KEGG   DISEASE: Neoplastic meningitis
Entry
H01668                      Disease                                
Name
Neoplastic meningitis
Description
Neoplastic meningitis (NM) is a diffuse dissemination of tumor cells into the cerebrospinal fluid (CSF) and/or leptomeninges. NM is reported in patients with solid tumours (carcinomatous meningitis), haematological malignancies (leukaemic or lymphomatous meningitis), or primary brain tumours. Malignant cells reach the CSF and meninges by direct invasion from tumors located near or within the central nervous system (CNS), or via the bloodstream or other pathways that contact the CNS. The molecular changes responsible for the development of NM are not well delineated, but it is likely that they involve changes in molecules responsible for tumor cell adhesion, migration, and proliferation.
Category
Nervous system disease
Brite
Human diseases [BR:br08402]
 Nervous system diseases
  Other nervous and sensory system diseases
   H01668  Neoplastic meningitis
Human diseases in ICD-11 classification [BR:br08403]
 08 Diseases of the nervous system
  Other disorders of the nervous system
   8E40  Disorders of the meninges excluding infection
    H01668  Neoplastic meningitis
Drug
Cytarabine [DR:D00168]
Other DBs
ICD-11: 8E40.0
ICD-10: G03
MeSH: D008581
Reference
PMID:18776058 (marker, drug)
  Authors
Chamberlain MC
  Title
Neoplastic meningitis.
  Journal
Oncologist 13:967-77 (2008)
DOI:10.1634/theoncologist.2008-0138
Reference
PMID:25031995 (drug)
  Authors
Fields MM
  Title
How to recognize and treat neoplastic meningitis.
  Journal
J Adv Pract Oncol 4:155-60 (2013)
DOI:10.6004/jadpro.2013.4.3.3
Reference
  Authors
Strik H, Prommel P
  Title
Diagnosis and individualized therapy of neoplastic meningitis.
  Journal
Expert Rev Anticancer Ther 10:1137-48 (2010)
DOI:10.1586/era.10.86
Reference
PMID:16632315 (marker, drug)
  Authors
Gleissner B, Chamberlain MC
  Title
Neoplastic meningitis.
  Journal
Lancet Neurol 5:443-52 (2006)
DOI:10.1016/S1474-4422(06)70443-4
Reference
  Authors
Mammoser AG, Groves MD
  Title
Biology and therapy of neoplastic meningitis.
  Journal
Curr Oncol Rep 12:41-9 (2010)
DOI:10.1007/s11912-009-0079-2
Reference
  Authors
Groves MD
  Title
The pathogenesis of neoplastic meningitis.
  Journal
Curr Oncol Rep 5:15-23 (2003)
DOI:10.1007/s11912-003-0082-y
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