KEGG ORTHOLOGY: K10054

ORTHOLOGY: K10054

Entry

K10054                      KO

Symbol

PML, TRIM19

Name

E3 SUMO-protein ligase PML [EC:2.3.2.-]

Pathway

map04120

Ubiquitin mediated proteolysis

map04144

Endocytosis

map05164

Influenza A

map05168

Herpes simplex virus 1 infection

map05200

Pathways in cancer

map05202

Transcriptional misregulation in cancer

map05221

Acute myeloid leukemia

Disease

H00003

Acute myeloid leukemia

H02542

Acute promyelocytic leukemia

Brite

KEGG Orthology (KO) [BR:ko00001]
09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    K10054  PML, TRIM19; E3 SUMO-protein ligase PML
09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K10054  PML, TRIM19; E3 SUMO-protein ligase PML
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K10054  PML, TRIM19; E3 SUMO-protein ligase PML
   05202 Transcriptional misregulation in cancer
    K10054  PML, TRIM19; E3 SUMO-protein ligase PML
  09162 Cancer: specific types
   05221 Acute myeloid leukemia
    K10054  PML, TRIM19; E3 SUMO-protein ligase PML
  09172 Infectious disease: viral
   05164 Influenza A
    K10054  PML, TRIM19; E3 SUMO-protein ligase PML
   05168 Herpes simplex virus 1 infection
    K10054  PML, TRIM19; E3 SUMO-protein ligase PML
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system
    K10054  PML, TRIM19; E3 SUMO-protein ligase PML
Ubiquitin system [BR:ko04121]
Ubiquitin ligases (E3)
  UBL E3 ligases
   K10054  PML, TRIM19; E3 SUMO-protein ligase PML

Genes

HSA:

5371(PML)

PTR:	453736(PML)

PPS:	100993007(PML)

GGO:	101145052(PML)

PON:	100445630(PML)

PPYG:

129013825(PML)

NLE:	100607016(PML)

HMH:	116481890(PML)

SSYN:

129482272(PML)

MCC:	700379(PML)

MCF:	102135847(PML)

MTHB:

126958947

MNI:	105463766(PML)

CSAB:

103245348(PML)

CATY:

105573504(PML)

PANU:

101019999(PML)

TGE:	112627469(PML)

MLEU:

105529856(PML)

RRO:	104678056 115891998 115897517 115897528

RBB:	108524152(PML)

TFN:	117070383(PML)

PTEH:

111526997(PML)

CANG:

105505178(PML)

CJC:	100388843(PML)

SBQ:	101042469(PML)

CIMI:

108317496(PML)

ANAN:

105733469(PML)

CSYR:

103252591(PML)

MMUR:

105862152(PML)

LCAT:

123624147(PML)

PCOQ:

105807294(PML)

OGA:	100964010(PML)

MMU:	18854(Pml)

MCAL:

110301964(Pml)

MPAH:

110327943(Pml)

RNO:	315713(Pml)

MCOC:

116072502(Pml)

ANU:	117698954(Pml)

ASYL:

127688984(Pml)

MUN:	110554829(Pml)

CGE:	100757598(Pml)

MAUA:

101822740(Pml)

PROB:

127231823(Pml)

PLEU:

114708922(Pml)

MORG:

121466108(Pml)

MFOT:

126507457

AAMP:

119809756(Pml)

NGI:	103736862(Pml)

HGL:	101707749(Pml)

CPOC:

100720832(Pml)

CCAN:

109687659

DORD:

105982530(Pml)

DSP:	122123005(Pml)

DMER:

138841926(Pml)

PLOP:

125338693(Pml)

NCAR:

124977205

MMMA:

107137956(Pml)

ITI:	101965085(Pml)

OCU:

100351382

OPI:	101532169(PML)

TUP:	102474405(PML)

GVR:	103588070(PML)

CFA:	487641(PML)

CLUD:

112675609(PML)

VVP:	112918012(PML)

VLG:	121477099(PML)

NPO:	129506200(PML)

AML:	100475070(PML)

UMR:	103679001(PML)

UAH:	113240956(PML)

UAR:	123790696(PML)

ELK:

111153323

LLV:

125103723

MPUF:

101690003(PML)

MNP:	131999180(PML)

MLK:	131835794(PML)

NVS:	122894441(PML)

ORO:	101365827(PML)

EJU:	114206500(PML)

ZCA:	113909431(PML)

MLX:	118003638(PML)

NSU:	110584044(PML)

LWW:	102748183(PML)

FCA:	101086975(PML)

PYU:	121041973(PML)

PCOO:

112855523(PML)

PBG:	122468444(PML)

PVIV:

125167943(PML)

LRUF:

124508418

LGF:	123582730(PML)

AJU:

106979429

PTG:	102963011(PML)

PPAD:

109262710(PML)

PUC:

125910134

PLEZ:

122221810(PML)

HHV:	120235727(PML)

BTA:	100138545(PML)

BOM:	102286043(PML)

BIU:	109575524(PML)

BBUB:

102394614(PML)

BBIS:

104991003(PML)

CHX:	102173973(PML)

OAS:	101111580(PML)

BTAX:

128066395(PML)

CSUM:

138095386(PML)

ODA:	120875435(PML)

CCAD:

122455037(PML)

MREE:

136146919(PML)

OVR:	110139845(PML)

MBEZ:

129550473(PML)

SSC:	100157336(PML)

CFR:	102504760(PML)

CBAI:

105069203(PML)

CDK:	105087276(PML)

VPC:	102527691(PML)

BACU:

103013991(PML)

BMUS:

118890744(PML)

LVE:	103090340(PML)

OOR:	101283102(PML)

LALB:

132523095(PML)

GMF:	115862814(PML)

DDP:	132420837(PML)

DLE:	111177808(PML)

PCAD:

102983450(PML)

PSIU:

116748348(PML)

PPHC:

136119364(PML)

NASI:

112410980(PML)

ECB:	100062744(PML)

EPZ:	103560966(PML)

EAI:	106836652(PML)

MYB:	102242938(PML)

MYD:	102775373(PML)

MMYO:

118675706(PML)

MLF:	102430294(PML)

MDT:	132212147(PML)

MYUM:

139020705(PML)

PKL:	118728971(PML)

EFUS:

103300198(PML)

MNA:	107528565(PML)

DRO:	112301759(PML)

SHON:

118987769(PML)

AJM:	119041301(PML)

PDIC:

114493028(PML)

PHAS:

123825168(PML)

MMF:	118627567(PML)

PPAM:

129064051(PML)

HAI:	109396273(PML)

RFQ:	117023255(PML)

PALE:

102895190(PML)

PGIG:

120597873(PML)

PVP:	105306822(PML)

RAY:	107500111(PML)

TOD:	119238431(PML)

SARA:

101549024(PML)

SFUM:

130036869(PML)

SETR:

126011387(PML) 126022405

LAV:	100663907(PML)

TMU:

101356208

ETF:	101659033(PML)

DNM:	101415116(PML)

MDO:	100029464(PML)

GAS:	123234352(PML)

SHR:	100925902(PML)

AFZ:

127551992

PCW:	110214069(PML)

TVP:	118828313(PML)

PBRV:

138148504(PML)

OAA:	100076474(PML)

TACU:

119928406(PML)

GGA:	100857563(PMLL) 415302(PML)

PCOC:

116244554 116244555(PML)

MGP:	104912756(PML) 104912761

CJO:	107318588 107318590(PML)

TPAI:

128075353 128075354(PML)

LMUT:

125698236 125698237(PML)

NMEL:

110403842(PML) 110403910

APLA:

101796105 113844857(PML)

ACYG:

106044181 106044208(PML)

CATA:

118258114(PML) 118258158

AFUL:

116493504 116493700

LSR:	110482659(PML)

PMOA:

120508901(PML)

OTC:	121343475(PML)

PRUF:

121365540(PML)

ATRC:

139597004(PML)

OMA:	130257306(PML)

PHI:	102107893(PML)

PMAJ:

107209110(PML)

ACOE:

138116582(PML)

ETL:	114059791(PML) 114060460

ZLE:	135452080(PML)

SVG:	106861050(PML)

SATI:

136367193(PML)

CCIC:

134049279(PML)

FPG:	101910511(PML) 101910853

FCH:	102050333 102050681

SHAB:

115613245

ACUN:

113483848 113483936(PML)

TALA:

104365630 116961042

ACHC:

115341086(PML) 115342201

HALD:

104315924

HLE:	104834367 104834683

AGEN:

126043632 126043917

HHAR:

128150954 128151363

GCL:	127020709 127020710

LDI:	104346739(PML)

PPUS:

135182796 135182797

AVIT:

104278606

EGZ:	104130712 104130714(PML)

NNI:	104016797 104016799

PADL:

103922051 103922053(PML)

AFOR:

103898606(PML)

CBOY:

140655416 140656040

CLV:	102095362 110355096

CNIC:

CUCA:

TEO:

OHA:

ACAR:

RTD:	128915128 128915138(PML)

CRID:

134520695 134521130

AAM:	106500165(PML) 106500166

AROW:

112967281 112967292(PML)

NPD:

112951022

DNE:	112992206 112992639

SCAM:

104144587

ASN:	102372629(PML) 102372873 102378535

AMJ:	102575005(PML)

PSS:	102454618(PML)

CMY:	102944212 102947589

CCAY:

125644128 125644129(PML)

DCC:	119862208 119862209

CPIC:

101946293 101948754(PML)

TST:	117883765 117884168

CABI:

116820314 116820315(PML)

MRV:	120373120 120373385(PML)

ASAO:

132762635(PML)

PVT:	110084440(PML)

SUND:

121932865 121932867(PML)

PMUR:

107300488 107300489 107300858 107300869 107301028

CTIG:

120305554(PML) 120305555

TSR:	106552979(PML)

PGUT:

117661038 117661039

PCAE:

139323968 139324100

APRI:

131184528 131184820(PML)

PTEX:

113442253(PML)

NSS:	113423215(PML) 113423236

VKO:	123033788(PML)

PMUA:

114604002 114604613

PRAF:

128421238 128421240(PML)

ZVI:	118083900(PML) 118084213

HCG:	128334684 128334685 128335181

GJA:

107109157

STOW:

125424529 125446179(PML)

EMC:	129345462 129345655

LOC:	102687136(pml)

PSPA:

121294526 121294899 121295091 121299280

ARUT:

117427732 117427810 117429037 117429166 117963211 117963212

RTP:

LERI:

HAKA:

CRG:

Reference

PMID:11025664

Authors

Guo A, Salomoni P, Luo J, Shih A, Zhong S, Gu W, Pandolfi PP

Title

The function of PML in p53-dependent apoptosis.

Journal

Nat Cell Biol 2:730-6 (2000)
DOI:10.1038/35036365

Sequence

[hsa:5371]

Reference

PMID:15356634

Authors

Lin HK, Bergmann S, Pandolfi PP

Title

Cytoplasmic PML function in TGF-beta signalling.

Journal

Nature 431:205-11 (2004)
DOI:10.1038/nature02783

Sequence

[hsa:5371] [mmu:18854]

Reference

PMID:1652369

Authors

de The H, Lavau C, Marchio A, Chomienne C, Degos L, Dejean A

Title

The PML-RAR alpha fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR.

Journal

Cell 66:675-84 (1991)
DOI:10.1016/0092-8674(91)90113-D

Sequence

[hsa:5371]

LinkDB

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