KEGG   DRUG: Tretinoin
Entry
D00094                      Drug                                   
Name
Tretinoin (JAN/USP/INN);
Avita (TN);
Renova (TN);
Retin A (TN);
Tretinoin (TN)
Product
ALTRENO (Bausch Health US), ATRALIN (Bausch Health US), RENOVA (Bausch Health US LLC), RETIN-A (Bausch Health US), RETIN-A MICRO (Bausch Health US LLC), TRETINOIN CREAM (Obagi Cosmeceuticals LLC), VESANOID (H2-Pharma)
  Generic
TRETINOIN (A-S Medication Solutions), TRETINOIN (A-S Medication Solutions), TRETINOIN (A-S Medication Solutions), TRETINOIN (A-S Medication Solutions), TRETINOIN (A-S Medication Solutions), TRETINOIN (Actavis Pharma), TRETINOIN (Alembic Pharmaceuticals), TRETINOIN (American Health Packaging), TRETINOIN (Aurobindo Pharma Limited), TRETINOIN (Aurobindo Pharma Limited), TRETINOIN (AvKARE), TRETINOIN (Bryant Ranch Prepack), TRETINOIN (Bryant Ranch Prepack), TRETINOIN (Bryant Ranch Prepack), TRETINOIN (Bryant Ranch Prepack), TRETINOIN (Bryant Ranch Prepack), TRETINOIN (Bryant Ranch Prepack), TRETINOIN (Bryant Ranch Prepack), TRETINOIN (Bryant Ranch Prepack), TRETINOIN (Encube Ethicals Private Limited), TRETINOIN (Encube Ethicals Private Limited), TRETINOIN (Endo USA), TRETINOIN (Glenmark Pharmaceuticals), TRETINOIN (H2-Pharma), TRETINOIN (MICROSPHERE) (Mayne Pharma), TRETINOIN (Major Pharmaceuticals), TRETINOIN (Mylan Pharmaceuticals), TRETINOIN (Mylan Pharmaceuticals), TRETINOIN (Mylan Pharmaceuticals), TRETINOIN (NORTHSTAR RX LLC), TRETINOIN (NORTHSTAR RX LLC), TRETINOIN (NORTHSTAR RX LLC), TRETINOIN (NuCare Pharmaceuticals), TRETINOIN (NuCare Pharmaceuticals), TRETINOIN (Obagi Cosmeceuticals LLC), TRETINOIN (Oceanside Pharmaceuticals), TRETINOIN (Oceanside Pharmaceuticals), TRETINOIN (Padagis US LLC), TRETINOIN (Preferred Pharmaceuticals), TRETINOIN (REMEDYREPACK), TRETINOIN (Taro Pharmaceuticals U.S.A.), TRETINOIN (Taro Pharmaceuticals U.S.A.), TRETINOIN (Taro Pharmaceuticals U.S.A.), TRETINOIN (Viona Pharmaceuticals), TRETINOIN (Zydus Lifesciences Limited)
Formula
C20H28O2
Exact mass
300.2089
Mol weight
300.43
Structure
Simcomp
Class
Vitamin and mineral
 DG01604  Retinol derivative
Remark
Same as: C00777
Therapeutic category: 4291
ATC code: D10AD01 L01XF01
Chemical structure group: DG00433
Product (DG00433): D00094<JP/US> D01516<JP>
Product (mixture): D11084<US> D12338<US> D12499<US>
Efficacy
Antineoplastic, Keratolytic, Retinoic acid receptor (RAR) agonist
  Disease
Acne vulgaris [DS:H01445]
Comment
Vesanoid (TN): discontinued in FDA
Target
PML-RARA [HSA:5371 5914] [KO:K10054 K08527]
NR1B (RAR) [HSA:5914 5915 5916] [KO:K08527 K08528 K08529]
  Pathway
hsa04659  Th17 cell differentiation
hsa05200  Pathways in cancer
hsa05202  Transcriptional misregulation in cancer
hsa05221  Acute myeloid leukemia
Interaction
Structure map
map07223  Retinoic acid receptor (RAR) and retinoid X receptor (RXR) agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D10 ANTI-ACNE PREPARATIONS
   D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
    D10AD Retinoids for topical use in acne
     D10AD01 Tretinoin
      D00094  Tretinoin (JAN/USP/INN) <JP/US>
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01X OTHER ANTINEOPLASTIC AGENTS
    L01XF Retinoids for cancer treatment
     L01XF01 Tretinoin
      D00094  Tretinoin (JAN/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Antineoplastics
  Retinoids
   Tretinoin
    D00094  Tretinoin (JAN/USP/INN)
 Dermatological Agents
  Acne and Rosacea Agents
   Retinoids
    Tretinoin
     D00094  Tretinoin (JAN/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  42  Antineoplastics
   429  Miscellaneous
    4291  Other Antitumors
     D00094  Tretinoin (JAN/USP/INN)
Drug groups [BR:br08330]
 Vitamin and mineral
  DG01604  Retinol derivative
   DG00433  Tretinoin
    D00094  Tretinoin
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Thyroid hormone like receptors
   Retinoic acid receptor (RAR)
    NR1B (RAR)
     D00094  Tretinoin (JAN/USP/INN) <JP/US>
    PML-RARA
     D00094  Tretinoin (JAN/USP/INN) <JP/US>
Drug groups [BR:br08330]
 Vitamin and mineral
  DG01604  Retinol derivative
   DG00433  Tretinoin
Other DBs
CAS: 302-79-4
PubChem: 7847162
ChEBI: 15367
PDB-CCD: REA[PDBj]
LigandBox: D00094
NIKKAJI: J1.518K
LinkDB
KCF data

ATOM        22
            1   C1x C    14.4200  -19.8100
            2   C1x C    14.4200  -21.2100
            3   C1x C    15.6324  -21.9100
            4   C2y C    16.8449  -21.2100
            5   C2y C    16.8449  -19.8100
            6   C1z C    15.6324  -19.1100
            7   C1a C    16.4540  -17.9930
            8   C1a C    14.6889  -18.0557
            9   C1a C    18.0760  -21.9210
            10  C2b C    18.0760  -19.0990
            11  C2b C    19.2812  -19.7947
            12  C2c C    20.4635  -19.1119
            13  C2b C    21.6575  -19.8012
            14  C1a C    20.4635  -17.7102
            15  C2b C    22.8454  -19.1152
            16  C2b C    24.0365  -19.8029
            17  C2c C    25.2259  -19.1161
            18  C2b C    26.4162  -19.8034
            19  C6a C    27.6061  -19.1163
            20  O6a O    28.7962  -19.8035
            21  C1a C    25.2260  -17.7102
            22  O6a O    27.6061  -17.7102
BOND        22
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 2
            5     5   6 1
            6     1   6 1
            7     6   7 1
            8     6   8 1
            9     4   9 1
            10    5  10 1
            11   10  11 2
            12   11  12 1
            13   12  13 2
            14   12  14 1
            15   13  15 1
            16   15  16 2
            17   16  17 1
            18   17  18 2
            19   18  19 1
            20   19  20 1
            21   17  21 1
            22   19  22 2

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