KEGG   DRUG: Cytarabine
Entry
D00168                      Drug                                   
Name
Cytarabine (JP18/USP/INN);
ARA-C;
Depocyt (TN)
Product
  Generic
Formula
C9H13N3O5
Exact mass
243.0855
Mol weight
243.2166
Structure
Simcomp
Class
Antineoplastic
 DG02018  Antimetabolite
  DG01958  Nucleic acid derivative, antineoplastic
   DG01439  Arabinofuranosyl type antineoplastic
Remark
Same as: C02961
Therapeutic category: 4224
ATC code: L01BC01
Chemical structure group: DG00686
Product (DG00686): D00168<JP/US> D03046<JP>
Product (mixture): D11390<US>
Efficacy
Antineoplastic, Antimetabolite, DNA polymerase inhibitor
  Disease
Lymphomatous meningitis [DS:H01668]
Acute myeloid leukemia [DS:H00003]
Chronic myelocytic leukemia [DS:H00004]
Comment
Active metabolite: Cytarabine-5;-triphosphate (ara-CTP)
Target
DNA polymerase
Interaction
Structure map
map07041  Antineoplastics - antimetabolic agents
map07046  Immunosuppressive agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01B ANTIMETABOLITES
    L01BC Pyrimidine analogues
     L01BC01 Cytarabine
      D00168  Cytarabine (JP18/USP/INN) <JP/US>
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  42  Antineoplastics
   422  Antimetabolites
    4224  Cytosines
     D00168  Cytarabine (JP18/USP/INN)
Drug groups [BR:br08330]
 Antineoplastic
  DG02018  Antimetabolite
   DG01958  Nucleic acid derivative, antineoplastic
    DG01439  Arabinofuranosyl type antineoplastic
     DG00686  Cytarabine
      D00168  Cytarabine
Drug classes [BR:br08332]
 Antineoplastic
  DG02018  Antimetabolite
   D00168  Cytarabine
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00168  Cytarabine
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D00168
Prodrugs [br08324.html]
 D00168
Drug groups [BR:br08330]
 Antineoplastic
  DG02018  Antimetabolite
   DG01958  Nucleic acid derivative, antineoplastic
    DG01439  Arabinofuranosyl type antineoplastic
     DG00686  Cytarabine
Other DBs
CAS: 147-94-4
PubChem: 7847236
ChEBI: 28680
PDB-CCD: AR3[PDBj]
LigandBox: D00168
NIKKAJI: J2.958K
LinkDB
KCF data

ATOM        17
            1   C1y C    22.3986  -17.4645
            2   N4y N    23.7916  -16.8812
            3   O2x O    21.2637  -16.6396
            4   C1y C    21.9658  -18.7927
            5   C8y C    25.0030  -17.5661
            6   C8x C    23.7682  -15.4827
            7   C1y C    20.1286  -17.4645
            8   C1y C    20.5616  -18.7927
            9   O1a O    22.7848  -19.9278
            10  N5x N    26.2080  -16.8485
            11  O5x O    25.0208  -18.9659
            12  C8x C    24.9731  -14.7651
            13  C1b C    18.7947  -17.0317
            14  O1a O    19.7425  -19.9278
            15  C8y C    26.1901  -15.4486
            16  O1a O    17.7591  -17.9735
            17  N1a N    27.3966  -14.7369
BOND        18
            1     1   2 1 #Up
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     4   8 1
            8     4   9 1 #Up
            9     5  10 1
            10    5  11 2
            11    6  12 2
            12    7  13 1 #Up
            13    8  14 1 #Down
            14   10  15 2
            15   13  16 1
            16   15  17 1
            17    7   8 1
            18   12  15 1

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