| Entry |
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| Name |
Ibuprofen lysine (USAN);
Ibuprofen L-lysine (JAN);
Solufenum;
Neoprofen (TN) |
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| Product |
|
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| Generic |
|
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| Formula |
C13H18O2. C6H14N2O2
|
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| Exact mass |
352.2362
|
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| Mol weight |
352.47
|
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| Structure |
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| Simcomp |
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| Class |
Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
DG01908 Anti-inflammatory drug, propionic acid derivative
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
|
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| Remark |
| Therapeutic category: | 2190 |
| Product (DG00245): | D00126<JP/US> D01122<JP> D06606<JP/US> |
|
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| Efficacy |
Anti-inflammatory, COX inhibitor |
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| Disease |
Patent ductus arteriosus [DS: H01630] |
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| Comment |
Propionic acid derivative
|
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| Target |
|
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| Pathway |
|
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| Metabolism |
Enzyme: CYP2C9 [HSA: 1559]
|
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| Interaction |
|
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| Structure map |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C01 CARDIAC THERAPY
C01E OTHER CARDIAC PREPARATIONS
C01EB Other cardiac preparations
C01EB16 Ibuprofen
D06606 Ibuprofen lysine (USAN) <JP/US>
G GENITO URINARY SYSTEM AND SEX HORMONES
G02 OTHER GYNECOLOGICALS
G02C OTHER GYNECOLOGICALS
G02CC Antiinflammatory products for vaginal administration
G02CC01 Ibuprofen
D06606 Ibuprofen lysine (USAN) <JP/US>
M MUSCULO-SKELETAL SYSTEM
M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
M01A ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
M01AE Propionic acid derivatives
M01AE01 Ibuprofen
D06606 Ibuprofen lysine (USAN) <JP/US>
M02 TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
M02A TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
M02AA Antiinflammatory preparations, non-steroids for topical use
M02AA13 Ibuprofen
D06606 Ibuprofen lysine (USAN) <JP/US>
R RESPIRATORY SYSTEM
R02 THROAT PREPARATIONS
R02A THROAT PREPARATIONS
R02AX Other throat preparations
R02AX02 Ibuprofen
D06606 Ibuprofen lysine (USAN) <JP/US>
USP drug classification [BR:br08302]
Analgesics
Nonsteroidal Anti-inflammatory Drugs
Ibuprofen
D06606 Ibuprofen lysine (USAN)
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
21 Cardiovascular agents
219 Miscellaneous
2190 Miscellaneous
D06606 Ibuprofen lysine (USAN); Ibuprofen L-lysine (JAN)
Drug groups [BR:br08330]
Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
DG01908 Anti-inflammatory drug, propionic acid derivative
DG00245 Ibuprofen
D06606 Ibuprofen lysine
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
DG00245 Ibuprofen
D06606 Ibuprofen lysine
Drug classes [BR:br08332]
Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
D06606 Ibuprofen lysine
Target-based classification of drugs [BR:br08310]
Enzymes
Oxidoreductases (EC1)
Prostaglandin synthase
PTGS1 (COX1)
D06606 Ibuprofen lysine (USAN) <JP/US>
PTGS2 (COX2)
D06606 Ibuprofen lysine (USAN) <JP/US>
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
D06606
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D06606
Drug groups [BR:br08330]
Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
DG01908 Anti-inflammatory drug, propionic acid derivative
DG00245 Ibuprofen
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
DG00245 Ibuprofen
|
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 25
1 O6a O 20.3332 -6.2439
2 C6a C 19.1211 -6.9446
3 C1c C 17.9081 -6.2451
4 O6a O 19.1217 -8.3447
5 C8y C 16.6960 -6.9458
6 C8x C 15.4888 -6.2435
7 C8x C 14.2768 -6.9443
8 C8y C 14.2774 -8.3444
9 C8x C 15.4903 -9.0437
10 C8x C 16.7023 -8.3429
11 C1b C 13.0652 -9.0449
12 C1c C 11.8523 -8.3456
13 C1a C 10.6402 -9.0462
14 C1a C 11.8516 -6.9455
15 C1a C 17.9073 -4.8397
16 C1c C 25.1750 -7.3860
17 C1b C 26.3902 -6.7082
18 C6a C 24.0241 -6.6381
19 N1a N 25.2159 -8.7940
20 C1b C 27.5997 -7.4211
21 O6a O 22.7971 -7.3218
22 O6a O 24.0240 -5.2357
23 C1b C 28.8269 -6.7373
24 C1b C 30.0364 -7.4562
25 N1a N 31.2633 -6.7724
BOND 24
1 2 4 2
2 3 5 1
3 5 6 2
4 6 7 1
5 7 8 2
6 8 9 1
7 9 10 2
8 10 5 1
9 8 11 1
10 1 2 1
11 11 12 1
12 12 13 1
13 2 3 1
14 12 14 1
15 3 15 1
16 16 17 1
17 16 18 1
18 16 19 1 #Down
19 17 20 1
20 18 21 1
21 18 22 2
22 20 23 1
23 23 24 1
24 24 25 1
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