KEGG   DRUG: PiroxicamHelp
Entry
D00127                      Drug                                   

Name
Piroxicam (JP17/USP/INN);
Feldene (TN)
Product
  Generic
PIROXICAM (A-S Medication Solutions), PIROXICAM (A-S Medication Solutions), PIROXICAM (Aphena Pharma Solutions - Tennessee), PIROXICAM (AvKARE), PIROXICAM (DIRECT RX), PIROXICAM (DIRECT RX), PIROXICAM (Golden State Medical Supply), PIROXICAM (H.J. Harkins Company), FELDENE (Keltman Pharmaceuticals), PIROXICAM (Lake Erie Medical DBA Quality Care Products LLC), PIROXICAM (Lake Erie Medical DBA Quality Care Products LLC), PIROXICAM (Micro Labs Limited), PIROXICAM (Mylan Pharmaceuticals), PIROXICAM (Nivagen Pharmaceuticals), PIROXICAM (Northstar Rx LLC), PIROXICAM (Nostrum Laboratories), PIROXICAM (PD-Rx Pharmaceuticals), PIROXICAM (Proficient Rx LP), PIROXICAM (Proficient Rx LP), PIROXICAM (Rebel Distributors Corp), PIROXICAM (Rebel Distributors Corp), PIROXICAM (Strides Shasun Limited), PIROXICAM (Sun Pharmaceutical Industries), PIROXICAM (Teva Pharmaceuticals USA), PIROXICAM (Unichem Pharmaceuticals (USA)), PIROXICAM (Unit Dose Services), PIROXICAM (Vensun Pharmaceuticals), PIROXICAM (West-Ward Pharmaceuticals Corp)
Formula
C15H13N3O4S
Exact mass
331.0627
Mol weight
331.3464
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Anti-inflammatory
 DG01504  Nonsteroidal antiinflammatory drug (NSAID)
  DG01910  Antiinflammatory drug, oxicams
 DG01910  Antiinflammatory drug, oxicams
Enzyme substrate
 DG01642  CYP2C9 substrate
 DG01633  CYP3A substrate
Remark
Same as: C01608
Therapeutic category: 1149 2649
ATC code: M01AC01 M02AA07 S01BC06
Chemical structure group: DG00752
Product (DG00752): D00127<JP/US>
Efficacy
Analgesic, Anti-inflammatory, Antirheumatic, COX inhibitor
  Disease
Rheumatoid arthritis [DS:H00630]
Comment
Oxicams
Target
PTGS1 (COX1) [HSA:5742] [KO:K00509]
PTGS2 (COX2) [HSA:5743] [KO:K11987]
  Pathway
hsa00590  Arachidonic acid metabolism
Metabolism
Enzyme: CYP2C9 [HSA:1559]
Interaction
Drug interaction
Structure map
map07219  Cyclooxygenase inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 M MUSCULO-SKELETAL SYSTEM
  M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
   M01A ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
    M01AC Oxicams
     M01AC01 Piroxicam
      D00127  Piroxicam (JP17/USP/INN) <JP/US>
  M02 TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
   M02A TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
    M02AA Antiinflammatory preparations, non-steroids for topical use
     M02AA07 Piroxicam
      D00127  Piroxicam (JP17/USP/INN) <JP/US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BC Antiinflammatory agents, non-steroids
     S01BC06 Piroxicam
      D00127  Piroxicam (JP17/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Analgesics
  Nonsteroidal Anti-inflammatory Drugs
   Piroxicam
    D00127  Piroxicam (JP17/USP/INN)
 Anti-inflammatory Agents
  Nonsteroidal Anti-inflammatory Drugs
   Piroxicam
    D00127  Piroxicam (JP17/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   114  Antipyretics and analgesics, anti-inflammatory agents
    1149  Others
     D00127  Piroxicam (JP17/USP/INN)
 2  Agents affecting individual organs
  26  Epidermides
   264  Analgesics, anti-itchings, astringents, anti-inflammatory agents
    2649  Others
     D00127  Piroxicam (JP17/USP/INN)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for integumentary system
  57 Analgesic, antipruritic, astringent, and anti-inflammatory remedies (incl. gel patches)
   D00127  Piroxicam (JP17/USP/INN)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Piroxicam
    D00127  Piroxicam (JP17/USP/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Prostaglandin synthase
    PTGS1 (COX1)
     D00127  Piroxicam (JP17/USP/INN) <JP/US>
    PTGS2 (COX2)
     D00127  Piroxicam (JP17/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00127  Piroxicam
Drug classes of therapeutic agents [br08360.html]
 Antirheumatic and antigout agents
  D00127
 Anesthetics, analgesics and anti-inflammatory drugs
  D00127
Rx-to-OTC switch list in Japan [br08314.html]
 D00127
Pharmacogenomic biomarkers [br08341.html]
 Polymorphisms and germline mutations
  D00127
Prodrugs [br08324.html]
 D00127
BRITE hierarchy
Other DBs
CAS: 36322-90-4
PubChem: 7847195
ChEBI: 8249
ChEMBL: CHEMBL527
DrugBank: DB00554
LigandBox: D00127
NIKKAJI: J3.498C
LinkDB All DBs
KCF data Show

ATOM        23
            1   C8y C    21.6417  -19.0786
            2   C8y C    21.6417  -20.4557
            3   C8y C    22.8309  -18.3776
            4   C8x C    20.4462  -18.3965
            5   S2x S    22.8434  -21.1442
            6   C8x C    20.4462  -21.1504
            7   C8y C    24.0327  -19.0724
            8   O1a O    22.8247  -17.0194
            9   C8x C    19.2695  -19.0786
            10  N4y N    23.9752  -20.4619
            11  O3c O    21.2912  -22.1144
            12  O3c O    24.2329  -22.0643
            13  C8x C    19.2695  -20.4557
            14  C5a C    25.2092  -18.3840
            15  C1a C    25.2218  -21.1378
            16  O5a O    25.2031  -17.0257
            17  N1b N    26.3932  -19.0594
            18  C8y C    27.5703  -18.3716
            19  N5x N    28.7479  -19.0436
            20  C8x C    29.9249  -18.3558
            21  C8x C    29.9178  -16.9927
            22  C8x C    28.7338  -16.3171
            23  C8x C    27.5569  -17.0049
BOND        25
            1     3   8 1
            2     4   9 2
            3     5  10 1
            4     5  11 2
            5     5  12 2
            6     6  13 2
            7     7  14 1
            8    10  15 1
            9    14  16 2
            10    7  10 1
            11    9  13 1
            12   14  17 1
            13    1   2 2
            14   17  18 1
            15    1   3 1
            16    1   4 1
            17    2   5 1
            18    2   6 1
            19    3   7 2
            20   18  19 2
            21   19  20 1
            22   20  21 2
            23   21  22 1
            24   22  23 2
            25   23  18 1

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