KEGG   DISEASE: Rheumatoid arthritis
H00630                      Disease                                

Rheumatoid arthritis
Rheumatoid arthritis (RA) is a common autoimmune disease that primarily manifests as chronic inflammatory arthropathy. Persistent synovitis leads to cartilage destruction, bone erosions and periarticular decalcification, subsequently resulting in impaired joint function. It is more common between the ages of 35 and 50 years, affecting three times more women than men. Susceptibility to RA is genetically determined with multiple genes contributing. Inheritance of HLA DRB1 alleles encoding a distinctive five-amino-acid sequence known as the "shared epitope" (SE) is the best characterized genetic risk factor. The mechanism by which the SE alleles contribute to the development of RA is not very clear. It has been postulated that the presence of these conserved sequences in the antigen-binding groove alters the way antigenic peptides are bound to and presented to T-cell lymphocytes. This, in turn, may trigger abnormal immune responses and lead to RA.
Immune system disease
Human diseases [BR:br08402]
 Immune system diseases
  Allergies and autoimmune diseases
   H00630  Rheumatoid arthritis
Human diseases in ICD-11 classification [BR:br08403]
 15 Diseases of the musculoskeletal system or connective tissue
   Inflammatory arthropathies
    FA20  Rheumatoid arthritis
     H00630  Rheumatoid arthritis
hsa05323  Rheumatoid arthritis
Triamcinolone acetonide [DR:D00983]
Dexamethasone [DR:D00292]
Dexamethasone sodium phosphate [DR:D00975]
Hydrocortisone [DR:D00088]
Hydrocortisone sodium succinate [DR:D00978]
Prednisolone [DR:D00472]
Prednisolone sodium phosphate [DR:D00981]
Prednisone [DR:D00473]
Sulfasalazine [DR:D00448]
Indomethacin [DR:D00141]
Methylprednisolone [DR:D00407]
Methylprednisolone sodium succinate [DR:D00751]
Methylprednisolone acetate [DR:D00979]
Naproxen [DR:D00118]
Naproxen sodium [DR:D00970]
Corticotropin [DR:D00146]
Cortisone acetate [DR:D00973]
Methotrexate [DR:D00142]
Methotrexate sodium [DR:D02115]
Rituximab [DR:D02994]
Celecoxib [DR:D00567]
Leflunomide [DR:D00749]
Abatacept [DR:D03203]
Tofacitinib citrate [DR:D09783]
Baricitinib [DR:D10308]
Upadacitinib hydrate [DR:D11048]
Etanercept [DR:D00742]
Infliximab [DR:D02598]
Adalimumab [DR:D02597]
Certolizumab pegol [DR:D03441]
Golimumab [DR:D04358]
Anakinra [DR:D02934]
Tocilizumab [DR:D02596]
Sarilumab [DR:D10161]
Cyclosporine [DR:D00184]
Azathioprine [DR:D00238]
Diclofenac sodium and misoprostol [DR:D11091]
Piroxicam [DR:D00127]
Fenoprofen calcium [DR:D00968]
Flurbiprofen [DR:D00330]
Oxaprozin [DR:D00463]
Ibuprofen and famotidine [DR:D11575]
Naproxen and esomeprazole magnesium [DR:D11576]
Meclofenamate sodium [DR:D00169]
Auranofin [DR:D00237]
Salsalate [DR:D00428]
Hydroxychloroquine sulfate [DR:D02114]
Lobenzarit sodium [DR:D01808]
Other DBs
ICD-11: FA20
ICD-10: M05
MeSH: D001172
PMID:27338350 (gene, drug)
Chung IM, Ketharnathan S, Thiruvengadam M, Rajakumar G
Rheumatoid Arthritis: The Stride from Research to Clinical Practice.
Int J Mol Sci 17:E900 (2016)
Papadakis MA and McPhee SJ |(ed)
Current Medical Diagnosis & Treatment 2015, Fifty-Fourth Edition
McGraw Hill Education
PMID:23998731 (drug)
Meier FM, Frerix M, Hermann W, Muller-Ladner U
Current immunotherapy in rheumatoid arthritis.
Immunotherapy 5:955-74 (2013)
Boissier MC, Semerano L, Challal S, Saidenberg-Kermanac'h N, Falgarone G
Rheumatoid arthritis: from autoimmunity to synovitis and joint destruction.
J Autoimmun 39:222-8 (2012)

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