KEGG   COMPOUND: C05981
Entry
C05981                      Compound                               
Name
Phosphatidylinositol-3,4,5-trisphosphate;
1-Phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate;
1,2-Diacyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-bisphosphate)
Formula
C11H20O22P4R2
Structure
Comment
Generic compound in reaction hierarchy
Reaction
R04504 R04513 R04545 R09827
Pathway
map00562  Inositol phosphate metabolism
map01100  Metabolic pathways
map01521  EGFR tyrosine kinase inhibitor resistance
map04012  ErbB signaling pathway
map04014  Ras signaling pathway
map04062  Chemokine signaling pathway
map04068  FoxO signaling pathway
map04070  Phosphatidylinositol signaling system
map04071  Sphingolipid signaling pathway
map04072  Phospholipase D signaling pathway
map04140  Autophagy - animal
map04144  Endocytosis
map04150  mTOR signaling pathway
map04151  PI3K-Akt signaling pathway
map04152  AMPK signaling pathway
map04210  Apoptosis
map04211  Longevity regulating pathway
map04212  Longevity regulating pathway - worm
map04213  Longevity regulating pathway - multiple species
map04218  Cellular senescence
map04370  VEGF signaling pathway
map04510  Focal adhesion
map04611  Platelet activation
map04613  Neutrophil extracellular trap formation
map04650  Natural killer cell mediated cytotoxicity
map04660  T cell receptor signaling pathway
map04662  B cell receptor signaling pathway
map04664  Fc epsilon RI signaling pathway
map04666  Fc gamma R-mediated phagocytosis
map04722  Neurotrophin signaling pathway
map04810  Regulation of actin cytoskeleton
map04910  Insulin signaling pathway
map04914  Progesterone-mediated oocyte maturation
map04917  Prolactin signaling pathway
map04919  Thyroid hormone signaling pathway
map04926  Relaxin signaling pathway
map04931  Insulin resistance
map04960  Aldosterone-regulated sodium reabsorption
map04973  Carbohydrate digestion and absorption
map05010  Alzheimer disease
map05131  Shigellosis
map05132  Salmonella infection
map05135  Yersinia infection
map05142  Chagas disease
map05145  Toxoplasmosis
map05160  Hepatitis C
map05162  Measles
map05163  Human cytomegalovirus infection
map05164  Influenza A
map05165  Human papillomavirus infection
map05166  Human T-cell leukemia virus 1 infection
map05167  Kaposi sarcoma-associated herpesvirus infection
map05168  Herpes simplex virus 1 infection
map05169  Epstein-Barr virus infection
map05170  Human immunodeficiency virus 1 infection
map05200  Pathways in cancer
map05207  Chemical carcinogenesis - receptor activation
map05208  Chemical carcinogenesis - reactive oxygen species
map05210  Colorectal cancer
map05212  Pancreatic cancer
map05213  Endometrial cancer
map05214  Glioma
map05215  Prostate cancer
map05218  Melanoma
map05220  Chronic myeloid leukemia
map05221  Acute myeloid leukemia
map05222  Small cell lung cancer
map05223  Non-small cell lung cancer
map05224  Breast cancer
map05225  Hepatocellular carcinoma
map05226  Gastric cancer
map05231  Choline metabolism in cancer
map05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
map05415  Diabetic cardiomyopathy
map05417  Lipid and atherosclerosis
Network
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06162  Hepatitis B virus (HBV)
nt06163  Hepatitis C virus (HCV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165  Epstein-Barr virus (EBV)
nt06166  Human papillomavirus (HPV)
nt06167  Human cytomegalovirus (HCMV)
nt06168  Herpes simplex virus 1 (HSV-1)
nt06169  Measles virus (MV)
nt06170  Influenza A virus (IAV)
nt06181  Salmonella
nt06182  Shigella
nt06214  PI3K signaling (cancer)
nt06224  CXCR signaling (cancer)
nt06260  Colorectal cancer
nt06261  Gastric cancer
nt06262  Pancreatic cancer
nt06263  Hepatocellular carcinoma
nt06264  Renal cell carcinoma
nt06266  Non-small cell lung cancer
nt06267  Small cell lung cancer
nt06268  Melanoma
nt06270  Breast cancer
nt06271  Endometrial cancer
nt06272  Prostate cancer
nt06273  Glioma
nt06275  Acute myeloid leukemia
nt06276  Chronic myeloid leukemia
nt06462  Spinocerebellar ataxia
nt06464  Amyotrophic lateral sclerosis
nt06530  PI3K signaling
nt06537  TCR/BCR signaling
nt06541  Cytoskeleton in neurons
nt06543  NRG-ERBB signaling
Enzyme
2.7.1.153       3.1.3.36        3.1.3.67        3.1.3.86
Brite
Lipids [BR:br08002]
 GP  Glycerophospholipids
  GP09 Glycerophosphoinositol trisphosphates
   GP0901 Diacylglycerophosphoinositol trisphosphates
    C05981  1,2-Diacyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-bisphosphate)
Other DBs
PubChem: 8260
LinkDB
KCF data

ATOM        39
            1   O1c O    26.0886  -23.8676
            2   P1b P    27.4862  -23.8618
            3   O1c O    28.8802  -23.8618
            4   O2b O    27.4862  -22.4667
            5   O1c O    27.4862  -25.2570
            6   P1b P    30.1416  -16.8696
            7   O2b O    30.1359  -18.2607
            8   O1c O    28.7492  -16.8753
            9   O1c O    30.1359  -15.4700
            10  O1c O    31.5410  -16.8696
            11  C1y C    28.7058  -18.9618
            12  C1y C    28.7058  -20.3645
            13  C1y C    27.4862  -18.2756
            14  C1y C    27.4862  -21.0754
            15  O2b O    29.9137  -21.0637
            16  C1y C    26.2911  -18.9618
            17  O1a O    27.4862  -16.8843
            18  C1y C    26.2911  -20.3645
            19  P1b P    31.3073  -21.0580
            20  O2b O    25.0747  -18.2614
            21  O1a O    25.0832  -21.0580
            22  O1c O    32.6985  -21.0580
            23  O1c O    31.3073  -19.6667
            24  O1c O    31.3073  -22.4574
            25  P1b P    23.6836  -18.2497
            26  O2b O    22.2840  -18.2497
            27  O1c O    23.6893  -16.8503
            28  O1c O    23.6777  -19.6410
            29  C1b C    22.2840  -16.8535
            30  C1c C    21.0768  -16.1592
            31  C1b C    21.0768  -14.7702
            32  O7a O    19.8754  -16.8535
            33  O7a O    22.2840  -14.0703
            34  C7a C    18.6668  -16.1521
            35  C7a C    22.2840  -12.6751
            36  O6a O    18.6668  -14.7631
            37  R   R    17.4655  -16.8464
            38  O6a O    21.0698  -11.9869
            39  R   R    23.4994  -11.9798
BOND        39
            1    11  13 1
            2    12  14 1
            3    12  15 1 #Down
            4    13  16 1
            5    13  17 1 #Down
            6    14  18 1
            7    14   4 1 #Up
            8    15  19 1
            9    16  20 1 #Up
            10   18  21 1 #Up
            11   19  22 1
            12   19  23 1
            13   19  24 2
            14   20  25 1
            15   25  26 1
            16   25  27 1
            17   25  28 2
            18   16  18 1
            19    2   4 1
            20    2   5 2
            21    1   2 1
            22    2   3 1
            23    6   7 1
            24    6   8 2
            25    6   9 1
            26    6  10 1
            27   11   7 1 #Up
            28   11  12 1
            29   26  29 1
            30   29  30 1
            31   30  31 1
            32   30  32 1 #Down
            33   31  33 1
            34   32  34 1
            35   33  35 1
            36   34  36 2
            37   34  37 1
            38   35  38 2
            39   35  39 1

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