09225
CFAC : CFAEC_02955(fhuC) CFAEC_09125(yusV3)
BFV : C628_03820 C628_10210
RPY : Y013_10260 Y013_14380
RRT : 4535765_03879(fhuC_1) 4535765_03906(yusV_2)
RCR : NCTC10994_00985(yusV_1) NCTC10994_03403(fhuC)
RGOR : NMQ04_16910 NMQ04_17030
DCO : SAMEA4475696_1398(hmuV_2)
CGRN : 4412665_00465(fhuC_1)
AMYZ : HUW46_06622(fecE_3)
ACTI : UA75_17240 UA75_21835
ACAD : UA74_16705 UA74_21355
AHG : AHOG_14760(hmuV1) AHOG_18850(yusV7)
ACTA : C1701_00145 C1701_03905
CROS : N8J89_32270 N8J89_32390
NED : HUN01_01535 HUN01_03040
DFO : Dform_00902 Dform_00929
PSUB : Pelsub_P0107 Pelsub_P1029
ABAO : BEQ56_04670 BEQ56_06580
PMET : G4Y79_08950 G4Y79_21630
OCY : OSSY52_12070 OSSY52_17550(chuC)
FNC : HMPREF0946_00254 HMPREF0946_01342
FNT : HMPREF0405_00053 HMPREF0405_01001
FUS : HMPREF0409_00812 HMPREF0409_01804
FNE : FSDG_00380 FSDG_02379
FHW : RN87_03310 RN87_07120
FPD : CTM68_06050 CTM68_10185
FVA : FV113G1_19040 FV113G1_31860
FUL : C4N20_14515 C4N20_14540
FNF : BSQ88_02385 BSQ88_07420
FCI : I6I83_00130 I6I83_07765
FHO : H9Q81_05150 H9Q81_05485
FPOL : ERS445057_00161(hmuV_1) ERS445057_01448(yusV_1)
CSOM : MKD34_00105 MKD34_06370
AVE : Arcve_1002 Arcve_1651
MANQ : L1994_02650 L1994_02755
HJT : DVR14_19525 DVR14_23655
MER : MMINT_11040 MMINT_13030
MARC : AR505_0422 AR505_0520
» show all
Taxonomy
Reference
Authors
Friedrich MJ, de Veaux LC, Kadner RJ
Title
Nucleotide sequence of the btuCED genes involved in vitamin B12 transport in Escherichia coli and homology with components of periplasmic-binding-protein-dependent transport systems.
Journal
Sequence
Reference
Authors
Kuan G, Dassa E, Saurin W, Hofnung M, Saier MH Jr.
Title
Phylogenetic analyses of the ATP-binding constituents of bacterial extracytoplasmic receptor-dependent ABC-type nutrient uptake permeases.
Journal
Reference
Authors
Saier MH Jr.
Title
Molecular phylogeny as a basis for the classification of transport proteins from bacteria, archaea and eukarya.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 7.6.2.8
ExPASy - ENZYME nomenclature database: 7.6.2.8
BRENDA, the Enzyme Database: 7.6.2.8
LinkDB
All DBs