KEGG   COMPOUND: C06573Help
Entry
C06573                      Compound                               

Name
Amphotericin B
Formula
C47H73NO17
Exact mass
923.4879
Mol weight
924.079
Structure
Mol fileKCF fileDB search
Sequence
0 Mak  1 Mtk  2 Mtd  3 Mad  4 Mad  5 Mad  6 Mad  7 Mad  8 Mad
9 Mak  10 Mak  11 Mtk  12 Man  13 Mak  14 Mak  15 Mae  16 Mak
17 Mak  18 Man
  Gene
0 amphA [UP:Q93NW8]; 1-2 amphB [UP:Q93NW7]; 3-8 amphC [UP:Q93NW6];
9-14 amphI [UP:Q93NX9]; 15-17 amphJ [UP:Q93NX8]; 18 amphK
[UP:Q93NX7]
  Organism
Streptomyces nodosus
  Type
PK
Remark
Same as: D00203
Pathway
map01052  Type I polyketide structures
Brite
Lipids [BR:br08002]
 PK  Polyketides
  PK06 Plyenes
   C06573  Amphotericin B
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AB Antiinfectives and antiseptics for local oral treatment
     A01AB04 Amphotericin B
      D00203  Amphotericin B (JP17/USP/INN) <JP/US>
  A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
   A07A INTESTINAL ANTIINFECTIVES
    A07AA Antibiotics
     A07AA07 Amphotericin B
      D00203  Amphotericin B (JP17/USP/INN) <JP/US>
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G01 GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS
   G01A ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS
    G01AA Antibiotics
     G01AA03 Amphotericin B
      D00203  Amphotericin B (JP17/USP/INN) <JP/US>
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J02 ANTIMYCOTICS FOR SYSTEMIC USE
   J02A ANTIMYCOTICS FOR SYSTEMIC USE
    J02AA Antibiotics
     J02AA01 Amphotericin B
      D00203  Amphotericin B (JP17/USP/INN) <JP/US>
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  61  Antibiotics
   617  Acting mainly on mold
    6173  Amphotericin B
     D00203  Amphotericin B (JP17/USP/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00203  Amphotericin B
  D00203  Amphotericin B tablets
  D00203  Amphotericin B syrup
  D00203  Amphotericin B for injection
Antiinfectives [br08350.html]
 Antifungals
  D00203
BRITE hierarchy
Other DBs
CAS: 1397-89-3
PubChem: 8802
ChEBI: 2682
ChEMBL: CHEMBL267345 CHEMBL364143
LIPIDMAPS: LMPK06000002
3DMET: B02075
NIKKAJI: J3.666H
LinkDB All DBs
KCF data Show

ATOM        65
            1   C1y C    29.7211  -15.6126
            2   C1y C    30.9385  -14.9057
            3   O2x O    28.4992  -14.9115
            4   C1b C    29.7211  -17.0089
            5   C1y C    30.9385  -13.5094
            6   C6a C    32.1544  -15.6068
            7   C1z C    28.4992  -13.5094
            8   C1c C    28.5109  -17.7100
            9   C1x C    29.7211  -12.8083
            10  O1a O    32.1485  -12.8025
            11  O6a O    32.1544  -17.0089
            12  O6a O    33.3646  -14.9057
            13  C1b C    27.2948  -12.8142
            14  O1a O    28.4933  -12.1071
            15  O2a O    28.5167  -19.1121
            16  C2b C    27.3065  -17.0206
            17  C1c C    26.0845  -13.5151
            18  C1y C    27.3065  -19.8191
            19  C2b C    26.0962  -17.7158
            20  C1b C    24.8674  -12.8200
            21  O1a O    26.0845  -14.9174
            22  C1y C    27.3124  -21.2282
            23  O2x O    26.0962  -19.1181
            24  C2b C    24.8860  -17.0335
            25  C1c C    23.6572  -13.5211
            26  C1y C    26.1022  -21.9295
            27  O1a O    28.5297  -21.9164
            28  C1y C    24.8860  -19.8191
            29  C2b C    23.6689  -17.7346
            30  C1c C    22.4471  -12.8259
            31  O1a O    23.6631  -14.9232
            32  C1y C    24.8860  -21.2282
            33  N1a N    26.1022  -23.3314
            34  C1a C    23.6631  -19.1308
            35  C2b C    22.4587  -17.0393
            36  C1b C    21.2427  -13.5339
            37  O1a O    22.4471  -11.4236
            38  O1a O    23.6689  -21.9352
            39  C2b C    21.2544  -17.7405
            40  C1b C    20.0253  -12.8386
            41  C2b C    20.0442  -17.0452
            42  C1c C    18.8151  -13.5399
            43  C2b C    18.8268  -17.7463
            44  C1b C    17.6049  -12.8446
            45  O1a O    18.8151  -14.9418
            46  C2b C    17.6166  -17.0510
            47  C1c C    16.3947  -13.5456
            48  C2b C    16.4064  -17.7522
            49  C1b C    15.1833  -12.8503
            50  O1a O    16.4006  -14.9478
            51  C2b C    15.2021  -17.0568
            52  C7a C    13.9731  -13.5516
            53  C2b C    13.9789  -17.7580
            54  O7a O    12.7629  -12.8563
            55  O6a O    13.9731  -14.9535
            56  C2b C    12.7688  -17.0627
            57  C1c C    11.5527  -13.5573
            58  C2b C    11.5586  -17.7639
            59  C1c C    11.5527  -14.9595
            60  C1a C    10.3355  -12.8563
            61  C1c C    10.3355  -17.0627
            62  C1c C    10.3355  -15.6607
            63  C1a C    12.7688  -15.6607
            64  C1a C     9.1336  -17.7639
            65  O1a O     9.1336  -14.9595
BOND        67
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1 #Up
            6     3   7 1
            7     4   8 1
            8     5   9 1
            9     5  10 1 #Down
            10    6  11 1
            11    6  12 2
            12    7  13 1
            13    7  14 1 #Up
            14    8  15 1 #Up
            15    8  16 1
            16   13  17 1
            17   15  18 1
            18   16  19 2
            19   17  20 1
            20   17  21 1 #Up
            21   18  22 1
            22   18  23 1 #Up
            23   19  24 1
            24   20  25 1
            25   22  26 1
            26   22  27 1 #Up
            27   23  28 1
            28   24  29 2
            29   25  30 1
            30   25  31 1 #Up
            31   26  32 1
            32   26  33 1 #Up
            33   28  34 1 #Up
            34   29  35 1
            35   30  36 1
            36   30  37 1 #Up
            37   32  38 1 #Down
            38   35  39 2
            39   36  40 1
            40   39  41 1
            41   40  42 1
            42   41  43 2
            43   42  44 1
            44   42  45 1 #Up
            45   43  46 1
            46   44  47 1
            47   46  48 2
            48   47  49 1
            49   47  50 1 #Up
            50   48  51 1
            51   49  52 1
            52   51  53 2
            53   52  54 1
            54   52  55 2
            55   53  56 1
            56   54  57 1
            57   56  58 2
            58   57  59 1
            59   57  60 1 #Down
            60   58  61 1
            61   59  62 1
            62   59  63 1 #Down
            63   61  64 1 #Down
            64   62  65 1 #Up
            65    7   9 1
            66   28  32 1
            67   61  62 1

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