KEGG   DRUG: Ibuprofen
Entry
D00126                      Drug                                   

Name
Ibuprofen (JP17/USP/INN);
Advil (TN);
Motrin (TN)
Product
  Generic
IBU (RedPharm Drug), IBU (RedPharm Drug), IBU (RedPharm Drug), IBUPROFEN (DIRECT RX), IBUPROFEN (Direct_Rx), IBUPROFEN (A-S Medication Solutions), IBU (A-S Medication Solutions), IBUPROFEN (A-S Medication Solutions), IBUPROFEN (A-S Medication Solutions), IBUPROFEN (A-S Medication Solutions), IBUPROFEN (A-S Medication Solutions), IBUPROFEN (A-S Medication Solutions), IBUPROFEN (A-S Medication Solutions), IBUPROFEN (A-S Medication Solutions), IBUPROFEN (A-S Medication Solutions), IBUPROFEN (A-S Medication Solutions), IBUPROFEN (A-S Medication Solutions), IBU (A-S Medication Solutions), IBUPROFEN (A-S Medication Solutions), IBUPROFEN (A-S Medication Solutions), IBUPROFEN (A-S Medication Solutions), IBUPROFEN (A-S Medication Solutions), IBU (A-S Medication Solutions), IBU (A-S Medication Solutions), IBUPROFEN (A-S Medication Solutions), IBUPROFEN (Actavis Pharma), IBUPROFEN (AiPing Pharmaceutical), IBUPROFEN (AiPing Pharmaceutical), IBUPROFEN (American Health Packaging), IBUPROFEN (Amneal Pharmaceuticals LLC), IBUPROFEN (Amneal Pharmaceuticals NY LLC), IBUPROFEN (Amneal Pharmaceuticals of New York LLC), IBUPROFEN (Amneal Pharmaceuticals of New York LLC), IBUPROFEN (Amneal Pharmaceuticals of New York LLC), IBUPROFEN (Amneal Pharmaceuticals of New York LLC), IBUPROFEN (Aphena Pharma Solutions - Tennessee), IBUPROFEN (Aphena Pharma Solutions - Tennessee), IBUPROFEN (Aphena Pharma Solutions - Tennessee), IBUPROFEN (Aphena Pharma Solutions - Tennessee), IBU (Aphena Pharma Solutions - Tennessee), IBUPROFEN (Aphena Pharma Solutions - Tennessee), IBUPROFEN (Aphena Pharma Solutions - Tennessee), IBUPROFEN (Aphena Pharma Solutions - Tennessee), IBUPROFEN (Aphena Pharma Solutions - Tennessee), IBUPROFEN (Aphena Pharma Solutions - Tennessee), IBUPROFEN (Aphena Pharma Solutions - Tennessee), IBUPROFEN (Aphena Pharma Solutions - Tennessee), IBU (Aphena Pharma Solutions - Tennessee), IBUPROFEN (Ascend Laboratories), IBUPROFEN (Aurobindo Pharma Limited), IBUPROFEN (AvKARE), IBUPROFEN (AvKARE), IBUPROFEN (Bryant Ranch Prepack), IBUPROFEN (Bryant Ranch Prepack), IBUPROFEN (Bryant Ranch Prepack), IBUPROFEN (Bryant Ranch Prepack), IBUPROFEN (Bryant Ranch Prepack), IBUPROFEN (Bryant Ranch Prepack), IBUPROFEN (Bryant Ranch Prepack), IBUPROFEN (Bryant Ranch Prepack), IBUPROFEN (Bryant Ranch Prepack), IBUPROFEN (Bryant Ranch Prepack), IBUPROFEN (Bryant Ranch Prepack), IBUPROFEN (Bryant Ranch Prepack), IBUPROFEN (Bryant Ranch Prepack), IBUPROFEN (Cardinal Health), IBUPROFEN (Cardinal Health), IBUPROFEN (Cardinal Health), IBUPROFEN (Contract Pharmacy Services-PA), IBUPROFEN (Contract Pharmacy Services-PA), IBUPROFEN (Contract Pharmacy Services-PA), IBUPROFEN (Contract Pharmacy Services-PA), IBUPROFEN (Contract Pharmacy Services-PA), IBUPROFEN (DIRECTRX), IBUPROFEN (Denton Pharma), IBUPROFEN (Denton Pharma), IBUPROFEN (Denton Pharma), IBU (Denton Pharma), IBUPROFEN (Denton Pharma), IBUPROFEN (Denton Pharma), IBUPROFEN (Denton Pharma), IBUPROFEN (Direct_Rx), IBUPROFEN (Direct_Rx), IBUPROFEN (Direct_Rx), IBU (Dr. Reddy's Laboratories Limited), IBU (Golden State Medical Supply), IBUPROFEN (Granules India Limited), IBUPROFEN (Hi-Tech Pharmacal), IBU (Lake Erie Medical DBA Quality Care Products LLC), IBU (Lake Erie Medical DBA Quality Care Products LLC), IBUPROFEN (Lake Erie Medical DBA Quality Care Products LLC), IBUPROFEN (Legacy Pharmaceutical Packaging), IBUPROFEN (MARKSANS PHARMA LIMITED), IBUPROFEN (Major Pharmaceuticals), IBUPROFEN (McKesson Corporation dba SKY Packaging), IBUPROFEN (Medsource Pharmaceuticals), IBUPROFEN (Medsource Pharmaceuticals), IBUPROFEN (Method Pharmaceuticals), IBU (NCS HealthCare of KY), IBUPROFEN (NCS HealthCare of KY), IBUPROFEN (NCS HealthCare of KY), IBUPROFEN (Northwind Pharmaceuticals), IBUPROFEN (Northwind Pharmaceuticals), IBU (NuCare Pharmaceuticals), IBU (NuCare Pharmaceuticals), IBU (NuCare Pharmaceuticals), IBUPROFEN (NuCare Pharmaceuticals), IBU (NuCare Pharmaceuticals), IBU (NuCare Pharmaceuticals), IBUPROFEN (NuCare Pharmaceuticals), IBUPROFEN (NuCare Pharmaceuticals), IBU (NuCare Pharmaceuticals), IBUPROFEN (NuCare Pharmaceuticals), IBUPROFEN (NuCare Pharmaceuticals), IBUPROFEN (NuCare Pharmaceuticals), IBUPROFEN (NuCare Pharmaceuticals), IBUPROFEN (NuCare Pharmaceuticals), IBU (NuCare Pharmaceuticals), IBUPROFEN (NuCare Pharmaceuticals), IBUPROFEN (NuCare Pharmaceuticals), IBUPROFEN (NuCare Pharmaceuticals), IBUPROFEN (NuCare Pharmaceuticals), IBUPROFEN (NuCare Pharmaceuticals), IBUPROFEN (NuCare Pharmaceuticals), IBUPROFEN (NuCare Pharmaceuticals), IBUPROFEN (NuCare Pharmaceuticals), IBUPROFEN (NuCare Pharmaceuticals), IBUPROFEN (NuCare Pharmaceuticals), IBUPROFEN (NuCare Pharmaceuticals), IBUPROFEN (NuCare Pharmaceuticals), IBUPROFEN (NuCare Pharmaceuticals), IBUPROFEN (NuCare Pharmaceuticals), IBUPROFEN (NuCare Pharmaceuticals), IBUPROFEN (NuCare Pharmaceuticals), IBUPROFEN (NuCare Pharmaceuticals), IBUPROFEN (NuCare Pharmaceuticals), IBUPROFEN (NuCare Pharmaceuticalsf), IBUPROFEN (PD-Rx Pharmaceuticals), IBUPROFEN (PD-Rx Pharmaceuticals), IBUPROFEN (PD-Rx Pharmaceuticals), IBUPROFEN (PD-Rx Pharmaceuticals), IBUPROFEN (PD-Rx Pharmaceuticals), IBUPROFEN (PD-Rx Pharmaceuticals), IBUPROFEN (PD-Rx Pharmaceuticals), IBUPROFEN (PD-Rx Pharmaceuticals), IBUPROFEN (PD-Rx Pharmaceuticals), IBUPROFEN (PD-Rx Pharmaceuticals), IBUPROFEN (PD-Rx Pharmaceuticals), IBUPROFEN (PD-Rx Pharmaceuticals), IBUPROFEN (Perrigo New York), IBUPROFEN (PharmPak), IBUPROFEN (PharmPak), IBUPROFEN (PharmPak), IBUPROFEN (Pharmaceutical Associates), IBUPROFEN (Pharmaceutical Associates), IBUPROFEN (Preferred Pharmaceuticals), IBUPROFEN (Preferred Pharmaceuticals), IBUPROFEN (Preferred Pharmaceuticals), IBUPROFEN (Preferred Pharmaceuticals), IBUPROFEN (Preferred Pharmaceuticals), IBUPROFEN (Preferred Pharmaceuticals), IBUPROFEN (Preferred Pharmaceuticals), IBUPROFEN (Proficient Rx LP), IBUPROFEN (Proficient Rx LP), IBUPROFEN (Proficient Rx LP), IBUPROFEN (Proficient Rx LP), IBUPROFEN (Proficient Rx LP), IBU (Proficient Rx LP), IBUPROFEN (Proficient Rx LP), IBUPROFEN (Proficient Rx LP), IBUPROFEN (Proficient Rx LP), IBUPROFEN (Proficient Rx LP), IBUPAK (PureTek Corporation), IBUPROFEN (QPharma), IBUPROFEN (QPharma), IBUPROFEN (QPharma), IBUPROFEN (Quality Care Products), IBUPROFEN (REMEDYREPACK), IBUPROFEN (REMEDYREPACK), IBUPROFEN (REMEDYREPACK), IBUPROFEN (REMEDYREPACK), IBUPROFEN (REMEDYREPACK), IBUPROFEN (REMEDYREPACK), IBUPROFEN (REMEDYREPACK), IBUPROFEN (REMEDYREPACK), IBUPROFEN (REMEDYREPACK), IBUPROFEN (RPK Pharmaceuticals), IBU (RPK Pharmaceuticals), IBU (RPK Pharmaceuticals), IBUPROFEN (RedPharm Drug), IBUPROFEN (RedPharm Drug), IBUPROFEN (RedPharm Drug), IBUPROFEN (RedPharm Drug), IBUPROFEN (RedPharm Drug), IBUPROFEN (RedPharm Drug), IBUPROFEN (RedPharm Drug), IBUPROFEN (RedPharm Drug), IBUPROFEN (RedPharm Drug), IBUPROFEN (RedPharm Drug), IBUPROFEN (RedPharm Drug), IBUPROFEN (RedPharm Drug), IBUPROFEN (RedPharm Drug), IBUPROFEN (RedPharm Drug), IBUPROFEN (RedPharm Drug), IBUPROFEN (RedPharm Drug), IBUPROFEN (RedPharm Drug), IBU (St. Mary's Medical Park Pharmacy), IBU (St. Mary's Medical Park Pharmacy), IBUPROFEN (St. Mary's Medical Park Pharmacy), IBUPROFEN (St. Mary's Medical Park Pharmacy), IBUPROFEN (St. Mary's Medical Park Pharmacy), IBUPROFEN (St. Mary's Medical Park Pharmacy), IBUPROFEN (St. Mary's Medical Park Pharmacy), IBUPROFEN (St. Mary's Medical Park Pharmacy), IBUPROFEN (Strides Pharma), IBUPROFEN (Strides Pharma Science Limited), IBUPROFEN (TIME CAP LABORATORIES), IBUPROFEN (Taro Pharmaceuticals U.S.A.), IBUPROFEN (VistaPharm), IBUPROFEN (medsource pharmaceuticals), IBUPROFEN (Advanced Rx Pharmacy of Tennessee), MOTRIN (Advanced Rx Pharmacy of Tennessee), MOTRIN (Advanced Rx Pharmacy of Tennessee), MOTRIN (Advanced Rx Pharmacy of Tennessee), IBUPROFEN (Aurobindo Pharma Limited), IBUPROFEN ORAL (Bryant Ranch Prepack)
Formula
C13H18O2
Exact mass
206.1307
Mol weight
206.2808
Structure
Simcomp
Class
Anti-inflammatory
 DG01908  Anti-inflammatory drug, propionic acid derivatives
 DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
  DG01908  Anti-inflammatory drug, propionic acid derivatives
Metabolizing enzyme substrate
 DG01642  CYP2C9 substrate
Remark
Same as: C01588
Therapeutic category: 1149
ATC code: C01EB16 G02CC01 M01AE01 M02AA13 R02AX02
Chemical structure group: DG00245
Product (DG00245): D00126<JP/US> D01122<JP> D06606<JP/US>
Product (mixture): D02152<US> D11573<US> D11575<US>
Efficacy
Analgesic, Anti-inflammatory, Antipyretic, COX inhibitor
Comment
Propionic acid derivative
Target
PTGS1 (COX1) [HSA:5742] [KO:K00509]
PTGS2 (COX2) [HSA:5743] [KO:K11987]
  Pathway
hsa00590  Arachidonic acid metabolism
Metabolism
Enzyme: CYP2C9 [HSA:1559]
Interaction
Structure map
map07048  Antimigraines
map07219  Cyclooxygenase inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01E OTHER CARDIAC PREPARATIONS
    C01EB Other cardiac preparations
     C01EB16 Ibuprofen
      D00126  Ibuprofen (JP17/USP/INN) <JP/US>
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G02 OTHER GYNECOLOGICALS
   G02C OTHER GYNECOLOGICALS
    G02CC Antiinflammatory products for vaginal administration
     G02CC01 Ibuprofen
      D00126  Ibuprofen (JP17/USP/INN) <JP/US>
 M MUSCULO-SKELETAL SYSTEM
  M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
   M01A ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
    M01AE Propionic acid derivatives
     M01AE01 Ibuprofen
      D00126  Ibuprofen (JP17/USP/INN) <JP/US>
  M02 TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
   M02A TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
    M02AA Antiinflammatory preparations, non-steroids for topical use
     M02AA13 Ibuprofen
      D00126  Ibuprofen (JP17/USP/INN) <JP/US>
 R RESPIRATORY SYSTEM
  R02 THROAT PREPARATIONS
   R02A THROAT PREPARATIONS
    R02AX Other throat preparetions
     R02AX02 Ibuprofen
      D00126  Ibuprofen (JP17/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Analgesics
  Nonsteroidal Anti-inflammatory Drugs
   Ibuprofen
    D00126  Ibuprofen (JP17/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   114  Antipyretics and analgesics, anti-inflammatory agents
    1149  Others
     D00126  Ibuprofen (JP17/USP/INN)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for nervous and sensory systems
  01 Cold remedy (oral use)
   D00126  Ibuprofen (JP17/USP/INN)
  03 Antipyretic analgesic agents
   D00126  Ibuprofen (JP17/USP/INN)
Risk category of Japanese OTC drugs [BR:br08312]
 Designated second-class OTC drugs
  Inorganic and organic chemicals
   Ibuprofen
    D00126  Ibuprofen (JP17/USP/INN)
 Second-class OTC drugs
  Inorganic and organic chemicals
   Ibuprofen
    D00126  Ibuprofen (JP17/USP/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Prostaglandin synthase
    PTGS1 (COX1)
     D00126  Ibuprofen (JP17/USP/INN) <JP/US>
    PTGS2 (COX2)
     D00126  Ibuprofen (JP17/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00126  Ibuprofen
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D00126
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00126
Prodrugs [br08324.html]
 D00126
Rx-to-OTC switch list in the USA [br08315.html]
 D00126
Rx-to-OTC switch list in Japan [br08314.html]
 D00126
Other DBs
CAS: 15687-27-1
PubChem: 7847194
ChEBI: 5855
ChEMBL: CHEMBL521
DrugBank: DB01050
LigandBox: D00126
NIKKAJI: J3.134H
LinkDB
KCF data

ATOM        15
            1   O6a O    26.6164  -16.3136
            2   C6a C    25.4050  -17.0138
            3   C1c C    24.1928  -16.3148
            4   O6a O    25.4056  -18.4130
            5   C8y C    22.9815  -17.0150
            6   C8x C    21.7750  -16.3132
            7   C8x C    20.5638  -17.0135
            8   C8y C    20.5644  -18.4127
            9   C8x C    21.7765  -19.1116
            10  C8x C    22.9878  -18.4113
            11  C1b C    19.3530  -19.1128
            12  C1c C    18.1408  -18.4139
            13  C1a C    16.9295  -19.1141
            14  C1a C    18.1401  -17.0147
            15  C1a C    24.1920  -14.9103
BOND        15
            1     2   4 2
            2     3   5 1
            3     5   6 2
            4     6   7 1
            5     7   8 2
            6     8   9 1
            7     9  10 2
            8    10   5 1
            9     8  11 1
            10    1   2 1
            11   11  12 1
            12   12  13 1
            13    2   3 1
            14   12  14 1
            15    3  15 1

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