KEGG   DRUG: Indomethacin
Entry
D00141                      Drug                                   
Name
Indomethacin (USP);
Indometacin (JP18/INN);
Aconip (TN);
Indocin (TN)
Product
INDOCIN (Zyla Life Sciences US LLC), INDOMETHACIN (Fresenius Kabi USA), INDOMETHACIN (Fresenius Kabi USA), INDOMETHACIN (Fresenius Kabi USA)
  Generic
INDOCIN (Zyla Life Sciences US LLC), INDOMETHACIN (A-S Medication Solutions), INDOMETHACIN (A-S Medication Solutions), INDOMETHACIN (A-S Medication Solutions), INDOMETHACIN (A-S Medication Solutions), INDOMETHACIN (A-S Medication Solutions), INDOMETHACIN (ANI Pharmaceuticals), INDOMETHACIN (Advanced Rx Pharmacy of Tennessee), INDOMETHACIN (American Health Packaging), INDOMETHACIN (Amneal Pharmaceuticals LLC), INDOMETHACIN (Amneal Pharmaceuticals NY LLC), INDOMETHACIN (Asclemed USA), INDOMETHACIN (Asclemed USA), INDOMETHACIN (AvPAK), INDOMETHACIN (Bryant Ranch Prepack), INDOMETHACIN (Bryant Ranch Prepack), INDOMETHACIN (Bryant Ranch Prepack), INDOMETHACIN (Bryant Ranch Prepack), INDOMETHACIN (Bryant Ranch Prepack), INDOMETHACIN (Bryant Ranch Prepack), INDOMETHACIN (Bryant Ranch Prepack), INDOMETHACIN (Bryant Ranch Prepack), INDOMETHACIN (Bryant Ranch Prepack), INDOMETHACIN (Bryant Ranch Prepack), INDOMETHACIN (Bryant Ranch Prepack), INDOMETHACIN (Bryant Ranch Prepack), INDOMETHACIN (Bryant Ranch Prepack), INDOMETHACIN (Bryant Ranch Prepack), INDOMETHACIN (Bryant Ranch Prepack), INDOMETHACIN (Camber Pharmaceuticals), INDOMETHACIN (Camber Pharmaceuticals), INDOMETHACIN (Chartwell RX), INDOMETHACIN (Chartwell RX), INDOMETHACIN (DIRECT RX), INDOMETHACIN (Glenmark Pharmaceuticals), INDOMETHACIN (Glenmark Pharmaceuticals), INDOMETHACIN (Hikma Pharmaceuticals USA), INDOMETHACIN (KVK-Tech), INDOMETHACIN (Northwind Pharmaceuticals), INDOMETHACIN (Northwind Pharmaceuticals), INDOMETHACIN (Northwind Pharmaceuticals), INDOMETHACIN (Northwind Pharmaceuticals), INDOMETHACIN (NuCare Pharmaceuticals), INDOMETHACIN (NuCare Pharmaceuticals), INDOMETHACIN (NuCare Pharmaceuticals), INDOMETHACIN (PD-Rx Pharmaceuticals), INDOMETHACIN (PD-Rx Pharmaceuticals), INDOMETHACIN (PD-Rx Pharmaceuticals), INDOMETHACIN (PD-Rx Pharmaceuticals), INDOMETHACIN (PD-Rx Pharmaceuticals), INDOMETHACIN (PD-Rx Pharmaceuticals), INDOMETHACIN (Preferred Pharmaceuticals), INDOMETHACIN (Preferred Pharmaceuticals), INDOMETHACIN (Preferred Pharmaceuticals), INDOMETHACIN (Preferred Pharmaceuticals), INDOMETHACIN (Proficient Rx LP), INDOMETHACIN (Proficient Rx LP), INDOMETHACIN (Proficient Rx LP), INDOMETHACIN (Proficient Rx LP), INDOMETHACIN (Proficient Rx LP), INDOMETHACIN (Proficient Rx LP), INDOMETHACIN (REMEDYREPACK), INDOMETHACIN (REMEDYREPACK), INDOMETHACIN (REMEDYREPACK), INDOMETHACIN (REMEDYREPACK), INDOMETHACIN (RedPharm Drug), INDOMETHACIN (RedPharm Drug), INDOMETHACIN (RedPharm Drug), INDOMETHACIN (RedPharm Drug), INDOMETHACIN (ST. MARY'S MEDICAL PARK PHARMACY), INDOMETHACIN (St. Mary's Medical Park Pharmacy), INDOMETHACIN (Viona Pharmaceuticals), INDOMETHACIN (XLCare Pharmaceuticals), INDOMETHACIN (Zydus Lifesciences Limited), INDOMETHACIN (Zydus Lifesciences Limited), INDOMETHACIN (Zydus Lifesciences Limited), INDOMETHACIN (Zydus Pharmaceuticals USA), INDOMETHACIN (Zydus Pharmaceuticals USA), INDOMETHACIN (Zydus Pharmaceuticals USA)
Formula
C19H16ClNO4
Exact mass
357.0768
Mol weight
357.79
Structure
Simcomp
Class
Anti-inflammatory
 DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
  DG01906  Anti-inflammatory drug, acetic acid derivatives
   DG01899  Anti-inflammatory drug, indoleacetic acid derivatives
Remark
Same as: C01926
Therapeutic category: 1145 2649
ATC code: C01EB03 M01AB01 M02AA23 S01BC01
Chemical structure group: DG00241
Product (DG00241): D00141<JP/US> D01565<JP> D02110<JP>
Efficacy
Analgesic, Anti-inflammatory, Antipyretic, COX inhibitor
  Disease
Rheumatoid arthritis [DS:H00630]
Ankylosing spondylitis [DS:H01674]
Acute gouty arthritis [DS:H01532]
Comment
Indole acetic acid derivative
Target
PTGS1 (COX1) [HSA:5742] [KO:K00509]
PTGS2 (COX2) [HSA:5743] [KO:K11987]
  Pathway
hsa00590  Arachidonic acid metabolism
Interaction
Structure map
map07219  Cyclooxygenase inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01E OTHER CARDIAC PREPARATIONS
    C01EB Other cardiac preparations
     C01EB03 Indometacin
      D00141  Indomethacin (USP) <JP/US>
 M MUSCULO-SKELETAL SYSTEM
  M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
   M01A ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
    M01AB Acetic acid derivatives and related substances
     M01AB01 Indometacin
      D00141  Indomethacin (USP) <JP/US>
  M02 TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
   M02A TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
    M02AA Antiinflammatory preparations, non-steroids for topical use
     M02AA23 Indometacin
      D00141  Indomethacin (USP) <JP/US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BC Antiinflammatory agents, non-steroids
     S01BC01 Indometacin
      D00141  Indomethacin (USP) <JP/US>
USP drug classification [BR:br08302]
 Analgesics
  Nonsteroidal Anti-inflammatory Drugs
   Indomethacin
    D00141  Indomethacin (USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   114  Antipyretics and analgesics, anti-inflammatory agents
    1145  Indomethacins
     D00141  Indomethacin (USP); Indometacin (JP18/INN)
 2  Agents affecting individual organs
  26  Epidermides
   264  Analgesics, anti-itchings, astringents, anti-inflammatory agents
    2649  Others
     D00141  Indomethacin (USP); Indometacin (JP18/INN)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for integumentary system
  57 Analgesic, antipruritic, astringent, and anti-inflammatory remedies (incl. gel patches)
   D00141  Indomethacin (USP)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Indometacin
    D00141  Indomethacin (USP)
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
   DG01906  Anti-inflammatory drug, acetic acid derivatives
    DG01899  Anti-inflammatory drug, indoleacetic acid derivatives
     DG00241  Indometacin
      D00141  Indomethacin
Drug classes [BR:br08332]
 Anti-inflammatory
  DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
   D00141  Indomethacin
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Prostaglandin synthase
    PTGS1 (COX1)
     D00141  Indomethacin (USP) <JP/US>
    PTGS2 (COX2)
     D00141  Indomethacin (USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00141  Indometacin
  D00141  Indometacin capsules
  D00141  Indometacin suppositories
Prodrugs [br08324.html]
 D00141
Rx-to-OTC switch list in Japan [br08314.html]
 D00141
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
   DG01906  Anti-inflammatory drug, acetic acid derivatives
    DG01899  Anti-inflammatory drug, indoleacetic acid derivatives
     DG00241  Indometacin
Other DBs
CAS: 53-86-1
PubChem: 7847209
ChEBI: 49662
PDB-CCD: IMN[PDBj]
LigandBox: D00141
NIKKAJI: J1.368D
LinkDB
KCF data

ATOM        25
            1   C8y C    23.8648  -19.0768
            2   C8y C    23.8564  -20.5490
            3   C1a C    25.1409  -21.2966
            4   C6a C    26.4256  -19.0915
            5   C1b C    25.1494  -18.3439
            6   C8y C    21.5264  -20.4363
            7   C8y C    21.5264  -19.0827
            8   N4y N    22.7025  -21.1172
            9   C8x C    20.3428  -21.1031
            10  C8x C    20.3428  -18.3946
            11  C5a C    22.7118  -22.4351
            12  C8x C    19.1807  -20.4363
            13  C8y C    19.1807  -19.0827
            14  C8y C    21.9087  -22.9293
            15  O2a O    18.0197  -18.4158
            16  C8x C    20.7461  -22.2186
            17  C8x C    21.8611  -24.2805
            18  C1a C    16.8577  -19.0968
            19  C8x C    19.5535  -22.8588
            20  C8x C    20.6841  -24.9202
            21  C8y C    19.5286  -24.2071
            22  X   Cl   18.3219  -24.7917
            23  O6a O    27.7101  -18.3588
            24  O6a O    26.4256  -20.5638
            25  O5a O    23.9557  -23.1242
BOND        27
            1     2   3 1
            2     6   7 2
            3     6   8 1
            4     6   9 1
            5     7   1 1
            6     7  10 1
            7     8   2 1
            8     8  11 1
            9     9  12 2
            10   10  13 2
            11   11  14 1
            12   13  15 1
            13   14  16 2
            14   14  17 1
            15   15  18 1
            16   16  19 1
            17   17  20 2
            18   19  21 2
            19   21  22 1
            20   12  13 1
            21   20  21 1
            22    4   5 1
            23    4  23 1
            24    5   1 1
            25    4  24 2
            26    1   2 2
            27   11  25 2

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