| Entry |
|
|---|
| Name |
Chloramphenicol (JP18/USP/INN);
Amphicol (TN);
Chloromycetin (TN);
Econochlor (TN) |
|---|
| Formula |
C11H12Cl2N2O5
|
|---|
| Exact mass |
322.0123
|
|---|
| Mol weight |
323.13
|
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| Structure |
|
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| Simcomp |
|
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| Source |
Streptomyces venezuelae [TAX: 54571], Streptomyces omiyaensis [TAX: 68247]
|
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| Class |
Antibacterial
DG01576 Amphenicol type antibacterial
Metabolizing enzyme inhibitor
DG01933 CYP2C19 inhibitor
|
|---|
| Remark |
| Product (DG00399): | D00104<JP> D02185<JP/US> |
| Product (mixture): | D04106<JP> D04753<JP> |
|
|---|
| Efficacy |
Antibacterial, Antirickettsial, Protein biosynthesis inhibitor |
|---|
| Comment |
Natural product
Amphenicol derivative
|
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| Target |
50S ribosomal subunit |
|---|
| Pathway |
|
|---|
| Interaction |
CYP inhibition: CYP2C19 [HSA: 1557]
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
D DERMATOLOGICALS
D06 ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE
D06A ANTIBIOTICS FOR TOPICAL USE
D06AX Other antibiotics for topical use
D06AX02 Chloramphenicol
D00104 Chloramphenicol (JP18/USP/INN) <JP>
D10 ANTI-ACNE PREPARATIONS
D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
D10AF Antiinfectives for treatment of acne
D10AF03 Chloramphenicol
D00104 Chloramphenicol (JP18/USP/INN) <JP>
G GENITO URINARY SYSTEM AND SEX HORMONES
G01 GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS
G01A ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS
G01AA Antibiotics
G01AA05 Chloramphenicol
D00104 Chloramphenicol (JP18/USP/INN) <JP>
J ANTIINFECTIVES FOR SYSTEMIC USE
J01 ANTIBACTERIALS FOR SYSTEMIC USE
J01B AMPHENICOLS
J01BA Amphenicols
J01BA01 Chloramphenicol
D00104 Chloramphenicol (JP18/USP/INN) <JP>
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01A ANTIINFECTIVES
S01AA Antibiotics
S01AA01 Chloramphenicol
D00104 Chloramphenicol (JP18/USP/INN) <JP>
S02 OTOLOGICALS
S02A ANTIINFECTIVES
S02AA Antiinfectives
S02AA01 Chloramphenicol
D00104 Chloramphenicol (JP18/USP/INN) <JP>
S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
S03A ANTIINFECTIVES
S03AA Antiinfectives
S03AA08 Chloramphenicol
D00104 Chloramphenicol (JP18/USP/INN) <JP>
USP drug classification [BR:br08302]
Antibacterials
Antibacterials, Other
Chloramphenicol
D00104 Chloramphenicol (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
13 Agents affecting sensory organs
131 Ophthalmic agents
1317 Ophthalmic antibiotics
D00104 Chloramphenicol (JP18/USP/INN)
132 Otic and nasal agents
1325 Otolaryngologic antibiotics
D00104 Chloramphenicol (JP18/USP/INN)
2 Agents affecting individual organs
25 Urogenital and anal organ agents
252 Genital organ agents
2521 Antibiotics
D00104 Chloramphenicol (JP18/USP/INN)
26 Epidermides
263 Suppurative dermatosis agents
2634 Antibiotics for external use
D00104 Chloramphenicol (JP18/USP/INN)
6 Agents against pathologic organisms and parasites
61 Antibiotics
615 Acting mainly on gram-positive bacteria, gram-negative bacteria, rickettsia and chlamydia
6151 Chloramphenicols
D00104 Chloramphenicol (JP18/USP/INN)
Classification of Japanese OTC drugs [BR:br08313]
Agents for integumentary system
56 Purulent skin remedies
D00104 Chloramphenicol (JP18/USP/INN)
Risk category of Japanese OTC drugs [BR:br08312]
Second-class OTC drugs
Inorganic and organic chemicals
Chloramphenicol
D00104 Chloramphenicol (JP18/USP/INN)
Drug groups [BR:br08330]
Antibacterial
DG01576 Amphenicol type antibacterial
DG00399 Chloramphenicol
D00104 Chloramphenicol
Metabolizing enzyme inhibitor
DG01933 CYP2C19 inhibitor
D00104 Chloramphenicol
Antimicrobials [BR:br08307]
Antibacterials
Protein biosynthesis inhibitor
Amphenicol
D00104 Chloramphenicol (JP18/USP/INN) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00104 Chloramphenicol
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00104
Prodrugs [br08324.html]
D00104
Drug groups [BR:br08330]
Antibacterial
DG01576 Amphenicol type antibacterial
DG00399 Chloramphenicol
Antimicrobials abbreviations [BR:br08327]
Antibacterials
Protein biosynthesis inhibitor
Amphenicol
DG00399 Chloramphenicol
Prodrugs [br08324.html]
DG00399
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 20
1 C8y C 21.4200 -17.2900
2 C1c C 21.4200 -18.6900
3 C8x C 20.2300 -16.5900
4 C8x C 22.6800 -16.5900
5 C1c C 22.6100 -19.3900
6 O1a O 20.2300 -19.3900
7 C8x C 20.2300 -15.1900
8 C8x C 22.6800 -15.1900
9 N1b N 23.8700 -18.6900
10 C1b C 22.6100 -20.7900
11 C8y C 21.4200 -14.4900
12 C5a C 25.0600 -19.3900
13 O1a O 21.4200 -21.4900
14 N2b N 21.4200 -13.0900 #+
15 C1c C 26.2500 -18.6900
16 O5a O 25.0600 -20.7900
17 O3a O 20.2300 -12.3900
18 O3a O 22.6100 -12.3900 #-
19 X Cl 27.5100 -19.3900
20 X Cl 26.2500 -17.2900
BOND 20
1 1 2 1
2 1 3 2
3 1 4 1
4 2 5 1
5 2 6 1 #Down
6 3 7 1
7 4 8 2
8 5 9 1
9 5 10 1
10 7 11 2
11 9 12 1
12 10 13 1
13 11 14 1
14 12 15 1
15 12 16 2
16 14 17 2
17 14 18 1
18 15 19 1
19 15 20 1
20 8 11 1
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