KEGG   COMPOUND: C07443
Entry
C07443                      Compound                               
Name
Phenytoin
Formula
C15H12N2O2
Exact mass
252.0899
Mol weight
252.27
Structure
Remark
Same as: D00512
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N03 ANTIEPILEPTICS
   N03A ANTIEPILEPTICS
    N03AB Hydantoin derivatives
     N03AB02 Phenytoin
      D00512  Phenytoin (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Anticonvulsants
  Sodium Channel Agents
   Phenytoin
    D00512  Phenytoin (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   113  Antiepileptics
    1132  Hydantoins
     D00512  Phenytoin (JP18/USP/INN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG03199  Antiepileptic agent
   DG02031  Hydantoin antiepileptic
    DG00846  Phenytoin
     D00512  Phenytoin
 Metabolizing enzyme substrate
  DG01642  CYP2C9 substrate
   DG00846  Phenytoin
    D00512  Phenytoin
  DG01639  CYP2C19 substrate
   DG00846  Phenytoin
    D00512  Phenytoin
 Metabolizing enzyme inducer
  DG02891  CYP2B6 inducer
   DG00846  Phenytoin
    D00512  Phenytoin
  DG02853  CYP3A/CYP3A4 inducer
   DG00846  Phenytoin
    D00512  Phenytoin
 Transporter inducer
  DG01893  ABCB1 inducer
   DG00846  Phenytoin
    D00512  Phenytoin
Drug classes [BR:br08332]
 Neuropsychiatric agent
  DG03199  Antiepileptic agent
   D00512  Phenytoin
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Sodium channels
    SCN1A
     D00512  Phenytoin (JP18/USP/INN) <JP/US>
    SCN2A
     D00512  Phenytoin (JP18/USP/INN) <JP/US>
    SCN3A
     D00512  Phenytoin (JP18/USP/INN) <JP/US>
    SCN4A
     D00512  Phenytoin (JP18/USP/INN) <JP/US>
    SCN5A
     D00512  Phenytoin (JP18/USP/INN) <JP/US>
    SCN8A
     D00512  Phenytoin (JP18/USP/INN) <JP/US>
    SCN9A
     D00512  Phenytoin (JP18/USP/INN) <JP/US>
    SCN10A
     D00512  Phenytoin (JP18/USP/INN) <JP/US>
    SCN11A
     D00512  Phenytoin (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00512  Phenytoin
  D00512  Phenytoin tablets
  D00512  Phenytoin powder
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00512
 Drug transporters
  D00512
Pharmacogenomic biomarkers [br08341.html]
 Polymorphisms and mutations affecting drug response
  D00512
Prodrugs [br08324.html]
 D00512
Prodrugs [br08324.html]
 C07443
Other DBs
CAS: 57-41-0
PubChem: 9647
ChEBI: 8107
NIKKAJI: J2.325F
LinkDB
KCF data

ATOM        19
            1   C8x C    28.4200  -18.1300
            2   C8x C    28.4200  -19.5300
            3   C8x C    29.6100  -20.2300
            4   C8x C    30.8700  -19.5300
            5   C8y C    30.8700  -18.1300
            6   C8x C    29.6100  -17.4300
            7   C8x C    33.2500  -19.5300
            8   C8y C    33.2500  -18.1300
            9   C1z C    32.0600  -17.4300
            10  C8x C    34.5100  -20.2300
            11  C8x C    35.7000  -19.5300
            12  C8x C    35.7000  -18.1300
            13  C8x C    34.5100  -17.4300
            14  N1x N    33.1800  -16.5900
            15  C2y C    32.6900  -15.2600
            16  N2x N    31.2900  -15.2600
            17  C5x C    30.9400  -16.5900
            18  O1a O    33.4600  -14.0700
            19  O5x O    29.5400  -16.5900
BOND        21
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     7   8 1
            8     8   9 1
            9     5   9 1
            10    7  10 2
            11   10  11 1
            12   11  12 2
            13   12  13 1
            14    8  13 2
            15    9  14 1
            16   14  15 1
            17   15  16 2
            18   16  17 1
            19    9  17 1
            20   15  18 1
            21   17  19 2

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